ATE82276T1 - Benzthiazol-derivate, ihre anwendung und pharmazeutische zusammensetzungen, die sie enthalten. - Google Patents

Benzthiazol-derivate, ihre anwendung und pharmazeutische zusammensetzungen, die sie enthalten.

Info

Publication number
ATE82276T1
ATE82276T1 AT88109552T AT88109552T ATE82276T1 AT E82276 T1 ATE82276 T1 AT E82276T1 AT 88109552 T AT88109552 T AT 88109552T AT 88109552 T AT88109552 T AT 88109552T AT E82276 T1 ATE82276 T1 AT E82276T1
Authority
AT
Austria
Prior art keywords
pharmaceutical compositions
contain
applications
benzthiazole derivatives
benzthiazole
Prior art date
Application number
AT88109552T
Other languages
English (en)
Inventor
Shinya Abe
Mitsuaki Miyamoto
Masayuki Tanaka
Kozo Akasaka
Kenji Hayashi
Tetsuya Kawahara
Toshi Katayama
Yoshinori Sakuma
Takeshi Suzuki
Isao Yamatsu
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Application granted granted Critical
Publication of ATE82276T1 publication Critical patent/ATE82276T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/84—Naphthothiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Paper (AREA)
AT88109552T 1987-06-17 1988-06-15 Benzthiazol-derivate, ihre anwendung und pharmazeutische zusammensetzungen, die sie enthalten. ATE82276T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP15098787 1987-06-17
EP88109552A EP0295656B1 (de) 1987-06-17 1988-06-15 Benzthiazol-Derivate, ihre Anwendung und pharmazeutische Zusammensetzungen, die sie enthalten

Publications (1)

Publication Number Publication Date
ATE82276T1 true ATE82276T1 (de) 1992-11-15

Family

ID=15508808

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88109552T ATE82276T1 (de) 1987-06-17 1988-06-15 Benzthiazol-derivate, ihre anwendung und pharmazeutische zusammensetzungen, die sie enthalten.

Country Status (21)

Country Link
US (1) US4929623A (de)
EP (1) EP0295656B1 (de)
JP (1) JP2793195B2 (de)
KR (1) KR910005709B1 (de)
CN (1) CN1030757A (de)
AT (1) ATE82276T1 (de)
AU (1) AU610186B2 (de)
CA (1) CA1322369C (de)
DD (1) DD282686A5 (de)
DE (1) DE3875809T2 (de)
DK (1) DK328888A (de)
ES (1) ES2045017T3 (de)
FI (1) FI91859C (de)
GR (1) GR3006207T3 (de)
HU (1) HU205347B (de)
NO (1) NO170929C (de)
NZ (1) NZ224946A (de)
PH (1) PH26553A (de)
PT (1) PT87747B (de)
SU (1) SU1731051A3 (de)
ZA (1) ZA884277B (de)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0375510B1 (de) * 1988-12-15 1992-11-11 Rhone-Poulenc Sante 2-Imino-6-polyfluoralkoxy-benzothiazol-Derivate, Verfahren zu deren Herstellung und Arzneimittel, die sie enthalten
IL97249A (en) * 1990-02-23 1995-01-24 Takeda Chemical Industries Ltd Compounds of 7,6,5,4-tetrahydrothiazole] B-5,4 [pyridine and compounds of 5,6-dihydro-H4-pyrrolo] D-3,2 [thiazole, their manufacture, and pharmaceutical compositions including or
IE920921A1 (en) * 1991-04-04 1992-10-07 Eisai Co Ltd Benzothiazole derivative
US5296486A (en) * 1991-09-24 1994-03-22 Boehringer Ingelheim Pharmaceuticals, Inc. Leukotriene biosynthesis inhibitors
US5350760A (en) * 1993-08-04 1994-09-27 Merck Frosst Canada, Inc. Aza-5,5-fused hetrocyclic acids as leukotriene antagonists
WO1997048694A1 (en) * 1996-06-20 1997-12-24 Board Of Regents, The University Of Texas System Compounds and methods for providing pharmacologically active preparations and uses thereof
JP2002516820A (ja) 1997-11-13 2002-06-11 ヒスタテク・エルエルシー 低分子量ペプチド及び喘息及び炎症の治療方法
US6686357B1 (en) 1999-07-15 2004-02-03 Pfizer, Inc. FKBP inhibitors
GB9815696D0 (en) * 1998-07-20 1998-09-16 Pfizer Ltd Heterocyclics
EP1150565A1 (de) * 1999-02-08 2001-11-07 LION bioscience AG Thiazol-derivate und sie enthaltende kombinatorische bibliotheken
EP1178977B1 (de) * 1999-05-12 2005-06-01 Neurosearch A/S Ionenkanal modulierende mittel
TWI284639B (en) 2000-01-24 2007-08-01 Shionogi & Co A compound having thrombopoietin receptor agonistic effect
CA2408156A1 (en) * 2000-05-05 2001-11-15 Millennium Pharmaceuticals, Inc. Heterobicyclic sulfonamides and their use as platelet adp receptor inhibitors
US6756047B2 (en) 2000-05-12 2004-06-29 The University Of Toledo Method and compositions for treating persistent pulmonary hypertension using aralkyl ester soft drugs
US6750238B1 (en) * 2000-05-12 2004-06-15 The University Of Toledo Aralkyl ester soft drugs
US7049326B2 (en) * 2000-05-12 2006-05-23 The University Of Toledo Method and compositions for temporarily incapacitating subjects
NZ522928A (en) 2000-06-21 2005-05-27 F Benzothiazole derivatives
US6620811B2 (en) * 2001-11-19 2003-09-16 Hoffmann-La Roche Inc. Isonicotin- and nicotinamide derivatives of benzothiazoles
US6624163B2 (en) 2001-11-29 2003-09-23 Hoffman-La Roche Inc. Benzothiazole derivatives
US7338956B2 (en) * 2002-08-07 2008-03-04 Sanofi-Aventis Deutschland Gmbh Acylamino-substituted heteroaromatic compounds and their use as pharmaceuticals
US7087761B2 (en) 2003-01-07 2006-08-08 Hoffmann-La Roche Inc. Cyclization process for substituted benzothiazole derivatives
DE602004016328D1 (de) * 2003-05-13 2008-10-16 Hoffmann La Roche 2-imidazo-benzothiazole als adenosin-rezeptor liganden
AU2004251814B2 (en) * 2003-05-19 2009-07-23 F. Hoffmann-La Roche Ag Benzothiazole derivatives as adenosine receptor ligands
EP1628662B1 (de) * 2003-05-21 2007-02-14 F. Hoffmann-La Roche Ag Benzothiazole derivate und ihre anwendung in der behandlung von adenosine a2a rezeptor vermittelte krankheiten
MXPA05012772A (es) * 2003-05-30 2006-02-13 Hoffmann La Roche Derivados de benzotiazol y uso de los mismos en el tratamiento de enfermedades relacionadas con el receptor a2a de adenosina.
US20050118291A1 (en) * 2003-09-10 2005-06-02 Mian-Ying Wang Formulations and methods for treating breast cancer with Morinda citrifolia and methylsulfonymethane
US7601746B2 (en) 2003-08-12 2009-10-13 Shionogi & Co., Ltd. Compounds exhibiting thrombopoietin receptor agonism
CN1956983B (zh) 2004-05-24 2010-05-26 弗·哈夫曼-拉罗切有限公司 4-羟基-4-甲基-哌啶-1-甲酸(4-甲氧基-7-吗啉-4-基-苯并噻唑-2-基)-酰胺
NZ552650A (en) * 2004-08-05 2010-09-30 Hoffmann La Roche Substituted N-acyl-2-aminothiazoles
CA2586931C (en) 2004-11-05 2013-08-06 Paul Spurr Process for preparation of isonicotinic acid derivatives
RU2412943C2 (ru) 2005-03-23 2011-02-27 Ф. Хоффманн-Ля Рош Аг ПРОИЗВОДНЫЕ АЦЕТИЛЕНИЛ-ПИРАЗОЛО-ПИРИМИДИНА В КАЧЕСТВЕ АНТАГОНИСТОВ mGluR2
ES2340321T3 (es) 2005-09-27 2010-06-01 F.Hoffmann-La Roche Ag Oxadiazolilpirazolo-pirimidinas, como antagonistas de mglur2.
US8394842B2 (en) 2006-03-28 2013-03-12 High Point Pharmaceuticals, Llc Benzothiazoles having histamine H3 receptor activity
CA2721099C (en) * 2008-04-11 2017-04-25 Janssen Pharmaceutica Nv Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene a4 hydrolase
UY32138A (es) 2008-09-25 2010-04-30 Boehringer Ingelheim Int Amidas sustituidas del ácido 2-(2,6-dicloro-fenilamino)-6-fluoro-1-metil-1h-bencimidazol-5-carboxílico y sus sales farmacéuticamente aceptables
UY32470A (es) 2009-03-05 2010-10-29 Boehringer Ingelheim Int Derivados de 2-{2-cloro-5-[(sustituido) metil]fenilamino} -1-metil]fenilamino}-1-metilbencimidazol-5-carboxamidas-n-(sustituidas) y sus sales fisiológicamente aceptables, composiciones conteniéndolos y aplicaciones
WO2010106016A1 (en) * 2009-03-17 2010-09-23 Glaxo Group Limited Pyrimidine derivatives used as itk inhibitors
US8759537B2 (en) 2010-08-20 2014-06-24 Boehringer Ingelheim International Gmbh 3H-imidazo [4, 5-C] pyridine-6-carboxamides as anti-inflammatory agents
US8586604B2 (en) 2010-08-20 2013-11-19 Boehringer Ingelheim International Gmbh Inhibitors of the microsomal prostaglandin E2 synthase-1
UY33779A (es) 2010-12-10 2012-07-31 Boehringer Ingelheim Int ?2-(fenilamino)-1H-bencimidazol-5-carboxamidas novedosas?
US8466186B2 (en) 2010-12-10 2013-06-18 Boehringer Ingelheim International Gmbh Compounds
US8486968B2 (en) 2010-12-10 2013-07-16 Boehringer Ingelheim International Gmbh Compounds
CN102872012B (zh) * 2011-11-03 2015-03-25 成都医学院 一种抑制蛋白激酶化合物的用途
CN113959912B (zh) * 2020-07-20 2024-06-21 深圳迈瑞生物医疗电子股份有限公司 抗血小板聚集干扰的白细胞检测方法、试剂及其应用
CN113959911B (zh) * 2020-07-20 2024-06-18 深圳迈瑞生物医疗电子股份有限公司 抗血小板聚集干扰的检测方法、试剂及其应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2617198A (en) * 1945-06-13 1952-11-11 Better Packages Inc Pull-out measuring tape dispenser
DE927507C (de) * 1953-02-24 1955-05-09 Bayer Ag Verfahren zur Herstellung von Derivaten des 6-Oxy-2-aminobenzthiazols
GB808191A (en) * 1956-07-13 1959-01-28 Robert Ronald Davies New dyestuff intermediates
US4006242A (en) * 1973-07-18 1977-02-01 Schering Corporation Certain benzothiazoles used in the treatment of helminthiasis
AR204835A1 (es) * 1973-07-18 1976-03-05 Scherico Ltd Procedimiento para preparar benzotiazol-2-carbamatos de etilo
DK148476C (da) 1975-04-25 1985-12-16 Scherico Ltd Analogifremgangsmaade til fremstilling af methyl-6-n-propoxybenzothiazol-2-carbamat
JPS5221054A (en) * 1975-08-11 1977-02-17 Teijin Ltd Polyamide composition
DE2656468A1 (de) * 1976-12-14 1978-06-15 Boehringer Mannheim Gmbh N-(benzthiazol-2-yl)-oxamidsaeure- derivate und verfahren zu ihrer herstellung
DE2963316D1 (en) * 1978-01-18 1982-09-02 Hoechst Ag Process for the preparation of 2-amino-arylenothiazole compounds and their ring n-substituted derivatives
JPS5740492A (en) * 1980-08-22 1982-03-06 Yamanouchi Pharmaceut Co Ltd Novel 2-phenylimidazo 2,1-b benzothiazole derivative
US4581457A (en) * 1984-09-21 1986-04-08 American Home Products Corporation Heterocyclic sulfonamides

Also Published As

Publication number Publication date
DK328888D0 (da) 1988-06-16
DE3875809T2 (de) 1993-04-15
NO882627D0 (no) 1988-06-15
DD282686A5 (de) 1990-09-19
NO882627L (no) 1988-12-19
JP2793195B2 (ja) 1998-09-03
FI882692L (fi) 1988-12-18
KR910005709B1 (ko) 1991-08-02
NZ224946A (en) 1990-07-26
NO170929C (no) 1993-01-06
GR3006207T3 (de) 1993-06-21
DK328888A (da) 1988-12-18
DE3875809D1 (de) 1992-12-17
JPS6479162A (en) 1989-03-24
FI91859B (fi) 1994-05-13
PH26553A (en) 1992-08-19
ES2045017T3 (es) 1994-01-16
FI91859C (fi) 1994-08-25
NO170929B (no) 1992-09-21
AU1769988A (en) 1988-12-22
EP0295656B1 (de) 1992-11-11
PT87747A (pt) 1988-07-01
PT87747B (pt) 1992-10-30
HU205347B (en) 1992-04-28
US4929623A (en) 1990-05-29
KR890000451A (ko) 1989-03-14
FI882692A0 (fi) 1988-06-07
CN1030757A (zh) 1989-02-01
ZA884277B (en) 1989-03-29
EP0295656A1 (de) 1988-12-21
HUT47554A (en) 1989-03-28
AU610186B2 (en) 1991-05-16
SU1731051A3 (ru) 1992-04-30
CA1322369C (en) 1993-09-21

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