ES2045017T3 - Derivado de benzotiazol, su utilizacion y compuestos farmaceuticos que lo comprenden. - Google Patents

Derivado de benzotiazol, su utilizacion y compuestos farmaceuticos que lo comprenden.

Info

Publication number
ES2045017T3
ES2045017T3 ES88109552T ES88109552T ES2045017T3 ES 2045017 T3 ES2045017 T3 ES 2045017T3 ES 88109552 T ES88109552 T ES 88109552T ES 88109552 T ES88109552 T ES 88109552T ES 2045017 T3 ES2045017 T3 ES 2045017T3
Authority
ES
Spain
Prior art keywords
benzotiazole
understand
derived
pharmaceutical compounds
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88109552T
Other languages
English (en)
Inventor
Shinya Abe
Mitsuaki Miyamoto
Masayuki Tanaka
Kozo Akasaka
Kenji Hayashi
Tetsuya Kawahara
Toshi Katayama
Yoshinori Sakuma
Takeshi Suzuki
Isao Yamatsu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Application granted granted Critical
Publication of ES2045017T3 publication Critical patent/ES2045017T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/84—Naphthothiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Paper (AREA)

Abstract

LA INVENCION SE REFIERE A UN COMPUESTO DE BENZOTIAZOL QUE TIENE LA FORMULA GENERAL (I) (EN LA QUE R2O ES UN ESTER O AMIDA Y -NR5R6 ES UN GRUPO AMINO DIVERSAMENTE SUSTITUIDO), Y A COMPOSICIONES FARMCEUTICAS QUE LO CONTIENEN, QUE SON EFECTIVAS PARA INHIBIR LA PRODUCCION DE LEUCOTRIENO. LOS COMPUESTOS SE PUEDEN EMPLEAR EN LA PREPARACION DE MEDICAMETOS EFECTIVOS CONTRA LA ALERGIA, ASMA, AFECCIONES DE LA PIEL, RINITIS ALERGICA Y AFECCIONES DEL SISTEMA CARDIOVASCULAR.
ES88109552T 1987-06-17 1988-06-15 Derivado de benzotiazol, su utilizacion y compuestos farmaceuticos que lo comprenden. Expired - Lifetime ES2045017T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15098787 1987-06-17

Publications (1)

Publication Number Publication Date
ES2045017T3 true ES2045017T3 (es) 1994-01-16

Family

ID=15508808

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88109552T Expired - Lifetime ES2045017T3 (es) 1987-06-17 1988-06-15 Derivado de benzotiazol, su utilizacion y compuestos farmaceuticos que lo comprenden.

Country Status (21)

Country Link
US (1) US4929623A (es)
EP (1) EP0295656B1 (es)
JP (1) JP2793195B2 (es)
KR (1) KR910005709B1 (es)
CN (1) CN1030757A (es)
AT (1) ATE82276T1 (es)
AU (1) AU610186B2 (es)
CA (1) CA1322369C (es)
DD (1) DD282686A5 (es)
DE (1) DE3875809T2 (es)
DK (1) DK328888A (es)
ES (1) ES2045017T3 (es)
FI (1) FI91859C (es)
GR (1) GR3006207T3 (es)
HU (1) HU205347B (es)
NO (1) NO170929C (es)
NZ (1) NZ224946A (es)
PH (1) PH26553A (es)
PT (1) PT87747B (es)
SU (1) SU1731051A3 (es)
ZA (1) ZA884277B (es)

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IL97249A (en) * 1990-02-23 1995-01-24 Takeda Chemical Industries Ltd Compounds of 7,6,5,4-tetrahydrothiazole] B-5,4 [pyridine and compounds of 5,6-dihydro-H4-pyrrolo] D-3,2 [thiazole, their manufacture, and pharmaceutical compositions including or
IE920921A1 (en) * 1991-04-04 1992-10-07 Eisai Co Ltd Benzothiazole derivative
US5296486A (en) * 1991-09-24 1994-03-22 Boehringer Ingelheim Pharmaceuticals, Inc. Leukotriene biosynthesis inhibitors
US5350760A (en) * 1993-08-04 1994-09-27 Merck Frosst Canada, Inc. Aza-5,5-fused hetrocyclic acids as leukotriene antagonists
WO1997048694A1 (en) * 1996-06-20 1997-12-24 Board Of Regents, The University Of Texas System Compounds and methods for providing pharmacologically active preparations and uses thereof
AU8477998A (en) 1997-11-13 1999-06-07 Histatek, Llc Small peptides and methods for treatment of asthma and inflammation
GB9815696D0 (en) * 1998-07-20 1998-09-16 Pfizer Ltd Heterocyclics
EP1150565A1 (en) * 1999-02-08 2001-11-07 LION bioscience AG Thiazole derivatives and combinatorial libraries thereof
DE60020556T2 (de) * 1999-05-12 2005-10-27 Neurosearch A/S Ionenkanal modulierende mittel
US6509464B1 (en) 1999-07-15 2003-01-21 Pfizer Inc FKBP inhibitors
TWI284639B (en) * 2000-01-24 2007-08-01 Shionogi & Co A compound having thrombopoietin receptor agonistic effect
JP2003532728A (ja) * 2000-05-05 2003-11-05 コー セラピューティックス， インコーポレイテッド ヘテロ二環式スルホンアミドおよび血小板ａｄｐレセプターインヒビターとしてのそれらの使用
US6750238B1 (en) * 2000-05-12 2004-06-15 The University Of Toledo Aralkyl ester soft drugs
US6756047B2 (en) * 2000-05-12 2004-06-29 The University Of Toledo Method and compositions for treating persistent pulmonary hypertension using aralkyl ester soft drugs
US7049326B2 (en) * 2000-05-12 2006-05-23 The University Of Toledo Method and compositions for temporarily incapacitating subjects
MXPA02012596A (es) 2000-06-21 2003-04-10 Hoffmann La Roche Derivados de benzotiazol.
US6620811B2 (en) * 2001-11-19 2003-09-16 Hoffmann-La Roche Inc. Isonicotin- and nicotinamide derivatives of benzothiazoles
US6624163B2 (en) * 2001-11-29 2003-09-23 Hoffman-La Roche Inc. Benzothiazole derivatives
US7338956B2 (en) * 2002-08-07 2008-03-04 Sanofi-Aventis Deutschland Gmbh Acylamino-substituted heteroaromatic compounds and their use as pharmaceuticals
US7087761B2 (en) 2003-01-07 2006-08-08 Hoffmann-La Roche Inc. Cyclization process for substituted benzothiazole derivatives
US20050118291A1 (en) * 2003-09-10 2005-06-02 Mian-Ying Wang Formulations and methods for treating breast cancer with Morinda citrifolia and methylsulfonymethane
EP1655291B1 (en) 2003-08-12 2016-08-03 Shionogi & Co., Ltd. Compounds having thrombopoietin receptor agonism
EA011279B1 (ru) 2004-05-24 2009-02-27 Ф. Хоффманн-Ля Рош Аг (4-метокси-7-морфолин-4-илбензотиазол-2-ил)-амид 4-гидрокси-4-метилпиперидин-1-карбоновой кислоты
JP2008508336A (ja) * 2004-08-05 2008-03-21 エフ．ホフマン−ラ　ロシュ　アーゲー 置換されたｎ−アシル−２−アミノチアゾール
CN101056857B (zh) 2004-11-05 2010-12-01 弗·哈夫曼-拉罗切有限公司 异烟酸衍生物的制备方法
CA2602444C (en) 2005-03-23 2013-03-19 F.Hoffmann-La Roche Ag Acetylenyl-pyrazolo-pyrimidine derivatives as mglur2 antagonists
KR101121292B1 (ko) 2005-09-27 2012-04-13 에프. 호프만-라 로슈 아게 Ｍｇｌｕｒ2 길항제로서 옥사다이아졸일 피라졸로-피리미딘
JP2009531376A (ja) 2006-03-28 2009-09-03 ハイ ポイント ファーマシューティカルズ，リミティド ライアビリティ カンパニー ヒスタミンｈ３受容体活性を有するベンゾチアゾール
EP2336125B1 (en) * 2008-04-11 2013-01-09 Janssen Pharmaceutica N.V. Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene A4 hydrolase
UY32138A (es) 2008-09-25 2010-04-30 Boehringer Ingelheim Int Amidas sustituidas del ácido 2-(2,6-dicloro-fenilamino)-6-fluoro-1-metil-1h-bencimidazol-5-carboxílico y sus sales farmacéuticamente aceptables
UY32470A (es) 2009-03-05 2010-10-29 Boehringer Ingelheim Int Derivados de 2-{2-cloro-5-[(sustituido) metil]fenilamino} -1-metil]fenilamino}-1-metilbencimidazol-5-carboxamidas-n-(sustituidas) y sus sales fisiológicamente aceptables, composiciones conteniéndolos y aplicaciones
US20120058984A1 (en) * 2009-03-17 2012-03-08 Catherine Mary Alder Pyrimidine derivatives used as itk inhibitors
US8586604B2 (en) 2010-08-20 2013-11-19 Boehringer Ingelheim International Gmbh Inhibitors of the microsomal prostaglandin E2 synthase-1
US8759537B2 (en) 2010-08-20 2014-06-24 Boehringer Ingelheim International Gmbh 3H-imidazo [4, 5-C] pyridine-6-carboxamides as anti-inflammatory agents
US8486968B2 (en) 2010-12-10 2013-07-16 Boehringer Ingelheim International Gmbh Compounds
UY33779A (es) 2010-12-10 2012-07-31 Boehringer Ingelheim Int ?2-(fenilamino)-1H-bencimidazol-5-carboxamidas novedosas?
US8466186B2 (en) 2010-12-10 2013-06-18 Boehringer Ingelheim International Gmbh Compounds
CN102872012B (zh) * 2011-11-03 2015-03-25 成都医学院 一种抑制蛋白激酶化合物的用途
CN113959911A (zh) * 2020-07-20 2022-01-21 深圳迈瑞生物医疗电子股份有限公司 抗血小板聚集干扰的检测方法、试剂及其应用
CN113959912A (zh) * 2020-07-20 2022-01-21 深圳迈瑞生物医疗电子股份有限公司 抗血小板聚集干扰的白细胞检测方法、试剂及其应用

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Also Published As

Publication number Publication date
DK328888A (da) 1988-12-18
EP0295656A1 (en) 1988-12-21
US4929623A (en) 1990-05-29
DD282686A5 (de) 1990-09-19
FI882692A (fi) 1988-12-18
KR910005709B1 (ko) 1991-08-02
DE3875809D1 (de) 1992-12-17
HU205347B (en) 1992-04-28
FI91859C (fi) 1994-08-25
SU1731051A3 (ru) 1992-04-30
AU610186B2 (en) 1991-05-16
AU1769988A (en) 1988-12-22
DK328888D0 (da) 1988-06-16
JPS6479162A (en) 1989-03-24
EP0295656B1 (en) 1992-11-11
PH26553A (en) 1992-08-19
FI91859B (fi) 1994-05-13
DE3875809T2 (de) 1993-04-15
NZ224946A (en) 1990-07-26
FI882692A0 (fi) 1988-06-07
NO170929C (no) 1993-01-06
PT87747B (pt) 1992-10-30
GR3006207T3 (es) 1993-06-21
PT87747A (pt) 1988-07-01
KR890000451A (ko) 1989-03-14
NO882627L (no) 1988-12-19
ATE82276T1 (de) 1992-11-15
CN1030757A (zh) 1989-02-01
NO882627D0 (no) 1988-06-15
ZA884277B (en) 1989-03-29
HUT47554A (en) 1989-03-28
JP2793195B2 (ja) 1998-09-03
CA1322369C (en) 1993-09-21
NO170929B (no) 1992-09-21

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