DE3875809T2 - Benzthiazol-derivate, ihre anwendung und pharmazeutische zusammensetzungen, die sie enthalten. - Google Patents

Benzthiazol-derivate, ihre anwendung und pharmazeutische zusammensetzungen, die sie enthalten.

Info

Publication number
DE3875809T2
DE3875809T2 DE8888109552T DE3875809T DE3875809T2 DE 3875809 T2 DE3875809 T2 DE 3875809T2 DE 8888109552 T DE8888109552 T DE 8888109552T DE 3875809 T DE3875809 T DE 3875809T DE 3875809 T2 DE3875809 T2 DE 3875809T2
Authority
DE
Germany
Prior art keywords
pharmaceutical compositions
benzthiazole derivatives
benzthiazole
derivatives
effective
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8888109552T
Other languages
English (en)
Other versions
DE3875809D1 (de
Inventor
Shinya Abe
Mitsuaki Miyamoto
Masayuki Tanaka
Kozo Akasaka
Kenji Hayashi
Tetsuya Kawahara
Toshi Katayama
Yoshinori Sakuma
Takeshi Suzuki
Isao Yamatsu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Application granted granted Critical
Publication of DE3875809D1 publication Critical patent/DE3875809D1/de
Publication of DE3875809T2 publication Critical patent/DE3875809T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/84—Naphthothiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
DE8888109552T 1987-06-17 1988-06-15 Benzthiazol-derivate, ihre anwendung und pharmazeutische zusammensetzungen, die sie enthalten. Expired - Fee Related DE3875809T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15098787 1987-06-17

Publications (2)

Publication Number Publication Date
DE3875809D1 DE3875809D1 (de) 1992-12-17
DE3875809T2 true DE3875809T2 (de) 1993-04-15

Family

ID=15508808

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8888109552T Expired - Fee Related DE3875809T2 (de) 1987-06-17 1988-06-15 Benzthiazol-derivate, ihre anwendung und pharmazeutische zusammensetzungen, die sie enthalten.

Country Status (21)

Country Link
US (1) US4929623A (de)
EP (1) EP0295656B1 (de)
JP (1) JP2793195B2 (de)
KR (1) KR910005709B1 (de)
CN (1) CN1030757A (de)
AT (1) ATE82276T1 (de)
AU (1) AU610186B2 (de)
CA (1) CA1322369C (de)
DD (1) DD282686A5 (de)
DE (1) DE3875809T2 (de)
DK (1) DK328888A (de)
ES (1) ES2045017T3 (de)
FI (1) FI91859C (de)
GR (1) GR3006207T3 (de)
HU (1) HU205347B (de)
NO (1) NO170929C (de)
NZ (1) NZ224946A (de)
PH (1) PH26553A (de)
PT (1) PT87747B (de)
SU (1) SU1731051A3 (de)
ZA (1) ZA884277B (de)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE68903484T2 (de) * 1988-12-15 1993-03-18 Rhone Poulenc Sante 2-imino-6-polyfluoralkoxy-benzothiazol-derivate, verfahren zu deren herstellung und arzneimittel, die sie enthalten.
IL97249A (en) * 1990-02-23 1995-01-24 Takeda Chemical Industries Ltd Compounds of 7,6,5,4-tetrahydrothiazole] B-5,4 [pyridine and compounds of 5,6-dihydro-H4-pyrrolo] D-3,2 [thiazole, their manufacture, and pharmaceutical compositions including or
IE920921A1 (en) * 1991-04-04 1992-10-07 Eisai Co Ltd Benzothiazole derivative
US5296486A (en) * 1991-09-24 1994-03-22 Boehringer Ingelheim Pharmaceuticals, Inc. Leukotriene biosynthesis inhibitors
US5350760A (en) * 1993-08-04 1994-09-27 Merck Frosst Canada, Inc. Aza-5,5-fused hetrocyclic acids as leukotriene antagonists
BR9711805A (pt) 1996-06-20 2002-01-15 Regents The Univesity Of Texas Compostos e métodos para providenciar preparações farmacologicamente ativas e uso dos mesmos
EP1037651B1 (de) * 1997-11-13 2009-05-27 Mowycal Lending, LLC Kleine peptide und methoden zur behandlung von asthma und entzündungen
GB9815696D0 (en) * 1998-07-20 1998-09-16 Pfizer Ltd Heterocyclics
AU3487500A (en) * 1999-02-08 2000-08-25 Lion Bioscience Ag Thiazole derivatives and combinatorial libraries thereof
AU4537500A (en) * 1999-05-12 2000-12-05 Neurosearch A/S Ion channel modulating agents
US6509464B1 (en) 1999-07-15 2003-01-21 Pfizer Inc FKBP inhibitors
TWI284639B (en) * 2000-01-24 2007-08-01 Shionogi & Co A compound having thrombopoietin receptor agonistic effect
CA2408156A1 (en) * 2000-05-05 2001-11-15 Millennium Pharmaceuticals, Inc. Heterobicyclic sulfonamides and their use as platelet adp receptor inhibitors
US6750238B1 (en) * 2000-05-12 2004-06-15 The University Of Toledo Aralkyl ester soft drugs
US7049326B2 (en) * 2000-05-12 2006-05-23 The University Of Toledo Method and compositions for temporarily incapacitating subjects
US6756047B2 (en) * 2000-05-12 2004-06-29 The University Of Toledo Method and compositions for treating persistent pulmonary hypertension using aralkyl ester soft drugs
MXPA02012596A (es) 2000-06-21 2003-04-10 Hoffmann La Roche Derivados de benzotiazol.
US6620811B2 (en) 2001-11-19 2003-09-16 Hoffmann-La Roche Inc. Isonicotin- and nicotinamide derivatives of benzothiazoles
US6624163B2 (en) * 2001-11-29 2003-09-23 Hoffman-La Roche Inc. Benzothiazole derivatives
US7338956B2 (en) * 2002-08-07 2008-03-04 Sanofi-Aventis Deutschland Gmbh Acylamino-substituted heteroaromatic compounds and their use as pharmaceuticals
US7087761B2 (en) 2003-01-07 2006-08-08 Hoffmann-La Roche Inc. Cyclization process for substituted benzothiazole derivatives
EP1655291B1 (de) 2003-08-12 2016-08-03 Shionogi & Co., Ltd. Verbindungen mit thrombopoietinrezeptoragonismus
US20050118291A1 (en) * 2003-09-10 2005-06-02 Mian-Ying Wang Formulations and methods for treating breast cancer with Morinda citrifolia and methylsulfonymethane
PT1753760E (pt) 2004-05-24 2008-02-12 Hoffmann La Roche '' - metoxi - 7 - morfolin - 4 - il - benzotiazol - 2 - il) - amida do ácido 4 - hidroxi - 4 - metil - piperidina - 1 - carboxílico''
MX2007001271A (es) * 2004-08-05 2007-03-21 Hoffmann La Roche N-acil-2-aminotiazoles sustituidos.
DE602005008095D1 (de) 2004-11-05 2008-08-21 Hoffmann La Roche Verfahren zur herstellung von isonikotinsäurederivaten
RU2412943C2 (ru) 2005-03-23 2011-02-27 Ф. Хоффманн-Ля Рош Аг ПРОИЗВОДНЫЕ АЦЕТИЛЕНИЛ-ПИРАЗОЛО-ПИРИМИДИНА В КАЧЕСТВЕ АНТАГОНИСТОВ mGluR2
ATE463495T1 (de) 2005-09-27 2010-04-15 Hoffmann La Roche Oxadiazolylpyrazolopyrimidine als mglur2- antagonisten
KR101280333B1 (ko) 2006-03-28 2013-07-02 하이 포인트 파마슈티칼스, 엘엘씨 히스타민 ｈ３ 수용체 활성을 갖는 벤조티아졸
ES2440746T3 (es) * 2008-04-11 2014-01-30 Janssen Pharmaceutica, N.V. Triazolopiridina-2-iloxi-fenil y triazolopiridina-iloxi-fenil amino como moduladores del leucotrieno A4 hidrolasa
UY32138A (es) 2008-09-25 2010-04-30 Boehringer Ingelheim Int Amidas sustituidas del ácido 2-(2,6-dicloro-fenilamino)-6-fluoro-1-metil-1h-bencimidazol-5-carboxílico y sus sales farmacéuticamente aceptables
UY32470A (es) 2009-03-05 2010-10-29 Boehringer Ingelheim Int Derivados de 2-{2-cloro-5-[(sustituido) metil]fenilamino} -1-metil]fenilamino}-1-metilbencimidazol-5-carboxamidas-n-(sustituidas) y sus sales fisiológicamente aceptables, composiciones conteniéndolos y aplicaciones
EP2408769A1 (de) * 2009-03-17 2012-01-25 Glaxo Group Limited Als itk-inhibitoren verwendete pyrimidinderivate
US8759537B2 (en) 2010-08-20 2014-06-24 Boehringer Ingelheim International Gmbh 3H-imidazo [4, 5-C] pyridine-6-carboxamides as anti-inflammatory agents
US8586604B2 (en) 2010-08-20 2013-11-19 Boehringer Ingelheim International Gmbh Inhibitors of the microsomal prostaglandin E2 synthase-1
US8486968B2 (en) 2010-12-10 2013-07-16 Boehringer Ingelheim International Gmbh Compounds
US8466186B2 (en) 2010-12-10 2013-06-18 Boehringer Ingelheim International Gmbh Compounds
US8674113B2 (en) 2010-12-10 2014-03-18 Boehringer Ingelheim International Gmbh Compounds
CN102872012B (zh) * 2011-11-03 2015-03-25 成都医学院 一种抑制蛋白激酶化合物的用途
CN113959911A (zh) * 2020-07-20 2022-01-21 深圳迈瑞生物医疗电子股份有限公司 抗血小板聚集干扰的检测方法、试剂及其应用
CN113959912A (zh) * 2020-07-20 2022-01-21 深圳迈瑞生物医疗电子股份有限公司 抗血小板聚集干扰的白细胞检测方法、试剂及其应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2617198A (en) * 1945-06-13 1952-11-11 Better Packages Inc Pull-out measuring tape dispenser
DE927507C (de) * 1953-02-24 1955-05-09 Bayer Ag Verfahren zur Herstellung von Derivaten des 6-Oxy-2-aminobenzthiazols
GB808191A (en) * 1956-07-13 1959-01-28 Robert Ronald Davies New dyestuff intermediates
AR204835A1 (es) * 1973-07-18 1976-03-05 Scherico Ltd Procedimiento para preparar benzotiazol-2-carbamatos de etilo
US4006242A (en) * 1973-07-18 1977-02-01 Schering Corporation Certain benzothiazoles used in the treatment of helminthiasis
DK148476C (da) * 1975-04-25 1985-12-16 Scherico Ltd Analogifremgangsmaade til fremstilling af methyl-6-n-propoxybenzothiazol-2-carbamat
JPS5221054A (en) * 1975-08-11 1977-02-17 Teijin Ltd Polyamide composition
DE2656468A1 (de) * 1976-12-14 1978-06-15 Boehringer Mannheim Gmbh N-(benzthiazol-2-yl)-oxamidsaeure- derivate und verfahren zu ihrer herstellung
DE2963316D1 (en) * 1978-01-18 1982-09-02 Hoechst Ag Process for the preparation of 2-amino-arylenothiazole compounds and their ring n-substituted derivatives
JPS5740492A (en) * 1980-08-22 1982-03-06 Yamanouchi Pharmaceut Co Ltd Novel 2-phenylimidazo 2,1-b benzothiazole derivative
US4581457A (en) * 1984-09-21 1986-04-08 American Home Products Corporation Heterocyclic sulfonamides

Also Published As

Publication number Publication date
DK328888D0 (da) 1988-06-16
DK328888A (da) 1988-12-18
EP0295656B1 (de) 1992-11-11
SU1731051A3 (ru) 1992-04-30
CN1030757A (zh) 1989-02-01
DD282686A5 (de) 1990-09-19
PT87747B (pt) 1992-10-30
NO882627L (no) 1988-12-19
ATE82276T1 (de) 1992-11-15
US4929623A (en) 1990-05-29
FI882692A (fi) 1988-12-18
FI91859B (fi) 1994-05-13
ZA884277B (en) 1989-03-29
NO882627D0 (no) 1988-06-15
JP2793195B2 (ja) 1998-09-03
CA1322369C (en) 1993-09-21
HU205347B (en) 1992-04-28
HUT47554A (en) 1989-03-28
AU1769988A (en) 1988-12-22
NO170929B (no) 1992-09-21
AU610186B2 (en) 1991-05-16
PT87747A (pt) 1988-07-01
EP0295656A1 (de) 1988-12-21
KR890000451A (ko) 1989-03-14
JPS6479162A (en) 1989-03-24
FI882692A0 (fi) 1988-06-07
FI91859C (fi) 1994-08-25
NZ224946A (en) 1990-07-26
GR3006207T3 (de) 1993-06-21
PH26553A (en) 1992-08-19
DE3875809D1 (de) 1992-12-17
ES2045017T3 (es) 1994-01-16
KR910005709B1 (ko) 1991-08-02
NO170929C (no) 1993-01-06

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee