PT86986A - Substituted 9-amino-tetrahydroacridines and related compounds a process for their preparation and their use as medicaments - Google Patents

Substituted 9-amino-tetrahydroacridines and related compounds a process for their preparation and their use as medicaments

Info

Publication number
PT86986A
PT86986A PT86986A PT8698688A PT86986A PT 86986 A PT86986 A PT 86986A PT 86986 A PT86986 A PT 86986A PT 8698688 A PT8698688 A PT 8698688A PT 86986 A PT86986 A PT 86986A
Authority
PT
Portugal
Prior art keywords
tetrahydroacridines
medicines
amino
substituted
preparation
Prior art date
Application number
PT86986A
Other languages
English (en)
Other versions
PT86986B (pt
Inventor
Gregory Michael Shutske
Grover Cleveland Helsley
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Publication of PT86986A publication Critical patent/PT86986A/pt
Publication of PT86986B publication Critical patent/PT86986B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08—Nitrogen atoms
    • C07D219/10—Nitrogen atoms attached in position 9
    • C07D219/12—Amino-alkylamino radicals attached in position 9
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08—Nitrogen atoms
    • C07D219/10—Nitrogen atoms attached in position 9
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/06—Oxygen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
PT86986A 1987-03-17 1988-03-16 Processo para a preparacao de 9-amino-tetra-hidroacridinas e de compostos relacionados bem como de composicoes farmaceuticas que os contem PT86986B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2673087A 1987-03-17 1987-03-17

Publications (2)

Publication Number Publication Date
PT86986A true PT86986A (pt) 1988-04-01
PT86986B PT86986B (pt) 1992-06-30

Family

ID=21833471

Family Applications (1)

Application Number Title Priority Date Filing Date
PT86986A PT86986B (pt) 1987-03-17 1988-03-16 Processo para a preparacao de 9-amino-tetra-hidroacridinas e de compostos relacionados bem como de composicoes farmaceuticas que os contem

Country Status (15)

Country Link
US (1) US5391553A (pt)
EP (1) EP0282959A3 (pt)
JP (1) JP2888485B2 (pt)
KR (1) KR960015001B1 (pt)
AU (2) AU635370B2 (pt)
CA (1) CA1318675C (pt)
DK (1) DK172864B1 (pt)
FI (1) FI91401C (pt)
HU (1) HU201018B (pt)
IL (1) IL85741A (pt)
NO (1) NO173498C (pt)
NZ (1) NZ223875A (pt)
PH (1) PH25124A (pt)
PT (1) PT86986B (pt)
ZA (1) ZA881865B (pt)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL87861A0 (en) * 1987-10-05 1989-03-31 Pfizer 4-aminopyridine derivatives
US5202440A (en) * 1987-10-05 1993-04-13 Pfizer Inc. Certain 9-amino-2-(or 4)-oxa 1,2,3,4-tetrahydro- or 1,2,3,4,5,6,7,8-octahydro-acridines
US5008853A (en) 1987-12-02 1991-04-16 Xerox Corporation Representation of collaborative multi-user activities relative to shared structured data objects in a networked workstation environment
DE3889302T2 (de) 1987-12-03 1994-10-20 Mitsubishi Chem Ind 9-(Acylamino)tetrahydroacridinderivate und wahrnehmungssteigernde Mittel davon als aktiver Wirkstoff.
US4868177A (en) * 1988-11-09 1989-09-19 Hoechst-Roussel Pharmaceuticals, Inc. 1,2,3,4-tetrahydro-1,9-acridinediamines, pharmaceutical compositions and use
FI90417C (fi) * 1988-11-16 1994-02-10 Hoechst Marion Roussel Inc Menetelmä terapeuttisesti aktiivisten hydroksi-1,2,3,4-tetrahydroaminoakridiinien valmistamiseksi
JP2720517B2 (ja) * 1989-05-31 1998-03-04 三菱化学株式会社 ９―アシルアミノーテトラヒドロアクリジン誘導体および該誘導体を有効成分とする記憶障害改善剤
US5112829A (en) * 1989-11-28 1992-05-12 Hoechst-Roussel Pharmaceuticals Inc. Hexahydro-1H-quino[4,3,2-ef][1,4]benzoxazepines and related compounds
US4994452A (en) * 1989-11-28 1991-02-19 Hoechst-Roussel Pharmaceuticals Inc. Hexahydro-1H-quino[4,3,2-ef][1,4]benzoxazepines and related compounds
RU2024509C1 (ru) * 1991-05-07 1994-12-15 Всероссийский научный центр по безопасности биологически активных веществ Производные 9-аминоакридина или их соли с органическими или неорганическими кислотами, проявляющие психотропную, антиамнестическую и липидрегулирующую активность
GB9524346D0 (en) * 1995-11-29 1996-01-31 Univ Strathclyde Polycyclic compounds
US5783584A (en) * 1995-12-11 1998-07-21 Mayo Foundation For Medical Education And Research THA analogs useful as cholinesterase inhibitors
US5929093A (en) * 1996-06-13 1999-07-27 Mayo Foundation For Medical Education And Research Bifunctional acetylcholinesterase reactivators
TW521072B (en) * 1997-06-02 2003-02-21 Meiji Seika Kaisha 4-quinolinol derivatives and fungicides containing the same as an active ingredient used for agriculture and horticulture
JP4685742B2 (ja) * 1997-06-02 2011-05-18 明治製菓株式会社 ４−キノリノール誘導体及びこれを有効成分として含有する農園芸用殺菌剤
ES2144353B1 (es) * 1997-12-26 2001-01-01 Consejo Superior Investigacion Nuevos analogos de tacrina: potenciales agentes neuroprotectores para las enfermedades de alzheimer y parkinson. su procedimiento de obtencion.
US6218383B1 (en) 1998-08-07 2001-04-17 Targacept, Inc. Pharmaceutical compositions for the prevention and treatment of central nervous system disorders
ES2168926B1 (es) * 1999-12-14 2003-10-16 Prous Science S A Derivados de ciclopenta- ciclohexa- y ciclohepta (b)quinoleina, procedimiento para su fabricacion, utilizacion y composicion farmaceutica correspondiente.
CA2456594A1 (en) * 2001-08-06 2003-02-20 Mitsubishi Pharma Corporation Preventives/remedies for cholinergic neuropathy
CA2512765A1 (en) * 2003-01-08 2004-07-29 Mitsubishi Pharma Corporation Therapeutic agent for schizophrenia
EP2533645B1 (en) * 2010-02-09 2016-07-27 The Johns Hopkins University Methods and compositions for improving cognitive function
CN102219740B (zh) * 2010-09-10 2013-02-13 长春华洋高科技有限公司 1，2，3，4，5，6，7，8-八氢-9-苯乙酰胺基吖啶及制备方法和药用用途
JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物
EP2968237A4 (en) 2013-03-15 2016-08-31 Univ Johns Hopkins METHOD AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION
EP2968220B1 (en) 2013-03-15 2021-05-05 Agenebio, Inc. Methods and compositions for improving cognitive function
RU2567388C1 (ru) * 2014-12-10 2015-11-10 Открытое акционерное общество "Нижегородский химико-фармацевтический завод" Способ получения 9-бутиламино-3,3-диметил-3,4-дигидроакридин-1(2н)-она гидрохлорида
MX384391B (es) 2015-05-22 2025-03-14 Agenebio Inc Composiciones farmacéuticas de levetiracetam de liberación extendida.
BR112018001960A2 (pt) 2015-08-03 2018-09-18 Bristol-Myers Squibb Company compostos heterocíclicos úteis como moduladores de tnf alfa
KR101953366B1 (ko) 2018-12-26 2019-02-28 정종문 침향을 포함하는 기억력 및 인지능력을 향상시키는 기능성 건강식품 및 이의 제조방법
CN111704576A (zh) * 2020-06-17 2020-09-25 菏泽学院 一种轴手性9-芳基四氢吖啶的合成方法及应用

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3232945A (en) * 1962-08-13 1966-02-01 S E Massengill Company 7,8,9,10-tetrahalo-6h-cyclohepta-(b)-quinolines
US3318895A (en) * 1963-12-05 1967-05-09 Squibb & Sons Inc Production of 12-substituted-6, 7, 8, 9, 10, 11-hexahydrocycloocta[b]quinolines
US3318896A (en) * 1963-12-05 1967-05-09 Squibb & Sons Inc Production of 12-substituted-6, 7, 8, 9, 10, 11-hexahydrocycloocta[b]quinolines
BE658695A (pt) * 1964-02-03 1965-07-22
US3580915A (en) * 1968-09-16 1971-05-25 American Home Prod 1,2,3,4-tetrahydrobenzol(b)(1,6)naphthyridine derivatives
US3541066A (en) * 1968-09-16 1970-11-17 American Home Prod 2,3-dihydro-1,4-ethanobenzo(b)(1,5)naphthyridine derivatives
US3637706A (en) * 1970-04-30 1972-01-25 American Home Prod 10-(4 - (lower)alkylpiperazino) - 1 2 3 4-tetrahydrobenzo(b)(1 6) naphthyridine derivatives useful as cns depressants
US3657233A (en) * 1970-04-30 1972-04-18 American Home Prod 10-morpholino-1 2 3 4-tetrahydrobenzo(b)(1 6)naphthyridine derivatives
US3647800A (en) * 1970-04-30 1972-03-07 American Home Prod 10-substituted - 1 2 3 4 - tetrahydrobenzo(b)(1 6)naphthyridines useful as cns depressants
US3674790A (en) * 1970-05-01 1972-07-04 American Home Prod 2,10-disubstituted-1,2,3,4-tetrahydrobenzo(bhq (1,6)naphthyridines useful as cns depressants
ES431307A1 (es) * 1973-11-16 1976-09-01 Thomae Gmbh Dr K Procedimiento para la preparacion de nuevos derivados de quinoleina.
US4108998A (en) * 1976-11-08 1978-08-22 American Home Products Corp. Furo[3,4-b]quinoline derivatives and pharmaceutical compositions and methods employing them
JPS6147466A (ja) * 1984-08-10 1986-03-07 Dainippon Pharmaceut Co Ltd アミン誘導体
DE3582995D1 (de) * 1984-10-25 1991-07-04 Hoechst Roussel Pharma 9-amino-1,2,3,4-tetrahydroacridin-1-ol und verwandte verbindungen, verfahren zu ihrer herstellung und verwendung als arzneimittel.
US4695573A (en) * 1984-10-25 1987-09-22 Hoechst-Roussel Pharmaceuticals Inc. 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds
US4631286A (en) * 1984-10-25 1986-12-23 Hoechst-Roussel Pharmaceuticals Inc. 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds
US4816456A (en) * 1986-10-01 1989-03-28 Summers William K Administration of monoamine acridines in cholinergic neuronal deficit states
EP0268871A1 (en) * 1986-10-31 1988-06-01 Sumitomo Pharmaceuticals Company, Limited Quinoline derivatives
AU634004B2 (en) * 1987-03-17 1993-02-11 Hoechst Marion Roussel, Inc. Intermediates for substituted 9-amino-tetrahydro-acridines, a process for their preparation and their use as medicaments
US4762841A (en) * 1987-03-30 1988-08-09 Hoechst-Roussel Pharmaceuticals Inc. Substituted 9-amino-spiro(cycloalkyl(b)quinoline-2,1'cycloalkanes)
US4851536A (en) * 1987-05-07 1989-07-25 American Home Products Corporation Cyclohexylquinolines as inhibitors of interleukin 1
DE3889302T2 (de) * 1987-12-03 1994-10-20 Mitsubishi Chem Ind 9-(Acylamino)tetrahydroacridinderivate und wahrnehmungssteigernde Mittel davon als aktiver Wirkstoff.
US4868177A (en) * 1988-11-09 1989-09-19 Hoechst-Roussel Pharmaceuticals, Inc. 1,2,3,4-tetrahydro-1,9-acridinediamines, pharmaceutical compositions and use
US4999430A (en) * 1989-07-31 1991-03-12 Warner-Lambert Company Derivatives of 1,2,3,4-tetrahydro-9-acrisinamine
GB8917568D0 (en) * 1989-08-01 1989-09-13 Morton Oswald Compounds

Also Published As

Publication number Publication date
AU608300B2 (en) 1991-03-28
JP2888485B2 (ja) 1999-05-10
FI91401B (fi) 1994-03-15
ZA881865B (en) 1988-11-30
PH25124A (en) 1991-02-19
DK143588A (da) 1988-09-18
FI91401C (fi) 1994-06-27
NZ223875A (en) 1991-01-29
PT86986B (pt) 1992-06-30
FI881223A7 (fi) 1988-09-18
CA1318675C (en) 1993-06-01
DK172864B1 (da) 1999-08-23
EP0282959A3 (en) 1989-05-31
NO881164D0 (no) 1988-03-16
FI881223A0 (fi) 1988-03-15
AU6824190A (en) 1991-03-14
DK143588D0 (da) 1988-03-16
NO881164L (no) 1988-09-19
KR960015001B1 (ko) 1996-10-23
KR880011111A (ko) 1988-10-26
HU201018B (en) 1990-09-28
AU6824090A (en) 1991-05-02
AU1314188A (en) 1988-09-15
EP0282959A2 (en) 1988-09-21
IL85741A0 (en) 1988-08-31
HUT46672A (en) 1988-11-28
AU635370B2 (en) 1993-03-18
NO173498B (no) 1993-09-13
IL85741A (en) 1996-05-14
AU633668B2 (en) 1993-02-04
JPS63238063A (ja) 1988-10-04
NO173498C (no) 1993-12-22
US5391553A (en) 1995-02-21

Similar Documents

Publication Publication Date Title
PT86986A (pt) Substituted 9-amino-tetrahydroacridines and related compounds a process for their preparation and their use as medicaments
FI903215A7 (fi) Heteroaryyliamino- ja heteroaryylioksipyridiiniamiineja ja niihin liittyviä yhdisteitä, menetelmä niiden valmistamiseksi sekä niiden käyttö lääkkeinä
DK89090D0 (da) Farmaceutisk praeparat
FI892640A0 (fi) Menetelmä piperidinoalkanoli-ibuprofeeniyhdistelmää sisältävän farmaseuttisen koostumuksen valmistamiseksi
NO177038C (no) Fremgangsmåte for fremstilling av et farmasöytisk doseringssystem
NO166111C (no) Fremgangsmaate for fremstilling av et konfekt- eller farmasiprodukt.
NO882103D0 (no) Fremgangsmaate for fremstilling av et farmasoeytisk preparat
IS3339A7 (is) Ný efnablanda lyfja
DK705488A (da) Farmaceutisk praeparat
PT88225A (pt) Processo para a preparacao de formulacoes farmaceuticas contendo di-hidropiridinas
NO173590C (no) Fremgangsmaate for fremstilling av et stabilt nikorandilholdig farmasoeytisk preparat
FI93106C (fi) Menetelmä lääkeaineina käyttökelpoisten 2-iminobentsotiatsoliinijohdannaisten valmistamiseksi
NO177485C (no) Fremgangsmåte for fremstilling av et farmasöytisk inhalasjonspreparat
FI884240L (fi) Menetelmä paikalliseen käyttöön tarkoitetun farmaseuttisen valmisteen valmistamiseksi
FI895983A0 (fi) Menetelmä lääkeaineina käyttökelpoisten 2-bentsotiatsoliinijohdannaisten valmistamiseksi
NO179396C (no) Fremgangsmåte ved fremstilling av en medikamentell administreringsform for drövtyggere
ZA884878B (en) Substituted benzimidazoles,a process for the preparation thereof,pharmaceutical formulations containing them,and the use thereof
PT87672A (pt) Process for preparing a pharmaceutical composition
PT87564A (pt) Process for preparing substituted vinylcephalosporins useful as medicaments
PT87186A (pt) Imidazothiadiazine derivatives a process for preparing the same and their use as medicaments
DK139388D0 (da) Farmaceutisk praeparat
PT86642A (pt) Arylthiadiazolylsulfonamides and derivatives a process for thir preparation and their use as medicaments
DK276288A (da) Farmaceutisk praeparat
PT87287A (pt) Fused heteroalkylene quinolinamines a process and intermediates for their preparation and their use as medicaments
FI895370A7 (fi) 1-aminoalkyyli-3-oksisubstituoitu-4-aryyli-1,3,4,5-tetra-hydro-2H-1,3-bentsodiatsepin-2-oneja, menetelmä niiden valmistamiseksi ja niiden käyttö lääkkeinä

Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19911210

MM3A Annulment or lapse

Effective date: 20050613