ZA881865B - Substituted 9-amino-tetrahydroacridines and related compounds,a process for their preparation and their use as medicaments - Google Patents

Substituted 9-amino-tetrahydroacridines and related compounds,a process for their preparation and their use as medicaments

Info

Publication number
ZA881865B
ZA881865B ZA881865A ZA881865A ZA881865B ZA 881865 B ZA881865 B ZA 881865B ZA 881865 A ZA881865 A ZA 881865A ZA 881865 A ZA881865 A ZA 881865A ZA 881865 B ZA881865 B ZA 881865B
Authority
ZA
South Africa
Prior art keywords
tetrahydroacridines
medicaments
amino
substituted
preparation
Prior art date
Application number
ZA881865A
Other languages
English (en)
Inventor
Gregory Michael Shutske
Michael Shutske Gregory
Grover Cleveland Helsley
Cleveland Helsley Grover
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Publication of ZA881865B publication Critical patent/ZA881865B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08—Nitrogen atoms
    • C07D219/10—Nitrogen atoms attached in position 9
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08—Nitrogen atoms
    • C07D219/10—Nitrogen atoms attached in position 9
    • C07D219/12—Amino-alkylamino radicals attached in position 9
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/06—Oxygen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
ZA881865A 1987-03-17 1988-03-16 Substituted 9-amino-tetrahydroacridines and related compounds,a process for their preparation and their use as medicaments ZA881865B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2673087A 1987-03-17 1987-03-17

Publications (1)

Publication Number Publication Date
ZA881865B true ZA881865B (en) 1988-11-30

Family

ID=21833471

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA881865A ZA881865B (en) 1987-03-17 1988-03-16 Substituted 9-amino-tetrahydroacridines and related compounds,a process for their preparation and their use as medicaments

Country Status (15)

Country Link
US (1) US5391553A (xx)
EP (1) EP0282959A3 (xx)
JP (1) JP2888485B2 (xx)
KR (1) KR960015001B1 (xx)
AU (2) AU633668B2 (xx)
CA (1) CA1318675C (xx)
DK (1) DK172864B1 (xx)
FI (1) FI91401C (xx)
HU (1) HU201018B (xx)
IL (1) IL85741A (xx)
NO (1) NO173498C (xx)
NZ (1) NZ223875A (xx)
PH (1) PH25124A (xx)
PT (1) PT86986B (xx)
ZA (1) ZA881865B (xx)

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IL87861A0 (en) * 1987-10-05 1989-03-31 Pfizer 4-aminopyridine derivatives
US5008853A (en) 1987-12-02 1991-04-16 Xerox Corporation Representation of collaborative multi-user activities relative to shared structured data objects in a networked workstation environment
US4985430A (en) 1987-12-03 1991-01-15 Mitsubishi Kasei Corporation 9-acylamino-tetrahydroacridine derivatives and memory enhancing agent containing said derivative as active ingredient
US4868177A (en) * 1988-11-09 1989-09-19 Hoechst-Roussel Pharmaceuticals, Inc. 1,2,3,4-tetrahydro-1,9-acridinediamines, pharmaceutical compositions and use
KR0156241B1 (ko) * 1988-11-16 1998-11-16 도날드 알.토센 하이드록시-1,2,3,4-테트라하이드로아미노아크리딘, 이의 제조방법 및 이를 함유하는 약제학적 조성물
JP2720517B2 (ja) * 1989-05-31 1998-03-04 三菱化学株式会社 ９―アシルアミノーテトラヒドロアクリジン誘導体および該誘導体を有効成分とする記憶障害改善剤
US5112829A (en) * 1989-11-28 1992-05-12 Hoechst-Roussel Pharmaceuticals Inc. Hexahydro-1H-quino[4,3,2-ef][1,4]benzoxazepines and related compounds
US4994452A (en) * 1989-11-28 1991-02-19 Hoechst-Roussel Pharmaceuticals Inc. Hexahydro-1H-quino[4,3,2-ef][1,4]benzoxazepines and related compounds
RU2024509C1 (ru) * 1991-05-07 1994-12-15 Всероссийский научный центр по безопасности биологически активных веществ Производные 9-аминоакридина или их соли с органическими или неорганическими кислотами, проявляющие психотропную, антиамнестическую и липидрегулирующую активность
GB9524346D0 (en) * 1995-11-29 1996-01-31 Univ Strathclyde Polycyclic compounds
US5783584A (en) * 1995-12-11 1998-07-21 Mayo Foundation For Medical Education And Research THA analogs useful as cholinesterase inhibitors
US5929093A (en) * 1996-06-13 1999-07-27 Mayo Foundation For Medical Education And Research Bifunctional acetylcholinesterase reactivators
JP4685742B2 (ja) * 1997-06-02 2011-05-18 明治製菓株式会社 ４−キノリノール誘導体及びこれを有効成分として含有する農園芸用殺菌剤
TW521072B (en) * 1997-06-02 2003-02-21 Meiji Seika Kaisha 4-quinolinol derivatives and fungicides containing the same as an active ingredient used for agriculture and horticulture
ES2144353B1 (es) * 1997-12-26 2001-01-01 Consejo Superior Investigacion Nuevos analogos de tacrina: potenciales agentes neuroprotectores para las enfermedades de alzheimer y parkinson. su procedimiento de obtencion.
US6218383B1 (en) 1998-08-07 2001-04-17 Targacept, Inc. Pharmaceutical compositions for the prevention and treatment of central nervous system disorders
ES2168926B1 (es) * 1999-12-14 2003-10-16 Prous Science S A Derivados de ciclopenta- ciclohexa- y ciclohepta (b)quinoleina, procedimiento para su fabricacion, utilizacion y composicion farmaceutica correspondiente.
US20040235884A1 (en) * 2001-08-06 2004-11-25 Ken Takashina Preventives/remedies for cholinergic neuropathy
JP4598674B2 (ja) * 2003-01-08 2010-12-15 田辺三菱製薬株式会社 統合失調症治療剤
WO2011100373A1 (en) * 2010-02-09 2011-08-18 The Johns Hopkins University Methods and compositions for improving cognitive function
CN102219740B (zh) 2010-09-10 2013-02-13 长春华洋高科技有限公司 1，2，3，4，5，6，7，8-八氢-9-苯乙酰胺基吖啶及制备方法和药用用途
US10154988B2 (en) 2012-11-14 2018-12-18 The Johns Hopkins University Methods and compositions for treating schizophrenia
CN105142623A (zh) 2013-03-15 2015-12-09 艾吉因生物股份有限公司 用于改善认知功能的方法和组合物
EP2968237A4 (en) 2013-03-15 2016-08-31 Univ Johns Hopkins METHOD AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION
RU2567388C1 (ru) * 2014-12-10 2015-11-10 Открытое акционерное общество "Нижегородский химико-фармацевтический завод" Способ получения 9-бутиламино-3,3-диметил-3,4-дигидроакридин-1(2н)-она гидрохлорида
US10159648B2 (en) 2015-05-22 2018-12-25 Agenebio, Inc. Extended release pharmaceutical compositions of levetiracetam
CA2994717A1 (en) 2015-08-03 2017-02-09 Bristol-Myers Squibb Company Heterocyclic compounds useful as modulators of tnf alpha
KR101953366B1 (ko) 2018-12-26 2019-02-28 정종문 침향을 포함하는 기억력 및 인지능력을 향상시키는 기능성 건강식품 및 이의 제조방법
CN111704576A (zh) * 2020-06-17 2020-09-25 菏泽学院 一种轴手性9-芳基四氢吖啶的合成方法及应用

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US3637706A (en) * 1970-04-30 1972-01-25 American Home Prod 10-(4 - (lower)alkylpiperazino) - 1 2 3 4-tetrahydrobenzo(b)(1 6) naphthyridine derivatives useful as cns depressants
US3657233A (en) * 1970-04-30 1972-04-18 American Home Prod 10-morpholino-1 2 3 4-tetrahydrobenzo(b)(1 6)naphthyridine derivatives
US3674790A (en) * 1970-05-01 1972-07-04 American Home Prod 2,10-disubstituted-1,2,3,4-tetrahydrobenzo(bhq (1,6)naphthyridines useful as cns depressants
ES431307A1 (es) * 1973-11-16 1976-09-01 Thomae Gmbh Dr K Procedimiento para la preparacion de nuevos derivados de quinoleina.
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JPS6147466A (ja) * 1984-08-10 1986-03-07 Dainippon Pharmaceut Co Ltd アミン誘導体
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DE3582995D1 (de) * 1984-10-25 1991-07-04 Hoechst Roussel Pharma 9-amino-1,2,3,4-tetrahydroacridin-1-ol und verwandte verbindungen, verfahren zu ihrer herstellung und verwendung als arzneimittel.
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US4868177A (en) * 1988-11-09 1989-09-19 Hoechst-Roussel Pharmaceuticals, Inc. 1,2,3,4-tetrahydro-1,9-acridinediamines, pharmaceutical compositions and use
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Also Published As

Publication number Publication date
NO881164D0 (no) 1988-03-16
US5391553A (en) 1995-02-21
IL85741A0 (en) 1988-08-31
NO173498C (no) 1993-12-22
FI881223A0 (fi) 1988-03-15
JPS63238063A (ja) 1988-10-04
KR880011111A (ko) 1988-10-26
HU201018B (en) 1990-09-28
IL85741A (en) 1996-05-14
PT86986B (pt) 1992-06-30
PH25124A (en) 1991-02-19
NZ223875A (en) 1991-01-29
FI91401B (fi) 1994-03-15
AU1314188A (en) 1988-09-15
FI881223A (fi) 1988-09-18
FI91401C (fi) 1994-06-27
PT86986A (pt) 1988-04-01
AU608300B2 (en) 1991-03-28
KR960015001B1 (ko) 1996-10-23
CA1318675C (en) 1993-06-01
AU6824190A (en) 1991-03-14
JP2888485B2 (ja) 1999-05-10
AU6824090A (en) 1991-05-02
NO173498B (no) 1993-09-13
EP0282959A3 (en) 1989-05-31
DK172864B1 (da) 1999-08-23
AU635370B2 (en) 1993-03-18
HUT46672A (en) 1988-11-28
AU633668B2 (en) 1993-02-04
DK143588A (da) 1988-09-18
NO881164L (no) 1988-09-19
DK143588D0 (da) 1988-03-16
EP0282959A2 (en) 1988-09-21

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