NO881164L - Substituerte 9-amino-tetrahydroakridiner og relaterte forbindelser, en fremgangsmaate for deres fremstilling og deres bruk som medikamenter. - Google Patents

Substituerte 9-amino-tetrahydroakridiner og relaterte forbindelser, en fremgangsmaate for deres fremstilling og deres bruk som medikamenter.

Info

Publication number
NO881164L
NO881164L NO88881164A NO881164A NO881164L NO 881164 L NO881164 L NO 881164L NO 88881164 A NO88881164 A NO 88881164A NO 881164 A NO881164 A NO 881164A NO 881164 L NO881164 L NO 881164L
Authority
NO
Norway
Prior art keywords
tetrahydroacridines
medicines
amino
substituted
procedure
Prior art date
Application number
NO88881164A
Other languages
English (en)
Other versions
NO881164D0 (no
NO173498B (no
NO173498C (no
Inventor
Gregory Michael Shutske
Grover Cleveland Helsley
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Publication of NO881164D0 publication Critical patent/NO881164D0/no
Publication of NO881164L publication Critical patent/NO881164L/no
Publication of NO173498B publication Critical patent/NO173498B/no
Publication of NO173498C publication Critical patent/NO173498C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08—Nitrogen atoms
    • C07D219/10—Nitrogen atoms attached in position 9
    • C07D219/12—Amino-alkylamino radicals attached in position 9
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08—Nitrogen atoms
    • C07D219/10—Nitrogen atoms attached in position 9
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/06—Oxygen atoms
NO881164A 1987-03-17 1988-03-16 Analogifremgangsmaate for fremstilling av substituerte 9-amino-tetrahydroakridiner NO173498C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2673087A 1987-03-17 1987-03-17

Publications (4)

Publication Number Publication Date
NO881164D0 NO881164D0 (no) 1988-03-16
NO881164L true NO881164L (no) 1988-09-19
NO173498B NO173498B (no) 1993-09-13
NO173498C NO173498C (no) 1993-12-22

Family

ID=21833471

Family Applications (1)

Application Number Title Priority Date Filing Date
NO881164A NO173498C (no) 1987-03-17 1988-03-16 Analogifremgangsmaate for fremstilling av substituerte 9-amino-tetrahydroakridiner

Country Status (15)

Country Link
US (1) US5391553A (no)
EP (1) EP0282959A3 (no)
JP (1) JP2888485B2 (no)
KR (1) KR960015001B1 (no)
AU (2) AU635370B2 (no)
CA (1) CA1318675C (no)
DK (1) DK172864B1 (no)
FI (1) FI91401C (no)
HU (1) HU201018B (no)
IL (1) IL85741A (no)
NO (1) NO173498C (no)
NZ (1) NZ223875A (no)
PH (1) PH25124A (no)
PT (1) PT86986B (no)
ZA (1) ZA881865B (no)

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US5008853A (en) 1987-12-02 1991-04-16 Xerox Corporation Representation of collaborative multi-user activities relative to shared structured data objects in a networked workstation environment
US4985430A (en) 1987-12-03 1991-01-15 Mitsubishi Kasei Corporation 9-acylamino-tetrahydroacridine derivatives and memory enhancing agent containing said derivative as active ingredient
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JP2720517B2 (ja) * 1989-05-31 1998-03-04 三菱化学株式会社 ９―アシルアミノーテトラヒドロアクリジン誘導体および該誘導体を有効成分とする記憶障害改善剤
US5112829A (en) * 1989-11-28 1992-05-12 Hoechst-Roussel Pharmaceuticals Inc. Hexahydro-1H-quino[4,3,2-ef][1,4]benzoxazepines and related compounds
US4994452A (en) * 1989-11-28 1991-02-19 Hoechst-Roussel Pharmaceuticals Inc. Hexahydro-1H-quino[4,3,2-ef][1,4]benzoxazepines and related compounds
RU2024509C1 (ru) * 1991-05-07 1994-12-15 Всероссийский научный центр по безопасности биологически активных веществ Производные 9-аминоакридина или их соли с органическими или неорганическими кислотами, проявляющие психотропную, антиамнестическую и липидрегулирующую активность
GB9524346D0 (en) * 1995-11-29 1996-01-31 Univ Strathclyde Polycyclic compounds
US5783584A (en) * 1995-12-11 1998-07-21 Mayo Foundation For Medical Education And Research THA analogs useful as cholinesterase inhibitors
US5929093A (en) * 1996-06-13 1999-07-27 Mayo Foundation For Medical Education And Research Bifunctional acetylcholinesterase reactivators
JP4685742B2 (ja) * 1997-06-02 2011-05-18 明治製菓株式会社 ４−キノリノール誘導体及びこれを有効成分として含有する農園芸用殺菌剤
TW521072B (en) * 1997-06-02 2003-02-21 Meiji Seika Kaisha 4-quinolinol derivatives and fungicides containing the same as an active ingredient used for agriculture and horticulture
ES2144353B1 (es) * 1997-12-26 2001-01-01 Consejo Superior Investigacion Nuevos analogos de tacrina: potenciales agentes neuroprotectores para las enfermedades de alzheimer y parkinson. su procedimiento de obtencion.
US6218383B1 (en) 1998-08-07 2001-04-17 Targacept, Inc. Pharmaceutical compositions for the prevention and treatment of central nervous system disorders
ES2168926B1 (es) * 1999-12-14 2003-10-16 Prous Science S A Derivados de ciclopenta- ciclohexa- y ciclohepta (b)quinoleina, procedimiento para su fabricacion, utilizacion y composicion farmaceutica correspondiente.
WO2003013522A1 (fr) * 2001-08-06 2003-02-20 Mitsubishi Pharma Corporation Compositions prophylactiques/therapeutiques destinees a la neuropathie cholinergique
EP1598355A4 (en) * 2003-01-08 2010-01-27 Mitsubishi Tanabe Pharma Corp THERAPEUTIC AGENT FOR SCHIZOPHRENIA
CA2789014C (en) 2010-02-09 2019-01-15 Michela Gallagher Methods and compositions for improving cognitive function
CN102219740B (zh) 2010-09-10 2013-02-13 长春华洋高科技有限公司 1，2，3，4，5，6，7，8-八氢-9-苯乙酰胺基吖啶及制备方法和药用用途
JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物
CA2904767C (en) 2013-03-15 2022-06-21 Agenebio, Inc. Methods and compositions for improving cognitive function
WO2014144663A1 (en) 2013-03-15 2014-09-18 The Johns Hopkins University Methods and compositions for improving cognitive function
RU2567388C1 (ru) * 2014-12-10 2015-11-10 Открытое акционерное общество "Нижегородский химико-фармацевтический завод" Способ получения 9-бутиламино-3,3-диметил-3,4-дигидроакридин-1(2н)-она гидрохлорида
WO2016191288A1 (en) 2015-05-22 2016-12-01 Agenebio, Inc. Extended release pharmaceutical compositions of levetiracetam
BR112018001960A2 (pt) 2015-08-03 2018-09-18 Bristol-Myers Squibb Company compostos heterocíclicos úteis como moduladores de tnf alfa
KR101953366B1 (ko) 2018-12-26 2019-02-28 정종문 침향을 포함하는 기억력 및 인지능력을 향상시키는 기능성 건강식품 및 이의 제조방법
CN111704576A (zh) * 2020-06-17 2020-09-25 菏泽学院 一种轴手性9-芳基四氢吖啶的合成方法及应用

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US3232945A (en) * 1962-08-13 1966-02-01 S E Massengill Company 7,8,9,10-tetrahalo-6h-cyclohepta-(b)-quinolines
US3318896A (en) * 1963-12-05 1967-05-09 Squibb & Sons Inc Production of 12-substituted-6, 7, 8, 9, 10, 11-hexahydrocycloocta[b]quinolines
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US3657233A (en) * 1970-04-30 1972-04-18 American Home Prod 10-morpholino-1 2 3 4-tetrahydrobenzo(b)(1 6)naphthyridine derivatives
US3674790A (en) * 1970-05-01 1972-07-04 American Home Prod 2,10-disubstituted-1,2,3,4-tetrahydrobenzo(bhq (1,6)naphthyridines useful as cns depressants
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US4108998A (en) * 1976-11-08 1978-08-22 American Home Products Corp. Furo[3,4-b]quinoline derivatives and pharmaceutical compositions and methods employing them
JPS6147466A (ja) * 1984-08-10 1986-03-07 Dainippon Pharmaceut Co Ltd アミン誘導体
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US4631286A (en) * 1984-10-25 1986-12-23 Hoechst-Roussel Pharmaceuticals Inc. 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds
EP0179383B1 (en) * 1984-10-25 1991-05-29 Hoechst-Roussel Pharmaceuticals Incorporated 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds, a process for their preparation and their use as medicaments
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AU634004B2 (en) * 1987-03-17 1993-02-11 Hoechst Marion Roussel, Inc. Intermediates for substituted 9-amino-tetrahydro-acridines, a process for their preparation and their use as medicaments
US4762841A (en) * 1987-03-30 1988-08-09 Hoechst-Roussel Pharmaceuticals Inc. Substituted 9-amino-spiro(cycloalkyl(b)quinoline-2,1'cycloalkanes)
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US4985430A (en) * 1987-12-03 1991-01-15 Mitsubishi Kasei Corporation 9-acylamino-tetrahydroacridine derivatives and memory enhancing agent containing said derivative as active ingredient
US4868177A (en) * 1988-11-09 1989-09-19 Hoechst-Roussel Pharmaceuticals, Inc. 1,2,3,4-tetrahydro-1,9-acridinediamines, pharmaceutical compositions and use
US4999430A (en) * 1989-07-31 1991-03-12 Warner-Lambert Company Derivatives of 1,2,3,4-tetrahydro-9-acrisinamine
GB8917568D0 (en) * 1989-08-01 1989-09-13 Morton Oswald Compounds

Also Published As

Publication number Publication date
DK143588D0 (da) 1988-03-16
PT86986B (pt) 1992-06-30
DK143588A (da) 1988-09-18
EP0282959A3 (en) 1989-05-31
US5391553A (en) 1995-02-21
JP2888485B2 (ja) 1999-05-10
HUT46672A (en) 1988-11-28
JPS63238063A (ja) 1988-10-04
DK172864B1 (da) 1999-08-23
AU633668B2 (en) 1993-02-04
ZA881865B (en) 1988-11-30
AU635370B2 (en) 1993-03-18
NO881164D0 (no) 1988-03-16
FI91401B (fi) 1994-03-15
NO173498B (no) 1993-09-13
NZ223875A (en) 1991-01-29
AU608300B2 (en) 1991-03-28
AU1314188A (en) 1988-09-15
AU6824090A (en) 1991-05-02
KR880011111A (ko) 1988-10-26
KR960015001B1 (ko) 1996-10-23
PH25124A (en) 1991-02-19
EP0282959A2 (en) 1988-09-21
IL85741A (en) 1996-05-14
FI881223A0 (fi) 1988-03-15
AU6824190A (en) 1991-03-14
IL85741A0 (en) 1988-08-31
PT86986A (pt) 1988-04-01
FI91401C (fi) 1994-06-27
FI881223A (fi) 1988-09-18
NO173498C (no) 1993-12-22
HU201018B (en) 1990-09-28
CA1318675C (en) 1993-06-01

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