DK132789D0 - 9-halogen-(z)-prostaglandinderivater, fremgangsmaade til deres fremstilling og deres anvendelse som laegemiddel - Google Patents

9-halogen-(z)-prostaglandinderivater, fremgangsmaade til deres fremstilling og deres anvendelse som laegemiddel

Info

Publication number
DK132789D0
DK132789D0 DK132789A DK132789A DK132789D0 DK 132789 D0 DK132789 D0 DK 132789D0 DK 132789 A DK132789 A DK 132789A DK 132789 A DK132789 A DK 132789A DK 132789 D0 DK132789 D0 DK 132789D0
Authority
DK
Denmark
Prior art keywords
prostagland
ingredients
halogen
medicine
procedures
Prior art date
Application number
DK132789A
Other languages
English (en)
Other versions
DK132789A (da
DK170889B1 (da
Inventor
Bernd Buchmann
Werner Skuballa
Karl-Heinz Thierauch
Helmut Vorbrueggen
Bernd Raduechel
Olaf Loge
Walter Elger
Claus-Steffen Stuerzebecher
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25857817&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK132789(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE19873724189 external-priority patent/DE3724189A1/de
Priority claimed from DE19873724190 external-priority patent/DE3724190A1/de
Application filed by Schering Ag filed Critical Schering Ag
Publication of DK132789A publication Critical patent/DK132789A/da
Publication of DK132789D0 publication Critical patent/DK132789D0/da
Application granted granted Critical
Publication of DK170889B1 publication Critical patent/DK170889B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0025—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing keto groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK132789A 1987-07-17 1989-03-17 9-halogen-prostanderivater og lægemidler indeholdende dem DK170889B1 (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
DE19873724189 DE3724189A1 (de) 1987-07-17 1987-07-17 9-halogen-(z)-(delta)(pfeil hoch)4(pfeil hoch)-prostaglandinderivate, verfahren zu ihrer herstellung und ihrer verwendung als arzneimittel
DE3724189 1987-07-17
DE19873724190 DE3724190A1 (de) 1987-07-17 1987-07-17 9-halogen-3-oxa-(z)-(delta)(pfeil hoch)5(pfeil hoch)-prostaglandinderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3724190 1987-07-17
DE8800452 1988-07-15
PCT/DE1988/000452 WO1989000559A1 (en) 1987-07-17 1988-07-15 9-halogen-(z)-prostaglandin derivatives, process for manufacturing them, and their use as drugs

Publications (3)

Publication Number Publication Date
DK132789A DK132789A (da) 1989-03-17
DK132789D0 true DK132789D0 (da) 1989-03-17
DK170889B1 DK170889B1 (da) 1996-03-04

Family

ID=25857817

Family Applications (1)

Application Number Title Priority Date Filing Date
DK132789A DK170889B1 (da) 1987-07-17 1989-03-17 9-halogen-prostanderivater og lægemidler indeholdende dem

Country Status (12)

Country Link
US (1) US6225347B1 (da)
EP (1) EP0299914B2 (da)
JP (1) JP2716986B2 (da)
CA (1) CA1322197C (da)
DE (1) DE3880034D1 (da)
DK (1) DK170889B1 (da)
ES (1) ES2054860T5 (da)
HU (1) HU206084B (da)
IE (1) IE62483B1 (da)
IL (1) IL87116A (da)
NZ (1) NZ225436A (da)
WO (1) WO1989000559A1 (da)

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DE3923797A1 (de) * 1989-07-14 1991-01-24 Schering Ag 9-fluor-prostaglandin-derivate, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung
DE4008925A1 (de) * 1990-03-16 1991-09-19 Schering Ag 9-halogenprostaglandin-clathrate und ihre verwendung als arzneimittel
DE4024347A1 (de) * 1990-07-27 1992-01-30 Schering Ag Cyclopentanderivate, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung
DE4036140A1 (de) * 1990-11-09 1992-05-14 Schering Ag 9-halogen-11ss-hydroxy-prostaglandinderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
EP0652211A1 (en) * 1992-07-24 1995-05-10 Taisho Pharmaceutical Co. Ltd Prostaglandin derivative
DK0656889T3 (da) * 1992-08-31 1999-03-22 Schering Ag 9-chlorprostaglandinestere og -amider og deres anvendelse ved fremstilling af lægemidler
DE4229050A1 (de) * 1992-08-31 1994-03-03 Schering Ag Neue 9-Chlor-Prostaglandin-Ester und -amide
DE4229048A1 (de) * 1992-08-31 1994-03-03 Schering Ag Ester von 9-Chlor-Prostaglandinen, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung
ATE153855T1 (de) * 1992-10-13 1997-06-15 Alcon Lab Inc Zusammensetzungen zur behandlung von glaukoma die prostaglandine und clonidinderivate enthalten
AU669226B2 (en) * 1992-10-20 1996-05-30 Fumie Sato Prostaglandine derivative
US5627209A (en) * 1993-12-15 1997-05-06 Alcon Laboratories, Inc. Use of certain 9-haloprostaglandins to treat glaucoma and ocular hypertension
AU687906B2 (en) * 1993-12-15 1998-03-05 Alcon Laboratories, Inc. Use of certain prostaglandin analogues to treat glaucoma and ocular hypertension
US5721273A (en) 1993-12-15 1998-02-24 Alcon Laboratories, Inc. Use of certain 9-halo-13,14-dihydroprostaglandins to treat glaucoma and ocular hypertension
US5807892A (en) * 1994-09-30 1998-09-15 Alcon Laboratories, Inc. Use of certain prostaglandin analogues to treat glaucoma and ocular hypertension
US6294563B1 (en) 1994-10-27 2001-09-25 Allergan Sales, Inc. Combinations of prostaglandins and brimonidine or derivatives thereof
CA2237898A1 (en) * 1995-11-17 1997-05-29 Louis Desantis Jr. Combination therapy for treating glaucoma
US6441047B2 (en) 1995-11-17 2002-08-27 Alcon Manufacturing Ltd.. Combination therapy for treating glaucoma
US5700835A (en) * 1995-12-22 1997-12-23 Alcon Laboratories, Inc. 3-Oxa-D-prostaglandins for lowering IOP
WO1997023225A1 (en) * 1995-12-22 1997-07-03 Alcon Laboratories, Inc. Combinations of dp and fp type prostaglandins for lowering iop
US5599838A (en) * 1996-02-23 1997-02-04 Taisho Pharmaceutical Co., Ltd. Prostaglandin derivatives
KR20000053228A (ko) 1996-11-12 2000-08-25 제임스 에이. 아노 안압강하제로서의 프로스타글란딘의 시스-δ⁴ 유사체
US6015922A (en) * 1997-12-19 2000-01-18 Alcon Laboratories, Inc. N-alkyl-N-alkoxycarboxamides and methods of use in prostaglandin synthesis
US6740679B1 (en) * 1999-02-05 2004-05-25 Baylor University Medical Center Nutritional supplement or pharmaceutical preparation comprising triglycerides with seven-carbon fatty acid
US20030162833A1 (en) 2001-08-01 2003-08-28 Roe Charles R. Fatty acid treatment for cardiac patients
EP1219600A4 (en) 1999-08-13 2004-11-03 Taisho Pharmaceutical Co Ltd PROSTAGLANDIN DERIVATIVES
KR100698433B1 (ko) * 1999-09-10 2007-03-22 사또, 후미에 프로스타글란딘 유도체
GB0012249D0 (en) * 2000-05-19 2000-07-12 Chirotech Technology Ltd Process for the preparation of 11-oxaprostaglandins
US20040266880A1 (en) * 2002-02-22 2004-12-30 Fumie Sato Antipruritics
US7737182B2 (en) 2002-08-09 2010-06-15 Taisho Pharmaceutical Co., Ltd. Pharmaceuticals for xerosis
CA2465103C (en) * 2002-08-09 2011-04-26 Taisho Pharmaceutical Co., Ltd. Use of a prostaglandin derivative as an anti-pruritic agent
JP4477504B2 (ja) * 2002-11-13 2010-06-09 大正製薬株式会社 鎮痒剤
MX2007000304A (es) 2004-07-02 2007-06-15 Baylor Res Inst Metodo de tratamiento de enfermedad de almacenamiento de glucogeno o polisacaridos.
MY144968A (en) * 2005-04-11 2011-11-30 Xenon Pharmaceuticals Inc Spiro-oxindole compounds and their uses as therapeutic agents
MY145694A (en) * 2005-04-11 2012-03-30 Xenon Pharmaceuticals Inc Spiroheterocyclic compounds and their uses as therapeutic agents
EP3205644A1 (en) 2005-12-29 2017-08-16 Celtaxsys Inc. Diamine derivatives as inhibitors of leukotriene a4 hydrolase
EP2073806B1 (en) 2006-10-12 2012-02-15 Xenon Pharmaceuticals Inc. Use of spiro-oxindole compounds as therapeutic agents
US20110294842A9 (en) * 2006-10-12 2011-12-01 Xenon Pharmaceuticals Inc. Spiro (furo [3, 2-c] pyridine-3-3' -indol) -2' (1'h)-one derivatives and related compounds for the treatment of sodium-channel mediated diseases, such as pain
EP2350091B1 (en) * 2008-10-17 2015-06-03 Xenon Pharmaceuticals Inc. Spiro-oxindole compounds and their use as therapeutic agents
CN106928247A (zh) 2008-10-17 2017-07-07 泽农医药公司 螺羟吲哚化合物及其作为治疗剂的用途
AR077252A1 (es) 2009-06-29 2011-08-10 Xenon Pharmaceuticals Inc Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos
PE20170202A1 (es) * 2009-10-14 2017-03-24 Xenon Pharmaceuticals Inc Metodos sinteticos para compuestos espiro-oxoindol
US20110086899A1 (en) * 2009-10-14 2011-04-14 Xenon Pharmaceuticals Inc. Pharmaceutical compositions for oral administration
MA34083B1 (fr) 2010-02-26 2013-03-05 Xenon Pharmaceuticals Inc Compositions pharmaceutques de composé spiro-oxindole pour administration topique et leur utilisation en tant qu'agents thérapeutiques
US9487535B2 (en) 2012-04-12 2016-11-08 Xenon Pharmaceuticals Inc. Asymmetric syntheses for spiro-oxindole compounds useful as therapeutic agents
MX2015011677A (es) 2013-03-14 2016-07-08 Celtaxsys Inc Inhibidores de leucotrieno a4 hidrolasa.
US9682033B2 (en) 2015-02-05 2017-06-20 Teva Pharmaceuticals International Gmbh Methods of treating postherpetic neuralgia with a topical formulation of a spiro-oxindole compound
WO2017218920A1 (en) 2016-06-16 2017-12-21 Teva Pharmaceuticals International Gmbh Asymmetric synthesis of funapide
WO2018107158A1 (en) 2016-12-09 2018-06-14 Celtaxsys, Inc. Monamine and monoamine derivatives as inhibitors of leukotriene a4 hydrolase
CA3045887A1 (en) 2016-12-09 2018-06-14 Celtaxsys, Inc. Pendant amines and derivatives as inhibitors of leukotriene a4 hydrolase
RU2019119652A (ru) 2016-12-09 2021-01-11 Селтакссис, Инк. Ингибиторы лейкотриен-а4-гидролазы

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE754114A (fr) 1969-07-29 1971-01-29 Upjohn Co Nouveaux composes de la classe des prostaglandines et leur procede de preparation
US3936487A (en) 1970-06-17 1976-02-03 The Upjohn Company 3-Oxa prostaglandin Fα-type compounds
US3954835A (en) 1972-04-27 1976-05-04 The Upjohn Company 4,5-Cis-didehydro-PGF1 compounds
US3980694A (en) 1974-04-11 1976-09-14 The Upjohn Company 4-Oxa phenyl-substituted PGA compounds
DE2845770A1 (de) 1978-10-19 1980-04-30 Schering Ag Neue prostacyclin-derivate und verfahren zu ihrer herstellung
DE2950027A1 (de) 1979-12-10 1981-06-11 Schering Ag Berlin Und Bergkamen, 1000 Berlin 9-chlor-prostaglandinderivate, verfahren zur herstellung und verwendung als arzneimittel
DE3048906A1 (de) 1980-12-19 1982-07-15 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3126924A1 (de) * 1981-07-03 1983-01-20 Schering Ag, 1000 Berlin Und 4619 Bergkamen 9-fluor-prostaglandinderivate, verfahren zur herstellung und verwendung als arzneimittel
US4579958A (en) 1983-12-23 1986-04-01 G. D. Searle & Co. 5-fluoro-3-oxa-6,7-didehydro-PGI1 compounds
US4971987A (en) * 1984-07-27 1990-11-20 Schering Aktiengesellschaft New carbacycline, process for their production and their use as a drug
DE3510978A1 (de) * 1985-03-22 1986-09-25 Schering AG, Berlin und Bergkamen, 1000 Berlin Neue 9-halogenprostaglandine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
EP0652211A1 (en) 1992-07-24 1995-05-10 Taisho Pharmaceutical Co. Ltd Prostaglandin derivative

Also Published As

Publication number Publication date
EP0299914B2 (de) 2003-04-23
US6225347B1 (en) 2001-05-01
DE3880034D1 (de) 1993-05-13
ES2054860T5 (es) 2003-11-01
EP0299914B1 (de) 1993-04-07
HUT51222A (en) 1990-04-28
IL87116A (en) 1993-03-15
JPH02502009A (ja) 1990-07-05
DK132789A (da) 1989-03-17
NZ225436A (en) 1991-04-26
IE882189L (en) 1989-01-17
CA1322197C (en) 1993-09-14
DK170889B1 (da) 1996-03-04
ES2054860T3 (es) 1994-08-16
HU206084B (en) 1992-08-28
IE62483B1 (en) 1995-02-08
IL87116A0 (en) 1988-12-30
EP0299914A1 (de) 1989-01-18
JP2716986B2 (ja) 1998-02-18
WO1989000559A1 (en) 1989-01-26

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