DK172864B1 - 4-Amino-2,3-alkylen-quinolinderivater, farmaceutisk præparat indeholdende disse, anvendelse af derivaterne til fremstilling - Google Patents

4-Amino-2,3-alkylen-quinolinderivater, farmaceutisk præparat indeholdende disse, anvendelse af derivaterne til fremstilling Download PDF

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Publication number
DK172864B1
DK172864B1 DK198801435A DK143588A DK172864B1 DK 172864 B1 DK172864 B1 DK 172864B1 DK 198801435 A DK198801435 A DK 198801435A DK 143588 A DK143588 A DK 143588A DK 172864 B1 DK172864 B1 DK 172864B1
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Prior art keywords
alkyl
formula
compound
aryl
hydrogen
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Application number
DK198801435A
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Danish (da)
English (en)
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DK143588D0 (da
DK143588A (da
Inventor
Gregory Michael Shutske
Grover Cleveland Helsley
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Hoechst Roussel Pharma
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Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Publication of DK143588D0 publication Critical patent/DK143588D0/da
Publication of DK143588A publication Critical patent/DK143588A/da
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08—Nitrogen atoms
    • C07D219/10—Nitrogen atoms attached in position 9
    • C07D219/12—Amino-alkylamino radicals attached in position 9
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08—Nitrogen atoms
    • C07D219/10—Nitrogen atoms attached in position 9
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/06—Oxygen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DK198801435A 1987-03-17 1988-03-16 4-Amino-2,3-alkylen-quinolinderivater, farmaceutisk præparat indeholdende disse, anvendelse af derivaterne til fremstilling DK172864B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2673087A 1987-03-17 1987-03-17
US2673087 1987-03-17

Publications (3)

Publication Number Publication Date
DK143588D0 DK143588D0 (da) 1988-03-16
DK143588A DK143588A (da) 1988-09-18
DK172864B1 true DK172864B1 (da) 1999-08-23

Family

ID=21833471

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198801435A DK172864B1 (da) 1987-03-17 1988-03-16 4-Amino-2,3-alkylen-quinolinderivater, farmaceutisk præparat indeholdende disse, anvendelse af derivaterne til fremstilling

Country Status (15)

Country Link
US (1) US5391553A (no)
EP (1) EP0282959A3 (no)
JP (1) JP2888485B2 (no)
KR (1) KR960015001B1 (no)
AU (2) AU635370B2 (no)
CA (1) CA1318675C (no)
DK (1) DK172864B1 (no)
FI (1) FI91401C (no)
HU (1) HU201018B (no)
IL (1) IL85741A (no)
NO (1) NO173498C (no)
NZ (1) NZ223875A (no)
PH (1) PH25124A (no)
PT (1) PT86986B (no)
ZA (1) ZA881865B (no)

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IL87861A0 (en) * 1987-10-05 1989-03-31 Pfizer 4-aminopyridine derivatives
US5008853A (en) 1987-12-02 1991-04-16 Xerox Corporation Representation of collaborative multi-user activities relative to shared structured data objects in a networked workstation environment
US4985430A (en) 1987-12-03 1991-01-15 Mitsubishi Kasei Corporation 9-acylamino-tetrahydroacridine derivatives and memory enhancing agent containing said derivative as active ingredient
US4868177A (en) * 1988-11-09 1989-09-19 Hoechst-Roussel Pharmaceuticals, Inc. 1,2,3,4-tetrahydro-1,9-acridinediamines, pharmaceutical compositions and use
KR0156241B1 (ko) * 1988-11-16 1998-11-16 도날드 알.토센 하이드록시-1,2,3,4-테트라하이드로아미노아크리딘, 이의 제조방법 및 이를 함유하는 약제학적 조성물
JP2720517B2 (ja) * 1989-05-31 1998-03-04 三菱化学株式会社 ９―アシルアミノーテトラヒドロアクリジン誘導体および該誘導体を有効成分とする記憶障害改善剤
US5112829A (en) * 1989-11-28 1992-05-12 Hoechst-Roussel Pharmaceuticals Inc. Hexahydro-1H-quino[4,3,2-ef][1,4]benzoxazepines and related compounds
US4994452A (en) * 1989-11-28 1991-02-19 Hoechst-Roussel Pharmaceuticals Inc. Hexahydro-1H-quino[4,3,2-ef][1,4]benzoxazepines and related compounds
RU2024509C1 (ru) * 1991-05-07 1994-12-15 Всероссийский научный центр по безопасности биологически активных веществ Производные 9-аминоакридина или их соли с органическими или неорганическими кислотами, проявляющие психотропную, антиамнестическую и липидрегулирующую активность
GB9524346D0 (en) * 1995-11-29 1996-01-31 Univ Strathclyde Polycyclic compounds
US5783584A (en) * 1995-12-11 1998-07-21 Mayo Foundation For Medical Education And Research THA analogs useful as cholinesterase inhibitors
US5929093A (en) * 1996-06-13 1999-07-27 Mayo Foundation For Medical Education And Research Bifunctional acetylcholinesterase reactivators
JP4685742B2 (ja) * 1997-06-02 2011-05-18 明治製菓株式会社 ４−キノリノール誘導体及びこれを有効成分として含有する農園芸用殺菌剤
TW521072B (en) * 1997-06-02 2003-02-21 Meiji Seika Kaisha 4-quinolinol derivatives and fungicides containing the same as an active ingredient used for agriculture and horticulture
ES2144353B1 (es) * 1997-12-26 2001-01-01 Consejo Superior Investigacion Nuevos analogos de tacrina: potenciales agentes neuroprotectores para las enfermedades de alzheimer y parkinson. su procedimiento de obtencion.
US6218383B1 (en) 1998-08-07 2001-04-17 Targacept, Inc. Pharmaceutical compositions for the prevention and treatment of central nervous system disorders
ES2168926B1 (es) * 1999-12-14 2003-10-16 Prous Science S A Derivados de ciclopenta- ciclohexa- y ciclohepta (b)quinoleina, procedimiento para su fabricacion, utilizacion y composicion farmaceutica correspondiente.
WO2003013522A1 (fr) * 2001-08-06 2003-02-20 Mitsubishi Pharma Corporation Compositions prophylactiques/therapeutiques destinees a la neuropathie cholinergique
EP1598355A4 (en) * 2003-01-08 2010-01-27 Mitsubishi Tanabe Pharma Corp THERAPEUTIC AGENT FOR SCHIZOPHRENIA
CA2789014C (en) 2010-02-09 2019-01-15 Michela Gallagher Methods and compositions for improving cognitive function
CN102219740B (zh) 2010-09-10 2013-02-13 长春华洋高科技有限公司 1，2，3，4，5，6，7，8-八氢-9-苯乙酰胺基吖啶及制备方法和药用用途
JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物
CA2904767C (en) 2013-03-15 2022-06-21 Agenebio, Inc. Methods and compositions for improving cognitive function
WO2014144663A1 (en) 2013-03-15 2014-09-18 The Johns Hopkins University Methods and compositions for improving cognitive function
RU2567388C1 (ru) * 2014-12-10 2015-11-10 Открытое акционерное общество "Нижегородский химико-фармацевтический завод" Способ получения 9-бутиламино-3,3-диметил-3,4-дигидроакридин-1(2н)-она гидрохлорида
WO2016191288A1 (en) 2015-05-22 2016-12-01 Agenebio, Inc. Extended release pharmaceutical compositions of levetiracetam
BR112018001960A2 (pt) 2015-08-03 2018-09-18 Bristol-Myers Squibb Company compostos heterocíclicos úteis como moduladores de tnf alfa
KR101953366B1 (ko) 2018-12-26 2019-02-28 정종문 침향을 포함하는 기억력 및 인지능력을 향상시키는 기능성 건강식품 및 이의 제조방법
CN111704576A (zh) * 2020-06-17 2020-09-25 菏泽学院 一种轴手性9-芳基四氢吖啶的合成方法及应用

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US3232945A (en) * 1962-08-13 1966-02-01 S E Massengill Company 7,8,9,10-tetrahalo-6h-cyclohepta-(b)-quinolines
US3318896A (en) * 1963-12-05 1967-05-09 Squibb & Sons Inc Production of 12-substituted-6, 7, 8, 9, 10, 11-hexahydrocycloocta[b]quinolines
US3318895A (en) * 1963-12-05 1967-05-09 Squibb & Sons Inc Production of 12-substituted-6, 7, 8, 9, 10, 11-hexahydrocycloocta[b]quinolines
BE658695A (no) * 1964-02-03 1965-07-22
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US3541066A (en) * 1968-09-16 1970-11-17 American Home Prod 2,3-dihydro-1,4-ethanobenzo(b)(1,5)naphthyridine derivatives
US3647800A (en) * 1970-04-30 1972-03-07 American Home Prod 10-substituted - 1 2 3 4 - tetrahydrobenzo(b)(1 6)naphthyridines useful as cns depressants
US3637706A (en) * 1970-04-30 1972-01-25 American Home Prod 10-(4 - (lower)alkylpiperazino) - 1 2 3 4-tetrahydrobenzo(b)(1 6) naphthyridine derivatives useful as cns depressants
US3657233A (en) * 1970-04-30 1972-04-18 American Home Prod 10-morpholino-1 2 3 4-tetrahydrobenzo(b)(1 6)naphthyridine derivatives
US3674790A (en) * 1970-05-01 1972-07-04 American Home Prod 2,10-disubstituted-1,2,3,4-tetrahydrobenzo(bhq (1,6)naphthyridines useful as cns depressants
ES431307A1 (es) * 1973-11-16 1976-09-01 Thomae Gmbh Dr K Procedimiento para la preparacion de nuevos derivados de quinoleina.
US4108998A (en) * 1976-11-08 1978-08-22 American Home Products Corp. Furo[3,4-b]quinoline derivatives and pharmaceutical compositions and methods employing them
JPS6147466A (ja) * 1984-08-10 1986-03-07 Dainippon Pharmaceut Co Ltd アミン誘導体
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EP0179383B1 (en) * 1984-10-25 1991-05-29 Hoechst-Roussel Pharmaceuticals Incorporated 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds, a process for their preparation and their use as medicaments
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AU634004B2 (en) * 1987-03-17 1993-02-11 Hoechst Marion Roussel, Inc. Intermediates for substituted 9-amino-tetrahydro-acridines, a process for their preparation and their use as medicaments
US4762841A (en) * 1987-03-30 1988-08-09 Hoechst-Roussel Pharmaceuticals Inc. Substituted 9-amino-spiro(cycloalkyl(b)quinoline-2,1'cycloalkanes)
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US4985430A (en) * 1987-12-03 1991-01-15 Mitsubishi Kasei Corporation 9-acylamino-tetrahydroacridine derivatives and memory enhancing agent containing said derivative as active ingredient
US4868177A (en) * 1988-11-09 1989-09-19 Hoechst-Roussel Pharmaceuticals, Inc. 1,2,3,4-tetrahydro-1,9-acridinediamines, pharmaceutical compositions and use
US4999430A (en) * 1989-07-31 1991-03-12 Warner-Lambert Company Derivatives of 1,2,3,4-tetrahydro-9-acrisinamine
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Also Published As

Publication number Publication date
DK143588D0 (da) 1988-03-16
PT86986B (pt) 1992-06-30
DK143588A (da) 1988-09-18
EP0282959A3 (en) 1989-05-31
US5391553A (en) 1995-02-21
JP2888485B2 (ja) 1999-05-10
HUT46672A (en) 1988-11-28
JPS63238063A (ja) 1988-10-04
AU633668B2 (en) 1993-02-04
ZA881865B (en) 1988-11-30
AU635370B2 (en) 1993-03-18
NO881164D0 (no) 1988-03-16
NO881164L (no) 1988-09-19
FI91401B (fi) 1994-03-15
NO173498B (no) 1993-09-13
NZ223875A (en) 1991-01-29
AU608300B2 (en) 1991-03-28
AU1314188A (en) 1988-09-15
AU6824090A (en) 1991-05-02
KR880011111A (ko) 1988-10-26
KR960015001B1 (ko) 1996-10-23
PH25124A (en) 1991-02-19
EP0282959A2 (en) 1988-09-21
IL85741A (en) 1996-05-14
FI881223A0 (fi) 1988-03-15
AU6824190A (en) 1991-03-14
IL85741A0 (en) 1988-08-31
PT86986A (pt) 1988-04-01
FI91401C (fi) 1994-06-27
FI881223A (fi) 1988-09-18
NO173498C (no) 1993-12-22
HU201018B (en) 1990-09-28
CA1318675C (en) 1993-06-01

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PBP Patent lapsed

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