PT85225B - Processo para a preparacao de novos factores indutivos do desenvolvimento osseo e de composicoes farmaceuticas que os contem - Google Patents

Info

Publication number

PT85225B

PT85225B PT85225A PT8522587A PT85225B PT 85225 B PT85225 B PT 85225B PT 85225 A PT85225 A PT 85225A PT 8522587 A PT8522587 A PT 8522587A PT 85225 B PT85225 B PT 85225B

Authority

PT

Portugal

Prior art keywords

arg

gly

pro

asp

glu

Prior art date

1986-07-01

Links

• Espacenet
• Global Dossier
• Discuss

• 238000000034 method Methods 0.000 title claims abstract description 58
• 230000001939 inductive effect Effects 0.000 title claims abstract description 44
• 230000008569 process Effects 0.000 title claims abstract description 33
• 238000002360 preparation method Methods 0.000 title claims description 14
• 239000008194 pharmaceutical composition Substances 0.000 title claims description 6
• 238000011161 development Methods 0.000 title description 11
• 210000000988 bone and bone Anatomy 0.000 claims abstract description 118
• 238000011282 treatment Methods 0.000 claims abstract description 7
• 239000003795 chemical substances by application Substances 0.000 claims description 247
• RLMISHABBKUNFO-WHFBIAKZSA-N Ala-Ala-Gly Chemical compound C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(O)=O RLMISHABBKUNFO-WHFBIAKZSA-N 0.000 claims description 167
• 108090000623 proteins and genes Proteins 0.000 claims description 70
• 125000003729 nucleotide group Chemical group 0.000 claims description 55
• 239000002773 nucleotide Substances 0.000 claims description 54
• 150000001413 amino acids Chemical class 0.000 claims description 53
• 108091028043 Nucleic acid sequence Proteins 0.000 claims description 47
• 102000004169 proteins and genes Human genes 0.000 claims description 46
• 230000006698 induction Effects 0.000 claims description 39
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 37
• 108010029020 prolylglycine Proteins 0.000 claims description 34
• 239000000203 mixture Substances 0.000 claims description 26
• 230000014461 bone development Effects 0.000 claims description 25
• XBGGUPMXALFZOT-UHFFFAOYSA-N glycyl-L-tyrosine hemihydrate Natural products NCC(=O)NC(C(O)=O)CC1=CC=C(O)C=C1 XBGGUPMXALFZOT-UHFFFAOYSA-N 0.000 claims description 24
• 239000011159 matrix material Substances 0.000 claims description 23
• KKBWDNZXYLGJEY-UHFFFAOYSA-N Gly-Arg-Pro Natural products NCC(=O)NC(CCNC(=N)N)C(=O)N1CCCC1C(=O)O KKBWDNZXYLGJEY-UHFFFAOYSA-N 0.000 claims description 21
• 239000013598 vector Substances 0.000 claims description 21
• KOSRFJWDECSPRO-UHFFFAOYSA-N alpha-L-glutamyl-L-glutamic acid Natural products OC(=O)CCC(N)C(=O)NC(CCC(O)=O)C(O)=O KOSRFJWDECSPRO-UHFFFAOYSA-N 0.000 claims description 20
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• 108010055341 glutamyl-glutamic acid Proteins 0.000 claims description 20
• RNKSNIBMTUYWSH-YFKPBYRVSA-N L-prolylglycine Chemical compound [O-]C(=O)CNC(=O)[C@@H]1CCC[NH2+]1 RNKSNIBMTUYWSH-YFKPBYRVSA-N 0.000 claims description 19
• 239000002299 complementary DNA Substances 0.000 claims description 19
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• KLKHFFMNGWULBN-VKHMYHEASA-N Asn-Gly Chemical compound NC(=O)C[C@H](N)C(=O)NCC(O)=O KLKHFFMNGWULBN-VKHMYHEASA-N 0.000 claims description 17
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• VBKIFHUVGLOJKT-FKZODXBYSA-N Asn-Thr Chemical compound C[C@@H]([C@@H](C(=O)O)NC(=O)[C@H](CC(=O)N)N)O VBKIFHUVGLOJKT-FKZODXBYSA-N 0.000 claims description 12
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• BBIXOODYWPFNDT-CIUDSAMLSA-N Ile-Pro Chemical compound CC[C@H](C)[C@H](N)C(=O)N1CCC[C@H]1C(O)=O BBIXOODYWPFNDT-CIUDSAMLSA-N 0.000 claims description 11
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• WXUOJXIGOPMDJM-SRVKXCTJSA-N Leu-Lys-Asn Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(O)=O WXUOJXIGOPMDJM-SRVKXCTJSA-N 0.000 claims description 10
• BRSGXFITDXFMFF-IHRRRGAJSA-N Lys-Arg-His Chemical compound C1=C(NC=N1)C[C@@H](C(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)N BRSGXFITDXFMFF-IHRRRGAJSA-N 0.000 claims description 10
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• ALHULIGNEXGFRM-QWRGUYRKSA-N Phe-Cys-Gly Chemical compound OC(=O)CNC(=O)[C@H](CS)NC(=O)[C@@H](N)CC1=CC=CC=C1 ALHULIGNEXGFRM-QWRGUYRKSA-N 0.000 claims description 10
• MLQVJYMFASXBGZ-IHRRRGAJSA-N Pro-Asn-Tyr Chemical compound C1C[C@H](NC1)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)O MLQVJYMFASXBGZ-IHRRRGAJSA-N 0.000 claims description 10
• HQIZDMIGUJOSNI-IUCAKERBSA-N Arg-Gly-Arg Chemical compound N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(O)=O HQIZDMIGUJOSNI-IUCAKERBSA-N 0.000 claims description 9
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