PT80773B - Processo para a preparacao dos profarmacos benzoatos substituidos de derivados de 3-hidroximorfinanos de compostos intermedios na sua preparacao e de composicoes farmaceuticas que os contem - Google Patents

Processo para a preparacao dos profarmacos benzoatos substituidos de derivados de 3-hidroximorfinanos de compostos intermedios na sua preparacao e de composicoes farmaceuticas que os contem

Info

Publication number
PT80773B
PT80773B PT80773A PT8077385A PT80773B PT 80773 B PT80773 B PT 80773B PT 80773 A PT80773 A PT 80773A PT 8077385 A PT8077385 A PT 8077385A PT 80773 B PT80773 B PT 80773B
Authority
PT
Portugal
Prior art keywords
profarmacles
hydroxymorfinoan
derivatives
contain
preparation
Prior art date
Application number
PT80773A
Other languages
English (en)
Portuguese (pt)
Other versions
PT80773A (en
Inventor
Elie Gabriel Shami
Original Assignee
Du Pont Merck Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont Merck Pharma filed Critical Du Pont Merck Pharma
Publication of PT80773A publication Critical patent/PT80773A/pt
Publication of PT80773B publication Critical patent/PT80773B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/28—Morphinans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PT80773A 1984-07-05 1985-07-04 Processo para a preparacao dos profarmacos benzoatos substituidos de derivados de 3-hidroximorfinanos de compostos intermedios na sua preparacao e de composicoes farmaceuticas que os contem PT80773B (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62792384A 1984-07-05 1984-07-05
US06/733,464 US4668685A (en) 1984-07-05 1985-05-14 Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists

Publications (2)

Publication Number Publication Date
PT80773A PT80773A (en) 1985-08-01
PT80773B true PT80773B (pt) 1987-10-20

Family

ID=27090564

Family Applications (1)

Application Number Title Priority Date Filing Date
PT80773A PT80773B (pt) 1984-07-05 1985-07-04 Processo para a preparacao dos profarmacos benzoatos substituidos de derivados de 3-hidroximorfinanos de compostos intermedios na sua preparacao e de composicoes farmaceuticas que os contem

Country Status (18)

Country Link
US (1) US4668685A (e)
EP (1) EP0170090B1 (e)
AU (1) AU578391B2 (e)
CA (1) CA1301150C (e)
DE (1) DE3573251D1 (e)
DK (1) DK160501C (e)
ES (1) ES8704443A1 (e)
FI (1) FI83215C (e)
GR (1) GR851653B (e)
HK (1) HK39790A (e)
HU (1) HU193995B (e)
IE (1) IE58136B1 (e)
IL (1) IL75721A (e)
MX (1) MX160445A (e)
NO (1) NO171209C (e)
NZ (1) NZ212641A (e)
PT (1) PT80773B (e)
SU (2) SU1450742A3 (e)

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EP1604667A1 (en) * 2004-06-08 2005-12-14 Euro-Celtique S.A. Opioids for the treatment of the restless leg syndrome
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US20080045610A1 (en) * 2004-09-23 2008-02-21 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
EP3228308A1 (en) * 2005-01-28 2017-10-11 Euro-Celtique S.A. Alcohol resistant dosage forms
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EP1695700A1 (en) * 2005-02-28 2006-08-30 Euro-Celtique S.A. Dosage form containing oxycodone and naloxone
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US10849981B2 (en) 2009-07-02 2020-12-01 KemPham, Inc. Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof
US8623888B2 (en) * 2009-07-15 2014-01-07 Mallinckrodt Llc 3-oxy-hydromorphone derivatives
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KR20170094251A (ko) 2014-12-02 2017-08-17 켐팜 인코포레이티드 옥시모르폰의 벤조산, 벤조산 유도체 및 헤테로아릴 카르복실산 콘쥬게이트, 이의 전구 약물, 제조 방법 및 용도
US10155771B2 (en) * 2015-11-04 2018-12-18 Noramco, Inc. Selective reduction of morphinan alkaloids
US10807995B2 (en) 2018-07-13 2020-10-20 Alkermes Pharma Ireland Limited Thienothiophene compounds for long-acting injectable compositions and related methods
WO2020012248A1 (en) 2018-07-13 2020-01-16 Alkermes Pharma Ireland Limited Novel naphthylenyl compounds for long-acting injectable compositions and related methods
US11186585B2 (en) 2018-08-17 2021-11-30 Kappa-Pharma LLC Compositions and methods of enhancing opioid receptor engagement by opioid hexadienoates and optionally substituted hexadienoates
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DE2323192A1 (de) * 1972-05-10 1973-12-13 Endo Lab Injizierbare, langwirkende antagonistpraeparate gegen narkotika und rauschgifte
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Also Published As

Publication number Publication date
IL75721A (en) 1990-04-29
MX160445A (es) 1990-03-02
IE851683L (en) 1986-01-05
EP0170090A1 (en) 1986-02-05
AU578391B2 (en) 1988-10-20
DK160501B (da) 1991-03-18
FI83215B (fi) 1991-02-28
IL75721A0 (en) 1985-11-29
HUT40132A (en) 1986-11-28
SU1450742A3 (ru) 1989-01-07
DK306885D0 (da) 1985-07-04
GR851653B (e) 1985-11-26
PT80773A (en) 1985-08-01
FI852659A0 (fi) 1985-07-04
CA1301150C (en) 1992-05-19
EP0170090B1 (en) 1989-09-27
FI852659L (fi) 1986-01-06
AU4451685A (en) 1986-01-09
SU1508960A3 (ru) 1989-09-15
ES544852A0 (es) 1987-04-01
NO852699L (no) 1986-01-06
NO171209B (no) 1992-11-02
HU193995B (en) 1987-12-28
US4668685A (en) 1987-05-26
FI83215C (fi) 1991-06-10
DK160501C (da) 1991-08-26
ES8704443A1 (es) 1987-04-01
DE3573251D1 (en) 1989-11-02
IE58136B1 (en) 1993-07-14
NZ212641A (en) 1988-10-28
HK39790A (en) 1990-06-01
NO171209C (no) 1993-02-10
DK306885A (da) 1986-01-06

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Legal Events

Date Code Title Description
PC3A Transfer or assignment

Free format text: 920721 DU PONT MERCK PHARMACEUTIVAL COMPANY,THE US

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19930930