ES2188481T3 - Derivados de polinalbufina. - Google Patents

Derivados de polinalbufina.

Info

Publication number
ES2188481T3
ES2188481T3 ES00303532T ES00303532T ES2188481T3 ES 2188481 T3 ES2188481 T3 ES 2188481T3 ES 00303532 T ES00303532 T ES 00303532T ES 00303532 T ES00303532 T ES 00303532T ES 2188481 T3 ES2188481 T3 ES 2188481T3
Authority
ES
Spain
Prior art keywords
polinalbufina
derivatives
polynalbuphine
chem
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES00303532T
Other languages
English (en)
Inventor
Oliver Yoa-Pu Hu
Cheng-Huei Hsiong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of ES2188481T3 publication Critical patent/ES2188481T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Anesthesiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

Derivado de polinalbufina que comprende un compuesto que tiene la siguiente **fórmula** en la que n es un número entero > 2; y R es un grupo hidrocarbil sustituido o no sustituido que tiene de 1 a 40 átomos de carbono, en el que los sustituyentes se seleccionan de entre alquil o alquileno lineal o ramificado que tiene de 1 a 8 átomos de carbono.
ES00303532T 2000-04-27 2000-04-27 Derivados de polinalbufina. Expired - Lifetime ES2188481T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP00303532A EP1149836B1 (en) 2000-04-27 2000-04-27 Polynalbuphine derivatives

Publications (1)

Publication Number Publication Date
ES2188481T3 true ES2188481T3 (es) 2003-07-01

Family

ID=8172948

Family Applications (1)

Application Number Title Priority Date Filing Date
ES00303532T Expired - Lifetime ES2188481T3 (es) 2000-04-27 2000-04-27 Derivados de polinalbufina.

Country Status (4)

Country Link
EP (1) EP1149836B1 (es)
AT (1) ATE233264T1 (es)
DE (1) DE60001487T2 (es)
ES (1) ES2188481T3 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7759358B2 (en) * 2003-07-23 2010-07-20 Crooks Peter A Oral bioavailable prodrugs
US8394812B2 (en) 2005-08-24 2013-03-12 Penwest Pharmaceuticals Co. Sustained release formulations of nalbuphine
JP2009506059A (ja) 2005-08-24 2009-02-12 ペンウエスト ファーマシューティカルズ カンパニー ナルブフィンの徐放性製剤
LT2701707T (lt) 2011-04-29 2021-01-25 Rutgers, The State University Of New Jersey Diskinezijos gydymo būdas
US10736889B2 (en) * 2011-04-29 2020-08-11 Rutgers, The State University Of New Jersey Method of treating dyskinesia
US9918980B2 (en) * 2011-04-29 2018-03-20 Rutgers, The State University Of New Jersey Method of treating dyskinesia
JP2021525225A (ja) * 2018-03-29 2021-09-24 ルモサ セラピューティクス カンパニー， リミテッド 掻痒症を治療するための組成物及び方法
WO2020012245A1 (en) 2018-07-13 2020-01-16 Alkermes Pharma Ireland Limited Thienothiophene-naltrexone prodrugs for long-acting injectable compositions
US10799496B2 (en) 2018-07-13 2020-10-13 Alkermes Pharma Ireland Limited Naphthylenyl compounds for long-acting injectable compositions and related methods
US11186585B2 (en) 2018-08-17 2021-11-30 Kappa-Pharma LLC Compositions and methods of enhancing opioid receptor engagement by opioid hexadienoates and optionally substituted hexadienoates
US10975099B2 (en) 2018-11-05 2021-04-13 Alkermes Pharma Ireland Limited Thiophene compounds for long-acting injectable compositions and related methods
CA3149152A1 (en) 2019-08-11 2021-02-18 Kappa-Pharma LLC Compositions and methods of enhancing opioid receptor engagement by opioid hexadienoates and optionally substituted hexadienoates
AU2021206252A1 (en) 2020-01-10 2022-07-28 Trevi Therapeutics, Inc. Methods of administering nalbuphine

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2323192A1 (de) * 1972-05-10 1973-12-13 Endo Lab Injizierbare, langwirkende antagonistpraeparate gegen narkotika und rauschgifte
US4668685A (en) * 1984-07-05 1987-05-26 E.I. Du Pont De Nemours And Company Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists
EP0615756B1 (en) * 1993-03-15 2001-06-27 National Science Council Nalbuphine esters and long-acting pharmaceutical compositions containing them

Also Published As

Publication number Publication date
EP1149836B1 (en) 2003-02-26
DE60001487T2 (de) 2003-12-24
ATE233264T1 (de) 2003-03-15
DE60001487D1 (de) 2003-04-03
EP1149836A1 (en) 2001-10-31

Similar Documents

Publication Publication Date Title
NO904377L (no) Tricykliske karbapenemforbindelser.
DE69929877D1 (de) BENZOCHINONDERIVATE ENTHALTENDE HEMMER VON NF-kB
ATE125539T1 (de) 1,4-benzothiazedinderivat.
PL333463A1 (en) Novel applications of 1,3-propanodiole derivatives
ES2188481T3 (es) Derivados de polinalbufina.
ATE263771T1 (de) Totalsynthese von acylfulvenen mit antitumorwirkung
EA200100310A1 (ru) Кислородсодержащие гетероциклические соединения
DK0695755T3 (da) Pyrrolocarbazoler
PT1043310E (pt) Derivados de bifenilamidina
ES2093037T3 (es) Derivados de beta-lactama y su preparacion.
ES2087247T3 (es) Inhibidor de aldosa reductasa.
EP1398306A3 (en) A (1'R, 2'S, 5'R)-3-l-Menthoxyalkan-1-ol cooling sensate
ES2157292T3 (es) Inhibidores 6-azaindol de la tromboxano sintasa.
DE69423339D1 (de) Epoxycyclohexendionderivat
DK1559714T3 (da) Fremgangsmåde til fremstilling af 2-alkyl-3-aminothiophenderivater og 3-aminothiophenderivater
DK0601191T3 (da) Hidtil ukendt tetracyklisk forbindelse
BR0210201A (pt) Composição
NO20004477L (no) Anvendelse av organiske karbonater for vasking av metalloverflater
DE60221250D1 (de) Bis(5-aryl-2-pyridyl)derivate
DK0381628T3 (da) Glycocyamidinderivater
FI901046A0 (fi) Stabilisering av polyprenylfoereningen.