ES2157292T3 - Inhibidores 6-azaindol de la tromboxano sintasa. - Google Patents

Inhibidores 6-azaindol de la tromboxano sintasa.

Info

Publication number
ES2157292T3
ES2157292T3 ES95300551T ES95300551T ES2157292T3 ES 2157292 T3 ES2157292 T3 ES 2157292T3 ES 95300551 T ES95300551 T ES 95300551T ES 95300551 T ES95300551 T ES 95300551T ES 2157292 T3 ES2157292 T3 ES 2157292T3
Authority
ES
Spain
Prior art keywords
inhibitors
tromboxan
sintasa
azaindol
integer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95300551T
Other languages
English (en)
Inventor
Joseph Anthony Jakubowski
Alan David Palkowitz
Sandra Kay Sigmund
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of ES2157292T3 publication Critical patent/ES2157292T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

DERIVADOS DEL TIPO 6 - AZAINDOL FUNCIONALES DE ACIDO SELECCIONADO COMO INHIBIDORES DE "SUITASA" DE THROMBOXANO, TENIENDO LA FORMULA (II): EN LA QUE N ES UN NUMERO ENTERO DE CERO A 3, M ES UN NUMERO ENTERO DE CERO A 2, R1 Y R2 SON RADICALES MONOVALENTES - (LA) - ES UN GRUPO DE ENLACE DE 4 A 8 ATOMOS DE CADENA, Y A ES UN GRUPO ACIDICO.
ES95300551T 1994-01-31 1995-01-30 Inhibidores 6-azaindol de la tromboxano sintasa. Expired - Lifetime ES2157292T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/189,212 US5468757A (en) 1994-01-31 1994-01-31 6-azaindole thromboxane synthase inhibitors

Publications (1)

Publication Number Publication Date
ES2157292T3 true ES2157292T3 (es) 2001-08-16

Family

ID=22696403

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95300551T Expired - Lifetime ES2157292T3 (es) 1994-01-31 1995-01-30 Inhibidores 6-azaindol de la tromboxano sintasa.

Country Status (11)

Country Link
US (1) US5468757A (es)
EP (1) EP0668279B1 (es)
JP (1) JPH0853448A (es)
AT (1) ATE202103T1 (es)
CA (1) CA2141231A1 (es)
DE (1) DE69521223T2 (es)
DK (1) DK0668279T3 (es)
ES (1) ES2157292T3 (es)
GR (1) GR3036570T3 (es)
PT (1) PT668279E (es)
SI (1) SI0668279T1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1023067T4 (da) * 1997-10-17 2011-12-12 Ark Therapeutics Ltd Anvendelse af inhibitorer af renin-angiotensin-systemet til behandling af hypoxi eller svækket metabolisk funktion
AU745579B2 (en) 1997-10-20 2002-03-21 F. Hoffmann-La Roche Ag Bicyclic kinase inhibitors
DE69914563T2 (de) 1998-10-30 2004-12-16 Eli Lilly And Co., Indianapolis Azaindol derivate und ihre Verwendung als antithrombotische Wirkstoffe
CA2367121A1 (en) * 1999-03-10 2000-09-14 Merck & Co., Inc. 6-azaindole compounds as antagonists of gonadotropin releasing hormone
WO2003009852A1 (en) * 2001-07-24 2003-02-06 Merck & Co., Inc. Tyrosine kinase inhibitors
GB0330043D0 (en) * 2003-12-24 2004-01-28 Pharmacia Italia Spa Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions comprising them
WO2005121140A1 (en) 2004-06-09 2005-12-22 Glaxo Group Limited Pyrrolopyridine derivatives
US20070155738A1 (en) 2005-05-20 2007-07-05 Alantos Pharmaceuticals, Inc. Heterobicyclic metalloprotease inhibitors
JP7478142B2 (ja) * 2018-06-07 2024-05-02 ディスアーム セラピューティクス， インコーポレイテッド Ｓａｒｍ１阻害剤

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1250844A (en) * 1981-06-22 1989-03-07 Neville Ford Substituted imidazo¬1,5-a|pyridines, process for their manufacture, pharmaceutical preparations containing these compounds and their therapeutic application
US4470986A (en) * 1982-12-21 1984-09-11 Ciba-Geigy Corporation Certain imidazo (1,5-A) pyridine aliphatic carboxylic acid derivatives and their use as selective thromboxane inhibitors
US4588732A (en) * 1982-12-21 1986-05-13 Ciba-Geigy Corporation Certain imidazo(1,5-a)pyridine derivatives and their use as thromboxane synthetase inhibitors
DE3302125A1 (de) * 1983-01-22 1984-07-26 Boehringer Ingelheim KG, 6507 Ingelheim Aminosaeure-derivate, verfahren zu ihrer herstellung und verwendung
FR2658511B1 (fr) * 1990-02-16 1992-06-19 Union Pharma Scient Appl Nouveaux derives de benzimidazole et d'azabenzimidazole, antagonistes des recepteurs au thromboxane; leurs procedes de preparation, compositions pharmaceutiques les contenant.
ATE173251T1 (de) * 1991-08-21 1998-11-15 Eisai Co Ltd Kondensierte pyrimidinderivate als antitumorverbindungen

Also Published As

Publication number Publication date
CA2141231A1 (en) 1995-08-01
ATE202103T1 (de) 2001-06-15
JPH0853448A (ja) 1996-02-27
DE69521223D1 (de) 2001-07-19
DK0668279T3 (da) 2001-08-27
DE69521223T2 (de) 2001-11-08
SI0668279T1 (en) 2001-12-31
US5468757A (en) 1995-11-21
GR3036570T3 (en) 2001-12-31
EP0668279A2 (en) 1995-08-23
PT668279E (pt) 2001-09-28
EP0668279A3 (en) 1995-08-30
EP0668279B1 (en) 2001-06-13

Similar Documents

Publication Publication Date Title
TR200000065T2 (tr) Epotilon türevleri.
TR199700844T1 (xx) Pirazolil-Benzoil T�revleri.
FI965020A (fi) Uusia yhdisteitä, menetelmiä niiden valmistamiseksi ja kasvaintenvastaisia aineita
PT90623A (pt) Processo para a preparacao de n-heterociclil-4-guanilalquil-benzamidas uteis como inibidores de protease
KR970704864A (ko) 세정제 조성물
DE69728544D1 (de) Totalsynthese von acylfulvenen mit antitumorwirkung
ES2157292T3 (es) Inhibidores 6-azaindol de la tromboxano sintasa.
TR200001740T2 (tr) Mikrobisidal ve bitkiye bağışıklık kazandırıcı aktiviteleri olan tiyazol-türevleri
ATE232528T1 (de) Pyrimidinylpyrazolderivate
ES2188481T3 (es) Derivados de polinalbufina.
PT947504E (pt) Derivados de vitamina d 16-eno
ES2169220T3 (es) Derivados de vitamina d3 con sustituyentes en la posicion 2.
ES2087247T3 (es) Inhibidor de aldosa reductasa.
DK0601191T3 (da) Hidtil ukendt tetracyklisk forbindelse
ATE245147T1 (de) Substituierte aminochinazolinon (thion) derivate
NO900732D0 (no) Arylalkylaminforbindelser.
BR0210201A (pt) Composição
NO20004477L (no) Anvendelse av organiske karbonater for vasking av metalloverflater
ES2121036T3 (es) Derivados de alquilenodiamina.
ATE420855T1 (de) 2-substituierte vitamin-d-derivate
DK1264836T3 (da) Fremgangsmåde til fremstilling af indolopyrrolocarbaxolderivater
ECSP982576A (es) Derivados de epotilona

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 668279

Country of ref document: ES