ATE202103T1 - 6-azaindole-hemmer der tromboxan-synthetase - Google Patents

6-azaindole-hemmer der tromboxan-synthetase

Info

Publication number
ATE202103T1
ATE202103T1 AT95300551T AT95300551T ATE202103T1 AT E202103 T1 ATE202103 T1 AT E202103T1 AT 95300551 T AT95300551 T AT 95300551T AT 95300551 T AT95300551 T AT 95300551T AT E202103 T1 ATE202103 T1 AT E202103T1
Authority
AT
Austria
Prior art keywords
tromboxane
synthetase
azaindole
integer
zero
Prior art date
Application number
AT95300551T
Other languages
English (en)
Inventor
Joseph Anthony Jakubowski
Alan David Palkowitz
Sandra Kay Sigmund
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE202103T1 publication Critical patent/ATE202103T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT95300551T 1994-01-31 1995-01-30 6-azaindole-hemmer der tromboxan-synthetase ATE202103T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/189,212 US5468757A (en) 1994-01-31 1994-01-31 6-azaindole thromboxane synthase inhibitors

Publications (1)

Publication Number Publication Date
ATE202103T1 true ATE202103T1 (de) 2001-06-15

Family

ID=22696403

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95300551T ATE202103T1 (de) 1994-01-31 1995-01-30 6-azaindole-hemmer der tromboxan-synthetase

Country Status (11)

Country Link
US (1) US5468757A (de)
EP (1) EP0668279B1 (de)
JP (1) JPH0853448A (de)
AT (1) ATE202103T1 (de)
CA (1) CA2141231A1 (de)
DE (1) DE69521223T2 (de)
DK (1) DK0668279T3 (de)
ES (1) ES2157292T3 (de)
GR (1) GR3036570T3 (de)
PT (1) PT668279E (de)
SI (1) SI0668279T1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2677910C (en) * 1997-10-17 2011-03-15 Ark Therapeutics Limited The use of inhibitors of the renin-angiotensin system for the treatment of cardiovascular diseases
CN1279682A (zh) 1997-10-20 2001-01-10 霍夫曼-拉罗奇有限公司 双环激酶抑制剂
ES2213984T3 (es) 1998-10-30 2004-09-01 Eli Lilly And Company Derivados de azaindol y su uso como agentes antitrombicos.
AU3395000A (en) * 1999-03-10 2000-09-28 Merck & Co., Inc. 6-azaindole compounds as antagonists of gonadotropin releasing hormone
US20040235867A1 (en) * 2001-07-24 2004-11-25 Bilodeau Mark T. Tyrosine kinase inhibitors
GB0330043D0 (en) * 2003-12-24 2004-01-28 Pharmacia Italia Spa Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions comprising them
PE20060430A1 (es) 2004-06-09 2006-05-25 Glaxo Group Ltd Derivados de pirrolopiridina como moduladores de los receptores cannabinoides
US20070155738A1 (en) 2005-05-20 2007-07-05 Alantos Pharmaceuticals, Inc. Heterobicyclic metalloprotease inhibitors
CN112839648A (zh) * 2018-06-07 2021-05-25 达萨玛治疗公司 Sarm1抑制剂

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1250844A (en) * 1981-06-22 1989-03-07 Neville Ford Substituted imidazo¬1,5-a|pyridines, process for their manufacture, pharmaceutical preparations containing these compounds and their therapeutic application
US4588732A (en) * 1982-12-21 1986-05-13 Ciba-Geigy Corporation Certain imidazo(1,5-a)pyridine derivatives and their use as thromboxane synthetase inhibitors
US4470986A (en) * 1982-12-21 1984-09-11 Ciba-Geigy Corporation Certain imidazo (1,5-A) pyridine aliphatic carboxylic acid derivatives and their use as selective thromboxane inhibitors
DE3302125A1 (de) * 1983-01-22 1984-07-26 Boehringer Ingelheim KG, 6507 Ingelheim Aminosaeure-derivate, verfahren zu ihrer herstellung und verwendung
FR2658511B1 (fr) * 1990-02-16 1992-06-19 Union Pharma Scient Appl Nouveaux derives de benzimidazole et d'azabenzimidazole, antagonistes des recepteurs au thromboxane; leurs procedes de preparation, compositions pharmaceutiques les contenant.
DE69227561T2 (de) * 1991-08-21 1999-06-02 Eisai Co Ltd Kondensierte Pyrimidinderivate als Antitumorverbindungen

Also Published As

Publication number Publication date
EP0668279B1 (de) 2001-06-13
PT668279E (pt) 2001-09-28
DE69521223D1 (de) 2001-07-19
EP0668279A3 (de) 1995-08-30
ES2157292T3 (es) 2001-08-16
DK0668279T3 (da) 2001-08-27
JPH0853448A (ja) 1996-02-27
EP0668279A2 (de) 1995-08-23
DE69521223T2 (de) 2001-11-08
CA2141231A1 (en) 1995-08-01
GR3036570T3 (en) 2001-12-31
SI0668279T1 (en) 2001-12-31
US5468757A (en) 1995-11-21

Similar Documents

Publication Publication Date Title
HUP9802859A2 (hu) Acil-amino-szalicilsav-amid-származékok és alkalmazásuk peszticidként
NO923528L (no) 3-benzyliden-1-karbamoyl-2-pyrrolidonanaloger
FI965020A (fi) Uusia yhdisteitä, menetelmiä niiden valmistamiseksi ja kasvaintenvastaisia aineita
PT90623A (pt) Processo para a preparacao de n-heterociclil-4-guanilalquil-benzamidas uteis como inibidores de protease
DK0918776T3 (da) Totalsyntese af antitumor acylfulvener
FI902555A0 (fi) Diarylstyrylkinolindisyror.
DK0477778T3 (da) Benzen-, pyridin- eller pyrimidinderivat
DE69521223D1 (de) 6-Azaindole-Hemmer der Tromboxan-Synthetase
DK0784055T3 (da) Pyrimidinylpyrazolderivater
PT947504E (pt) Derivados de vitamina d 16-eno
ES2188481T3 (es) Derivados de polinalbufina.
ES2169220T3 (es) Derivados de vitamina d3 con sustituyentes en la posicion 2.
FI940731A (fi) Amiditetratsolit ACAT-inhibiitoreina
CA2355098A1 (en) Chroman derivatives
IT1197348B (it) Cinnamilammine, processo per la loro preparazione e composizioni farmaceutiche che le contengono
ES2121036T3 (es) Derivados de alquilenodiamina.
DE60221250D1 (de) Bis(5-aryl-2-pyridyl)derivate
ATE420855T1 (de) 2-substituierte vitamin-d-derivate
EP0418655A3 (en) Conjugated gamma-hydroxybutenolide compounds and antiulcer agents containing the same as an effective ingredient
HUP9903545A2 (hu) Helyettesített triciklusos vegyületek, eljárás előállításukra és a vegyületeket tartalmazó gyógyászati készítmények

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee