DK160501C - Substituerede benzoatestere af 3-hydroxymorphinaner samt farmaceutiske praeparater indeholdende saadanne - Google Patents

Substituerede benzoatestere af 3-hydroxymorphinaner samt farmaceutiske praeparater indeholdende saadanne

Info

Publication number
DK160501C
DK160501C DK306885A DK306885A DK160501C DK 160501 C DK160501 C DK 160501C DK 306885 A DK306885 A DK 306885A DK 306885 A DK306885 A DK 306885A DK 160501 C DK160501 C DK 160501C
Authority
DK
Denmark
Prior art keywords
hydroxymorphinanes
testers
sugar
pharmaceutical preparations
preparations containing
Prior art date
Application number
DK306885A
Other languages
Danish (da)
English (en)
Other versions
DK160501B (da
DK306885D0 (da
DK306885A (da
Inventor
Elie Gabriel Shami
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont filed Critical Du Pont
Publication of DK306885D0 publication Critical patent/DK306885D0/da
Publication of DK306885A publication Critical patent/DK306885A/da
Publication of DK160501B publication Critical patent/DK160501B/da
Application granted granted Critical
Publication of DK160501C publication Critical patent/DK160501C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/28—Morphinans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK306885A 1984-07-05 1985-07-04 Substituerede benzoatestere af 3-hydroxymorphinaner samt farmaceutiske praeparater indeholdende saadanne DK160501C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US62792384A 1984-07-05 1984-07-05
US62792384 1984-07-05
US73346485 1985-05-14
US06/733,464 US4668685A (en) 1984-07-05 1985-05-14 Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists

Publications (4)

Publication Number Publication Date
DK306885D0 DK306885D0 (da) 1985-07-04
DK306885A DK306885A (da) 1986-01-06
DK160501B DK160501B (da) 1991-03-18
DK160501C true DK160501C (da) 1991-08-26

Family

ID=27090564

Family Applications (1)

Application Number Title Priority Date Filing Date
DK306885A DK160501C (da) 1984-07-05 1985-07-04 Substituerede benzoatestere af 3-hydroxymorphinaner samt farmaceutiske praeparater indeholdende saadanne

Country Status (18)

Country Link
US (1) US4668685A (e)
EP (1) EP0170090B1 (e)
AU (1) AU578391B2 (e)
CA (1) CA1301150C (e)
DE (1) DE3573251D1 (e)
DK (1) DK160501C (e)
ES (1) ES8704443A1 (e)
FI (1) FI83215C (e)
GR (1) GR851653B (e)
HK (1) HK39790A (e)
HU (1) HU193995B (e)
IE (1) IE58136B1 (e)
IL (1) IL75721A (e)
MX (1) MX160445A (e)
NO (1) NO171209C (e)
NZ (1) NZ212641A (e)
PT (1) PT80773B (e)
SU (2) SU1450742A3 (e)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4673679A (en) * 1986-05-14 1987-06-16 E. I. Du Pont De Nemours And Company Use of prodrugs of 3-hydroxymorphinans to prevent bitter taste upon buccal, nasal or sublingual administration
DK107688D0 (da) * 1988-03-01 1988-03-01 Novo Industri As Carbaminsyreestere af substituerede 7-hydroxy-2,3,4,5-tetrahydro-1h-3-benzazepiner
US6702705B1 (en) 1988-05-04 2004-03-09 Igen International, Inc. Prodrugs activated by targeted catalytic proteins
DK24089D0 (da) * 1989-01-20 1989-01-20 Hans Bundgaard Novel prodrug derivatives of biologically active agents containing hydroxyl groups or nh-acidic groups
US6258360B1 (en) * 1989-05-04 2001-07-10 Igen International, Inc. Prodrugs activated by targeted catalytic proteins
JPH06510529A (ja) * 1991-08-05 1994-11-24 イゲン，インコーポレーテッド 目標とする触媒性たんぱく質により活性化されるプロドラッグ
US5968551A (en) * 1991-12-24 1999-10-19 Purdue Pharma L.P. Orally administrable opioid formulations having extended duration of effect
ES2121988T3 (es) * 1992-01-23 1998-12-16 Toray Industries Derivado de morfinano y uso medicinal.
TW372972B (en) * 1992-10-23 1999-11-01 Novartis Ag Antiretroviral acyl compounds
EP0615756B1 (en) * 1993-03-15 2001-06-27 National Science Council Nalbuphine esters and long-acting pharmaceutical compositions containing them
DE69424853T2 (de) * 1993-07-23 2000-10-05 Toray Industries, Inc. Morphinan-derivate und ihre medizinische verwendung
US5376662A (en) * 1993-12-08 1994-12-27 Ockert; David M. Method of attenuating nerve injury induced pain
US5869669A (en) * 1996-07-26 1999-02-09 Penick Corporation Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates
US6225321B1 (en) * 1997-06-05 2001-05-01 Oliver Yoa-Pu Hu Long analgesic acting nalbuphine polyester derivative and method of use
NZ505193A (en) 1997-12-22 2003-03-28 Euro Celtique S Opioid agonist/antagonist combinations
US6375957B1 (en) 1997-12-22 2002-04-23 Euro-Celtique, S.A. Opioid agonist/opioid antagonist/acetaminophen combinations
ES2188481T3 (es) * 2000-04-27 2003-07-01 Oliver Yoa-Pu Hu Derivados de polinalbufina.
US6569449B1 (en) 2000-11-13 2003-05-27 University Of Kentucky Research Foundation Transdermal delivery of opioid antagonist prodrugs
ES2361148T3 (es) 2001-05-11 2011-06-14 Endo Pharmaceuticals Inc. Forma de dosificación de opioides de liberación controlada resistente al abuso.
MXPA04001647A (es) * 2001-08-23 2004-05-31 Akzo Nobel Nv Proceso para la preparacion de un derivado de 14-hidroxinormorfinona.
US20040033253A1 (en) * 2002-02-19 2004-02-19 Ihor Shevchuk Acyl opioid antagonists
PT1492505E (pt) 2002-04-05 2015-10-06 Euro Celtique Sa Preparação farmacêutica contendo oxicodona e naloxona
US20040202717A1 (en) 2003-04-08 2004-10-14 Mehta Atul M. Abuse-resistant oral dosage forms and method of use thereof
US20080020028A1 (en) * 2003-08-20 2008-01-24 Euro-Celtique S.A. Transdermal dosage form comprising an active agent and a salt and a free-base form of an adverse agent
EP1604666A1 (en) * 2004-06-08 2005-12-14 Euro-Celtique S.A. Opioids for the treatment of the Chronic Obstructive Pulmonary Disease (COPD)
EP1604667A1 (en) * 2004-06-08 2005-12-14 Euro-Celtique S.A. Opioids for the treatment of the restless leg syndrome
JP2008514612A (ja) * 2004-09-23 2008-05-08 ミシャロウ、アレクサンダー 対抗適応を誘発することにより神経伝達物質系を調節する方法
US20080045610A1 (en) * 2004-09-23 2008-02-21 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
EP3228308A1 (en) * 2005-01-28 2017-10-11 Euro-Celtique S.A. Alcohol resistant dosage forms
EP1702558A1 (en) * 2005-02-28 2006-09-20 Euro-Celtique S.A. Method and device for the assessment of bowel function
EP1695700A1 (en) * 2005-02-28 2006-08-30 Euro-Celtique S.A. Dosage form containing oxycodone and naloxone
WO2006126529A1 (ja) * 2005-05-25 2006-11-30 Shionogi & Co., Ltd. ６，７－不飽和－７－カルバモイル置換モルヒナン誘導体
US8163701B2 (en) 2005-08-19 2012-04-24 Signature Therapeutics, Inc. Prodrugs of active agents
GB0606124D0 (en) * 2006-03-28 2006-05-03 Reckitt Benckiser Healthcare Buprenorphine derivatives and uses thereof
US8178551B2 (en) * 2007-03-09 2012-05-15 Green Cross Corporation Orally bioavailable prodrugs of (+)-3-hydroxymorphinan for Parkinson'S disease prevention or treatment
CN102143740A (zh) * 2008-07-07 2011-08-03 欧洲凯尔特公司 阿片类拮抗剂治疗尿潴留的用途
AU2010223323B2 (en) 2009-03-10 2013-07-04 Euro-Celtique S.A. Immediate release pharmaceutical compositions comprising oxycodone and naloxone
UA102916C2 (uk) 2009-07-02 2013-08-27 Кемфарм, Інк. Композиція на основі кон'югату гідрокодону з бензойною кислотою, похідними бензойної кислоти або гетероарилкарбоновою кислотою, проліки, спосіб лікування від зловживань
US10849981B2 (en) 2009-07-02 2020-12-01 KemPham, Inc. Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof
US8623888B2 (en) * 2009-07-15 2014-01-07 Mallinckrodt Llc 3-oxy-hydromorphone derivatives
EP2639234B1 (en) 2010-11-12 2019-07-03 Shionogi&Co., Ltd. Crystalline 6,7-unsaturated-7-carbamoyl morphinane derivative, and method for producing same
MX362857B (es) 2011-10-26 2019-02-20 Kempharm Inc Star Acido benzoico, derivados de acido benzoico y conjugados de acido heteroarilcarboxilico de hidromorfona, profarmacos, metodos de elaboracion y uso de los mismos.
EP3024461B1 (en) 2013-07-23 2020-05-13 Euro-Celtique S.A. A combination of oxycodone and naloxone for use in treating pain in patients suffering from pain and a disease resulting in intestinal dysbiosis and/or increasing the risk for intestinal bacterial translocation
JP6400848B2 (ja) 2014-11-25 2018-10-03 ケムファーム・インコーポレーテッド オキシコドンの安息香酸、安息香酸誘導体及びヘテロアリールカルボン酸結合体
KR20170094251A (ko) 2014-12-02 2017-08-17 켐팜 인코포레이티드 옥시모르폰의 벤조산, 벤조산 유도체 및 헤테로아릴 카르복실산 콘쥬게이트, 이의 전구 약물, 제조 방법 및 용도
US10155771B2 (en) * 2015-11-04 2018-12-18 Noramco, Inc. Selective reduction of morphinan alkaloids
US10807995B2 (en) 2018-07-13 2020-10-20 Alkermes Pharma Ireland Limited Thienothiophene compounds for long-acting injectable compositions and related methods
WO2020012248A1 (en) 2018-07-13 2020-01-16 Alkermes Pharma Ireland Limited Novel naphthylenyl compounds for long-acting injectable compositions and related methods
US11186585B2 (en) 2018-08-17 2021-11-30 Kappa-Pharma LLC Compositions and methods of enhancing opioid receptor engagement by opioid hexadienoates and optionally substituted hexadienoates
WO2020094634A1 (en) 2018-11-05 2020-05-14 Alkermes Pharma Ireland Limited Thiophene prodrugs of naltroxene for long-acting injectable compositions and related methods
CN114828961B (zh) 2019-08-11 2024-03-29 卡帕制药有限责任公司 通过阿片类己二烯酸酯和任选取代的己二烯酸酯增强阿片受体结合的组合物及方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE224197C (e) *
US3254088A (en) * 1961-03-14 1966-05-31 Lewenstein Morphine derivative
FR1602610A (en) * 1962-10-10 1971-01-04 10.10.62.-17.4.63. 38445-15209 thebaine derivs
US3332950A (en) * 1963-03-23 1967-07-25 Endo Lab 14-hydroxydihydronormorphinone derivatives
IL26896A (en) * 1966-01-19 1970-11-30 Endo Lab 14 - Hydroxynormorphinins and 14 - Hydroxynormorphinones
GB1097167A (en) * 1966-05-31 1967-12-29 Shionogi & Co 3-hydroxy-6-oxo-n-phenethylmorphinan compounds and their production
CH543514A (de) * 1967-08-25 1973-10-31 Hoffmann La Roche Verfahren zur Herstellung von Morphinanderivaten
US3654280A (en) * 1968-03-21 1972-04-04 Shionogi & Co L-n allylic-3-hydroxy-6-oxomorphinans
DE2323192A1 (de) * 1972-05-10 1973-12-13 Endo Lab Injizierbare, langwirkende antagonistpraeparate gegen narkotika und rauschgifte
US4161597A (en) * 1976-12-20 1979-07-17 Research Corporation N-alkyl-14-hydroxymorphinans and derivatives
JPS59184182A (ja) * 1983-04-02 1984-10-19 Res Inst For Prod Dev ３−ベンゾイルチオ−４、５α−エポキシ−７α−〔１（Ｒ）−ヒドロキシ−１−メチルベンチル〕−６−メトキシ−１７−メチル−６、１４−エンド−エタノモルヒナン
JPS59184163A (ja) * 1983-04-02 1984-10-19 Res Inst For Prod Dev ３−ベンゾイルチオ−１７−メチルモルヒナン
JPS59184183A (ja) * 1983-04-02 1984-10-19 Res Inst For Prod Dev ３−ベンゾイルチオ−４、５α−エポキシ−７α−〔１（Ｒ）−ヒドロキシ−１−メチルブチル〕−６−メトキシ−１７−メチル−６、１４−エンド−エテノモルヒナン
JPS59186987A (ja) * 1983-04-06 1984-10-23 Res Inst For Prod Dev ３−ベンゾイルチオ−４、５α−エポキシ−７α−〔１（Ｒ）−ヒドロキシ−１−メチルブチル〕−６−メトキシ−１７−メチル−６、１４−エンド−エテノモルヒナン

Also Published As

Publication number Publication date
IL75721A (en) 1990-04-29
MX160445A (es) 1990-03-02
IE851683L (en) 1986-01-05
EP0170090A1 (en) 1986-02-05
AU578391B2 (en) 1988-10-20
DK160501B (da) 1991-03-18
FI83215B (fi) 1991-02-28
IL75721A0 (en) 1985-11-29
HUT40132A (en) 1986-11-28
SU1450742A3 (ru) 1989-01-07
DK306885D0 (da) 1985-07-04
GR851653B (e) 1985-11-26
PT80773A (en) 1985-08-01
FI852659A0 (fi) 1985-07-04
CA1301150C (en) 1992-05-19
EP0170090B1 (en) 1989-09-27
FI852659L (fi) 1986-01-06
AU4451685A (en) 1986-01-09
SU1508960A3 (ru) 1989-09-15
ES544852A0 (es) 1987-04-01
NO852699L (no) 1986-01-06
PT80773B (pt) 1987-10-20
NO171209B (no) 1992-11-02
HU193995B (en) 1987-12-28
US4668685A (en) 1987-05-26
FI83215C (fi) 1991-06-10
ES8704443A1 (es) 1987-04-01
DE3573251D1 (en) 1989-11-02
IE58136B1 (en) 1993-07-14
NZ212641A (en) 1988-10-28
HK39790A (en) 1990-06-01
NO171209C (no) 1993-02-10
DK306885A (da) 1986-01-06

Similar Documents

Publication Publication Date Title
DK160501C (da) Substituerede benzoatestere af 3-hydroxymorphinaner samt farmaceutiske praeparater indeholdende saadanne
DK154085A (da) N-aryl-n-(4-piperidinyl)-amider samt farmaceutiske praeparater deraf
DK164564C (da) Pakdaasetaetning samt anvendelse af denne
DK312386D0 (da) N-aralkyl-piperidenmethanolderivater samt disses fremstilling
MX9203040A (es) Derivados de quinona y composicion farmaceutica que los contiene.
DK164851C (da) N-phenylmethylenalkadienamider med analgetisk virkning samt farmaceutiske praeparater indeholdende samme
DK245087A (da) Triazolderivater samt herbicid indeholdende et saadant
DK164852C (da) N-phenylmethylenalkanamider med analgetisk virkning samt farmaceutiske praeparater indeholdende samme
DK430285A (da) N-substituerede derivater af 2-(pyridylalkensulfinyl)-benzimidazoler samt disses fremstilling
DK237187A (da) Farmaceutisk anvendelse af t-pa
ES296415Y (es) Reloj de agujas horaria y minutera de configuracion diferente
DK166355C (da) Adenosin-derivater samt farmaceutiske praeparater indeholdende saadanne derivater
DK497685A (da) Ketongruppeholdige oxindol-3-carboxamid-derivater og laegemiddel indeholdende saadanne derivater
DK537685D0 (da) Fremgangsmaade til fremstilling af isosilybinfrit silibinin samt laegemiddel med indhold deraf
DK226787A (da) Acryl-modificeret polyurethanbaseret klaebestof uden indhold af oploesningsmidler samt fremgangsmaade til fremstilling af et saadant klaebestof
DK164149C (da) Fremgangsmaade til fremstilling af et praeparat indeholdende methylhydroxyprogesteronacetat samt farmaceutisk praeparat indeholdende stoffet
DK312485A (da) Benzo(b)thiophen-derivater og farmaceutiske praeparater indeholdende disse
DK205986A (da) Proteinhydrolysat samt fremstilling deraf
DK475187D0 (da) Delta22-derivater af ll-f28249-forbindelser samt anvendelse deraf
DK196885D0 (da) Farmaceutiske praeparater indeholdende isoquinolinderivater og isoquinolinderivater indeholdende saadanne derivater
DK143188D0 (da) Farmaceutiske praeparater indeholdende pyranoquinolinforbindelser samt deres anvendelse
DK162186D0 (da) Aminoketonderivater samt laegemidler indeholdende saadanne derivater
DK211788D0 (da) Satellitoverningssystem
DK69387A (da) Cyanoderivater og fremgangsmaade til fremstilling deraf samt midler indeholdende derivaterne
IT8621570A1 (it) 2H-benzotriazoli 5-superiore alchil-sostituiti e composizioni stabilizzate

Legal Events

Date Code Title Description
PBP Patent lapsed