PT2907522T - Método para aumentar a dureza e rigidez óssea e para reduzir fraturas - Google Patents

Método para aumentar a dureza e rigidez óssea e para reduzir fraturas Download PDF

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Publication number
PT2907522T
PT2907522T PT15152726T PT15152726T PT2907522T PT 2907522 T PT2907522 T PT 2907522T PT 15152726 T PT15152726 T PT 15152726T PT 15152726 T PT15152726 T PT 15152726T PT 2907522 T PT2907522 T PT 2907522T
Authority
PT
Portugal
Prior art keywords
bone
pth
rhpth
use according
months
Prior art date
Application number
PT15152726T
Other languages
English (en)
Portuguese (pt)
Inventor
M HOCK Janet
A Gaich Gregory
H Dere Willard
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26792729&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT2907522(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PT2907522T publication Critical patent/PT2907522T/pt

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/29Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/12Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/18Drugs for disorders of the endocrine system of the parathyroid hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Steroid Compounds (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
PT15152726T 1998-08-19 1999-08-19 Método para aumentar a dureza e rigidez óssea e para reduzir fraturas PT2907522T (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9715198P 1998-08-19 1998-08-19
US9974698P 1998-09-10 1998-09-10

Publications (1)

Publication Number Publication Date
PT2907522T true PT2907522T (pt) 2017-10-23

Family

ID=26792729

Family Applications (4)

Application Number Title Priority Date Filing Date
PT15152726T PT2907522T (pt) 1998-08-19 1999-08-19 Método para aumentar a dureza e rigidez óssea e para reduzir fraturas
PT06027055T PT1769804E (pt) 1998-08-19 1999-08-19 Hpth(1-34) para a utilização na prevenção ou redução da incidência ou gravidade de fractura vertebral ou não vertebral num ser humano do sexo masculino
PT101804474T PT2266598T (pt) 1998-08-19 1999-08-19 Método de aumento da dureza e rigidez ósseas e redução de fraturas
PT99942350T PT1059933E (pt) 1998-08-19 1999-08-19 Utilizacao da hormona paratitoide que consiste da sequencia de aminoacidos 1-34 da hormona paratiroide humana para reduzir o risco de armas a fracturavertebral e nao vertebral

Family Applications After (3)

Application Number Title Priority Date Filing Date
PT06027055T PT1769804E (pt) 1998-08-19 1999-08-19 Hpth(1-34) para a utilização na prevenção ou redução da incidência ou gravidade de fractura vertebral ou não vertebral num ser humano do sexo masculino
PT101804474T PT2266598T (pt) 1998-08-19 1999-08-19 Método de aumento da dureza e rigidez ósseas e redução de fraturas
PT99942350T PT1059933E (pt) 1998-08-19 1999-08-19 Utilizacao da hormona paratitoide que consiste da sequencia de aminoacidos 1-34 da hormona paratiroide humana para reduzir o risco de armas a fracturavertebral e nao vertebral

Country Status (32)

Country Link
US (2) US6977077B1 (https=)
EP (3) EP2266598B1 (https=)
JP (5) JP2002523375A (https=)
KR (1) KR100454207B1 (https=)
CN (1) CN1205997C (https=)
AR (1) AR033639A1 (https=)
AT (1) ATE231000T1 (https=)
AU (1) AU746277B2 (https=)
BR (1) BR9909445A (https=)
CA (1) CA2325371C (https=)
CO (1) CO5130020A1 (https=)
CY (2) CY1113343T1 (https=)
CZ (1) CZ301017B6 (https=)
DE (2) DE15152726T1 (https=)
DK (4) DK2266598T3 (https=)
DZ (1) DZ2873A1 (https=)
EA (1) EA003362B1 (https=)
ES (4) ES2393200T3 (https=)
HR (1) HRP20000755A2 (https=)
HU (2) HU230697B1 (https=)
ID (1) ID29039A (https=)
IL (2) IL138829A0 (https=)
MY (1) MY129227A (https=)
NO (2) NO323984B1 (https=)
NZ (1) NZ507056A (https=)
PE (1) PE20001089A1 (https=)
PL (1) PL201688B1 (https=)
PT (4) PT2907522T (https=)
TR (1) TR200003455T2 (https=)
TW (1) TW576747B (https=)
UA (1) UA72205C2 (https=)
WO (1) WO2000010596A1 (https=)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6770623B1 (en) * 1997-12-09 2004-08-03 Eli Lilly And Company Stabilized teriparatide solutions
DZ2873A1 (fr) * 1998-08-19 2003-12-15 Lilly Co Eli Procédé pour augmenter la dureté et la rigidité osseuse.
US20040033950A1 (en) 2000-09-26 2004-02-19 Hock Janet M. Method of increasing bone toughness and stiffness and reducing fractures
WO2001022093A1 (en) * 1999-09-20 2001-03-29 Eli Lilly And Company Method for monitoring treatment with a parathyroid hormone
US7247609B2 (en) 2001-12-18 2007-07-24 Universitat Zurich Growth factor modified protein matrices for tissue engineering
EP1531855A4 (en) * 2002-01-10 2009-07-22 Osteotrophin Llc TREATMENT OF BONE DISEASES WITH SKELETTAL ANABOLIKA
US8088734B2 (en) 2003-01-21 2012-01-03 Unigene Laboratories Inc. Oral delivery of peptides
KR20060058133A (ko) * 2003-09-19 2006-05-29 화이자 프로덕츠 인코포레이티드 2-알킬리덴-19-노르-비타민 d 유도체 및 부갑상선호르몬의 조합을 포함하는 약학 조성물 및 방법
US20060189533A1 (en) * 2004-05-10 2006-08-24 Nastech Pharmaceutical Company Inc. Stable pharmaceutical dosage forms of teriparatide
CA2567056A1 (en) * 2004-05-10 2005-12-08 Nastech Pharmaceutical Company Inc. Compositions and methods for enhanced mucosal delivery of parathyroid hormone
US20060052305A1 (en) * 2004-05-10 2006-03-09 Nastech Pharmaceutical Company Inc. Method of treating osteoporosis using intranasal parathyroid hormone
US20060127320A1 (en) * 2004-05-10 2006-06-15 Nastech Pharmaceutical Company Inc. Method of delivering parathyroid hormone to a human
US7556821B2 (en) 2004-05-13 2009-07-07 Alza Corporation Apparatus and method for transdermal delivery of parathyroid hormone agents
US7648965B2 (en) 2004-05-14 2010-01-19 Unigene Laboratories Inc. Method for fostering bone formation and preservation
US20060069021A1 (en) * 2004-08-13 2006-03-30 Nastech Pharmaceutical Company Inc. Compositions and methods for intranasal administration of inactive analogs of PTH or inactivated preparations of PTH or PTH analogs
WO2006073711A2 (en) 2005-01-06 2006-07-13 Kuros Biosurgery Ag Use of a matrix comprising a contrast agent in soft tissues
US8575101B2 (en) 2005-01-06 2013-11-05 Kuros Biosurgery Ag Supplemented matrices for the repair of bone fractures
EP1879608A4 (en) * 2005-05-11 2009-11-11 Unigene Lab Inc METHOD FOR STIMULATING BONE FORMATION AND PRESERVATION
US20070173447A1 (en) * 2005-10-25 2007-07-26 Nastech Pharmaceutical Company Inc. Method for treating osteoporosis by intranasal delivery of teriparatide with an anti-resorptive agent
CA2628945A1 (en) * 2005-11-10 2007-05-24 Board Of Control Of Michigan Technological University Black bear parathyroid hormone and methods of using black bear parathyroid hormone
US20080051332A1 (en) * 2005-11-18 2008-02-28 Nastech Pharmaceutical Company Inc. Method of modulating hematopoietic stem cells and treating hematologic diseases using intranasal parathyroid hormone
US20080119408A1 (en) * 2006-07-07 2008-05-22 Nastech Pharmaceutical Company Inc. Pth formulations for intranasal delivery
EP1961765A1 (en) * 2006-12-08 2008-08-27 Zealand Pharma A/S Truncated PTH peptides with a cyclic conformation
DK2136850T3 (da) 2007-04-13 2012-04-10 Kuros Biosurgery Ag Polymervævforsegling
US20110137243A1 (en) * 2007-09-06 2011-06-09 Abbott Cardiovascular Systems Inc. Coating On A Balloon Device
US9457056B2 (en) * 2007-12-04 2016-10-04 Ben-Gurion University Of The Negev Research And Development Authority Peptides comprising alternating hydrophobic and anionic amino acids for treatment of osteoporosis
WO2009083544A2 (en) 2007-12-28 2009-07-09 Kuros Biosurgery Ag Pdgf fusion proteins incorporated into fibrin foams
KR20190095552A (ko) * 2009-09-09 2019-08-14 아사히 가세이 파마 가부시키가이샤 1회당 100∼200 단위의 pth가 주 1회 투여되는 것을 특징으로 하는, pth 함유 골다공증 치료/예방제
BR112012013725A2 (pt) 2009-12-07 2017-01-10 Univ Michigan Tech paratormônio de urso preto e métodos de usar o paratormônio de uso preto.
US9295663B2 (en) 2010-07-14 2016-03-29 Abbott Cardiovascular Systems Inc. Drug coated balloon with in-situ formed drug containing microspheres
WO2012111852A1 (ja) * 2011-02-17 2012-08-23 帝人ファーマ株式会社 椎体骨折治療剤及びその評価方法
EP2686027B1 (en) 2011-03-16 2021-05-05 Kuros Biosurgery AG Pharmaceutical formulation for use in spinal fusion
KR20150116467A (ko) 2011-06-07 2015-10-15 아사히 가세이 파마 가부시키가이샤 고순도 pth 함유 동결 건조 제제 및 그의 제조 방법
US9700485B2 (en) 2013-04-24 2017-07-11 Corning Incorporated Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients
US11492386B2 (en) 2016-02-01 2022-11-08 Eli Lilly And Company Parathyroid hormone-anti-RANKL antibody fusion compounds
US20190381341A1 (en) * 2017-02-01 2019-12-19 The Johns Hopkins University Parathyroid hormone and regeneration of degenerative discs disease
US20200289621A1 (en) * 2017-09-22 2020-09-17 Asahi Kasei Pharma Corporation Teriparatide-containing liquid pharmaceutical composition having excellent stability
ES3009869T3 (en) 2018-10-29 2025-03-31 Asahi Kasei Pharma Corp An improved teriparatide dosage regimen for use in preventing or treating osteoporosis characterized by administering teriparatide or salt thereof twice a week
EP4010360A1 (en) 2019-08-09 2022-06-15 Flagship Pioneering Innovations VI, LLC Modulators of parathyroid hormone receptor (pthr1)
GB2590692A (en) * 2019-12-24 2021-07-07 Corthotec Ltd Composition for improved bone fracture healing

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4086196A (en) 1975-03-28 1978-04-25 Armour Pharmaceutical Company Parathyroid hormone
IL78342A (en) 1985-04-04 1991-06-10 Gen Hospital Corp Pharmaceutical composition for treatment of osteoporosis in humans comprising a parathyroid hormone or a fragment thereof
DE3935738A1 (de) 1989-10-27 1991-05-08 Forssmann Wolf Georg Arzneimittel, enthaltend das humane parathormon-fragment (1-37) als aktiven wirkstoff
US5208041A (en) 1991-05-23 1993-05-04 Allelix Biopharmaceuticals Inc. Essentially pure human parathyroid hormone
US5556940A (en) 1994-06-20 1996-09-17 National Research Council Of Canada Parathyroid hormone analogues for the treatment of osteoporosis
JPH0873376A (ja) * 1994-09-07 1996-03-19 Asahi Chem Ind Co Ltd 骨粗鬆症治療薬
JPH10511095A (ja) * 1994-12-19 1998-10-27 ベス イスラエル ディーコネス メディカル センター インコーポレイテッド 副甲状腺ホルモン又はその作動薬の低用量継続投与
US5747456A (en) * 1994-12-19 1998-05-05 Beth Israel Deaconess Medical Center Continuous low-dose administration of parathyroid hormone or its agonist
EP1283035A3 (en) * 1994-12-22 2003-03-19 AstraZeneca AB Therapeutic preparation for inhalation containing parathyroid hormone
JPH08310965A (ja) * 1995-05-16 1996-11-26 Chugai Pharmaceut Co Ltd 骨癒合促進剤
HRP20000109A2 (en) * 1997-09-09 2001-02-28 Hoffmann La Roche FRACTURE HEALING USING PTHrP ANALOGS
ZA9811127B (en) 1997-12-09 2000-07-11 Lilly Co Eli Stabilized teriparatide solutions.
DZ2873A1 (fr) * 1998-08-19 2003-12-15 Lilly Co Eli Procédé pour augmenter la dureté et la rigidité osseuse.
US20040033950A1 (en) 2000-09-26 2004-02-19 Hock Janet M. Method of increasing bone toughness and stiffness and reducing fractures
US6907597B1 (en) 2000-10-13 2005-06-14 Ati International Srl Method and apparatus for constructing an executable program in memory
US6967759B2 (en) 2001-12-31 2005-11-22 Texas Instruments Incorporated Pulse width modulation sequence generation
JP5796714B2 (ja) 2012-01-13 2015-10-21 株式会社リコー 定着装置及び画像形成装置
EP2949301B1 (en) 2014-05-27 2018-04-18 The Procter and Gamble Company Absorbent core with curved and straight absorbent material areas

Also Published As

Publication number Publication date
CZ20004134A3 (cs) 2001-08-15
ES2190244T3 (es) 2003-07-16
EA003362B1 (ru) 2003-04-24
DE69904918D1 (de) 2003-02-20
ES2549551T3 (es) 2017-11-27
EP1059933B1 (en) 2003-01-15
EP2907522A1 (en) 2015-08-19
HU1200430D0 (hu) 2001-11-28
NO20072983L (no) 2000-11-24
JP2011021035A (ja) 2011-02-03
HRP20000755A2 (en) 2001-02-28
DK2266598T3 (en) 2017-05-15
EP1059933A1 (en) 2000-12-20
UA72205C2 (uk) 2005-02-15
EA200001015A1 (ru) 2001-02-26
US20050197294A1 (en) 2005-09-08
TW576747B (en) 2004-02-21
JP2017190332A (ja) 2017-10-19
US7163684B2 (en) 2007-01-16
HU230697B1 (hu) 2017-09-28
DE15152726T1 (de) 2015-12-10
CA2325371C (en) 2004-08-17
PT1059933E (pt) 2003-06-30
EP2266598B1 (en) 2017-02-22
EP2266598A1 (en) 2010-12-29
TR200003455T2 (tr) 2001-06-21
PL343595A1 (en) 2001-08-27
DE69904918T2 (de) 2003-11-13
HK1102496A1 (en) 2007-11-23
CN1205997C (zh) 2005-06-15
DK2907522T1 (da) 2015-10-19
DK2907522T3 (en) 2017-10-23
KR20010072763A (ko) 2001-07-31
JP6177718B2 (ja) 2017-08-09
CN1308545A (zh) 2001-08-15
MY129227A (en) 2007-03-30
HUP0101594A3 (en) 2002-01-28
AR033639A1 (es) 2004-01-07
DZ2873A1 (fr) 2003-12-15
CA2325371A1 (en) 2000-03-02
JP2015028065A (ja) 2015-02-12
ID29039A (id) 2001-07-26
PL201688B1 (pl) 2009-04-30
DK1769804T3 (da) 2012-10-15
US6977077B1 (en) 2005-12-20
HUP0101594A2 (hu) 2001-11-28
PT2266598T (pt) 2017-05-02
JP2014139220A (ja) 2014-07-31
IL138829A (en) 2011-01-31
WO2000010596A1 (en) 2000-03-02
AU746277B2 (en) 2002-04-18
JP2002523375A (ja) 2002-07-30
HK1212602A1 (en) 2016-06-17
NZ507056A (en) 2003-10-31
EP2907522B1 (en) 2017-08-02
ES2393200T3 (es) 2012-12-19
PE20001089A1 (es) 2000-11-04
PT1769804E (pt) 2012-11-13
KR100454207B1 (ko) 2004-10-26
NO20005947D0 (no) 2000-11-24
ES2621653T3 (es) 2017-07-04
NO20005947L (no) 2000-11-24
DK1059933T3 (da) 2003-04-07
CY1119552T1 (el) 2018-03-07
NO323984B1 (no) 2007-07-30
ATE231000T1 (de) 2003-02-15
IL138829A0 (en) 2001-10-31
AU5575099A (en) 2000-03-14
CY1113343T1 (el) 2016-06-22
CO5130020A1 (es) 2002-02-27
CZ301017B6 (cs) 2009-10-14
ES2549551T1 (es) 2015-10-29
BR9909445A (pt) 2000-12-12
HK1030545A1 (en) 2001-05-11

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