CY1113343T1 - hPTH(1-34) ΓΙΑ ΧΡΗΣΗ ΣΕ ΠΡΟΛΗΨΗ Ή ΜΕΙΩΣΗ ΤΗΣ ΣΥΧΝΟΤΗΤΑΣ Ή ΣΟΒΑΡΟΤΗΤΑΣ ΣΠΟΝΔΥΛΙΚΩΝ ΚΑΙ/Ή ΜΗ-ΣΠΟΝΔΥΛΙΚΩΝ ΚΑΤΑΓΜΑΤΩΝ ΣΕ ΕΝΑΝ ΑΝΤΡΑ - Google Patents
hPTH(1-34) ΓΙΑ ΧΡΗΣΗ ΣΕ ΠΡΟΛΗΨΗ Ή ΜΕΙΩΣΗ ΤΗΣ ΣΥΧΝΟΤΗΤΑΣ Ή ΣΟΒΑΡΟΤΗΤΑΣ ΣΠΟΝΔΥΛΙΚΩΝ ΚΑΙ/Ή ΜΗ-ΣΠΟΝΔΥΛΙΚΩΝ ΚΑΤΑΓΜΑΤΩΝ ΣΕ ΕΝΑΝ ΑΝΤΡΑInfo
- Publication number
- CY1113343T1 CY1113343T1 CY20121101096T CY121101096T CY1113343T1 CY 1113343 T1 CY1113343 T1 CY 1113343T1 CY 20121101096 T CY20121101096 T CY 20121101096T CY 121101096 T CY121101096 T CY 121101096T CY 1113343 T1 CY1113343 T1 CY 1113343T1
- Authority
- CY
- Cyprus
- Prior art keywords
- sport
- fractures
- reduce
- vertebral fractures
- hpth
- Prior art date
Links
- 108010049264 Teriparatide Proteins 0.000 title 1
- 230000002265 prevention Effects 0.000 title 1
- OGBMKVWORPGQRR-UMXFMPSGSA-N teriparatide Chemical compound C([C@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CNC=N1 OGBMKVWORPGQRR-UMXFMPSGSA-N 0.000 title 1
- 206010041569 spinal fracture Diseases 0.000 abstract 4
- 210000000988 bone and bone Anatomy 0.000 abstract 2
- 208000010392 Bone Fractures Diseases 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 102000003982 Parathyroid hormone Human genes 0.000 abstract 1
- 108090000445 Parathyroid hormone Proteins 0.000 abstract 1
- 208000014674 injury Diseases 0.000 abstract 1
- 239000000199 parathyroid hormone Substances 0.000 abstract 1
- 229960001319 parathyroid hormone Drugs 0.000 abstract 1
- 230000008733 trauma Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Endocrinology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Steroid Compounds (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
- Materials For Medical Uses (AREA)
Abstract
Η εφεύρεση αφορά σε μία μέθοδο για την αύξηση της σκληρότητας και/ή της ακαμψίας των οστών και/ή την μείωση της πιθανότητας και/ή της σοβαρότητας κατάγματος των οστών με την χορήγηση παραθυρεοειδικής ορμόνης. Η μέθοδος μπορεί να χρησιμοποιηθεί για την αύξηση της σκληρότητας ή της ακαμψίας των οστών σε μία θέση ενός εν δυνάμει ή πραγματικού τραύματος, όπως στο ισχίο ή στην σπονδυλική στήλη ενός ατόμου σε κίνδυνο ή που πάσχει από οστεοπόρωση. Η μέθοδος της εφεύρεσης μπορεί να μειώσει την συχνότητα σπονδυλικού κατάγματος, να μειώσει την συχνότητα πολλαπλών σπονδυλικών καταγμάτων, να μειώσει την σοβαρότητα σπονδυλικού κατάγματος, και/ή να μειώσει την συχνότητα μη σπονδυλικού κατάγματος.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9715198P | 1998-08-19 | 1998-08-19 | |
| US9974698P | 1998-09-10 | 1998-09-10 | |
| EP06027055A EP1769804B1 (en) | 1998-08-19 | 1999-08-19 | hPTH(1-34) for use in preventing or reducing the incidence or severity of vertebral and / or non vertebral fracture in a male human |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1113343T1 true CY1113343T1 (el) | 2016-06-22 |
Family
ID=26792729
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20121101096T CY1113343T1 (el) | 1998-08-19 | 2012-11-14 | hPTH(1-34) ΓΙΑ ΧΡΗΣΗ ΣΕ ΠΡΟΛΗΨΗ Ή ΜΕΙΩΣΗ ΤΗΣ ΣΥΧΝΟΤΗΤΑΣ Ή ΣΟΒΑΡΟΤΗΤΑΣ ΣΠΟΝΔΥΛΙΚΩΝ ΚΑΙ/Ή ΜΗ-ΣΠΟΝΔΥΛΙΚΩΝ ΚΑΤΑΓΜΑΤΩΝ ΣΕ ΕΝΑΝ ΑΝΤΡΑ |
| CY20171101077T CY1119552T1 (el) | 1998-08-19 | 2017-10-13 | Μεθοδος αυξησης της οστικης σκληροτητας και ακαμψιας και μειωσης των καταγματων |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20171101077T CY1119552T1 (el) | 1998-08-19 | 2017-10-13 | Μεθοδος αυξησης της οστικης σκληροτητας και ακαμψιας και μειωσης των καταγματων |
Country Status (33)
| Country | Link |
|---|---|
| US (2) | US6977077B1 (el) |
| EP (3) | EP2266598B1 (el) |
| JP (5) | JP2002523375A (el) |
| KR (1) | KR100454207B1 (el) |
| CN (1) | CN1205997C (el) |
| AR (1) | AR033639A1 (el) |
| AT (1) | ATE231000T1 (el) |
| AU (1) | AU746277B2 (el) |
| BR (1) | BR9909445A (el) |
| CA (1) | CA2325371C (el) |
| CO (1) | CO5130020A1 (el) |
| CY (2) | CY1113343T1 (el) |
| CZ (1) | CZ301017B6 (el) |
| DE (2) | DE15152726T1 (el) |
| DK (4) | DK2907522T3 (el) |
| DZ (1) | DZ2873A1 (el) |
| EA (1) | EA003362B1 (el) |
| ES (4) | ES2393200T3 (el) |
| HK (3) | HK1030545A1 (el) |
| HR (1) | HRP20000755A2 (el) |
| HU (2) | HU230697B1 (el) |
| ID (1) | ID29039A (el) |
| IL (2) | IL138829A0 (el) |
| MY (1) | MY129227A (el) |
| NO (2) | NO323984B1 (el) |
| NZ (1) | NZ507056A (el) |
| PE (1) | PE20001089A1 (el) |
| PL (1) | PL201688B1 (el) |
| PT (4) | PT1769804E (el) |
| TR (1) | TR200003455T2 (el) |
| TW (1) | TW576747B (el) |
| UA (1) | UA72205C2 (el) |
| WO (1) | WO2000010596A1 (el) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6770623B1 (en) * | 1997-12-09 | 2004-08-03 | Eli Lilly And Company | Stabilized teriparatide solutions |
| AR033639A1 (es) | 1998-08-19 | 2004-01-07 | Lilly Co Eli | Uso de hormonas paratiroideas para preparar medicamentos para reducir el riesgo de fracturas oseas vertebrales o no vertebrales en seres humanos con riesgo de padecer o que padecen osteoporosis |
| US20040033950A1 (en) * | 2000-09-26 | 2004-02-19 | Hock Janet M. | Method of increasing bone toughness and stiffness and reducing fractures |
| EP1222465A1 (en) * | 1999-09-20 | 2002-07-17 | Eli Lilly And Company | Method for monitoring treatment with a parathyroid hormone |
| US7247609B2 (en) | 2001-12-18 | 2007-07-24 | Universitat Zurich | Growth factor modified protein matrices for tissue engineering |
| EP1531855A4 (en) | 2002-01-10 | 2009-07-22 | Osteotrophin Llc | TREATMENT OF BONE DISEASES WITH SKELETTAL ANABOLIKA |
| US8088734B2 (en) | 2003-01-21 | 2012-01-03 | Unigene Laboratories Inc. | Oral delivery of peptides |
| MXPA06003064A (es) * | 2003-09-19 | 2006-05-31 | Pfizer Prod Inc | Composiciones farmaceuticas y metodos que comprenden combinaciones de derivados de 2-alquiliden-19-nor-vitamina d y hormona paratiroide. |
| US20060127320A1 (en) * | 2004-05-10 | 2006-06-15 | Nastech Pharmaceutical Company Inc. | Method of delivering parathyroid hormone to a human |
| RU2006143544A (ru) * | 2004-05-10 | 2008-06-20 | Нэстек Фармасьютикал Кампани Инк. (Us) | Композиции и способ для облегченной чресслизистой доставки паратиреоидного гормона |
| US20060052305A1 (en) * | 2004-05-10 | 2006-03-09 | Nastech Pharmaceutical Company Inc. | Method of treating osteoporosis using intranasal parathyroid hormone |
| US20060189533A1 (en) * | 2004-05-10 | 2006-08-24 | Nastech Pharmaceutical Company Inc. | Stable pharmaceutical dosage forms of teriparatide |
| BRPI0509788A (pt) | 2004-05-13 | 2007-10-23 | Alza Corp | aparato e método para liberação transdérmica de agentes de hormÈnio paratireóides |
| US7648965B2 (en) | 2004-05-14 | 2010-01-19 | Unigene Laboratories Inc. | Method for fostering bone formation and preservation |
| US20060069021A1 (en) * | 2004-08-13 | 2006-03-30 | Nastech Pharmaceutical Company Inc. | Compositions and methods for intranasal administration of inactive analogs of PTH or inactivated preparations of PTH or PTH analogs |
| US8575101B2 (en) | 2005-01-06 | 2013-11-05 | Kuros Biosurgery Ag | Supplemented matrices for the repair of bone fractures |
| WO2006073711A2 (en) * | 2005-01-06 | 2006-07-13 | Kuros Biosurgery Ag | Use of a matrix comprising a contrast agent in soft tissues |
| EP1879608A4 (en) * | 2005-05-11 | 2009-11-11 | Unigene Lab Inc | METHOD FOR STIMULATING BONE FORMATION AND PRESERVATION |
| US20070173447A1 (en) * | 2005-10-25 | 2007-07-26 | Nastech Pharmaceutical Company Inc. | Method for treating osteoporosis by intranasal delivery of teriparatide with an anti-resorptive agent |
| JP2009515535A (ja) * | 2005-11-10 | 2009-04-16 | ボード オブ コントロール オブ ミシガン テクノロジカル ユニヴァーシティー | クロクマの副甲状腺ホルモン及びクロクマの副甲状腺ホルモンを使用する方法 |
| US20080051332A1 (en) * | 2005-11-18 | 2008-02-28 | Nastech Pharmaceutical Company Inc. | Method of modulating hematopoietic stem cells and treating hematologic diseases using intranasal parathyroid hormone |
| US20080119408A1 (en) * | 2006-07-07 | 2008-05-22 | Nastech Pharmaceutical Company Inc. | Pth formulations for intranasal delivery |
| EP1961765A1 (en) * | 2006-12-08 | 2008-08-27 | Zealand Pharma A/S | Truncated PTH peptides with a cyclic conformation |
| WO2008125655A1 (en) | 2007-04-13 | 2008-10-23 | Kuros Biosurgery Ag | Polymeric tissue sealant |
| US20110137243A1 (en) * | 2007-09-06 | 2011-06-09 | Abbott Cardiovascular Systems Inc. | Coating On A Balloon Device |
| US9457056B2 (en) * | 2007-12-04 | 2016-10-04 | Ben-Gurion University Of The Negev Research And Development Authority | Peptides comprising alternating hydrophobic and anionic amino acids for treatment of osteoporosis |
| EP2227263A2 (en) | 2007-12-28 | 2010-09-15 | Kuros Biosurgery AG | Pdgf fusion proteins incorporated into fibrin foams |
| KR20170089018A (ko) | 2009-09-09 | 2017-08-02 | 아사히 가세이 파마 가부시키가이샤 | 1회당 100∼200 단위의 ｐｔｈ가 주 1회 투여되는 것을 특징으로 하는, ｐｔｈ 함유 골다공증 치료/예방제 |
| EP2509996A1 (en) | 2009-12-07 | 2012-10-17 | Michigan Technological University | Black bear parathyroid hormone and methods of using black bear parathyroid hormone |
| US9295663B2 (en) | 2010-07-14 | 2016-03-29 | Abbott Cardiovascular Systems Inc. | Drug coated balloon with in-situ formed drug containing microspheres |
| WO2012111852A1 (ja) * | 2011-02-17 | 2012-08-23 | 帝人ファーマ株式会社 | 椎体骨折治療剤及びその評価方法 |
| WO2012123028A1 (en) | 2011-03-16 | 2012-09-20 | Kuros Biosurgery Ag | Pharmaceutical formulation for use in spinal fusion |
| KR20150116467A (ko) | 2011-06-07 | 2015-10-15 | 아사히 가세이 파마 가부시키가이샤 | 고순도 ｐｔｈ 함유 동결 건조 제제 및 그의 제조 방법 |
| US9700485B2 (en) | 2013-04-24 | 2017-07-11 | Corning Incorporated | Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients |
| CN108601833B (zh) * | 2016-02-01 | 2022-11-15 | 伊莱利利公司 | 甲状旁腺激素-抗rankl抗体融合化合物 |
| US20190381341A1 (en) * | 2017-02-01 | 2019-12-19 | The Johns Hopkins University | Parathyroid hormone and regeneration of degenerative discs disease |
| JP6577683B2 (ja) * | 2017-09-22 | 2019-09-18 | 旭化成ファーマ株式会社 | 安定性に優れるテリパラチド含有液状医薬組成物 |
| CN111447943A (zh) | 2018-10-29 | 2020-07-24 | 旭化成制药株式会社 | 以按每周2次的频率给予特立帕肽或其盐为特征的骨质疏松症的预防或治疗方法 |
| EP4010360A1 (en) | 2019-08-09 | 2022-06-15 | Flagship Pioneering Innovations VI, LLC | Modulators of parathyroid hormone receptor (pthr1) |
| GB2590692A (en) * | 2019-12-24 | 2021-07-07 | Corthotec Ltd | Composition for improved bone fracture healing |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4086196A (en) | 1975-03-28 | 1978-04-25 | Armour Pharmaceutical Company | Parathyroid hormone |
| IL78342A (en) * | 1985-04-04 | 1991-06-10 | Gen Hospital Corp | Pharmaceutical composition for treatment of osteoporosis in humans comprising a parathyroid hormone or a fragment thereof |
| DE3935738A1 (de) | 1989-10-27 | 1991-05-08 | Forssmann Wolf Georg | Arzneimittel, enthaltend das humane parathormon-fragment (1-37) als aktiven wirkstoff |
| US5208041A (en) | 1991-05-23 | 1993-05-04 | Allelix Biopharmaceuticals Inc. | Essentially pure human parathyroid hormone |
| US5556940A (en) | 1994-06-20 | 1996-09-17 | National Research Council Of Canada | Parathyroid hormone analogues for the treatment of osteoporosis |
| JPH0873376A (ja) * | 1994-09-07 | 1996-03-19 | Asahi Chem Ind Co Ltd | 骨粗鬆症治療薬 |
| EP0800405A4 (en) * | 1994-12-19 | 1998-11-11 | Beth Israel Hospital | CONTINUOUS ADMINISTRATION OF LOW DOSES OF HORMONE PARATHYRO DIENNE OR ITS AGONIST |
| US5747456A (en) * | 1994-12-19 | 1998-05-05 | Beth Israel Deaconess Medical Center | Continuous low-dose administration of parathyroid hormone or its agonist |
| ATE238043T1 (de) * | 1994-12-22 | 2003-05-15 | Astrazeneca Ab | Parathyroidhormon pth enthaltende therapeutische zubereitung zur inhalation |
| JPH08310965A (ja) * | 1995-05-16 | 1996-11-26 | Chugai Pharmaceut Co Ltd | 骨癒合促進剤 |
| HU226866B1 (en) * | 1997-09-09 | 2009-12-28 | Hoffmann La Roche | Fracture healing using pthrp analogs |
| ZA9811127B (en) | 1997-12-09 | 2000-07-11 | Lilly Co Eli | Stabilized teriparatide solutions. |
| US20040033950A1 (en) | 2000-09-26 | 2004-02-19 | Hock Janet M. | Method of increasing bone toughness and stiffness and reducing fractures |
| AR033639A1 (es) * | 1998-08-19 | 2004-01-07 | Lilly Co Eli | Uso de hormonas paratiroideas para preparar medicamentos para reducir el riesgo de fracturas oseas vertebrales o no vertebrales en seres humanos con riesgo de padecer o que padecen osteoporosis |
| US6907597B1 (en) | 2000-10-13 | 2005-06-14 | Ati International Srl | Method and apparatus for constructing an executable program in memory |
| US6967759B2 (en) | 2001-12-31 | 2005-11-22 | Texas Instruments Incorporated | Pulse width modulation sequence generation |
| JP5796714B2 (ja) | 2012-01-13 | 2015-10-21 | 株式会社リコー | 定着装置及び画像形成装置 |
| EP2949301B1 (en) | 2014-05-27 | 2018-04-18 | The Procter and Gamble Company | Absorbent core with curved and straight absorbent material areas |
-
1999
- 1999-08-18 AR ARP990104133A patent/AR033639A1/es unknown
- 1999-08-18 DZ DZ990173A patent/DZ2873A1/xx active
- 1999-08-19 BR BR9909445-2A patent/BR9909445A/pt not_active Application Discontinuation
- 1999-08-19 EA EA200001015A patent/EA003362B1/ru not_active IP Right Cessation
- 1999-08-19 CN CNB998083534A patent/CN1205997C/zh not_active Expired - Lifetime
- 1999-08-19 KR KR10-2001-7002092A patent/KR100454207B1/ko not_active IP Right Cessation
- 1999-08-19 DK DK15152726.4T patent/DK2907522T3/en active
- 1999-08-19 PT PT06027055T patent/PT1769804E/pt unknown
- 1999-08-19 DE DE15152726.4T patent/DE15152726T1/de active Pending
- 1999-08-19 EP EP10180447.4A patent/EP2266598B1/en not_active Expired - Lifetime
- 1999-08-19 CO CO99052525A patent/CO5130020A1/es unknown
- 1999-08-19 US US09/647,278 patent/US6977077B1/en not_active Expired - Lifetime
- 1999-08-19 NZ NZ507056A patent/NZ507056A/en not_active IP Right Cessation
- 1999-08-19 CZ CZ20004134A patent/CZ301017B6/cs not_active IP Right Cessation
- 1999-08-19 JP JP2000565916A patent/JP2002523375A/ja active Pending
- 1999-08-19 WO PCT/US1999/018961 patent/WO2000010596A1/en active IP Right Grant
- 1999-08-19 ES ES06027055T patent/ES2393200T3/es not_active Expired - Lifetime
- 1999-08-19 AT AT99942350T patent/ATE231000T1/de not_active IP Right Cessation
- 1999-08-19 CA CA002325371A patent/CA2325371C/en not_active Expired - Lifetime
- 1999-08-19 UA UA2000095457A patent/UA72205C2/uk unknown
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- 1999-08-19 EP EP99942350A patent/EP1059933B1/en not_active Revoked
- 1999-08-19 DK DK10180447.4T patent/DK2266598T3/en active
- 1999-08-19 DK DK06027055.0T patent/DK1769804T3/da active
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- 1999-08-19 DK DK99942350T patent/DK1059933T3/da active
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- 1999-08-19 EP EP15152726.4A patent/EP2907522B1/en not_active Revoked
- 1999-08-19 HU HUP1200430 patent/HU1200430D0/hu not_active Application Discontinuation
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- 1999-08-19 DE DE69904918T patent/DE69904918T2/de not_active Expired - Lifetime
- 1999-10-26 TW TW088114185A patent/TW576747B/zh not_active IP Right Cessation
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2000
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2001
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2005
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2007
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2010
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2012
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2014
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2016
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2017
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