|
GB1419789A
(en)
|
1972-08-02 |
1975-12-31 |
Pfizer |
2-trifluoromethyl-4-quinolinols
|
|
WO1992000075A1
(en)
|
1990-06-29 |
1992-01-09 |
Pfizer Inc. |
Pyridopyrazine derivatives for treating substance abuse and addiction
|
|
NO179904C
(no)
|
1992-09-04 |
1997-01-08 |
Takeda Chemical Industries Ltd |
Kondenserte heterocykliske forbindelser og deres anvendelse
|
|
EP1308461A3
(en)
|
1993-01-25 |
2004-02-11 |
Takeda Chemical Industries, Ltd. |
Antibodies to beta-amyloids or their derivatives and use thereof
|
|
DE69628484T2
(de)
|
1995-03-24 |
2004-05-19 |
Takeda Chemical Industries, Ltd. |
Zyklische Verbindungen, ihre Herstellung und ihre Verwendung als Tachykininrezeptorantagonisten
|
|
DE19709877A1
(de)
|
1997-03-11 |
1998-09-17 |
Bayer Ag |
1,5-Dihydro-pyrazolo[3,4-d]-pyrimidinon-derivate
|
|
DK0994728T3
(da)
|
1997-04-09 |
2008-12-01 |
Intellect Neurosciences Inc |
Rekombinante antistoffer, som er specifikke for beta-amyloide ender, DNA, der koder derfor, samt fremgangsmåder til anvendelse heraf
|
|
US8173127B2
(en)
|
1997-04-09 |
2012-05-08 |
Intellect Neurosciences, Inc. |
Specific antibodies to amyloid beta peptide, pharmaceutical compositions and methods of use thereof
|
|
GB9722520D0
(en)
|
1997-10-24 |
1997-12-24 |
Pfizer Ltd |
Compounds
|
|
US6743427B1
(en)
|
1997-12-02 |
2004-06-01 |
Neuralab Limited |
Prevention and treatment of amyloidogenic disease
|
|
TWI239847B
(en)
|
1997-12-02 |
2005-09-21 |
Elan Pharm Inc |
N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
|
|
EP1060141B1
(en)
|
1998-03-03 |
2002-10-30 |
PPG Industries Ohio, Inc. |
Impregnated glass fiber strands and products including the same
|
|
US20020132817A1
(en)
|
1998-03-19 |
2002-09-19 |
Hideaki Natsugari |
Heterocyclic compounds, their production and use
|
|
AU1409100A
(en)
|
1998-11-27 |
2000-06-19 |
Takeda Chemical Industries Ltd. |
Drugs
|
|
DZ3295A1
(fr)
|
2000-02-24 |
2001-08-30 |
|
Anticorps humanises sequestrant un peptide amyloide .beta.
|
|
DE10045112A1
(de)
|
2000-09-11 |
2002-03-21 |
Merck Patent Gmbh |
Verwendung von Indolderivaten zur Behandlung von Erkrankungen des zentralen Nervensystems
|
|
NZ544691A
(en)
|
2000-11-03 |
2007-12-21 |
Proteotech Inc |
Methods of isolating amyloid-inhibiting compounds and use of compounds isolated from Uncaria tomentosa and related plants
|
|
JP2005503789A
(ja)
|
2001-08-17 |
2005-02-10 |
イーライ・リリー・アンド・カンパニー |
抗Ａβ抗体
|
|
US20030195205A1
(en)
|
2001-11-02 |
2003-10-16 |
Pfizer Inc. |
PDE9 inhibitors for treating cardiovascular disorders
|
|
DE10238723A1
(de)
|
2002-08-23 |
2004-03-11 |
Bayer Ag |
Phenyl-substituierte Pyrazolyprimidine
|
|
DE10238724A1
(de)
|
2002-08-23 |
2004-03-04 |
Bayer Ag |
Alkyl-substituierte Pyrazolpyrimidine
|
|
EP1549315A4
(en)
|
2002-09-11 |
2007-05-23 |
Merck & Co Inc |
DIHYDROXYPYRIDOPYRAZINE-1,6-DION COMPOUNDS AS HIV INTEGRASE INHIBITORS
|
|
JP2006504725A
(ja)
|
2002-10-09 |
2006-02-09 |
ファイザー・プロダクツ・インク |
神経変性障害治療用ピラゾール化合物
|
|
MXPA05003621A
(es)
|
2002-10-09 |
2005-10-19 |
Rinat Neuroscience Corp |
Metodos de tratamiento de la enfermedad de alzheimer usando anticuerpos dirigidos contra el peptido beta amiloide y composiciones de los mismos.
|
|
US20040157804A1
(en)
|
2002-10-16 |
2004-08-12 |
Gilead Sciences, Inc. |
Pre-organized tricyclic integrase inhibitor compounds
|
|
US20040220186A1
(en)
|
2003-04-30 |
2004-11-04 |
Pfizer Inc. |
PDE9 inhibitors for treating type 2 diabetes,metabolic syndrome, and cardiovascular disease
|
|
CA2528652A1
(en)
|
2003-06-19 |
2004-12-23 |
Pfizer Products Inc. |
Nk1 antagonist
|
|
CA2534532A1
(en)
|
2003-08-21 |
2005-03-10 |
Pfizer Products, Inc. |
Compounds for the treatment of neurodegenerative disorders
|
|
WO2005025616A1
(ja)
|
2003-09-09 |
2005-03-24 |
Takeda Pharmaceutical Company Limited |
抗体の用途
|
|
US7572799B2
(en)
|
2003-11-24 |
2009-08-11 |
Pfizer Inc |
Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors
|
|
GB0327319D0
(en)
|
2003-11-24 |
2003-12-24 |
Pfizer Ltd |
Novel pharmaceuticals
|
|
AU2005208887B2
(en)
|
2004-01-28 |
2010-02-25 |
Merck Sharp & Dohme Corp. |
Aminocyclopentyl pyridopyrazinone modulators of chemokine receptor activity
|
|
CA2555071A1
(en)
|
2004-02-02 |
2005-09-01 |
Pfizer Products Inc. |
Histamine-3 receptor modulators
|
|
EP1725102A4
(en)
|
2004-03-09 |
2009-04-29 |
Merck & Co Inc |
HIV integrase
|
|
EP1730119B1
(en)
|
2004-03-23 |
2008-06-25 |
Pfizer Products Incorporated |
Imidazole compounds for the treatment of neurodegenerative disorders
|
|
DE602005010413D1
(de)
|
2004-04-14 |
2008-11-27 |
Zhenhong R Cai |
Phosphonatanaloga von hiv-integrasehemmerverbindungen
|
|
US7456164B2
(en)
|
2004-05-07 |
2008-11-25 |
Pfizer, Inc |
3- or 4-monosubtituted phenol and thiophenol derivatives useful as H3 ligands
|
|
EP1595881A1
(en)
|
2004-05-12 |
2005-11-16 |
Pfizer Limited |
Tetrahydronaphthyridine derivates useful as histamine H3 receptor ligands
|
|
MX2007000998A
(es)
|
2004-07-30 |
2007-07-11 |
Rinat Neuroscience Corp |
Anticuerpos dirigidos peptido beta-amiloide y procedimientos que usan los mismos.
|
|
FR2877015B1
(fr)
|
2004-10-21 |
2007-10-26 |
Commissariat Energie Atomique |
Revetement nanostructure et procede de revetement.
|
|
GB0423356D0
(en)
|
2004-10-21 |
2004-11-24 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
US20090074775A1
(en)
|
2004-12-22 |
2009-03-19 |
David Michael Holtzman |
Use Of Anti-AB Antibody To Treat Traumatic Brain Injury
|
|
PE20061323A1
(es)
|
2005-04-29 |
2007-02-09 |
Rinat Neuroscience Corp |
Anticuerpos dirigidos contra el peptido amiloide beta y metodos que utilizan los mismos
|
|
WO2006121831A2
(en)
|
2005-05-10 |
2006-11-16 |
Merck & Co., Inc. |
Hiv integrase inhibitors
|
|
MX2007013215A
(es)
|
2005-05-12 |
2007-12-12 |
Pfizer |
Formas cristalinas anhidras de la n-[1-(2-etoxietil)-5-(n-etil-n- metilamino)-7-(4-metilpiridin-2-il-amino)-1h-pirazolo[4,3-d] pirimidina -3-carbonil] metanosulfonamida.
|
|
CA2603830A1
(en)
|
2005-05-24 |
2006-11-30 |
Pharmacia & Upjohn Co Llc |
PYRIDINE [2,3-B] PYRAZINONES
|
|
WO2006126083A1
(en)
|
2005-05-24 |
2006-11-30 |
Pharmacia & Upjohn Company Llc |
Pyridine [3 , 4-b] pyrazinone compounds as pde-5 inhibitors
|
|
WO2006126082A2
(en)
|
2005-05-24 |
2006-11-30 |
Pharmacia & Upjohn Company Llc |
Pyridine [3,4-b] pyrazinones as pde-5 inhibitors
|
|
CA2607499C
(en)
|
2005-06-22 |
2010-11-30 |
Pfizer Products Inc. |
Histamine-3 receptor antagonists
|
|
US20070060534A1
(en)
|
2005-06-30 |
2007-03-15 |
Threshold Pharmaceuticals, Inc. |
Anthracycline analogs
|
|
US8158673B2
(en)
|
2005-10-27 |
2012-04-17 |
Pfizer Inc. |
Histamine-3 receptor antagonists
|
|
CA2624625A1
(en)
|
2005-11-04 |
2007-05-10 |
Pfizer Limited |
Tetrahydronaphthyridine derivative
|
|
WO2007062332A2
(en)
|
2005-11-18 |
2007-05-31 |
Glaxo Group Limited |
Novel intermediates and their use
|
|
US20070197532A1
(en)
|
2005-11-18 |
2007-08-23 |
Cao Sheldon X |
Glucokinase activators
|
|
MY144960A
(en)
|
2005-11-24 |
2011-11-30 |
Eisai R&D Man Co Ltd |
Morpholine type cinnamide compound
|
|
US20070117839A1
(en)
|
2005-11-24 |
2007-05-24 |
Eisai R&D Management Co., Ltd. |
Two cyclic cinnamide compound
|
|
WO2007063385A2
(en)
|
2005-12-01 |
2007-06-07 |
Pfizer Products Inc. |
Spirocyclic amine histamine-3 receptor antagonists
|
|
WO2007069053A1
(en)
|
2005-12-14 |
2007-06-21 |
Pfizer Products Inc. |
Benzimidazole antagonists of the h-3 receptor
|
|
AU2007207481B2
(en)
*
|
2006-01-20 |
2012-08-23 |
Merck Sharp & Dohme Corp. |
Carbocyclic and heterocyclic arylsulfones as gamma secretase inhibitors
|
|
WO2007088450A2
(en)
|
2006-02-01 |
2007-08-09 |
Pfizer Products Inc. |
Chromane antagonist of the h-3 receptor
|
|
WO2007088462A1
(en)
|
2006-02-01 |
2007-08-09 |
Pfizer Products Inc. |
Spirochromane antagonists of the h-3 receptor
|
|
WO2007099423A1
(en)
|
2006-03-02 |
2007-09-07 |
Pfizer Products Inc. |
1-pyrrolidine indane derivatives as histamine-3 receptor antagonists
|
|
TWI378091B
(en)
|
2006-03-09 |
2012-12-01 |
Eisai R&D Man Co Ltd |
Multi-cyclic cinnamide derivatives
|
|
US20090163482A1
(en)
|
2006-03-13 |
2009-06-25 |
Mchardy Stanton Furst |
Tetralines antagonists of the h-3 receptor
|
|
AU2007242555B2
(en)
|
2006-04-21 |
2010-12-16 |
Pfizer Products Inc. |
Pyridine[3,4-b]pyrazinones
|
|
CA2651153C
(en)
|
2006-05-15 |
2014-04-29 |
Merck & Co., Inc. |
Antidiabetic bicyclic compounds
|
|
US8008287B2
(en)
|
2006-05-16 |
2011-08-30 |
Gilead Sciences, Inc. |
Integrase inhibitors
|
|
CA2651396A1
(en)
|
2006-05-19 |
2007-11-29 |
Eisai R&D Management Co., Ltd. |
Urea type cinnamide derivative
|
|
WO2007138431A2
(en)
|
2006-05-30 |
2007-12-06 |
Pfizer Products Inc. |
Azabicyclic ether histamine-3 antagonists
|
|
JP4585610B2
(ja)
|
2007-01-22 |
2010-11-24 |
ファイザー・プロダクツ・インク |
治療用化合物のトシル酸塩およびその医薬組成物
|
|
CA2676715A1
(en)
|
2007-02-12 |
2008-08-21 |
Merck & Co., Inc. |
Piperazine derivatives for treatment of ad and related conditions
|
|
JP2010518083A
(ja)
|
2007-02-12 |
2010-05-27 |
メルク・シャープ・エンド・ドーム・コーポレイション |
ピペリジン誘導体
|
|
TW200848054A
(en)
|
2007-02-28 |
2008-12-16 |
Eisai R&D Man Co Ltd |
Two cyclic oxomorpholine derivatives
|
|
WO2008137102A2
(en)
|
2007-05-04 |
2008-11-13 |
Torreypines Therapeutics, Inc. |
Methods of modulating amyloid beta and compounds useful therefor
|
|
MX2009012177A
(es)
|
2007-05-07 |
2009-11-23 |
Schering Corp |
Moduladores de gamma-secretasa.
|
|
ES2358863T3
(es)
|
2007-05-11 |
2011-05-16 |
F. Hoffmann-La Roche Ag |
Hetarilanilinas como moduladores de beta-amiloide.
|
|
CL2008001540A1
(es)
|
2007-05-29 |
2009-05-22 |
Sgx Pharmaceuticals Inc |
Compuestos derivados de pirrolopiridinas y pirazolopiridinas; composicion farmaceutica; y uso en el tratamiento del cancer.
|
|
RU2009148866A
(ru)
|
2007-06-01 |
2011-07-20 |
Шеринг Корпорейшн (US) |
Модуляторы гамма-секретазы
|
|
US8580956B2
(en)
|
2007-06-01 |
2013-11-12 |
Merck Sharp & Dohme Corp. |
Gamma secretase modulators
|
|
WO2008156580A1
(en)
|
2007-06-13 |
2008-12-24 |
Merck & Co., Inc. |
Triazole derivatives for treating alzheimer's disease and related conditions
|
|
WO2009005729A1
(en)
|
2007-06-29 |
2009-01-08 |
Schering Corporation |
Gamma secretase modulators
|
|
PE20090957A1
(es)
|
2007-08-06 |
2009-07-13 |
Schering Corp |
Moduladores de gamma secretasa
|
|
US7935815B2
(en)
|
2007-08-31 |
2011-05-03 |
Eisai R&D Management Co., Ltd. |
Imidazoyl pyridine compounds and salts thereof
|
|
CA2694401C
(en)
|
2007-08-31 |
2012-12-04 |
Eisai R&D Management Co., Ltd. |
Polycyclic compound
|
|
JP2010538068A
(ja)
|
2007-09-06 |
2010-12-09 |
シェーリング コーポレイション |
ガンマセクレターゼモジュレーター
|
|
CN101878202A
(zh)
|
2007-09-28 |
2010-11-03 |
先灵公司 |
γ-分泌酶调节剂
|
|
GB0720444D0
(en)
|
2007-10-18 |
2007-11-28 |
Glaxo Group Ltd |
Novel compounds
|
|
CN101910178A
(zh)
|
2007-11-05 |
2010-12-08 |
先灵公司 |
γ分泌酶调节剂
|
|
JP2011506336A
(ja)
|
2007-12-06 |
2011-03-03 |
シェーリング コーポレイション |
γ−セクレターゼ調節剤
|
|
CA2708300A1
(en)
|
2007-12-11 |
2009-06-18 |
Schering Corporation |
Gamma secretase modulators
|
|
MX2010006379A
(es)
|
2007-12-11 |
2010-09-07 |
Schering Corp |
Moduladores de la secretasa gamma.
|
|
CN101896461A
(zh)
|
2007-12-13 |
2010-11-24 |
安姆根有限公司 |
γ分泌酶调节剂
|
|
ATE535515T1
(de)
|
2008-01-11 |
2011-12-15 |
Hoffmann La Roche |
Modulatoren für amyloid beta
|
|
EP2257541B1
(en)
|
2008-02-22 |
2013-08-14 |
F. Hoffmann-La Roche AG |
Modulators for amyloid beta
|
|
US20100137320A1
(en)
|
2008-02-29 |
2010-06-03 |
Schering Corporation |
Gamma secretase modulators
|
|
US20110027264A1
(en)
|
2008-02-29 |
2011-02-03 |
Xianhai Huang |
Gamma secretase modulators for the treatment of alzheimer's disease
|
|
US20110118234A1
(en)
|
2008-05-05 |
2011-05-19 |
Kaustav Biswas |
Urea Compounds as Gamma Secretase Modulators
|
|
FR2933700B1
(fr)
*
|
2008-07-08 |
2010-07-30 |
Sanofi Aventis |
Derives de pyridino-pyridinones, leur preparation et leur application en therapeutique
|
|
TW201006801A
(en)
|
2008-07-18 |
2010-02-16 |
Lilly Co Eli |
Imidazole carboxamides
|
|
EP2312946A4
(en)
|
2008-08-13 |
2012-10-24 |
Merck Sharp & Dohme |
PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF MORBUS ALZHEIMER
|
|
US20110251172A1
(en)
|
2008-08-13 |
2011-10-13 |
Rivkin Alexey A |
Purine derivatives for treatment of alzheimer's disease
|
|
CN102137855A
(zh)
|
2008-08-27 |
2011-07-27 |
卫材R&D管理有限公司 |
制备某些肉桂酰胺化合物的方法
|
|
MX2011003246A
(es)
|
2008-10-09 |
2011-04-21 |
Hoffmann La Roche |
Moduladores de beta amiloide.
|
|
CN102272133A
(zh)
|
2008-11-06 |
2011-12-07 |
阿斯利康(瑞典)有限公司 |
淀粉样β的调节剂
|
|
JP2012508182A
(ja)
|
2008-11-06 |
2012-04-05 |
シェーリング コーポレイション |
γ−セクレターゼ調節剤
|
|
AU2009313524A1
(en)
|
2008-11-06 |
2010-05-14 |
Merck Sharp & Dohme Corp. |
Gamma secretase modulators
|
|
EP2355817A1
(en)
|
2008-11-10 |
2011-08-17 |
F. Hoffmann-La Roche AG |
Heterocyclic gamma secretase modulators
|
|
US8575150B2
(en)
|
2008-12-16 |
2013-11-05 |
Merck Sharp & Dohme Corp. |
Triazole derivatives for treatment of Alzheimer's disease
|
|
EP2379075A4
(en)
|
2008-12-16 |
2012-05-30 |
Merck Sharp & Dohme |
TRIAZOL DERIVATIVES FOR THE TREATMENT OF ALZHEIMER DISEASE
|
|
PA8854101A1
(es)
|
2008-12-18 |
2010-07-27 |
Ortho Mcneil Janssen Pharm |
Derivados de imidazol bicíclicos sustituidos como moduladores de gamma secretasa
|
|
EP2379525B1
(en)
|
2008-12-19 |
2015-07-29 |
Boehringer Ingelheim International GmbH |
Cyclic pyrimidin-4-carboxamides as ccr2 receptor antagonists for treatment of inflammation, asthma and copd
|
|
AR074702A1
(es)
|
2008-12-22 |
2011-02-02 |
Schering Corp |
Moduladores de gamma secretasa y composiciones farmaceuticas que los contienen
|
|
EP2379563B1
(en)
|
2008-12-22 |
2014-07-16 |
Merck Sharp & Dohme Corp. |
Gamma secretase modulators
|
|
TW201030002A
(en)
|
2009-01-16 |
2010-08-16 |
Bristol Myers Squibb Co |
Bicyclic compounds for the reduction of beta-amyloid production
|
|
EP2393804B1
(en)
|
2009-02-06 |
2014-04-16 |
Janssen Pharmaceuticals, Inc. |
Novel substituted bicyclic heterocyclic compounds as gamma secretase modulators
|
|
TWI461425B
(zh)
|
2009-02-19 |
2014-11-21 |
Janssen Pharmaceuticals Inc |
作為伽瑪分泌酶調節劑之新穎經取代的苯并唑、苯并咪唑、唑并吡啶及咪唑并吡啶衍生物類
|
|
MX2011006782A
(es)
|
2009-02-26 |
2011-07-20 |
Eisai R&D Man Co Ltd |
Sal de derivado de tetrahidrotriazolopiridina y un cristal de la misma.
|
|
JP2012051807A
(ja)
|
2009-02-26 |
2012-03-15 |
Eisai R & D Management Co Ltd |
アリールイミダゾール化合物
|
|
JP2012121809A
(ja)
|
2009-02-26 |
2012-06-28 |
Eisai R & D Management Co Ltd |
多環式化合物の製造法およびその中間体
|
|
JP2012051805A
(ja)
|
2009-02-26 |
2012-03-15 |
Eisai R & D Management Co Ltd |
テトラヒドロトリアゾロピリジン誘導体の製造方法
|
|
JP2012051806A
(ja)
|
2009-02-26 |
2012-03-15 |
Eisai R & D Management Co Ltd |
イミダゾリルピラジン誘導体
|
|
WO2010100606A1
(en)
|
2009-03-03 |
2010-09-10 |
Pfizer Inc. |
Novel phenyl imidazoles and phenyl triazoles as gamma-secretase modulators
|
|
CA2768664C
(en)
|
2009-08-07 |
2016-10-11 |
Dow Agrosciences Llc |
Pesticidal compositions
|
|
EP2491026A1
(en)
*
|
2009-10-20 |
2012-08-29 |
Pfizer Inc. |
Novel heteroaryl imidazoles and heteroaryl triazoles as gamma-secretase modulators
|
|
WO2011087776A1
(en)
*
|
2009-12-22 |
2011-07-21 |
Vertex Pharmaceuticals Incorporated |
Isoindolinone inhibitors of phosphatidylinositol 3-kinase
|
|
EP2691393B1
(en)
*
|
2011-03-31 |
2016-09-14 |
Pfizer Inc |
Novel bicyclic pyridinones
|
|
EP2850083B1
(en)
|
2012-05-16 |
2016-04-27 |
Janssen Pharmaceuticals, Inc. |
Substituted 3,4-dihydro-2h-pyrido[1,2-a]pyrazine-1,6-dione derivatives useful for the treatment of (inter alia) alzheimer's disease
|
|
UA110688C2
(uk)
|
2012-09-21 |
2016-01-25 |
Пфайзер Інк. |
Біциклічні піридинони
|
|
TWI614238B
(zh)
|
2012-09-21 |
2018-02-11 |
必治妥美雅史谷比公司 |
雙（氟烷基）－１，４－苯并二氮呯酮化合物及其前藥
|
|
JP6275161B2
(ja)
|
2012-12-20 |
2018-02-07 |
ヤンセン ファーマシューティカ エヌ．ベー． |
γセクレターゼ調節剤としての新規な三環式３，４−ジヒドロ−２Ｈ−ピリド［１，２−ａ］ピラジン−１，６−ジオン誘導体
|
|
CN104936958B
(zh)
|
2013-01-17 |
2019-07-26 |
詹森药业有限公司 |
作为γ分泌酶调节剂的新颖的经取代的吡啶并-哌嗪酮衍生物
|
|
ES2742078T3
(es)
|
2013-10-04 |
2020-02-13 |
Pfizer |
Piridonas bicíclicas novedosas como moduladores de gamma-secretasa
|
|
WO2015140614A1
(en)
|
2014-03-21 |
2015-09-24 |
Align Technology, Inc. |
Segmented orthodontic appliance with elastics
|
|
EA031419B1
(ru)
|
2014-04-01 |
2018-12-28 |
Пфайзер Инк. |
ХРОМЕН И 1,1a,2,7b-ТЕТРАГИДРОЦИКЛОПРОПА[c]ХРОМЕН ПИРИДОПИРАЗИНДИОНЫ В КАЧЕСТВЕ МОДУЛЯТОРА ГАММА-СЕКРЕТАЗЫ
|