PT2635583E - Derivados da coelenterazina e métodos de utilização da mesma - Google Patents
Derivados da coelenterazina e métodos de utilização da mesma Download PDFInfo
- Publication number
- PT2635583E PT2635583E PT117852178T PT11785217T PT2635583E PT 2635583 E PT2635583 E PT 2635583E PT 117852178 T PT117852178 T PT 117852178T PT 11785217 T PT11785217 T PT 11785217T PT 2635583 E PT2635583 E PT 2635583E
- Authority
- PT
- Portugal
- Prior art keywords
- methods
- same
- coelenterazine derivatives
- coelenterazine
- derivatives
- Prior art date
Links
- YHIPILPTUVMWQT-UHFFFAOYSA-N Oplophorus luciferin Chemical class C1=CC(O)=CC=C1CC(C(N1C=C(N2)C=3C=CC(O)=CC=3)=O)=NC1=C2CC1=CC=CC=C1 YHIPILPTUVMWQT-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/66—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving luciferase
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40941310P | 2010-11-02 | 2010-11-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2635583E true PT2635583E (pt) | 2015-09-11 |
Family
ID=44999921
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT117852178T PT2635583E (pt) | 2010-11-02 | 2011-11-02 | Derivados da coelenterazina e métodos de utilização da mesma |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9487520B2 (enExample) |
| EP (1) | EP2635583B1 (enExample) |
| JP (1) | JP6040157B2 (enExample) |
| KR (1) | KR101968475B1 (enExample) |
| CN (1) | CN103180324A (enExample) |
| AU (1) | AU2011323455B2 (enExample) |
| BR (1) | BR112013010484B1 (enExample) |
| CA (1) | CA2815381C (enExample) |
| DK (1) | DK2635583T3 (enExample) |
| ES (1) | ES2543913T3 (enExample) |
| IL (1) | IL225869A (enExample) |
| PL (1) | PL2635583T3 (enExample) |
| PT (1) | PT2635583E (enExample) |
| SG (1) | SG189494A1 (enExample) |
| WO (1) | WO2012061477A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2635583E (pt) | 2010-11-02 | 2015-09-11 | Promega Corp | Derivados da coelenterazina e métodos de utilização da mesma |
| US8669103B2 (en) * | 2010-11-02 | 2014-03-11 | Promega Corporation | Oplophorus-derived luciferases, novel coelenterazine substrates, and methods of use |
| EP2751089B1 (en) | 2011-09-02 | 2018-11-14 | Promega Corporation | Compounds and methods for assaying redox state of metabolically active cells and methods for measuring nad(p)/nad(p)h |
| EP2900833B1 (en) * | 2012-09-26 | 2018-05-30 | Promega Corporation | Real-time monitoring |
| CA2906166C (en) | 2013-03-15 | 2023-03-14 | G1 Therapeutics, Inc. | Hspc-sparing treatments for rb-positive abnormal cellular proliferation |
| JP6435315B2 (ja) | 2013-03-15 | 2018-12-05 | ジー１、セラピューティクス、インコーポレイテッドＧ１ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | 高活性抗新生物薬及び抗増殖剤 |
| JP6270127B2 (ja) * | 2014-01-17 | 2018-01-31 | 国立研究開発法人物質・材料研究機構 | ニコチンアデニンジヌクレオチド誘導体を検出する方法 |
| WO2015116867A1 (en) * | 2014-01-29 | 2015-08-06 | Promega Corporation | Quinone-masked probes as labeling reagents for cell uptake measurements |
| US9927430B2 (en) | 2014-01-29 | 2018-03-27 | Promega Corporation | Pro-substrates for live cell applications |
| US10513694B2 (en) | 2015-06-25 | 2019-12-24 | Promega Corporation | Thienopyrrole compounds and uses thereof |
| JP7092677B2 (ja) | 2016-02-15 | 2022-06-28 | プロメガ コーポレイション | セレンテラジン類似体 |
| EP3490991B1 (en) | 2016-07-28 | 2021-01-06 | Promega Corporation | Coelenterazine analogues |
| JP6978492B2 (ja) * | 2016-09-09 | 2021-12-08 | プロメガ コーポレイションPromega Corporation | 二重保護されたプロセレンテラジン基質 |
| EP4144738A1 (en) | 2016-11-01 | 2023-03-08 | Promega Corporation | Coelenterazine analogues tethered to energy acceptors |
| JP7139330B2 (ja) * | 2016-12-01 | 2022-09-20 | プロメガ コーポレイション | 細胞不透過性セレンテラジンアナログ |
| WO2018125992A1 (en) | 2016-12-28 | 2018-07-05 | Promega Corporation | Functionalized nanoluc inhibitors |
| EP3395803A1 (en) * | 2017-04-28 | 2018-10-31 | Institut Pasteur | Imidazopyrazine derivatives, process for preparation thereof, and their uses as luciferins |
| JP7419260B2 (ja) | 2018-05-01 | 2024-01-22 | プロメガ コーポレイション | ＮａｎｏＬｕｃ自殺基質としてのセレンテラジン化合物 |
| WO2019232384A1 (en) | 2018-06-01 | 2019-12-05 | Promega Corporation | Inhibitors of oplophorus luciferase-derived bioluminescent complexes |
| KR102114088B1 (ko) * | 2018-09-10 | 2020-06-17 | (주)신우에이엔티 | 웨이퍼 세정용 나노 버블 분사 구조 |
| BR112021006298A2 (pt) | 2018-10-03 | 2021-07-06 | Promega Corp | composições e métodos para estabilizar coelenterazina e análogos e derivados da mesma |
| US12241839B2 (en) | 2019-11-27 | 2025-03-04 | Promega Corporation | Multipartite luciferase peptides and polypeptides |
| EP4073512B1 (en) | 2019-12-10 | 2025-11-12 | Promega Corporation | Compositions and methods for bioluminescent detection using multifunctional probes |
| WO2022241249A1 (en) | 2021-05-13 | 2022-11-17 | Promega Corporation | Bioluminescent detection of dna synthesis |
Family Cites Families (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3477549D1 (en) | 1983-08-17 | 1989-05-11 | Allied Signal Inc | Gas generator and method of generating gas |
| JP3012274B2 (ja) * | 1989-03-22 | 2000-02-21 | 日本臓器製薬株式会社 | 新規ルシフェリン誘導体 |
| US5683888A (en) | 1989-07-22 | 1997-11-04 | University Of Wales College Of Medicine | Modified bioluminescent proteins and their use |
| US5368484A (en) | 1992-05-22 | 1994-11-29 | Atari Games Corp. | Vehicle simulator with realistic operating feedback |
| ES2301160T3 (es) | 1994-01-03 | 2008-06-16 | Promega Corporation | Luciferasas mutantes. |
| US6387675B1 (en) | 1994-01-03 | 2002-05-14 | Promega Corporation | Mutant luciferases |
| GB9501170D0 (en) | 1994-03-23 | 1995-03-08 | Secr Defence | Luciferases |
| JP3648763B2 (ja) | 1994-08-23 | 2005-05-18 | 日本油脂株式会社 | ウミホタルルシフェリン誘導体および糖加水分解酵素の定量方法 |
| GB9417593D0 (en) | 1994-09-01 | 1994-10-19 | Secr Defence | Luciferase labelling method |
| US5670356A (en) | 1994-12-12 | 1997-09-23 | Promega Corporation | Modified luciferase |
| AU707243B2 (en) | 1995-01-20 | 1999-07-08 | Promega Corporation | Mutant luciferases |
| JPH08294397A (ja) * | 1995-04-27 | 1996-11-12 | Nippon Oil & Fats Co Ltd | 免疫学的活性物質の測定方法 |
| US6522361B2 (en) | 1996-03-08 | 2003-02-18 | Sony Corporation | Electronic apparatus having the function of displaying the battery residual quantity and method for displaying the battery residual quantity |
| JP4026876B2 (ja) * | 1996-09-05 | 2007-12-26 | 日本食品化工株式会社 | 発光性シクロデキストリン誘導体及びその製造方法 |
| US5998204A (en) | 1997-03-14 | 1999-12-07 | The Regents Of The University Of California | Fluorescent protein sensors for detection of analytes |
| GB9707486D0 (en) | 1997-04-11 | 1997-05-28 | Secr Defence | Enzyme assays |
| US6429286B1 (en) | 1997-04-16 | 2002-08-06 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Immunoregulatory molecules for costimulatory signal transduction |
| WO1999014336A2 (en) | 1997-09-19 | 1999-03-25 | Promega Corporation | Thermostable luciferases and methods of production |
| US6602677B1 (en) | 1997-09-19 | 2003-08-05 | Promega Corporation | Thermostable luciferases and methods of production |
| GB9823468D0 (en) | 1998-10-28 | 1998-12-23 | Secr Defence | Novel enzyme |
| JP3694181B2 (ja) | 1999-01-05 | 2005-09-14 | キッコーマン株式会社 | 変異型ルシフェラーゼ、変異型ルシフェラーゼ遺伝子、新規な組み換え体ｄｎａ及び変異型ルシフェラーゼの製造法 |
| ATE374820T1 (de) | 1999-10-26 | 2007-10-15 | Secr Defence | Mutantenluciferase |
| GB9925161D0 (en) | 1999-10-26 | 1999-12-22 | Secr Defence | Novel enzyme |
| US20010046687A1 (en) | 2000-03-31 | 2001-11-29 | Dicesare Joseph L. | Method for the enhancement of luminescence intensity from a reaction between adenosine triphosphate (ATP) and a luciferase/luciferin reactant system |
| JP4613441B2 (ja) | 2000-04-26 | 2011-01-19 | チッソ株式会社 | 新規ルシフェラーゼおよび発光蛋白質 |
| DE60142761D1 (de) | 2000-04-26 | 2010-09-23 | Chisso Corp | Oplophorus Luciferase |
| US7118878B1 (en) | 2000-06-09 | 2006-10-10 | Promega Corporation | Method for increasing luminescence assay sensitivity |
| US7879540B1 (en) | 2000-08-24 | 2011-02-01 | Promega Corporation | Synthetic nucleic acid molecule compositions and methods of preparation |
| WO2002022854A2 (en) | 2000-09-13 | 2002-03-21 | Merck Patent Gmbh | Method for the detection and measurement of biomass |
| US7268229B2 (en) | 2001-11-02 | 2007-09-11 | Promega Corporation | Compounds to co-localize luminophores with luminescent proteins |
| CA2474695A1 (en) | 2002-02-01 | 2003-08-14 | Promega Corporation | Bioluminescent protease assay |
| AU2003267245C1 (en) | 2002-09-20 | 2008-05-29 | Promega Corporation | Luminescence-based methods and probes for measuring cytochrome P450 activity |
| EP1413584B1 (en) * | 2002-10-21 | 2005-03-02 | AXXAM S.r.l. | Photoprotein with improved bioluminescence |
| AU2003300008B2 (en) | 2002-12-23 | 2007-04-05 | Promega Corporation | Improved luciferase-based assays |
| DE10303265A1 (de) | 2003-01-28 | 2004-07-29 | Roche Diagnostics Gmbh | Fluorimetrische Bestimmung von Analyten durch ein intramolekulares Quencher-Fluorophor-Konjugat |
| EP1594962B1 (en) | 2003-01-31 | 2014-08-27 | Promega Corporation | Covalent tethering of functional groups to proteins |
| US7429472B2 (en) | 2003-01-31 | 2008-09-30 | Promega Corporation | Method of immobilizing a protein or molecule via a mutant dehalogenase that is bound to an immobilized dehalogenase substrate and linked directly or indirectly to the protein or molecule |
| AU2004210982B2 (en) | 2003-02-12 | 2008-12-18 | Promega Corporation | Methods and kits for dual enzymatic assays whereby light is quenched from luminescent reactions |
| US20040178545A1 (en) | 2003-03-14 | 2004-09-16 | Cates Larry E. | System for optically analyzing a molten metal bath |
| WO2005038029A2 (en) | 2003-10-10 | 2005-04-28 | Promega Corporation | Luciferase biosensor |
| ATE443070T1 (de) | 2004-01-08 | 2009-10-15 | Univ Zuerich | Metallkomplexe mit vitamin b12 als ligand |
| US7416854B2 (en) | 2004-01-22 | 2008-08-26 | Promega Corporation | Luminogenic and nonluminogenic multiplex assay |
| US7553632B2 (en) | 2004-01-22 | 2009-06-30 | Promega Corporation | Luminogenic and nonluminogenic multiplex assay |
| US20070087400A1 (en) | 2004-07-30 | 2007-04-19 | Aldis Darzins | Covalent tethering of functional groups to proteins and substrates therefor |
| US7425436B2 (en) | 2004-07-30 | 2008-09-16 | Promega Corporation | Covalent tethering of functional groups to proteins and substrates therefor |
| EP2395358B1 (en) | 2004-07-30 | 2017-03-29 | Promega Corporation | Covalent tethering of functional groups to proteins |
| US7728118B2 (en) | 2004-09-17 | 2010-06-01 | Promega Corporation | Synthetic nucleic acid molecule compositions and methods of preparation |
| JP4453528B2 (ja) * | 2004-10-26 | 2010-04-21 | 東京化成工業株式会社 | 新規化学発光試薬 |
| EP1700865A1 (en) | 2005-03-11 | 2006-09-13 | AXXAM S.r.l. | Photoproteins with enhanced bioluminescence and their use as intracellular calcium indicators |
| JP4639904B2 (ja) | 2005-03-30 | 2011-02-23 | チッソ株式会社 | 蛍光活性を有するルシフェラーゼの活性増強方法 |
| JP3844082B2 (ja) | 2005-04-08 | 2006-11-08 | キッコーマン株式会社 | 耐熱性ホタルルシフェラーゼ、耐熱性ホタルルシフェラーゼ遺伝子、新規な組み換え体ｄｎａ及び耐熱性ホタルルシフェラーゼの製造法 |
| EP2272973B1 (en) | 2005-05-31 | 2015-05-27 | Promega Corporation | Luminogenic and fluorogenic compounds and methods to detect molecules or conditions |
| EP1935986B1 (en) | 2005-05-31 | 2014-04-16 | Promega Corporation | Luminogenic and fluorogenic compounds and methods to detect molecules or conditions |
| KR20080039431A (ko) | 2005-08-17 | 2008-05-07 | 예다 리서치 앤드 디벨럽먼트 캄파니 리미티드 | 생물학적으로 활성인 혈청 파라옥소나제의 수준을 구하기위한 방법 및 조성물 |
| JP4999341B2 (ja) | 2005-09-06 | 2012-08-15 | 株式会社バイオエネックス | 変異型ホタルルシフェラーゼ、遺伝子、組換えベクター、形質転換体、及び変異型ホタルルシフェラーゼの製造方法 |
| EP2004813B1 (en) | 2006-04-03 | 2015-06-03 | Promega Corporation | Permuted and nonpermuted luciferase biosensors binding cyclic nucleotides |
| CN101636503B (zh) | 2006-10-24 | 2012-10-03 | 基因流股份有限公司 | 萤光素酶信号增强组合物 |
| CA2667697A1 (en) | 2006-10-30 | 2008-05-08 | Promega Corporation | Mutant hydrolase proteins with enhanced kinetics and functional expression |
| WO2008086035A2 (en) | 2007-01-10 | 2008-07-17 | Promega Corporation | Split mutant hydrolase fusion reporter and uses thereof |
| US20080248511A1 (en) | 2007-03-26 | 2008-10-09 | Promega Corporation | Methods to quench light from optical reactions |
| WO2009061413A2 (en) | 2007-11-05 | 2009-05-14 | Promega Corporation | Hybrid fusion reporter and uses thereof |
| EP2281046B1 (en) | 2008-05-19 | 2012-01-25 | Promega Corporation | LUCIFERASE BIOSENSORS FOR cAMP |
| JP5753083B2 (ja) | 2008-07-22 | 2015-07-22 | プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ | Ａｄｐ検出に基づく発光ホスホトランスフェラーゼまたはａｔｐヒドロラーゼのアッセイ法 |
| TWI354101B (en) | 2008-08-19 | 2011-12-11 | Univ Nat Taipei Technology | Fluorimetric indicator for biosensing and manufact |
| WO2010119721A1 (ja) | 2009-04-17 | 2010-10-21 | 独立行政法人産業技術総合研究所 | 超高輝度で安定な人工生物発光酵素 |
| DK2456864T3 (en) | 2009-05-01 | 2015-12-21 | Promega Corp | SYNTHETIC OPLOPHORUS luciferases WITH IMPROVED LIGHT MISSION |
| WO2011038219A1 (en) | 2009-09-24 | 2011-03-31 | Promega Corporation | Proteases having improved stability, solubility and activity |
| EP2569423B1 (en) | 2010-05-11 | 2015-12-02 | Promega Corporation | Mutant protease biosensors with enhanced detection characteristics |
| EP2611929B1 (en) | 2010-09-01 | 2016-01-13 | Promega Corporation | Oxidized glutathione assay |
| US9284188B2 (en) | 2010-09-03 | 2016-03-15 | The Regents Of The University Of California | Cytosolic delivery of materials with endosome-disrupting colloids |
| PT2635583E (pt) | 2010-11-02 | 2015-09-11 | Promega Corp | Derivados da coelenterazina e métodos de utilização da mesma |
| US8669103B2 (en) | 2010-11-02 | 2014-03-11 | Promega Corporation | Oplophorus-derived luciferases, novel coelenterazine substrates, and methods of use |
| EP2751089B1 (en) | 2011-09-02 | 2018-11-14 | Promega Corporation | Compounds and methods for assaying redox state of metabolically active cells and methods for measuring nad(p)/nad(p)h |
-
2011
- 2011-11-02 PT PT117852178T patent/PT2635583E/pt unknown
- 2011-11-02 CA CA2815381A patent/CA2815381C/en active Active
- 2011-11-02 CN CN201180052806XA patent/CN103180324A/zh active Pending
- 2011-11-02 AU AU2011323455A patent/AU2011323455B2/en active Active
- 2011-11-02 ES ES11785217.8T patent/ES2543913T3/es active Active
- 2011-11-02 US US13/287,519 patent/US9487520B2/en active Active
- 2011-11-02 SG SG2013030317A patent/SG189494A1/en unknown
- 2011-11-02 DK DK11785217.8T patent/DK2635583T3/en active
- 2011-11-02 PL PL11785217T patent/PL2635583T3/pl unknown
- 2011-11-02 JP JP2013537779A patent/JP6040157B2/ja active Active
- 2011-11-02 BR BR112013010484A patent/BR112013010484B1/pt active IP Right Grant
- 2011-11-02 EP EP11785217.8A patent/EP2635583B1/en active Active
- 2011-11-02 KR KR1020137014031A patent/KR101968475B1/ko active Active
- 2011-11-02 WO PCT/US2011/058924 patent/WO2012061477A1/en not_active Ceased
-
2013
- 2013-04-21 IL IL225869A patent/IL225869A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| BR112013010484A2 (pt) | 2016-07-05 |
| WO2012061477A1 (en) | 2012-05-10 |
| EP2635583A1 (en) | 2013-09-11 |
| AU2011323455A1 (en) | 2013-05-30 |
| IL225869A (en) | 2017-09-28 |
| KR101968475B1 (ko) | 2019-04-15 |
| JP2013544242A (ja) | 2013-12-12 |
| CA2815381A1 (en) | 2012-05-10 |
| ES2543913T3 (es) | 2015-08-25 |
| KR20140003430A (ko) | 2014-01-09 |
| US9487520B2 (en) | 2016-11-08 |
| AU2011323455B2 (en) | 2017-07-27 |
| PL2635583T3 (pl) | 2015-11-30 |
| JP6040157B2 (ja) | 2016-12-07 |
| SG189494A1 (en) | 2013-05-31 |
| CN103180324A (zh) | 2013-06-26 |
| IL225869A0 (en) | 2013-07-31 |
| DK2635583T3 (en) | 2015-08-03 |
| BR112013010484B1 (pt) | 2019-09-03 |
| EP2635583B1 (en) | 2015-06-03 |
| US20120107849A1 (en) | 2012-05-03 |
| CA2815381C (en) | 2019-03-19 |
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