CA2815381C - Coelenterazine derivatives and methods of using same - Google Patents

Coelenterazine derivatives and methods of using same Download PDF

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Publication number
CA2815381C
CA2815381C CA2815381A CA2815381A CA2815381C CA 2815381 C CA2815381 C CA 2815381C CA 2815381 A CA2815381 A CA 2815381A CA 2815381 A CA2815381 A CA 2815381A CA 2815381 C CA2815381 C CA 2815381C
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Canada
Prior art keywords
alkyl
coelenterazine
enzyme
substituted
compound
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CA2815381A
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English (en)
French (fr)
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CA2815381A1 (en
Inventor
Dieter H. Klaubert
Poncho Meisenheimer
James Unch
Wenhui Zhou
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Promega Corp
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Promega Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/66—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving luciferase

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA2815381A 2010-11-02 2011-11-02 Coelenterazine derivatives and methods of using same Active CA2815381C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40941310P 2010-11-02 2010-11-02
US61/409,413 2010-11-02
PCT/US2011/058924 WO2012061477A1 (en) 2010-11-02 2011-11-02 Coelenterazine derivatives and methods of using same

Publications (2)

Publication Number Publication Date
CA2815381A1 CA2815381A1 (en) 2012-05-10
CA2815381C true CA2815381C (en) 2019-03-19

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CA2815381A Active CA2815381C (en) 2010-11-02 2011-11-02 Coelenterazine derivatives and methods of using same

Country Status (15)

Country Link
US (1) US9487520B2 (enExample)
EP (1) EP2635583B1 (enExample)
JP (1) JP6040157B2 (enExample)
KR (1) KR101968475B1 (enExample)
CN (1) CN103180324A (enExample)
AU (1) AU2011323455B2 (enExample)
BR (1) BR112013010484B1 (enExample)
CA (1) CA2815381C (enExample)
DK (1) DK2635583T3 (enExample)
ES (1) ES2543913T3 (enExample)
IL (1) IL225869A (enExample)
PL (1) PL2635583T3 (enExample)
PT (1) PT2635583E (enExample)
SG (1) SG189494A1 (enExample)
WO (1) WO2012061477A1 (enExample)

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Also Published As

Publication number Publication date
EP2635583B1 (en) 2015-06-03
SG189494A1 (en) 2013-05-31
KR20140003430A (ko) 2014-01-09
BR112013010484A2 (pt) 2016-07-05
CN103180324A (zh) 2013-06-26
KR101968475B1 (ko) 2019-04-15
AU2011323455B2 (en) 2017-07-27
PT2635583E (pt) 2015-09-11
EP2635583A1 (en) 2013-09-11
IL225869A0 (en) 2013-07-31
IL225869A (en) 2017-09-28
WO2012061477A1 (en) 2012-05-10
JP2013544242A (ja) 2013-12-12
AU2011323455A1 (en) 2013-05-30
JP6040157B2 (ja) 2016-12-07
US9487520B2 (en) 2016-11-08
US20120107849A1 (en) 2012-05-03
ES2543913T3 (es) 2015-08-25
BR112013010484B1 (pt) 2019-09-03
PL2635583T3 (pl) 2015-11-30
DK2635583T3 (en) 2015-08-03
CA2815381A1 (en) 2012-05-10

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