PT1803718E - Derivados de 4-tetpazolil-4-fenilpiperidina para o tratamento da dor - Google Patents

Info

Publication number

PT1803718E

PT1803718E PT07006697T PT07006697T PT1803718E PT 1803718 E PT1803718 E PT 1803718E PT 07006697 T PT07006697 T PT 07006697T PT 07006697 T PT07006697 T PT 07006697T PT 1803718 E PT1803718 E PT 1803718E

Authority

PT

Portugal

Prior art keywords

tetrazolyl

alkyl

formula

those

phenylpiperidine

Prior art date

2002-11-18

Links

• Espacenet
• Global Dossier
• Discuss

• OGPKTRWLBLRODW-UHFFFAOYSA-N 4-phenyl-4-(2h-tetrazol-5-yl)piperidine Chemical class C1CNCCC1(C=1C=CC=CC=1)C1=NNN=N1 OGPKTRWLBLRODW-UHFFFAOYSA-N 0.000 title description 428
• 208000002193 Pain Diseases 0.000 title description 56
• 150000001875 compounds Chemical class 0.000 claims description 263
• -1 -OH Chemical group 0.000 claims description 131
• 150000003839 salts Chemical class 0.000 claims description 98
• 125000000217 alkyl group Chemical group 0.000 claims description 83
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 58
• 229910052799 carbon Inorganic materials 0.000 claims description 35
• 125000001072 heteroaryl group Chemical group 0.000 claims description 33
• 125000001624 naphthyl group Chemical group 0.000 claims description 32
• 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims description 31
• 125000005561 phenanthryl group Chemical group 0.000 claims description 31
• 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 28
• 125000005428 anthryl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C3C(*)=C([H])C([H])=C([H])C3=C([H])C2=C1[H] 0.000 claims description 27
• 125000006413 ring segment Chemical group 0.000 claims description 27
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 21
• 229910052739 hydrogen Inorganic materials 0.000 claims description 20
• 125000006833 (C1-C5) alkylene group Chemical group 0.000 claims description 19
• 229910052736 halogen Inorganic materials 0.000 claims description 9
• 150000002367 halogens Chemical class 0.000 claims description 8
• 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims description 7
• 239000008194 pharmaceutical composition Substances 0.000 claims description 6
• 125000005843 halogen group Chemical group 0.000 claims description 4
• 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
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• 239000000203 mixture Substances 0.000 description 93
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• XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 49
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