DE60322451D1 - 4-Tetrazolyl-4-Phenylpiperidinderivate zur Schmerzbehandlung - Google Patents

4-Tetrazolyl-4-Phenylpiperidinderivate zur Schmerzbehandlung

Info

Publication number
DE60322451D1
DE60322451D1 DE60322451T DE60322451T DE60322451D1 DE 60322451 D1 DE60322451 D1 DE 60322451D1 DE 60322451 T DE60322451 T DE 60322451T DE 60322451 T DE60322451 T DE 60322451T DE 60322451 D1 DE60322451 D1 DE 60322451D1
Authority
DE
Germany
Prior art keywords
tetrazolyl
pain
treatment
phenylpiperidine derivatives
phenylpiperidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60322451T
Other languages
German (de)
English (en)
Inventor
Zhengming Chen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Euro Celtique SA
Original Assignee
Euro Celtique SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euro Celtique SA filed Critical Euro Celtique SA
Application granted granted Critical
Publication of DE60322451D1 publication Critical patent/DE60322451D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE60322451T 2002-11-18 2003-11-17 4-Tetrazolyl-4-Phenylpiperidinderivate zur Schmerzbehandlung Expired - Lifetime DE60322451D1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US42738102P 2002-11-18 2002-11-18
US46027803P 2003-04-03 2003-04-03
US48848803P 2003-07-17 2003-07-17
US10/714,066 US7202259B2 (en) 2002-11-18 2003-11-13 Therapeutic agents useful for treating pain

Publications (1)

Publication Number Publication Date
DE60322451D1 true DE60322451D1 (de) 2008-09-04

Family

ID=32777221

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60322451T Expired - Lifetime DE60322451D1 (de) 2002-11-18 2003-11-17 4-Tetrazolyl-4-Phenylpiperidinderivate zur Schmerzbehandlung
DE60313021T Expired - Lifetime DE60313021T2 (de) 2002-11-18 2003-11-17 4-tetrazolyl-4-phenylpiperidindervate zur schmerzbehandlung

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE60313021T Expired - Lifetime DE60313021T2 (de) 2002-11-18 2003-11-17 4-tetrazolyl-4-phenylpiperidindervate zur schmerzbehandlung

Country Status (36)

Country Link
US (3) US7202259B2 (enExample)
EP (2) EP1803718B1 (enExample)
JP (2) JP4601429B2 (enExample)
KR (1) KR20050115221A (enExample)
CN (2) CN101648941A (enExample)
AP (1) AP2210A (enExample)
AR (1) AR047008A1 (enExample)
AT (2) ATE402167T1 (enExample)
AU (2) AU2003294313B2 (enExample)
BR (1) BR0316305A (enExample)
CA (1) CA2506242C (enExample)
CO (1) CO5690588A2 (enExample)
CR (2) CR7877A (enExample)
CY (2) CY1107682T1 (enExample)
DE (2) DE60322451D1 (enExample)
DK (2) DK1562932T3 (enExample)
EA (1) EA008621B1 (enExample)
EC (1) ECSP055840A (enExample)
ES (2) ES2285235T3 (enExample)
GE (1) GEP20084539B (enExample)
IL (1) IL209352A0 (enExample)
IS (2) IS2720B (enExample)
MA (1) MA27565A1 (enExample)
ME (1) MEP48108A (enExample)
MX (1) MXPA05004669A (enExample)
MY (1) MY135647A (enExample)
NI (1) NI200500087A (enExample)
NO (1) NO20052894L (enExample)
NZ (2) NZ572685A (enExample)
OA (1) OA13010A (enExample)
PT (2) PT1562932E (enExample)
RS (1) RS51047B (enExample)
SG (1) SG165998A1 (enExample)
SI (2) SI1803718T1 (enExample)
TW (2) TWI343917B (enExample)
WO (1) WO2004046132A1 (enExample)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7202259B2 (en) * 2002-11-18 2007-04-10 Euro-Celtique S.A. Therapeutic agents useful for treating pain
ME00276B (me) 2003-04-30 2011-05-10 Purdue Pharma Lp Transdermalni dozni oblik otporan na promjene koje sadrže komponentu aktivnog sredstva i komponentu suprotnog sredstva na mjestu koji je ispod sloja aktivnog sredstva
US8790689B2 (en) * 2003-04-30 2014-07-29 Purdue Pharma L.P. Tamper resistant transdermal dosage form
BRPI0506548A (pt) * 2004-01-30 2007-05-02 Euro Celtique Sa métodos para produzir compostos de 4-tetrazolil-4-fenilpiperidina
SE0401656D0 (sv) * 2004-06-24 2004-06-24 Astrazeneca Ab Chemical compounds
CA2628750C (en) * 2005-11-21 2013-02-12 Purdue Pharma L.P. 4-oxadiazolyl-piperidine compounds and use thereof
US20080051380A1 (en) 2006-08-25 2008-02-28 Auerbach Alan H Methods and compositions for treating cancer
WO2011056561A1 (en) 2009-10-27 2011-05-12 Beth Israel Deaconess Medical Center Methods and compositions for the generation and use of conformation-specific antibodies
ES2566828T3 (es) 2010-09-21 2016-04-15 Purdue Pharma L.P. Análogos de buprenorfina como agonistas y/o antagonistas del receptor opioide
CN102648915B (zh) * 2011-02-28 2015-04-15 鲁南制药集团股份有限公司 一种治疗或预防神经病理性疼痛的药物组合物
US10487114B2 (en) 2011-04-27 2019-11-26 Beth Israel Deaconess Medical Center, Inc. Methods for administering peptides for the generation of effective c/s conformation-specific antibodies to a human subject in need thereof
EP2917182B1 (en) 2012-11-09 2018-01-03 Purdue Pharma LP Benzomorphan analogs and the use thereof
US9175000B2 (en) 2012-12-07 2015-11-03 Purdue Pharma L.P. Buprenorphine analogs
US8980906B2 (en) 2012-12-14 2015-03-17 Purdue Pharma L.P. Pyridonemorphinan analogs and biological activity on opioid receptors
US8987287B2 (en) 2012-12-14 2015-03-24 Purdue Pharma L.P. Spirocyclic morphinans and their use
EP2951160B1 (en) 2013-01-31 2019-04-24 Purdue Pharma LP Benzomorphan analogs and the use thereof
US8969358B2 (en) 2013-03-15 2015-03-03 Purdue Pharma L.P. Buprenorphine analogs
WO2015097548A1 (en) 2013-12-26 2015-07-02 Purdue Pharma L.P. 7-beta-alkyl analogs of orvinols
WO2015097547A1 (en) 2013-12-26 2015-07-02 Purdue Pharma L.P. 10-substituted morphinan hydantoins
WO2015097545A1 (en) 2013-12-26 2015-07-02 Purdue Pharma L.P. Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans
WO2015100174A1 (en) 2013-12-26 2015-07-02 Purdue Pharma L.P. Ring-contracted morphinans and the use thereof
US9340542B2 (en) 2013-12-26 2016-05-17 Purdue Pharma L.P. Propellane-based compounds and the use thereof
WO2015099863A1 (en) 2013-12-27 2015-07-02 Purdue Pharma L.P. 6-substituted and 7-substituted morphinan analogs and the use thereof
CA2950567A1 (en) 2014-05-27 2015-12-03 Purdue Pharma L.P. Spirocyclic morphinans and use thereof
JP6360915B2 (ja) 2014-06-13 2018-07-18 パーデュー、ファーマ、リミテッド、パートナーシップ アザモルフィナン誘導体及びその使用
MA41125A (fr) 2014-12-05 2017-10-10 Purdue Pharma Lp Dérivés de 6.7-cyclomorphinane et leur utilisation
CA3018750A1 (en) 2016-03-22 2017-09-28 Regents Of The University Of Minnesota Combination for treating pain
IL322013A (en) 2016-07-29 2025-09-01 Janssen Pharmaceutica Nv Niraparib or its salts for use in the treatment of prostate cancer
WO2018125716A1 (en) 2017-01-02 2018-07-05 Purdue Pharma L.P. Morphinan derivatives and use thereof
JP2024518804A (ja) * 2021-05-21 2024-05-02 パーデュー、ファーマ、リミテッド、パートナーシップ 間質性膀胱炎／膀胱痛症候群を処置する方法
CN119421705A (zh) * 2022-06-24 2025-02-11 普渡制药公司 治疗或预防膀胱过度活动综合征的方法

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3536809A (en) * 1969-02-17 1970-10-27 Alza Corp Medication method
US3598122A (en) * 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US3598123A (en) * 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
BE775611A (fr) 1970-11-24 1972-03-16 Synthelabo Derives de la (diphenyl-3,3 propyl-1)-1 piperidine, leur preparation etles medicaments qui en contiennent
US4076717A (en) * 1971-12-15 1978-02-28 G. D. Searle & Co. Derivatives of 1-(3-cyano-3,3-diphenylpropyl)-4-phenylpiperidine-4-carboxylic acid
US3845770A (en) * 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3916899A (en) * 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US4008719A (en) * 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
IE58110B1 (en) * 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
DK162087D0 (da) * 1987-03-31 1987-03-31 Ferrosan As Piperidinforbindelser, deres fremstilling og anvendelse
US4831192A (en) * 1987-12-31 1989-05-16 Boc, Inc. Methods of preparing 4-heteropentacyclic-4-(N-phenyl)amido) piperidine derivatives and intermediate compounds
US5073543A (en) * 1988-07-21 1991-12-17 G. D. Searle & Co. Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
IT1229203B (it) * 1989-03-22 1991-07-25 Bioresearch Spa Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative.
US5120548A (en) * 1989-11-07 1992-06-09 Merck & Co., Inc. Swelling modulated polymeric drug delivery device
US5733566A (en) * 1990-05-15 1998-03-31 Alkermes Controlled Therapeutics Inc. Ii Controlled release of antiparasitic agents in animals
US5698155A (en) * 1991-05-31 1997-12-16 Gs Technologies, Inc. Method for the manufacture of pharmaceutical cellulose capsules
US5580578A (en) * 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
US5449989A (en) 1992-07-31 1995-09-12 Correa; Paulo N. Energy conversion system
US5606037A (en) 1992-11-09 1997-02-25 Biochem Pharma Inc. Processes antineoplastic heteronaphthoquinones
US5736523A (en) 1992-11-09 1998-04-07 Biochem Pharma Inc. Antineoplastic heteronapthoquinones
US5591767A (en) * 1993-01-25 1997-01-07 Pharmetrix Corporation Liquid reservoir transdermal patch for the administration of ketorolac
IT1270594B (it) * 1994-07-07 1997-05-07 Recordati Chem Pharm Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida
US6166085A (en) 1995-04-14 2000-12-26 The Regents Of The University Of California Method of producing analgesia
US5849737A (en) 1995-04-14 1998-12-15 The Regents Of The University Of California Compositions and methods for treating pain
AU6111796A (en) * 1995-06-12 1997-01-09 G.D. Searle & Co. Compositions comprising a cyclooxygenase-2 inhibitor and a 5 -lipoxygenase inhibitor
US6573282B1 (en) 1995-09-12 2003-06-03 Adolor Corporation Peripherally active anti-hyperalgesic opiates
US5849761A (en) 1995-09-12 1998-12-15 Regents Of The University Of California Peripherally active anti-hyperalgesic opiates
AU1208397A (en) 1995-12-28 1997-07-28 Takeda Chemical Industries Ltd. Diphenylmethane derivatives as mip-1alpha/rantes receptor antagonists
US6221888B1 (en) 1997-05-29 2001-04-24 Merck & Co., Inc. Sulfonamides as cell adhesion inhibitors
DE69704679T2 (de) * 1997-06-10 2001-09-13 Synthon Bv 4-phenylpiperidin-derivate
WO1999045011A1 (en) 1998-03-06 1999-09-10 Janssen Pharmaceutica N.V. Glycine transport inhibitors
US6423519B1 (en) * 1998-07-15 2002-07-23 Gpc Biotech Inc. Compositions and methods for inhibiting fungal growth
PE20001420A1 (es) 1998-12-23 2000-12-18 Pfizer Moduladores de ccr5
US7217714B1 (en) 1998-12-23 2007-05-15 Agouron Pharmaceuticals, Inc. CCR5 modulators
CZ20013289A3 (cs) 1999-03-12 2002-01-16 Boehringer Ingelheim Pharmaceuticals, Inc. Sloučeniny výhodné jako protizánětové prostředky
WO2001021169A1 (en) 1999-09-20 2001-03-29 Takeda Chemical Industries, Ltd. Mch antagonists
CA2324330A1 (en) 1999-11-08 2001-05-08 Ssp Co., Ltd. 4-hydroxy-4-phenylpiperidine derivatives and pharmaceuticals containing the same
DE60022226D1 (de) 1999-12-06 2005-09-29 Euro Celtique Sa Benzimidazolverbindungen die nociceptinrezeptoraffinität haben
JP2003518130A (ja) 1999-12-22 2003-06-03 メルク フロスト カナダ アンド カンパニー 蛋白チロシンホスファターゼ１ｂ（ｐｔｐ−１ｂ）阻害薬としてのホスホン酸誘導体
US6608052B2 (en) 2000-02-16 2003-08-19 Boehringer Ingelheim Pharmaceuticals, Inc. Compounds useful as anti-inflammatory agents
US6703525B2 (en) 2000-02-16 2004-03-09 Boehringer Ingelheim Pharmaceuticals, Inc. Sulfonamide intermediates and methods of producing same
AU4274401A (en) 2000-03-24 2001-10-03 Meiji Seika Kaisha Diphenylalkylamine derivatives useful as opioid delta receptor agonists
US6544981B2 (en) 2000-06-09 2003-04-08 Bristol-Myers Squibb Company Lactam inhibitors of factor Xa and method
CN1469862A (zh) 2000-10-12 2004-01-21 Ss制药株式会社 2,2-二苯基丁酰胺衍生物和含有它的药物
WO2002038185A2 (en) 2000-11-13 2002-05-16 Atrix Laboratories, Inc. Injectable sustained release delivery system with loperamide
US7202259B2 (en) * 2002-11-18 2007-04-10 Euro-Celtique S.A. Therapeutic agents useful for treating pain
BRPI0506548A (pt) * 2004-01-30 2007-05-02 Euro Celtique Sa métodos para produzir compostos de 4-tetrazolil-4-fenilpiperidina

Also Published As

Publication number Publication date
MEP48108A (en) 2011-02-10
GEP20084539B (en) 2008-11-25
ATE402167T1 (de) 2008-08-15
ATE358674T1 (de) 2007-04-15
DE60313021D1 (de) 2007-05-16
BR0316305A (pt) 2005-09-27
US20100069437A1 (en) 2010-03-18
EA008621B1 (ru) 2007-06-29
MY135647A (en) 2008-06-30
CR11037A (es) 2009-10-29
SI1562932T1 (sl) 2007-08-31
CA2506242C (en) 2011-07-05
IS8913A (is) 2010-07-21
CA2506242A1 (en) 2004-06-03
NO20052894D0 (no) 2005-06-14
TW200418828A (en) 2004-10-01
US7687518B2 (en) 2010-03-30
IL209352A0 (en) 2011-01-31
CN101648941A (zh) 2010-02-17
US7202259B2 (en) 2007-04-10
DK1803718T3 (da) 2008-10-27
JP2010163452A (ja) 2010-07-29
AU2010246411A1 (en) 2010-12-16
CO5690588A2 (es) 2006-10-31
SI1803718T1 (sl) 2008-12-31
DK1562932T3 (da) 2007-08-13
NI200500087A (es) 2007-07-24
ECSP055840A (es) 2005-08-11
WO2004046132A1 (en) 2004-06-03
SG165998A1 (en) 2010-11-29
NZ540068A (en) 2007-07-27
AU2003294313A1 (en) 2004-06-15
PT1803718E (pt) 2008-09-26
TW200819436A (en) 2008-05-01
TWI343917B (en) 2011-06-21
CY1108422T1 (el) 2014-04-09
AU2003294313B2 (en) 2010-08-26
US8026254B2 (en) 2011-09-27
EP1803718B1 (en) 2008-07-23
US20070179141A1 (en) 2007-08-02
RS20050375A (sr) 2007-11-15
EP1562932B9 (en) 2007-09-12
ES2312150T3 (es) 2009-02-16
NZ572685A (en) 2010-06-25
EP1562932A1 (en) 2005-08-17
US20040152689A1 (en) 2004-08-05
HK1086829A1 (zh) 2006-09-29
CR7877A (es) 2005-11-30
AP2005003297A0 (en) 2005-06-30
KR20050115221A (ko) 2005-12-07
RS51047B (sr) 2010-10-31
AP2210A (en) 2011-02-25
CY1107682T1 (el) 2013-04-18
OA13010A (en) 2006-11-10
NO20052894L (no) 2005-06-14
JP2006525944A (ja) 2006-11-16
CN1711256A (zh) 2005-12-21
ES2285235T3 (es) 2007-11-16
PT1562932E (pt) 2007-07-02
IS2720B (is) 2011-02-15
IS7812A (is) 2005-04-19
MXPA05004669A (es) 2005-06-08
EP1562932B1 (en) 2007-04-04
AR047008A1 (es) 2006-01-04
CN100567288C (zh) 2009-12-09
EA200500726A1 (ru) 2005-10-27
EP1803718A1 (en) 2007-07-04
MA27565A1 (fr) 2005-10-03
JP4601429B2 (ja) 2010-12-22
DE60313021T2 (de) 2007-12-13

Similar Documents

Publication Publication Date Title
DE60322451D1 (de) 4-Tetrazolyl-4-Phenylpiperidinderivate zur Schmerzbehandlung
IS8142A (is) Læknislyf gagnleg til meðferðar á verkjum
EE200200571A (et) Hüdroksüfenüülpiperidiin-4-ülideenmetüülbensamiidi derivaadid valu raviks
DE502004010131D1 (de) Pyridopyrimidinone zur behandlung von krebserkrankungen
NO20045554L (no) Fremgangsmate for behandling av diabetes
GB0329874D0 (en) Compounds useful for the treatment of diseases
ATE389742T1 (de) Gewebebehandlungsmittel
DE60328494D1 (de) Verbessertes system zur behandlung der stressbedingten harninkontinenz
DK1727801T3 (da) Til behandling af smerter anvendelige piperaziner
GB0213869D0 (en) The treatment of pain
ATE297914T1 (de) Hydroxyphenyl-piperazinyl-methyl-benzamid- derivate zur schmerzbehandlung
EE200200577A (et) Kinolinüülpiperidiin-4-ülideenmetüülbensamiidi derivaadid valu raviks
DK1553950T3 (da) Terapeutisk behandling
DE60221068D1 (de) Gerät zur tiefenwirksamen Hauttherapie
ATE482707T1 (de) 1-ä2h-1-benzopyran-2-on-8-ylü- piperazin- derivate zur behandlung von schmerzen
DE50308460D1 (de) Verwendung von ambroxol zur behandlung von chronischen schmerzen
ATE359270T1 (de) Phenyl-piperidin-4-yliden-methyl-benzamidderiva e zur behandlung von schmerz oder magen-darm- erkrankungen
GB0201025D0 (en) The treatment of degenerative diseases
NO20033160D0 (no) Anordning for behandling av gravann
DE602004003252D1 (de) Verwendung von 2h-ä1,3ü-oxazinoä3,2-aüindol-derivaten zur behandlung von neuropathischem schmerz
ATE433983T1 (de) Thiadibenzoazulenderivate zur behandlung von entzündlichen erkrankungen
EP1511474A4 (en) PROCESSING PROCESS
GB0325957D0 (en) The treatment of pain
DE602005023842D1 (de) 1-ä2h-1-benzopyran-2-on-8-ylü- piperazin- derivate zur behandlung von schmerzen
GB0322014D0 (en) The treatment of pain

Legal Events

Date Code Title Description
8364 No opposition during term of opposition