CA2506242C - 4-tetrazolyl-4phenylpiperidine derivatives for treating pain - Google Patents

4-tetrazolyl-4phenylpiperidine derivatives for treating pain Download PDF

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Publication number
CA2506242C
CA2506242C CA2506242A CA2506242A CA2506242C CA 2506242 C CA2506242 C CA 2506242C CA 2506242 A CA2506242 A CA 2506242A CA 2506242 A CA2506242 A CA 2506242A CA 2506242 C CA2506242 C CA 2506242C
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CA
Canada
Prior art keywords
compound
alkyl
tetrazolyl
pharmaceutically acceptable
acceptable salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2506242A
Other languages
English (en)
French (fr)
Other versions
CA2506242A1 (en
Inventor
Zhengming Chen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Euro Celtique SA
Original Assignee
Euro Celtique SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euro Celtique SA filed Critical Euro Celtique SA
Publication of CA2506242A1 publication Critical patent/CA2506242A1/en
Application granted granted Critical
Publication of CA2506242C publication Critical patent/CA2506242C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA2506242A 2002-11-18 2003-11-17 4-tetrazolyl-4phenylpiperidine derivatives for treating pain Expired - Fee Related CA2506242C (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US10/000,000 2002-10-07
US42738102P 2002-11-18 2002-11-18
US60/427,381 2002-11-18
US46027803P 2003-04-03 2003-04-03
US60/460,278 2003-04-03
US48848803P 2003-07-17 2003-07-17
US60/488,488 2003-07-17
US10/714,066 US7202259B2 (en) 2002-11-18 2003-11-13 Therapeutic agents useful for treating pain
PCT/US2003/036742 WO2004046132A1 (en) 2002-11-18 2003-11-17 4-tetrazolyl-4phenylpiperidine derivatives for treating pain

Publications (2)

Publication Number Publication Date
CA2506242A1 CA2506242A1 (en) 2004-06-03
CA2506242C true CA2506242C (en) 2011-07-05

Family

ID=32777221

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2506242A Expired - Fee Related CA2506242C (en) 2002-11-18 2003-11-17 4-tetrazolyl-4phenylpiperidine derivatives for treating pain

Country Status (36)

Country Link
US (3) US7202259B2 (enExample)
EP (2) EP1803718B1 (enExample)
JP (2) JP4601429B2 (enExample)
KR (1) KR20050115221A (enExample)
CN (2) CN101648941A (enExample)
AP (1) AP2210A (enExample)
AR (1) AR047008A1 (enExample)
AT (2) ATE402167T1 (enExample)
AU (2) AU2003294313B2 (enExample)
BR (1) BR0316305A (enExample)
CA (1) CA2506242C (enExample)
CO (1) CO5690588A2 (enExample)
CR (2) CR7877A (enExample)
CY (2) CY1107682T1 (enExample)
DE (2) DE60322451D1 (enExample)
DK (2) DK1562932T3 (enExample)
EA (1) EA008621B1 (enExample)
EC (1) ECSP055840A (enExample)
ES (2) ES2285235T3 (enExample)
GE (1) GEP20084539B (enExample)
IL (1) IL209352A0 (enExample)
IS (2) IS2720B (enExample)
MA (1) MA27565A1 (enExample)
ME (1) MEP48108A (enExample)
MX (1) MXPA05004669A (enExample)
MY (1) MY135647A (enExample)
NI (1) NI200500087A (enExample)
NO (1) NO20052894L (enExample)
NZ (2) NZ572685A (enExample)
OA (1) OA13010A (enExample)
PT (2) PT1562932E (enExample)
RS (1) RS51047B (enExample)
SG (1) SG165998A1 (enExample)
SI (2) SI1803718T1 (enExample)
TW (2) TWI343917B (enExample)
WO (1) WO2004046132A1 (enExample)

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US9340542B2 (en) 2013-12-26 2016-05-17 Purdue Pharma L.P. Propellane-based compounds and the use thereof
WO2015099863A1 (en) 2013-12-27 2015-07-02 Purdue Pharma L.P. 6-substituted and 7-substituted morphinan analogs and the use thereof
CA2950567A1 (en) 2014-05-27 2015-12-03 Purdue Pharma L.P. Spirocyclic morphinans and use thereof
JP6360915B2 (ja) 2014-06-13 2018-07-18 パーデュー、ファーマ、リミテッド、パートナーシップ アザモルフィナン誘導体及びその使用
MA41125A (fr) 2014-12-05 2017-10-10 Purdue Pharma Lp Dérivés de 6.7-cyclomorphinane et leur utilisation
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JP2024518804A (ja) * 2021-05-21 2024-05-02 パーデュー、ファーマ、リミテッド、パートナーシップ 間質性膀胱炎／膀胱痛症候群を処置する方法
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Also Published As

Publication number Publication date
MEP48108A (en) 2011-02-10
GEP20084539B (en) 2008-11-25
ATE402167T1 (de) 2008-08-15
ATE358674T1 (de) 2007-04-15
DE60313021D1 (de) 2007-05-16
BR0316305A (pt) 2005-09-27
US20100069437A1 (en) 2010-03-18
EA008621B1 (ru) 2007-06-29
MY135647A (en) 2008-06-30
DE60322451D1 (de) 2008-09-04
CR11037A (es) 2009-10-29
SI1562932T1 (sl) 2007-08-31
IS8913A (is) 2010-07-21
CA2506242A1 (en) 2004-06-03
NO20052894D0 (no) 2005-06-14
TW200418828A (en) 2004-10-01
US7687518B2 (en) 2010-03-30
IL209352A0 (en) 2011-01-31
CN101648941A (zh) 2010-02-17
US7202259B2 (en) 2007-04-10
DK1803718T3 (da) 2008-10-27
JP2010163452A (ja) 2010-07-29
AU2010246411A1 (en) 2010-12-16
CO5690588A2 (es) 2006-10-31
SI1803718T1 (sl) 2008-12-31
DK1562932T3 (da) 2007-08-13
NI200500087A (es) 2007-07-24
ECSP055840A (es) 2005-08-11
WO2004046132A1 (en) 2004-06-03
SG165998A1 (en) 2010-11-29
NZ540068A (en) 2007-07-27
AU2003294313A1 (en) 2004-06-15
PT1803718E (pt) 2008-09-26
TW200819436A (en) 2008-05-01
TWI343917B (en) 2011-06-21
CY1108422T1 (el) 2014-04-09
AU2003294313B2 (en) 2010-08-26
US8026254B2 (en) 2011-09-27
EP1803718B1 (en) 2008-07-23
US20070179141A1 (en) 2007-08-02
RS20050375A (sr) 2007-11-15
EP1562932B9 (en) 2007-09-12
ES2312150T3 (es) 2009-02-16
NZ572685A (en) 2010-06-25
EP1562932A1 (en) 2005-08-17
US20040152689A1 (en) 2004-08-05
HK1086829A1 (zh) 2006-09-29
CR7877A (es) 2005-11-30
AP2005003297A0 (en) 2005-06-30
KR20050115221A (ko) 2005-12-07
RS51047B (sr) 2010-10-31
AP2210A (en) 2011-02-25
CY1107682T1 (el) 2013-04-18
OA13010A (en) 2006-11-10
NO20052894L (no) 2005-06-14
JP2006525944A (ja) 2006-11-16
CN1711256A (zh) 2005-12-21
ES2285235T3 (es) 2007-11-16
PT1562932E (pt) 2007-07-02
IS2720B (is) 2011-02-15
IS7812A (is) 2005-04-19
MXPA05004669A (es) 2005-06-08
EP1562932B1 (en) 2007-04-04
AR047008A1 (es) 2006-01-04
CN100567288C (zh) 2009-12-09
EA200500726A1 (ru) 2005-10-27
EP1803718A1 (en) 2007-07-04
MA27565A1 (fr) 2005-10-03
JP4601429B2 (ja) 2010-12-22
DE60313021T2 (de) 2007-12-13

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