PT1589017E - Derivados de epotilona modificados na posição 12,13 - Google Patents
Derivados de epotilona modificados na posição 12,13Info
- Publication number
- PT1589017E PT1589017E PT50152362T PT05015236T PT1589017E PT 1589017 E PT1589017 E PT 1589017E PT 50152362 T PT50152362 T PT 50152362T PT 05015236 T PT05015236 T PT 05015236T PT 1589017 E PT1589017 E PT 1589017E
- Authority
- PT
- Portugal
- Prior art keywords
- epothilone derivatives
- modified epothilone
- modified
- derivatives
- epothilone
- Prior art date
Links
- 150000003883 epothilone derivatives Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8256498P | 1998-04-21 | 1998-04-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1589017E true PT1589017E (pt) | 2013-03-04 |
Family
ID=22171978
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT50152362T PT1589017E (pt) | 1998-04-21 | 1999-04-05 | Derivados de epotilona modificados na posição 12,13 |
| PT99916383T PT1073648E (pt) | 1998-04-21 | 1999-04-05 | Derivados de epotilona modificados em 12, 13 |
| PT99915273T PT1073647E (pt) | 1998-04-21 | 1999-04-05 | Derivados de 12,13-ciclopropano-epotilona |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT99916383T PT1073648E (pt) | 1998-04-21 | 1999-04-05 | Derivados de epotilona modificados em 12, 13 |
| PT99915273T PT1073647E (pt) | 1998-04-21 | 1999-04-05 | Derivados de 12,13-ciclopropano-epotilona |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US6380395B1 (enExample) |
| EP (3) | EP1073648B1 (enExample) |
| JP (2) | JP4476483B2 (enExample) |
| CN (1) | CN1142923C (enExample) |
| AR (2) | AR015774A1 (enExample) |
| AT (2) | ATE340177T1 (enExample) |
| AU (2) | AU757733B2 (enExample) |
| BR (1) | BR9909795A (enExample) |
| CA (2) | CA2323609A1 (enExample) |
| CY (2) | CY1105836T1 (enExample) |
| DE (2) | DE69941083D1 (enExample) |
| DK (3) | DK1589017T3 (enExample) |
| ES (3) | ES2273484T3 (enExample) |
| PE (1) | PE20000460A1 (enExample) |
| PT (3) | PT1589017E (enExample) |
| TR (1) | TR200003036T2 (enExample) |
| WO (2) | WO1999054319A1 (enExample) |
Families Citing this family (85)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6204388B1 (en) * | 1996-12-03 | 2001-03-20 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| US6242469B1 (en) | 1996-12-03 | 2001-06-05 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| US20050043376A1 (en) * | 1996-12-03 | 2005-02-24 | Danishefsky Samuel J. | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| GB9810659D0 (en) | 1998-05-18 | 1998-07-15 | Ciba Geigy Ag | Organic compounds |
| DE19826988A1 (de) | 1998-06-18 | 1999-12-23 | Biotechnolog Forschung Gmbh | Epothilon-Nebenkomponenten |
| WO2000031247A2 (en) | 1998-11-20 | 2000-06-02 | Kosan Biosciences, Inc. | Recombinant methods and materials for producing epothilone and epothilone derivatives |
| US6410301B1 (en) | 1998-11-20 | 2002-06-25 | Kosan Biosciences, Inc. | Myxococcus host cells for the production of epothilones |
| EE200100302A (et) * | 1998-12-02 | 2002-08-15 | Pfizer Products Inc. | Meetodid ja kompositsioonid p53 perekonna valgu konformatsioonilise stabiilsuse taastamiseks |
| US6780620B1 (en) * | 1998-12-23 | 2004-08-24 | Bristol-Myers Squibb Company | Microbial transformation method for the preparation of an epothilone |
| US20020058286A1 (en) * | 1999-02-24 | 2002-05-16 | Danishefsky Samuel J. | Synthesis of epothilones, intermediates thereto and analogues thereof |
| JP2002540154A (ja) * | 1999-03-29 | 2002-11-26 | ブリストル−マイヤーズ スクイブ カンパニー | オキシラニルエポチロン化合物からアジリジニルエポチロン化合物の製造法 |
| US7125875B2 (en) | 1999-04-15 | 2006-10-24 | Bristol-Myers Squibb Company | Cyclic protein tyrosine kinase inhibitors |
| ES2391550T3 (es) | 1999-04-15 | 2012-11-27 | Bristol-Myers Squibb Company | Inhibidores cíclicos de la proteína tirosina quinasa |
| US6593115B2 (en) * | 2000-03-24 | 2003-07-15 | Bristol-Myers Squibb Co. | Preparation of epothilone intermediates |
| EP1414384A4 (en) | 2000-10-13 | 2005-07-27 | Univ Mississippi | SYNTHESIS OF EPOTHILONES AND TRANSFORMATION ANALOGUE |
| JP2004521122A (ja) * | 2001-01-25 | 2004-07-15 | ブリストル−マイヤーズ スクイブ カンパニー | エポチロン類似体の非経口製剤 |
| WO2002058699A1 (en) * | 2001-01-25 | 2002-08-01 | Bristol-Myers Squibb Company | Pharmaceutical forms of epothilones for oral administration |
| AU2002245296B2 (en) * | 2001-01-25 | 2006-12-21 | Bristol-Myers Squibb Company | Methods of administering epothilone analogs for the treatment of cancer |
| KR100851719B1 (ko) * | 2001-01-25 | 2008-08-11 | 브리스톨-마이어스스퀴브컴파니 | 암 치료용 에포틸론 유사체의 투여 방법 |
| EP1368030A1 (en) | 2001-02-20 | 2003-12-10 | Bristol-Myers Squibb Company | Epothilone derivatives for the treatment of refractory tumors |
| IL156988A0 (en) | 2001-02-20 | 2004-02-08 | Bristol Myers Squibb Co | Pharmaceutical compositions containing epothilone derivatives |
| SK11082003A3 (sk) * | 2001-03-14 | 2004-08-03 | Bristol-Myers Squibb Company | Kombinácia analógov epotilónu a chemoterapeutických činidiel na liečenie proliferatívnych ochorení |
| EP1389209B1 (en) * | 2001-04-24 | 2009-04-08 | Purdue Research Foundation | Folate mimetics and folate-receptor binding conjugates thereof |
| MXPA03010909A (es) * | 2001-06-01 | 2004-02-17 | Bristol Myers Squibb Co | Derivados de epotilona. |
| EP1420780B1 (en) * | 2001-08-23 | 2008-10-01 | Novartis AG | Cyclopropyl and cyclobutyl epothilone analogs |
| WO2003026744A1 (en) * | 2001-09-25 | 2003-04-03 | Alcon, Inc. | The use of epothilones and analogs in conjunction with ophthalmic surgery |
| TW200303202A (en) * | 2002-02-15 | 2003-09-01 | Bristol Myers Squibb Co | Method of preparation of 21-amino epothilone derivatives |
| AU2003218107A1 (en) * | 2002-03-12 | 2003-09-29 | Bristol-Myers Squibb Company | C12-cyano epothilone derivatives |
| ATE452896T1 (de) | 2002-03-12 | 2010-01-15 | Bristol Myers Squibb Co | C3-cyanoepothilonderivate |
| TW200403994A (en) | 2002-04-04 | 2004-03-16 | Bristol Myers Squibb Co | Oral administration of EPOTHILONES |
| DE60326833D1 (de) * | 2002-05-15 | 2009-05-07 | Endocyte Inc | Vitamin-mitomycin-konjugate |
| TW200400191A (en) | 2002-05-15 | 2004-01-01 | Bristol Myers Squibb Co | Pharmaceutical compositions and methods of using C-21 modified epothilone derivatives |
| US7405234B2 (en) | 2002-05-17 | 2008-07-29 | Bristol-Myers Squibb Company | Bicyclic modulators of androgen receptor function |
| AU2003243561A1 (en) * | 2002-06-14 | 2003-12-31 | Bristol-Myers Squibb Company | Combination of epothilone analogs and chemotherapeutic agents for the treatment of proliferative diseases |
| US7256178B2 (en) * | 2002-07-31 | 2007-08-14 | Eisai Co., Ltd. | Physiologically active substances |
| CN100439374C (zh) * | 2002-08-02 | 2008-12-03 | 诺瓦提斯公司 | 埃坡霉素衍生物 |
| US7649006B2 (en) * | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| US6921769B2 (en) | 2002-08-23 | 2005-07-26 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| KR101173510B1 (ko) | 2002-08-23 | 2012-08-21 | 슬로안-케테링인스티튜트퍼캔서리서치 | 에포틸론, 이의 중간물질과 유사체의 합성 및 이들의 용도 |
| TWI291464B (en) | 2002-09-23 | 2007-12-21 | Bristol Myers Squibb Co | Methods for the preparation, isolation and purification of epothilone B, and X-ray crystal structures of epothilone B |
| AU2003279911A1 (en) * | 2002-10-09 | 2004-05-04 | Kosan Biosciences, Inc. | Therapeutic formulations |
| EP1553939A1 (en) * | 2002-10-11 | 2005-07-20 | Dana-Farber Cancer Institute, Inc. | Epothilone derivatives for the treatment of multiple myeloma |
| EP1567487A4 (en) | 2002-11-15 | 2005-11-16 | Bristol Myers Squibb Co | OPEN-CHAINED, PROLYL-FROSTED MODULATORS OF ANDROGEN RECEPTOR FUNCTION |
| EP2517729A3 (en) | 2003-01-27 | 2013-01-02 | Endocyte, Inc. | Vitamin receptor binding drug delivery conjugates |
| JP2007524655A (ja) * | 2003-10-09 | 2007-08-30 | コーザン バイオサイエンシス インコーポレイテッド | 治療製剤 |
| WO2005034964A1 (en) * | 2003-10-09 | 2005-04-21 | Kosan Biosciences, Inc. | Therapeutic formulations |
| US20050171167A1 (en) * | 2003-11-04 | 2005-08-04 | Haby Thomas A. | Process and formulation containing epothilones and analogs thereof |
| US7820702B2 (en) | 2004-02-04 | 2010-10-26 | Bristol-Myers Squibb Company | Sulfonylpyrrolidine modulators of androgen receptor function and method |
| US7378426B2 (en) | 2004-03-01 | 2008-05-27 | Bristol-Myers Squibb Company | Fused heterotricyclic compounds as inhibitors of 17β-hydroxysteroid dehydrogenase 3 |
| US7625923B2 (en) | 2004-03-04 | 2009-12-01 | Bristol-Myers Squibb Company | Bicyclic modulators of androgen receptor function |
| US7696241B2 (en) | 2004-03-04 | 2010-04-13 | Bristol-Myers Squibb Company | Bicyclic compounds as modulators of androgen receptor function and method |
| EP1789391B1 (en) | 2004-07-23 | 2017-06-28 | Endocyte, Inc. | Bivalent linkers and conjugates thereof |
| US10675326B2 (en) | 2004-10-07 | 2020-06-09 | The Board Of Trustees Of The University Of Illinois | Compositions comprising cupredoxins for treating cancer |
| EP1958625A1 (en) * | 2004-11-18 | 2008-08-20 | Brystol-Myers Squibb Company | Enteric coate bead comprising ixabepilone and preparation thereof |
| WO2006055742A1 (en) * | 2004-11-18 | 2006-05-26 | Bristol-Myers Squibb Company | Enteric coated bead comprising epothilone or epothilone analog, and preparation and administration thereof |
| CA2597647A1 (en) | 2005-02-11 | 2007-08-02 | University Of Southern California | Method of expressing proteins with disulfide bridges |
| CN101175757B (zh) | 2005-03-16 | 2012-11-14 | 恩多塞特公司 | 蝶酸及其缀合物的合成和纯化 |
| CA2607940C (en) | 2005-05-18 | 2009-12-15 | Aegera Therapeutics Inc. | Bir domain binding compounds |
| US8465724B2 (en) * | 2005-08-19 | 2013-06-18 | Endocyte, Inc. | Multi-drug ligand conjugates |
| US20080280937A1 (en) * | 2005-08-19 | 2008-11-13 | Christopher Paul Leamon | Ligand Conjugates of Vinca Alkaloids, Analogs, and Derivatives |
| EP2029156A4 (en) * | 2006-05-01 | 2010-07-21 | Univ Southern California | COMBINATION THERAPY FOR CANCER TREATMENT |
| SG171682A1 (en) | 2006-05-16 | 2011-06-29 | Aegera Therapeutics Inc | Iap bir domain binding compounds |
| AR062448A1 (es) * | 2006-05-25 | 2008-11-12 | Endocyte Inc | Conjugados de analogos de aziridinil-epotilona y composiciones farmaceuticas que comprenden los mismos |
| PE20080316A1 (es) * | 2006-05-25 | 2008-04-10 | Bristol Myers Squibb Co | Compuestos de aziridinil-epotilona |
| MX2009005849A (es) | 2006-12-04 | 2009-08-12 | Univ Illinois | Composiciones y metodos para tratar cancer con adn rico en cpg y cupredoxinas. |
| KR20090114414A (ko) | 2007-02-08 | 2009-11-03 | 더 보드 오브 트러스티즈 오브 더 유니버시티 오브 일리노이 | 쿠프레독신으로 암을 예방하는 조성물과 방법 |
| US20100104626A1 (en) * | 2007-02-16 | 2010-04-29 | Endocyte, Inc. | Methods and compositions for treating and diagnosing kidney disease |
| CA2680535C (en) * | 2007-03-14 | 2016-09-20 | Endocyte, Inc. | Binding ligand linked drug delivery conjugates of tubulysins |
| CN101754969A (zh) | 2007-05-25 | 2010-06-23 | 百时美施贵宝公司 | 制备埃坡霉素化合物和类似物的方法 |
| CA2690943A1 (en) | 2007-06-25 | 2008-12-31 | Endocyte, Inc. | Conjugates containing hydrophilic spacer linkers |
| US9877965B2 (en) | 2007-06-25 | 2018-01-30 | Endocyte, Inc. | Vitamin receptor drug delivery conjugates for treating inflammation |
| WO2009055562A1 (en) | 2007-10-25 | 2009-04-30 | Endocyte, Inc. | Tubulysins and processes for preparing |
| WO2009146152A2 (en) * | 2008-04-04 | 2009-12-03 | Emory University | Non-myelosuppressive compounds, pharmaceutical compositions thereof, and methods of treatment |
| TWI472329B (zh) * | 2008-04-24 | 2015-02-11 | 必治妥美雅史谷比公司 | 埃坡徽素d於治療包括阿茲海默症之tau相關疾病的用途 |
| US8802394B2 (en) | 2008-11-13 | 2014-08-12 | Radu O. Minea | Method of expressing proteins with disulfide bridges with enhanced yields and activity |
| WO2011098904A1 (en) | 2010-02-12 | 2011-08-18 | Aegera Therapeutics, Inc. | Iap bir domain binding compounds |
| EP2571525A4 (en) | 2010-05-18 | 2016-04-27 | Cerulean Pharma Inc | Compositions and methods for treating autoimmune and other diseases |
| CA2824521C (en) | 2011-01-20 | 2016-06-28 | Board Of Regents, The University Of Texas System | Mri markers, delivery and extraction systems, and related methods |
| CN102863474A (zh) | 2011-07-09 | 2013-01-09 | 陈小平 | 一类治疗细胞增殖性疾病的铂化合物、其制备方法和应用 |
| CN102993239A (zh) | 2011-09-19 | 2013-03-27 | 陈小平 | 离去基团含氨基或烷胺基的丁二酸衍生物的铂类化合物 |
| US10080805B2 (en) | 2012-02-24 | 2018-09-25 | Purdue Research Foundation | Cholecystokinin B receptor targeting for imaging and therapy |
| US20140080175A1 (en) | 2012-03-29 | 2014-03-20 | Endocyte, Inc. | Processes for preparing tubulysin derivatives and conjugates thereof |
| IN2015DN04147A (enExample) | 2012-10-16 | 2015-10-16 | Endocyte Inc | |
| EP2924044B1 (en) | 2012-11-17 | 2018-10-31 | Beijing Shuobai Pharmaceutical Co., LTD | Platinum compound of malonic acid derivative having leaving group containing amino or alkylamino |
| MA43178A (fr) * | 2015-10-16 | 2018-09-12 | Univ Rice William M | Analogues d'épothilone, procédés de synthèse, procédés de traitement, et conjugués médicamenteux de ceux-ci |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4138042C2 (de) | 1991-11-19 | 1993-10-14 | Biotechnolog Forschung Gmbh | Epothilone, deren Herstellungsverfahren sowie diese Verbindungen enthaltende Mittel |
| DE19639456A1 (de) | 1996-09-25 | 1998-03-26 | Biotechnolog Forschung Gmbh | Epothilon-Derivate, Herstellung und Mittel |
| US6288237B1 (en) | 1995-11-17 | 2001-09-11 | Gesellschaft Fur Biotechnologische Forschung Mbh (Gbf) | Epothilons C and D, preparation and compositions |
| DE19542986A1 (de) | 1995-11-17 | 1997-05-22 | Biotechnolog Forschung Gmbh | Epothilon-Derivate und deren Verwendung |
| DE19645362A1 (de) | 1996-10-28 | 1998-04-30 | Ciba Geigy Ag | Verfahren zur Herstellung von Epothilon A und B und Derivaten |
| DE19645361A1 (de) | 1996-08-30 | 1998-04-30 | Ciba Geigy Ag | Zwischenprodukte innerhalb der Totalsynthese von Epothilon A und B, Teil II |
| EP0923583A1 (de) | 1996-08-30 | 1999-06-23 | Novartis AG | Verfahren zur herstellung von epothilonen und zwischenprodukte innerhalb des verfahrens |
| KR100538095B1 (ko) | 1996-11-18 | 2005-12-21 | 게젤샤프트 퓌어 비오테크놀로기쉐 포르슝 엠베하(게베에프) | 에포틸론 씨, 디, 이 및 에프, 그 제조방법 및 세포증식 억제제와 식물 위생제로서의 이들의 용도 |
| US6515016B2 (en) | 1996-12-02 | 2003-02-04 | Angiotech Pharmaceuticals, Inc. | Composition and methods of paclitaxel for treating psoriasis |
| US6242469B1 (en) | 1996-12-03 | 2001-06-05 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| US6204388B1 (en) | 1996-12-03 | 2001-03-20 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| US6441186B1 (en) | 1996-12-13 | 2002-08-27 | The Scripps Research Institute | Epothilone analogs |
| US6380394B1 (en) | 1996-12-13 | 2002-04-30 | The Scripps Research Institute | Epothilone analogs |
| DE19701758A1 (de) | 1997-01-20 | 1998-07-23 | Wessjohann Ludgar A Dr | Epothilone-Synthesebausteine |
| CZ298027B6 (cs) | 1997-02-25 | 2007-05-30 | Gesellschaft Fuer Biotechnologische Forschung Mbh(Gbf) | Zpusob prípravy epothilon-N-oxidu a N-oxidy epothilonu |
| DE19713970B4 (de) | 1997-04-04 | 2006-08-31 | R&D-Biopharmaceuticals Gmbh | Epothilone-Synthesebausteine II - Prenylderivate |
| ATE225783T1 (de) | 1997-04-18 | 2002-10-15 | Studiengesellschaft Kohle Mbh | Selektive olefinmetathese von bi- oder polyfunktionellen substraten in komprimiertem kohlendioxid als reaktionsmedium |
| DE19821954A1 (de) | 1997-05-15 | 1998-11-19 | Biotechnolog Forschung Gmbh | Verfahren zur Herstellung eines Epothilon-Derivats |
| DE19720312A1 (de) | 1997-05-15 | 1998-11-19 | Hoechst Ag | Zubereitung mit erhöhter in vivo Verträglichkeit |
| DE19726627A1 (de) | 1997-06-17 | 1998-12-24 | Schering Ag | Zwischenprodukte, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von Epothilon |
| US6605599B1 (en) * | 1997-07-08 | 2003-08-12 | Bristol-Myers Squibb Company | Epothilone derivatives |
| PT1001951E (pt) | 1997-07-16 | 2003-02-28 | Schering Ag | Derivados de tiazolo, processo para a sua preparacao e utilizacao |
| JP2001512723A (ja) | 1997-08-09 | 2001-08-28 | シエーリング アクチエンゲゼルシヤフト | 新規エポチロン誘導体、その製法およびその薬学的使用 |
| TR200002299T2 (tr) | 1998-02-05 | 2000-11-21 | Novartis Ag | Epotilon kompozisyonları. |
| US6194181B1 (en) | 1998-02-19 | 2001-02-27 | Novartis Ag | Fermentative preparation process for and crystal forms of cytostatics |
| FR2775187B1 (fr) | 1998-02-25 | 2003-02-21 | Novartis Ag | Utilisation de l'epothilone b pour la fabrication d'une preparation pharmaceutique antiproliferative et d'une composition comprenant l'epothilone b comme agent antiproliferatif in vivo |
| AU758526B2 (en) | 1998-02-25 | 2003-03-20 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues therof |
| AU5036999A (en) | 1998-06-30 | 2000-01-17 | Schering Aktiengesellschaft | Epothilon derivatives, their preparation process, intermediate products and their pharmaceutical use |
| WO2000031247A2 (en) | 1998-11-20 | 2000-06-02 | Kosan Biosciences, Inc. | Recombinant methods and materials for producing epothilone and epothilone derivatives |
| DE69910831T2 (de) | 1998-12-22 | 2004-07-15 | Novartis Ag | Epothilonderivate und ihre verwendung als antitumormittel |
| NZ513268A (en) | 1999-02-18 | 2004-05-28 | Schering Ag | 16-halogen-epothilone derivatives, method for producing them and their pharmaceutical use |
| US6211412B1 (en) | 1999-03-29 | 2001-04-03 | The University Of Kansas | Synthesis of epothilones |
| PE20010116A1 (es) | 1999-04-30 | 2001-02-15 | Schering Ag | Derivados de 6-alquenil-, 6-alquinil- y 6-epoxi-epotilona, procedimientos para su preparacion |
-
1999
- 1999-03-29 US US09/280,192 patent/US6380395B1/en not_active Expired - Lifetime
- 1999-03-29 US US09/280,191 patent/US6399638B1/en not_active Expired - Lifetime
- 1999-04-05 DE DE69941083T patent/DE69941083D1/de not_active Expired - Lifetime
- 1999-04-05 EP EP99916383A patent/EP1073648B1/en not_active Expired - Lifetime
- 1999-04-05 DK DK05015236.2T patent/DK1589017T3/da active
- 1999-04-05 CN CNB998052663A patent/CN1142923C/zh not_active Expired - Fee Related
- 1999-04-05 BR BR9909795-8A patent/BR9909795A/pt not_active IP Right Cessation
- 1999-04-05 CA CA002323609A patent/CA2323609A1/en not_active Abandoned
- 1999-04-05 ES ES99916383T patent/ES2273484T3/es not_active Expired - Lifetime
- 1999-04-05 DK DK99916383T patent/DK1073648T3/da active
- 1999-04-05 EP EP99915273A patent/EP1073647B1/en not_active Expired - Lifetime
- 1999-04-05 JP JP2000544658A patent/JP4476483B2/ja not_active Expired - Fee Related
- 1999-04-05 AU AU33827/99A patent/AU757733B2/en not_active Ceased
- 1999-04-05 DE DE69933287T patent/DE69933287T2/de not_active Expired - Lifetime
- 1999-04-05 JP JP2000544657A patent/JP2002512238A/ja active Pending
- 1999-04-05 PT PT50152362T patent/PT1589017E/pt unknown
- 1999-04-05 PT PT99916383T patent/PT1073648E/pt unknown
- 1999-04-05 ES ES99915273T patent/ES2327803T3/es not_active Expired - Lifetime
- 1999-04-05 ES ES05015236T patent/ES2400049T3/es not_active Expired - Lifetime
- 1999-04-05 AU AU34716/99A patent/AU748526B2/en not_active Ceased
- 1999-04-05 DK DK99915273T patent/DK1073647T3/da active
- 1999-04-05 PT PT99915273T patent/PT1073647E/pt unknown
- 1999-04-05 WO PCT/US1999/007475 patent/WO1999054319A1/en not_active Ceased
- 1999-04-05 AT AT99916383T patent/ATE340177T1/de active
- 1999-04-05 AT AT99915273T patent/ATE435861T1/de active
- 1999-04-05 WO PCT/US1999/007448 patent/WO1999054318A1/en not_active Ceased
- 1999-04-05 CA CA2329181A patent/CA2329181C/en not_active Expired - Fee Related
- 1999-04-05 TR TR2000/03036T patent/TR200003036T2/xx unknown
- 1999-04-05 EP EP05015236A patent/EP1589017B1/en not_active Expired - Lifetime
- 1999-04-20 PE PE1999000331A patent/PE20000460A1/es not_active Application Discontinuation
- 1999-04-21 AR ARP990101834A patent/AR015774A1/es unknown
- 1999-04-21 AR ARP990101833A patent/AR015007A1/es unknown
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2006
- 2006-12-08 CY CY20061101766T patent/CY1105836T1/el unknown
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2009
- 2009-09-01 CY CY20091100911T patent/CY1109593T1/el unknown
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