DE60326833D1 - Vitamin-mitomycin-konjugate - Google Patents
Vitamin-mitomycin-konjugateInfo
- Publication number
- DE60326833D1 DE60326833D1 DE60326833T DE60326833T DE60326833D1 DE 60326833 D1 DE60326833 D1 DE 60326833D1 DE 60326833 T DE60326833 T DE 60326833T DE 60326833 T DE60326833 T DE 60326833T DE 60326833 D1 DE60326833 D1 DE 60326833D1
- Authority
- DE
- Germany
- Prior art keywords
- conjugates
- group
- folate
- mitomycin
- pathogenic cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000001717 pathogenic effect Effects 0.000 abstract 3
- 229960004857 mitomycin Drugs 0.000 abstract 2
- 229930192392 Mitomycin Natural products 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 229940127089 cytotoxic agent Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940014144 folate Drugs 0.000 abstract 1
- 102000006815 folate receptor Human genes 0.000 abstract 1
- 108020005243 folate receptor Proteins 0.000 abstract 1
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical group C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 abstract 1
- 235000019152 folic acid Nutrition 0.000 abstract 1
- 239000011724 folic acid Substances 0.000 abstract 1
- -1 mitomycin compound Chemical class 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
- C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
- A61K47/551—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds one of the codrug's components being a vitamin, e.g. niacinamide, vitamin B3, cobalamin, vitamin B12, folate, vitamin A or retinoic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38057902P | 2002-05-15 | 2002-05-15 | |
| US42591802P | 2002-11-13 | 2002-11-13 | |
| PCT/US2003/014969 WO2003097647A1 (en) | 2002-05-15 | 2003-05-13 | Vitamin-mitomycin conjugates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60326833D1 true DE60326833D1 (de) | 2009-05-07 |
Family
ID=29553501
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60326833T Expired - Lifetime DE60326833D1 (de) | 2002-05-15 | 2003-05-13 | Vitamin-mitomycin-konjugate |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7910594B2 (de) |
| EP (2) | EP2060272A3 (de) |
| JP (1) | JP4814520B2 (de) |
| KR (1) | KR20040106547A (de) |
| AT (1) | ATE426414T1 (de) |
| AU (1) | AU2003243226A1 (de) |
| CA (1) | CA2484640C (de) |
| DE (1) | DE60326833D1 (de) |
| ES (1) | ES2324708T3 (de) |
| WO (1) | WO2003097647A1 (de) |
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| CN101239190B (zh) * | 2003-01-27 | 2013-09-25 | 恩多塞特公司 | 维生素受体结合递药缀合物 |
| EP1592457B1 (de) * | 2003-01-27 | 2012-07-25 | Endocyte, Inc. | Folat-vinblastin konjugat als arzneimittel |
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| US20120269886A1 (en) | 2004-12-22 | 2012-10-25 | Nitto Denko Corporation | Therapeutic agent for pulmonary fibrosis |
| SI2730277T1 (sl) | 2004-12-22 | 2020-07-31 | Nitto Denko Corporation | Nosilec zdravila in komplet za nosilec zdravila za zaviranje fibroze |
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| AU2006230219A1 (en) | 2005-03-30 | 2006-10-05 | Endocyte, Inc. | Method for cancer prognosis using cellular folate vitamin receptor quantification |
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| US9951324B2 (en) | 2010-02-25 | 2018-04-24 | Purdue Research Foundation | PSMA binding ligand-linker conjugates and methods for using |
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| US10080805B2 (en) | 2012-02-24 | 2018-09-25 | Purdue Research Foundation | Cholecystokinin B receptor targeting for imaging and therapy |
| EP2822386B1 (de) | 2012-02-29 | 2021-05-05 | Purdue Research Foundation | Folatrezeptor-alpha-bindende liganden |
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| US9662402B2 (en) | 2012-10-16 | 2017-05-30 | Endocyte, Inc. | Drug delivery conjugates containing unnatural amino acids and methods for using |
| KR102575825B1 (ko) | 2012-11-15 | 2023-09-06 | 엔도사이트, 인코포레이티드 | Psma 발현 세포에 의해 야기되는 질병을 치료하기 위한 컨쥬게이트 |
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| EA035171B1 (ru) | 2013-11-14 | 2020-05-08 | Эндосайт, Инк. | Конъюгаты на основе связывающихся с psma лигандов или ингибиторов psma для позитронно-эмиссионной томографии |
| PT3122757T (pt) | 2014-02-28 | 2023-11-03 | Hangzhou Dac Biotech Co Ltd | Ligantes carregados e as suas utilizações em conjugação |
| JP6602034B2 (ja) | 2014-04-02 | 2019-11-06 | 日東電工株式会社 | 標的化分子およびその使用 |
| WO2015155810A1 (en) | 2014-04-07 | 2015-10-15 | Nitto Denko Corporation | Novel polymer-based hydrotropes for hydrophobic drug delivery |
| US10188759B2 (en) | 2015-01-07 | 2019-01-29 | Endocyte, Inc. | Conjugates for imaging |
| EP3270898B1 (de) * | 2015-03-17 | 2021-05-05 | Lipomedix Pharmaceuticals Ltd. | Verfahren zur behandlung von blasenkrebs |
| CA2980462C (en) | 2015-04-07 | 2023-08-01 | The Curators Of The University Of Missouri | Nanoparticle immunoconjugates |
| US10406238B2 (en) | 2015-05-11 | 2019-09-10 | Purdue Research Foundation | Ligand ionophore conjugates |
| BR112020020961A2 (pt) | 2018-04-17 | 2021-01-19 | Endocyte, Inc. | Métodos de tratamento de câncer |
| CN120097929A (zh) | 2019-05-20 | 2025-06-06 | 因多塞特股份有限公司 | 制备psma缀合物的方法 |
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| EP1523493B1 (de) * | 2002-07-09 | 2013-09-04 | Dömling, Alexander | Neue tubulysinanaloga |
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-
2003
- 2003-05-13 ES ES03752681T patent/ES2324708T3/es not_active Expired - Lifetime
- 2003-05-13 EP EP09002632A patent/EP2060272A3/de not_active Withdrawn
- 2003-05-13 JP JP2004505379A patent/JP4814520B2/ja not_active Expired - Fee Related
- 2003-05-13 AU AU2003243226A patent/AU2003243226A1/en not_active Abandoned
- 2003-05-13 EP EP03752681A patent/EP1504010B1/de not_active Expired - Lifetime
- 2003-05-13 US US10/513,372 patent/US7910594B2/en not_active Expired - Fee Related
- 2003-05-13 WO PCT/US2003/014969 patent/WO2003097647A1/en not_active Ceased
- 2003-05-13 DE DE60326833T patent/DE60326833D1/de not_active Expired - Lifetime
- 2003-05-13 CA CA2484640A patent/CA2484640C/en not_active Expired - Fee Related
- 2003-05-13 KR KR10-2004-7018375A patent/KR20040106547A/ko not_active Ceased
- 2003-05-13 AT AT03752681T patent/ATE426414T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US7910594B2 (en) | 2011-03-22 |
| WO2003097647A1 (en) | 2003-11-27 |
| EP1504010A4 (de) | 2007-03-28 |
| EP1504010B1 (de) | 2009-03-25 |
| KR20040106547A (ko) | 2004-12-17 |
| AU2003243226A1 (en) | 2003-12-02 |
| US20050165227A1 (en) | 2005-07-28 |
| JP4814520B2 (ja) | 2011-11-16 |
| EP1504010A1 (de) | 2005-02-09 |
| CA2484640C (en) | 2012-01-17 |
| CA2484640A1 (en) | 2003-11-27 |
| ATE426414T1 (de) | 2009-04-15 |
| ES2324708T3 (es) | 2009-08-13 |
| EP2060272A3 (de) | 2009-05-27 |
| EP2060272A2 (de) | 2009-05-20 |
| JP2005531564A (ja) | 2005-10-20 |
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