PT1017713E - Antagonistas cíclicos de receptores de c5a e de receptores acoplados à proteína g - Google Patents
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/472—Complement proteins, e.g. anaphylatoxin, C3a, C5a
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Transplantation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPO7550A AUPO755097A0 (en) | 1997-06-25 | 1997-06-25 | Receptor agonist and antagonist |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1017713E true PT1017713E (pt) | 2007-12-18 |
Family
ID=3801840
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT98930536T PT1017713E (pt) | 1997-06-25 | 1998-06-25 | Antagonistas cíclicos de receptores de c5a e de receptores acoplados à proteína g |
Country Status (11)
| Country | Link |
|---|---|
| US (5) | USRE41287E1 (enExample) |
| EP (1) | EP1017713B1 (enExample) |
| JP (1) | JP4686696B2 (enExample) |
| AT (1) | ATE377606T1 (enExample) |
| AU (2) | AUPO755097A0 (enExample) |
| CY (1) | CY1107133T1 (enExample) |
| DE (1) | DE69838678T2 (enExample) |
| DK (1) | DK1017713T3 (enExample) |
| ES (1) | ES2294816T3 (enExample) |
| PT (1) | PT1017713E (enExample) |
| WO (1) | WO1999000406A1 (enExample) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPO755097A0 (en) * | 1997-06-25 | 1997-07-17 | University Of Queensland, The | Receptor agonist and antagonist |
| AUPQ339899A0 (en) | 1999-10-13 | 1999-11-04 | University Of Queensland, The | Novel molecules |
| US7105567B2 (en) | 2000-08-10 | 2006-09-12 | Mitsubishi Pharma Corporation | 3-substituted urea derivatives and medicinal use thereof |
| EP1318140B9 (en) | 2000-09-14 | 2014-05-21 | Mitsubishi Tanabe Pharma Corporation | Novel amide derivatives and medicinal use thereof |
| AUPR833401A0 (en) * | 2001-10-17 | 2001-11-08 | University Of Queensland, The | G protein-coupled receptor antagonists |
| US8524862B2 (en) | 2002-03-19 | 2013-09-03 | Cincinnati Children's Hospital Medical Center | Muteins of C5a anaphylatoxin and methods of inhibiting C5a |
| JP2005530719A (ja) * | 2002-03-29 | 2005-10-13 | ニューロジェン コーポレーション | 病原性炎症要素を有する状態の治療のための組み合わせ療法 |
| AUPS160602A0 (en) * | 2002-04-08 | 2002-05-16 | University Of Queensland, The | Therapeutic method |
| AU2002950657A0 (en) | 2002-08-08 | 2002-09-12 | Alchemia Limited | Derivatives of monosaccharides for drug discovery |
| AU2003266858B2 (en) * | 2002-10-11 | 2006-09-14 | Vast Bioscience Pty Limited | Classes of compounds that interact with GPCRs |
| AU2002951995A0 (en) * | 2002-10-11 | 2002-10-31 | Alchemia Limited | Classes of compounds that interact with gpcrs |
| AU2002952086A0 (en) * | 2002-10-16 | 2002-11-07 | The University Of Queensland | Treatment of osteoarthritis |
| WO2004035078A1 (en) * | 2002-10-16 | 2004-04-29 | The University Of Queensland | Treatment of inflammatory bowel disease |
| AU2002952129A0 (en) * | 2002-10-17 | 2002-10-31 | The University Of Queensland | Treatment of hypersensitivity conditions |
| AU2003902354A0 (en) * | 2003-05-15 | 2003-05-29 | Harkin, Denis W. | Treatment of haemorrhagic shock |
| AU2003902586A0 (en) * | 2003-05-26 | 2003-06-12 | The University Of Queensland | Treatment of burns |
| WO2005014849A2 (en) * | 2003-07-03 | 2005-02-17 | Euro-Celtique, S.A. | Genes associated with responses to neuropathic pain |
| EP1498422A1 (de) | 2003-07-17 | 2005-01-19 | Jerini AG | C5a-Rezeptor-Antagonisten |
| CN101036057A (zh) * | 2004-10-04 | 2007-09-12 | 阿尔卡米亚有限公司 | 选择性抑制剂 |
| US20080161232A1 (en) * | 2005-01-17 | 2008-07-03 | Jerini Ag | C5a Receptor Antagonist |
| WO2006099330A2 (en) * | 2005-03-11 | 2006-09-21 | Potentia Pharmaceuticals, Inc. | Compositions comprising modulators of g-protein-coupled receptor for treatment of macular degeneration |
| EP1739078A1 (de) | 2005-05-30 | 2007-01-03 | Jerini AG | C5a-Rezeptor-Antagonisten |
| US20070292421A1 (en) * | 2005-07-28 | 2007-12-20 | Feinberg Bruce B | Method for treating preeclampsia |
| US8168584B2 (en) | 2005-10-08 | 2012-05-01 | Potentia Pharmaceuticals, Inc. | Methods of treating age-related macular degeneration by compstatin and analogs thereof |
| DK2148691T3 (en) | 2007-02-05 | 2015-08-17 | Apellis Pharmaceuticals Inc | Compstatinanaloger for use in the treatment of inflammatory states of the respiratory system |
| WO2009015087A2 (en) * | 2007-07-20 | 2009-01-29 | Potentia Pharmaceuticals, Inc. | Compositions and methods for treatment of trauma |
| WO2009121065A2 (en) * | 2008-03-28 | 2009-10-01 | Apellis Ag | Modulation and repletion/enhancement of the complement system for treatment of trauma |
| JP2011527119A (ja) * | 2008-07-02 | 2011-10-20 | サンゴバン・パフォーマンス・プラスティックス・シェンヌー | 枠付き装置、封止材およびその製造方法 |
| CN109045296A (zh) | 2008-11-10 | 2018-12-21 | 阿雷克森制药公司 | 用于治疗补体相关障碍的方法和组合物 |
| CA2825137A1 (en) * | 2010-01-22 | 2011-07-28 | University Of Louisville Research Foundation, Inc | Methods of treating or preventing periodontitis and diseases associated with periodontitis |
| NZ629829A (en) | 2010-04-30 | 2015-11-27 | Alexion Pharma Inc | Anti-c5a antibodies and methods for using the antibodies |
| US9895411B2 (en) | 2010-06-29 | 2018-02-20 | San Diego State University Research Foundation | Analogs of C5a and methods of using same |
| EP2468295A1 (en) * | 2010-12-21 | 2012-06-27 | Affiris AG | Vaccines based on peptides of the complement protein C5a |
| EP3524258B1 (en) | 2011-06-22 | 2025-10-01 | Apellis Pharmaceuticals, Inc. | Methods of treating chronic disorders with complement inhibitors |
| US9289467B2 (en) | 2011-08-10 | 2016-03-22 | Case Western Reserve University | Compositions and methods for treating bone conditions |
| WO2014043223A1 (en) * | 2012-09-11 | 2014-03-20 | Hospital For Special Surgery | Irhom2 inhibition for the treatment of complement mediated disorders |
| PT2920201T (pt) | 2012-11-15 | 2020-04-03 | Apellis Pharmaceuticals Inc | Análogos de compstatina de longa ação e composições e métodos relacionados |
| WO2014152391A1 (en) | 2013-03-15 | 2014-09-25 | Apellis Pharmaceuticals, Inc. | Cell-penetrating compstatin analogs and uses thereof |
| US10092620B2 (en) * | 2013-04-02 | 2018-10-09 | The Scripps Research Institute | Uses of cyclic peptides for treating and preventing atherosclerosis |
| KR102192596B1 (ko) | 2013-08-07 | 2020-12-18 | 알렉시온 파마슈티칼스, 인코포레이티드 | 비정형적 용혈성 요독증후군 (ahus) 바이오마커 단백질 |
| MX392574B (es) | 2015-10-07 | 2025-03-24 | Apellis Pharmaceuticals Inc | Análogos de compstatina de acción prolongada para usarse en el tratamiento de trastornos oculares |
| MX2019001153A (es) | 2016-07-29 | 2019-06-10 | Pfizer | Peptidos ciclicos como antagonistas del receptor c5a. |
| EP3532845A1 (en) | 2016-10-27 | 2019-09-04 | Alexion Pharmaceuticals, Inc. | Assay for c5b-9 deposition in complement-associated disorders |
| KR20190138806A (ko) | 2017-04-03 | 2019-12-16 | 인플라알엑스 게엠베하 | C5a 활성 억제제에 의한 염증 질병의 치료 |
| US10376595B2 (en) | 2017-04-03 | 2019-08-13 | Inflarx Gmbh | Treatment of inflammatory diseases with inhibitors of C5a activity |
| KR20190139931A (ko) | 2017-04-07 | 2019-12-18 | 아펠리스 파마슈티컬스 인코포레이티드 | 투여 요법 및 관련 조성물 및 방법 |
| CA3066689C (en) | 2017-06-23 | 2024-01-16 | Inflarx Gmbh | Treatment of inflammatory diseases with inhibitors of c5a activity |
| MA51162A (fr) | 2017-12-15 | 2020-10-21 | Apellis Pharmaceuticals Inc | Schémas posologiques et compositions et procédés associés |
| US20220356234A1 (en) | 2019-10-02 | 2022-11-10 | Alexion Pharmaceuticals, Inc. | Complement inhibitors for treating drug-induced complement-mediated response |
| IL296036A (en) | 2020-03-27 | 2022-10-01 | Inflarx Gmbh | Inhibitors of c5a for the treatment of corona virus infection |
| WO2021231720A1 (en) | 2020-05-15 | 2021-11-18 | Alexion Pharmaceuticals, Inc. | Method of using extracellular vesicles to detect complement activation, and uses thereof to assess and/or monitor treatment of a complement-mediated disease |
| WO2024238421A1 (en) | 2023-05-12 | 2024-11-21 | Alexion Pharmaceuticals, Inc. | Use of biomarkers for the identification and treatment of complement-mediated disorders |
| WO2024238422A1 (en) | 2023-05-12 | 2024-11-21 | Alexion Pharmaceuticals, Inc. | Use of a panel of lectins for detection of complement biomarkers in urine extracellular vesicles |
| US12180274B2 (en) | 2023-05-26 | 2024-12-31 | Inflarx Gmbh | Treatment of pneumonia and ARDS with inhibitors of C5a and IL-6 activity |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5386011A (en) * | 1990-12-27 | 1995-01-31 | Abbott Laboratories | Hexapeptide anaphylatoxin-receptor ligands |
| CN1142854A (zh) | 1993-12-06 | 1997-02-12 | 西巴-盖尔基股份公司 | 基本上不具有激动剂活性的C5a受体拮抗剂 |
| US5807824A (en) * | 1993-12-06 | 1998-09-15 | Ciba-Geigy Corporation | C5A receptor antagonists having substantially no agonist activity |
| US5614370A (en) | 1994-03-18 | 1997-03-25 | Merck & Co., Inc. | Assay to identify human C5a antagonists and agonists |
| US5696230A (en) | 1994-08-31 | 1997-12-09 | The Board Of Regents Of The University Of Nebraska | High-affinity response-selective C-terminal analogs of C5a anaphylatoxin |
| AUPO755097A0 (en) | 1997-06-25 | 1997-07-17 | University Of Queensland, The | Receptor agonist and antagonist |
| AUPR833401A0 (en) | 2001-10-17 | 2001-11-08 | University Of Queensland, The | G protein-coupled receptor antagonists |
| AUPS160602A0 (en) * | 2002-04-08 | 2002-05-16 | University Of Queensland, The | Therapeutic method |
| AU2002952086A0 (en) * | 2002-10-16 | 2002-11-07 | The University Of Queensland | Treatment of osteoarthritis |
-
1997
- 1997-06-25 AU AUPO7550A patent/AUPO755097A0/en not_active Abandoned
-
1998
- 1998-06-25 PT PT98930536T patent/PT1017713E/pt unknown
- 1998-06-25 DK DK98930536T patent/DK1017713T3/da active
- 1998-06-25 JP JP50515499A patent/JP4686696B2/ja not_active Expired - Fee Related
- 1998-06-25 AU AU80926/98A patent/AU744991B2/en not_active Ceased
- 1998-06-25 US US12/045,088 patent/USRE41287E1/en not_active Expired - Fee Related
- 1998-06-25 AT AT98930536T patent/ATE377606T1/de active
- 1998-06-25 US US09/446,109 patent/US6821950B1/en not_active Expired - Lifetime
- 1998-06-25 DE DE69838678T patent/DE69838678T2/de not_active Expired - Lifetime
- 1998-06-25 WO PCT/AU1998/000490 patent/WO1999000406A1/en not_active Ceased
- 1998-06-25 ES ES98930536T patent/ES2294816T3/es not_active Expired - Lifetime
- 1998-06-25 EP EP98930536A patent/EP1017713B1/en not_active Expired - Lifetime
-
2004
- 2004-09-10 US US10/937,852 patent/US20060160726A1/en not_active Abandoned
-
2008
- 2008-01-10 CY CY20081100033T patent/CY1107133T1/el unknown
- 2008-08-19 US US12/193,943 patent/US20090203760A1/en not_active Abandoned
-
2012
- 2012-01-12 US US13/348,869 patent/US20130005644A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1017713B1 (en) | 2007-11-07 |
| HK1029595A1 (en) | 2001-04-06 |
| DE69838678D1 (de) | 2007-12-20 |
| AU744991B2 (en) | 2002-03-07 |
| JP2002508767A (ja) | 2002-03-19 |
| EP1017713A1 (en) | 2000-07-12 |
| US20090203760A1 (en) | 2009-08-13 |
| AU8092698A (en) | 1999-01-19 |
| CY1107133T1 (el) | 2012-10-24 |
| US20060160726A1 (en) | 2006-07-20 |
| JP4686696B2 (ja) | 2011-05-25 |
| US20130005644A1 (en) | 2013-01-03 |
| ES2294816T3 (es) | 2008-04-01 |
| DE69838678T2 (de) | 2008-10-30 |
| WO1999000406A1 (en) | 1999-01-07 |
| EP1017713A4 (en) | 2002-07-24 |
| USRE41287E1 (en) | 2010-04-27 |
| ATE377606T1 (de) | 2007-11-15 |
| AUPO755097A0 (en) | 1997-07-17 |
| DK1017713T3 (da) | 2008-02-11 |
| US6821950B1 (en) | 2004-11-23 |
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