ATE525391T1 - Muteine des c5a anaphylatoxins, für solche muteine kodierende nukleinsäuremoleküle, sowie pharmazeutische verwendungen von muteinen des c5a anaphylatoxins - Google Patents
Muteine des c5a anaphylatoxins, für solche muteine kodierende nukleinsäuremoleküle, sowie pharmazeutische verwendungen von muteinen des c5a anaphylatoxinsInfo
- Publication number
- ATE525391T1 ATE525391T1 AT02807051T AT02807051T ATE525391T1 AT E525391 T1 ATE525391 T1 AT E525391T1 AT 02807051 T AT02807051 T AT 02807051T AT 02807051 T AT02807051 T AT 02807051T AT E525391 T1 ATE525391 T1 AT E525391T1
- Authority
- AT
- Austria
- Prior art keywords
- muteins
- anaphylatoxin
- nucleic acid
- acid molecules
- pharmaceutical uses
- Prior art date
Links
- 102100031506 Complement C5 Human genes 0.000 title abstract 7
- 101800001654 C5a anaphylatoxin Proteins 0.000 title abstract 6
- 150000007523 nucleic acids Chemical class 0.000 title abstract 3
- 102000039446 nucleic acids Human genes 0.000 title abstract 3
- 108020004707 nucleic acids Proteins 0.000 title abstract 3
- 102000005590 Anaphylatoxin C5a Receptor Human genes 0.000 abstract 3
- 108010059426 Anaphylatoxin C5a Receptor Proteins 0.000 abstract 3
- 239000002464 receptor antagonist Substances 0.000 abstract 3
- 229940044551 receptor antagonist Drugs 0.000 abstract 3
- 239000002773 nucleotide Substances 0.000 abstract 2
- 125000003729 nucleotide group Chemical group 0.000 abstract 2
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/472—Complement proteins, e.g. anaphylatoxin, C3a, C5a
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2002/003035 WO2003078457A1 (en) | 2002-03-19 | 2002-03-19 | MUTEINS OF THE C5a ANAPHYLATOXIN, NUCLEIC ACID MOLECULES ENCODING SUCH MUTEINS, AND PHARMACEUTICAL USES OF MUTEINS OF THE C5a ANAPHYLATOXIN |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE525391T1 true ATE525391T1 (de) | 2011-10-15 |
Family
ID=27838004
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02807051T ATE525391T1 (de) | 2002-03-19 | 2002-03-19 | Muteine des c5a anaphylatoxins, für solche muteine kodierende nukleinsäuremoleküle, sowie pharmazeutische verwendungen von muteinen des c5a anaphylatoxins |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8524862B2 (de) |
| EP (1) | EP1492811B1 (de) |
| JP (1) | JP4290564B2 (de) |
| AT (1) | ATE525391T1 (de) |
| WO (1) | WO2003078457A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040067532A1 (en) | 2002-08-12 | 2004-04-08 | Genetastix Corporation | High throughput generation and affinity maturation of humanized antibody |
| US20070141548A1 (en) * | 2005-03-11 | 2007-06-21 | Jorg Kohl | Organ transplant solutions and method for transplanting organs |
| EP2129681A2 (de) * | 2007-03-22 | 2009-12-09 | Novartis Ag | C5-antigene und deren verwendung |
| BRPI0816785A2 (pt) | 2007-09-14 | 2017-05-02 | Adimab Inc | bibliotecas de anticorpos sintéticos racionalmente desenhadas, e, usos para as mesmas |
| US8877688B2 (en) | 2007-09-14 | 2014-11-04 | Adimab, Llc | Rationally designed, synthetic antibody libraries and uses therefor |
| AU2011245117B2 (en) | 2010-04-30 | 2015-03-12 | Alexion Pharmaceuticals, Inc. | Anti-C5a antibodies and methods for using the antibodies |
| WO2017048495A1 (en) | 2015-09-14 | 2017-03-23 | Children's Hospital Medical Center | Methods and compositions for treatment of gaucher disease via modulation of c5a receptor |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4237113B4 (de) * | 1992-11-03 | 2006-10-12 | "Iba Gmbh" | Peptide und deren Fusionsproteine, Expressionsvektor und Verfahren zur Herstellung eines Fusionsproteins |
| US5807824A (en) * | 1993-12-06 | 1998-09-15 | Ciba-Geigy Corporation | C5A receptor antagonists having substantially no agonist activity |
| US5696230A (en) * | 1994-08-31 | 1997-12-09 | The Board Of Regents Of The University Of Nebraska | High-affinity response-selective C-terminal analogs of C5a anaphylatoxin |
| US6022951A (en) * | 1995-04-11 | 2000-02-08 | Univ Boston | Streptavidin mutants |
| AUPO755097A0 (en) | 1997-06-25 | 1997-07-17 | University Of Queensland, The | Receptor agonist and antagonist |
-
2002
- 2002-03-19 WO PCT/EP2002/003035 patent/WO2003078457A1/en active Application Filing
- 2002-03-19 JP JP2003576461A patent/JP4290564B2/ja not_active Expired - Fee Related
- 2002-03-19 AT AT02807051T patent/ATE525391T1/de not_active IP Right Cessation
- 2002-03-19 EP EP02807051A patent/EP1492811B1/de not_active Expired - Lifetime
- 2002-03-19 US US10/508,376 patent/US8524862B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP4290564B2 (ja) | 2009-07-08 |
| EP1492811A1 (de) | 2005-01-05 |
| WO2003078457A1 (en) | 2003-09-25 |
| EP1492811B1 (de) | 2011-09-21 |
| US20060052294A1 (en) | 2006-03-09 |
| US8524862B2 (en) | 2013-09-03 |
| JP2005536986A (ja) | 2005-12-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |