NO20043891L - Anti-A-beta-antistoffer og deres anvendelse - Google Patents

Anti-A-beta-antistoffer og deres anvendelse

Info

Publication number
NO20043891L
NO20043891L NO20043891A NO20043891A NO20043891L NO 20043891 L NO20043891 L NO 20043891L NO 20043891 A NO20043891 A NO 20043891A NO 20043891 A NO20043891 A NO 20043891A NO 20043891 L NO20043891 L NO 20043891L
Authority
NO
Norway
Prior art keywords
nucleic acid
molecules
antibody molecules
hosts
seq
Prior art date
Application number
NO20043891A
Other languages
English (en)
Other versions
NO336112B1 (no
Inventor
Manfred Brockhaus
Corinna Lohning
Michael Bardoff
Bernd Bohrmann
Walter Huber
Titus Kretzschmar
Hansruedi Loetscher
Christer Nordstedt
Christine Rothe
Original Assignee
Morphosys Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27741103&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20043891(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Morphosys Ag filed Critical Morphosys Ag
Publication of NO20043891L publication Critical patent/NO20043891L/no
Publication of NO336112B1 publication Critical patent/NO336112B1/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0007—Nervous system antigens; Prions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Psychology (AREA)

Abstract

Det beskrives antistoffmolekyler som spesifikt er i stand til å gjenkjenne to områder av pA4-peptidet, der det første området omfatter aminosyresekvensen AEFRHDSGY som vist i SEKV. ID nr. 1 eller et fragment derav, og der det andre området omfatter aminosyresekvensen VHHQKLVFFAEDVG som vist i SEKV. ID nr. 2 eller et fragment derav.Det beskrives videre nukleinsyremolekyler som koder oppfinnelsens antistoffmolekyler, og det beskrives vektorer og verter omfattende nevnte nukleinsyremolekyler som beskrevet.I tillegg beskriver foreliggende oppfinnelse preparater, fortrinnsvis farmasøytiske eller diagnostiske preparater, omfattende forbindelsene ifølge oppfinnelsen, så vel som spesifikke anvendelser for antistoffmolekylene, nukleinsyremolekylene, vektorene eller vertene.
NO20043891A 2002-02-20 2004-09-16 Anti-Aß-antistoffer og fremgangsmåte for fremstilling, samt nukleinsyremolekyler som koder for slike antistoffer, og vektorer og vertsceller omfattende nevnte nukleinsyremolekyler, i tillegg til farmasøytiske og diagnostiske preparater, så vel som spesifikke anvendelser av antistoffmolekylene, nukleinsyremolekylene, vektorene eller vertscellene¿ NO336112B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02003844 2002-02-20
PCT/EP2003/001759 WO2003070760A2 (en) 2002-02-20 2003-02-20 Anti-amyloid beta antibodies and their use

Publications (2)

Publication Number Publication Date
NO20043891L true NO20043891L (no) 2004-09-16
NO336112B1 NO336112B1 (no) 2015-05-18

Family

ID=27741103

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20043891A NO336112B1 (no) 2002-02-20 2004-09-16 Anti-Aß-antistoffer og fremgangsmåte for fremstilling, samt nukleinsyremolekyler som koder for slike antistoffer, og vektorer og vertsceller omfattende nevnte nukleinsyremolekyler, i tillegg til farmasøytiske og diagnostiske preparater, så vel som spesifikke anvendelser av antistoffmolekylene, nukleinsyremolekylene, vektorene eller vertscellene¿
NO20121017A NO20121017L (no) 2002-02-20 2012-09-10 Anti-Abeta-antistoffer og deres anvendelse samt metode for optimalisering og fremstilling av en farmasoytisk sammensetning

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO20121017A NO20121017L (no) 2002-02-20 2012-09-10 Anti-Abeta-antistoffer og deres anvendelse samt metode for optimalisering og fremstilling av en farmasoytisk sammensetning

Country Status (27)

Country Link
US (4) US7794719B2 (no)
EP (2) EP1481008A2 (no)
JP (2) JP4383888B2 (no)
KR (1) KR101038828B1 (no)
CN (4) CN1630665A (no)
AR (2) AR038568A1 (no)
AU (1) AU2003218995B2 (no)
BR (1) BRPI0307837B8 (no)
CA (1) CA2477012C (no)
CL (1) CL2004001122A1 (no)
CO (1) CO5601037A2 (no)
CY (1) CY1118037T1 (no)
DK (1) DK2368907T3 (no)
ES (1) ES2590684T3 (no)
HR (1) HRP20040712B1 (no)
HU (1) HUE030591T2 (no)
IL (2) IL163563A0 (no)
LT (1) LT2368907T (no)
MX (1) MXPA04008077A (no)
NO (2) NO336112B1 (no)
NZ (1) NZ534522A (no)
PL (1) PL216190B1 (no)
PT (1) PT2368907T (no)
RU (1) RU2341533C2 (no)
SI (1) SI2368907T1 (no)
WO (1) WO2003070760A2 (no)
ZA (1) ZA200406604B (no)

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