CY1107133T1 - Κυκλικοι ανταγωνιστες των υποδοχεων c5a και συζευγμενοι με πρωτεϊνη g υποδοχεις - Google Patents

Κυκλικοι ανταγωνιστες των υποδοχεων c5a και συζευγμενοι με πρωτεϊνη g υποδοχεις

Info

Publication number
CY1107133T1
CY1107133T1 CY20081100033T CY081100033T CY1107133T1 CY 1107133 T1 CY1107133 T1 CY 1107133T1 CY 20081100033 T CY20081100033 T CY 20081100033T CY 081100033 T CY081100033 T CY 081100033T CY 1107133 T1 CY1107133 T1 CY 1107133T1
Authority
CY
Cyprus
Prior art keywords
protein
competitors
conjugates
receptor
circular
Prior art date
Application number
CY20081100033T
Other languages
English (en)
Inventor
David Fairlie
Stephen Maxwell Taylor
Angela Monique Finch
Allan Wong
Original Assignee
The University Of Queensland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The University Of Queensland filed Critical The University Of Queensland
Publication of CY1107133T1 publication Critical patent/CY1107133T1/el

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/472—Complement proteins, e.g. anaphylatoxin, C3a, C5a
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Transplantation (AREA)

Abstract

Αυτή η εφεύρεση σχετίζεται με νέες κυκλικές ενώσεις οι οποίες έχουν την δυνατότητα να τροποποιήσουν την δραστηριότητα των συζευγμένων με πρωτεΐνη G υποδοχέων. Η εφεύρεση παρέχει αμφότερα αγωνιστές και ανταγωνιστές. Σύμφωνα με προτιμώμενες ενσωματώσεις, η εφεύρεση παρέχει κυκλικούς πεπτιδικούς και κυκλικούς ή μη-κυκλικούς μη-πεπτιδικούς ανταγωνιστές ή αγωνιστές του C5a. Οι ενώσεις της εφεύρεσης είναι αμφότερα ισχυρές και εκλεκτικές και είναι χρήσιμες όσον αφορά την αγωγή των καταστάσεων που μεσολαβούνται μέσω των συζευγμένων με πρωτεΐνη G υποδοχέων, ειδικότερα δε των καταστάσεων που μεσολαβούνται μέσω υπερ-έκφρασης ή υπο-ρύθμισης του C5a, όπως είναι μια ποικιλία φλεγμονωδών καταστάσεων.
CY20081100033T 1997-06-25 2008-01-10 Κυκλικοι ανταγωνιστες των υποδοχεων c5a και συζευγμενοι με πρωτεϊνη g υποδοχεις CY1107133T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPO7550A AUPO755097A0 (en) 1997-06-25 1997-06-25 Receptor agonist and antagonist
EP98930536A EP1017713B1 (en) 1997-06-25 1998-06-25 CYCLIC ANTAGONISTS OF C5a RECEPTORS AND G PROTEIN-COUPLED RECEPTORS

Publications (1)

Publication Number Publication Date
CY1107133T1 true CY1107133T1 (el) 2012-10-24

Family

ID=3801840

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20081100033T CY1107133T1 (el) 1997-06-25 2008-01-10 Κυκλικοι ανταγωνιστες των υποδοχεων c5a και συζευγμενοι με πρωτεϊνη g υποδοχεις

Country Status (12)

Country Link
US (5) USRE41287E1 (el)
EP (1) EP1017713B1 (el)
JP (1) JP4686696B2 (el)
AT (1) ATE377606T1 (el)
AU (2) AUPO755097A0 (el)
CY (1) CY1107133T1 (el)
DE (1) DE69838678T2 (el)
DK (1) DK1017713T3 (el)
ES (1) ES2294816T3 (el)
HK (1) HK1029595A1 (el)
PT (1) PT1017713E (el)
WO (1) WO1999000406A1 (el)

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AUPQ339899A0 (en) 1999-10-13 1999-11-04 University Of Queensland, The Novel molecules
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AU2002950657A0 (en) 2002-08-08 2002-09-12 Alchemia Limited Derivatives of monosaccharides for drug discovery
AU2003266858B2 (en) * 2002-10-11 2006-09-14 Vast Bioscience Pty Limited Classes of compounds that interact with GPCRs
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AU2002952086A0 (en) * 2002-10-16 2002-11-07 The University Of Queensland Treatment of osteoarthritis
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AUPS160602A0 (en) * 2002-04-08 2002-05-16 University Of Queensland, The Therapeutic method
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Also Published As

Publication number Publication date
AUPO755097A0 (en) 1997-07-17
HK1029595A1 (en) 2001-04-06
AU8092698A (en) 1999-01-19
US20060160726A1 (en) 2006-07-20
ATE377606T1 (de) 2007-11-15
JP4686696B2 (ja) 2011-05-25
JP2002508767A (ja) 2002-03-19
US20090203760A1 (en) 2009-08-13
USRE41287E1 (en) 2010-04-27
DK1017713T3 (da) 2008-02-11
PT1017713E (pt) 2007-12-18
US20130005644A1 (en) 2013-01-03
US6821950B1 (en) 2004-11-23
DE69838678D1 (de) 2007-12-20
AU744991B2 (en) 2002-03-07
EP1017713A4 (en) 2002-07-24
EP1017713A1 (en) 2000-07-12
DE69838678T2 (de) 2008-10-30
EP1017713B1 (en) 2007-11-07
WO1999000406A1 (en) 1999-01-07
ES2294816T3 (es) 2008-04-01

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