PT1003474E - Método de tratamento de olho seco com agonistas de receptores purinérgicos - Google Patents

Método de tratamento de olho seco com agonistas de receptores purinérgicos Download PDF

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Publication number
PT1003474E
PT1003474E PT98907434T PT98907434T PT1003474E PT 1003474 E PT1003474 E PT 1003474E PT 98907434 T PT98907434 T PT 98907434T PT 98907434 T PT98907434 T PT 98907434T PT 1003474 E PT1003474 E PT 1003474E
Authority
PT
Portugal
Prior art keywords
triphosphate
purinergic receptor
subject
disclosed
methods
Prior art date
Application number
PT98907434T
Other languages
English (en)
Inventor
Janet L Rideout
Karla M Jacobus
Benjamin R Yerxa
William Pendergast
Original Assignee
Inspire Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25170925&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT1003474(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Inspire Pharmaceuticals Inc filed Critical Inspire Pharmaceuticals Inc
Publication of PT1003474E publication Critical patent/PT1003474E/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
PT98907434T 1997-02-06 1998-02-06 Método de tratamento de olho seco com agonistas de receptores purinérgicos PT1003474E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/797,472 US5900407A (en) 1997-02-06 1997-02-06 Method of treating dry eye disease with uridine triphosphates and related compounds

Publications (1)

Publication Number Publication Date
PT1003474E true PT1003474E (pt) 2009-06-26

Family

ID=25170925

Family Applications (1)

Application Number Title Priority Date Filing Date
PT98907434T PT1003474E (pt) 1997-02-06 1998-02-06 Método de tratamento de olho seco com agonistas de receptores purinérgicos

Country Status (20)

Country Link
US (6) US5900407A (pt)
EP (1) EP1003474B1 (pt)
JP (3) JP3652707B2 (pt)
KR (1) KR100378443B1 (pt)
CN (1) CN1151775C (pt)
AT (1) ATE428400T1 (pt)
AU (1) AU735684B2 (pt)
BR (1) BR9809562A (pt)
CA (1) CA2280183C (pt)
DE (1) DE69840746D1 (pt)
DK (1) DK1003474T3 (pt)
ES (1) ES2325892T3 (pt)
HK (1) HK1025915A1 (pt)
ID (1) ID23375A (pt)
MY (1) MY120023A (pt)
NO (1) NO329118B1 (pt)
NZ (1) NZ337405A (pt)
PT (1) PT1003474E (pt)
WO (1) WO1998034593A1 (pt)
ZA (1) ZA98979B (pt)

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Also Published As

Publication number Publication date
US20050197316A1 (en) 2005-09-08
JP5373576B2 (ja) 2013-12-18
EP1003474A1 (en) 2000-05-31
DE69840746D1 (de) 2009-05-28
US8097600B2 (en) 2012-01-17
JP2005015491A (ja) 2005-01-20
US6887858B1 (en) 2005-05-03
US5900407A (en) 1999-05-04
MY120023A (en) 2005-08-30
ZA98979B (en) 1999-02-19
JP2001504858A (ja) 2001-04-10
KR100378443B1 (ko) 2003-03-29
ATE428400T1 (de) 2009-05-15
CA2280183C (en) 2008-04-22
ID23375A (id) 2000-04-20
WO1998034593A1 (en) 1998-08-13
DK1003474T3 (da) 2009-07-20
AU6324198A (en) 1998-08-26
NO993777L (no) 1999-10-05
CN1250369A (zh) 2000-04-12
JP2010111676A (ja) 2010-05-20
US20100330164A1 (en) 2010-12-30
JP3652707B2 (ja) 2005-05-25
HK1025915A1 (en) 2000-12-01
JP4664027B2 (ja) 2011-04-06
US20080009463A1 (en) 2008-01-10
US20020103157A1 (en) 2002-08-01
CA2280183A1 (en) 1998-08-13
US7759322B2 (en) 2010-07-20
US7235535B2 (en) 2007-06-26
NZ337405A (en) 2001-07-27
AU735684B2 (en) 2001-07-12
EP1003474B1 (en) 2009-04-15
KR20000070848A (ko) 2000-11-25
NO993777D0 (no) 1999-08-04
NO329118B1 (no) 2010-08-30
BR9809562A (pt) 2001-10-02
ES2325892T3 (es) 2009-09-23
CN1151775C (zh) 2004-06-02
US6916794B2 (en) 2005-07-12

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