BR0110418A - Método para tratamento da degeneração retiniana com agonistas do receptor purinérgico - Google Patents
Método para tratamento da degeneração retiniana com agonistas do receptor purinérgicoInfo
- Publication number
- BR0110418A BR0110418A BR0110418-7A BR0110418A BR0110418A BR 0110418 A BR0110418 A BR 0110418A BR 0110418 A BR0110418 A BR 0110418A BR 0110418 A BR0110418 A BR 0110418A
- Authority
- BR
- Brazil
- Prior art keywords
- analogs
- retinal degeneration
- retinal
- purinergic
- treatment
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"MéTODO PARA TRATAMENTO DA DEGENERAçãO RETINIANA COM AGONISTAS DO RECEPTOR PURINéRGICO". A presente invenção providencia um método de prevenção ou tratamento da degeneração retiniana oriunda de condições patofisiológicas ou físicas. O método compreende a administração a um paciente de uma composição farmacêutica compreendendo um ligante ao receptor P2Y purinérgico numa quantidade eficaz para elevar sua concentração extracelular para ativar os receptores P2Y superficiais celulares da glia e neuronais retinianos e produzir uma resposta neuroprotetora. Métodos de administração incluem bolus intra-vítreo e administração prolongada, liberação transescleral e administração sistêmica e tópica. A composição farmacêutica útil nesta invenção compreende um agonista do receptor purinérgico P2Y incluindo uridina 5'-di'- e trifosfato (UDP, UTP) e seus análogos, adenosina 5'-difosfato (ADP) e seus análogos, citidina 5'-di- e trifosfato (CDP, CTP) e seus análogos e compostos polifosfato de dinucleosídeo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/570,231 US6864243B1 (en) | 2000-05-12 | 2000-05-12 | Method for treating retinal degeneration with purinergic receptor agonists |
PCT/US2001/015606 WO2001087913A2 (en) | 2000-05-12 | 2001-05-10 | Method for treating retinal degeneration with purinergic receptor agonists |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0110418A true BR0110418A (pt) | 2003-04-08 |
Family
ID=24278788
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0110418-7A BR0110418A (pt) | 2000-05-12 | 2001-05-10 | Método para tratamento da degeneração retiniana com agonistas do receptor purinérgico |
Country Status (10)
Country | Link |
---|---|
US (2) | US6864243B1 (pt) |
EP (1) | EP1280536A2 (pt) |
JP (1) | JP2003533536A (pt) |
KR (1) | KR20030005303A (pt) |
AR (1) | AR029082A1 (pt) |
AU (2) | AU5977501A (pt) |
BR (1) | BR0110418A (pt) |
CA (1) | CA2408842A1 (pt) |
MX (1) | MXPA02008827A (pt) |
WO (1) | WO2001087913A2 (pt) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7223744B2 (en) | 1997-02-10 | 2007-05-29 | Inspire Pharmaceuticals, Inc. | Pharmaceutical formulation comprising dinucleoside polyphosphates and salts thereof |
US6596725B2 (en) | 1997-02-10 | 2003-07-22 | Inspire Pharmaceuticals, Inc. | Use of certain dinucleotides to stimulate removal of fluid in retinal detachment and retinal edema |
US6818629B2 (en) | 1997-02-10 | 2004-11-16 | Inspire Pharmaceuticals, Inc. | Pharmaceutical formulation comprising P1-(2'-deoxycytidine 5'-)P4-(uridine 5'-) tetraphosphate |
US7078391B2 (en) | 1997-02-10 | 2006-07-18 | Inspire Pharmaceuticals, Inc. | Method of treating edematous retinal disorders |
US6864243B1 (en) * | 2000-05-12 | 2005-03-08 | Inspire Pharmaceuticals, Inc. | Method for treating retinal degeneration with purinergic receptor agonists |
US6867199B2 (en) | 2000-08-21 | 2005-03-15 | Inspire Pharmaceuticals, Inc. | Dinucleoside polyphosphate compositions and their therapeutic use |
US6555675B2 (en) * | 2000-08-21 | 2003-04-29 | Inspire Pharmaceuticals, Inc. | Dinucleoside polyphosphate compositions and their therapuetic use as purinergic receptor agonists |
US7115585B2 (en) * | 2000-08-21 | 2006-10-03 | Inspire Pharmaceuticals, Inc. | Compositions for treating epithelial and retinal tissue diseases |
US7084128B2 (en) | 2002-01-18 | 2006-08-01 | Inspire Pharmaceuticals, Inc. | Method for reducing intraocular pressure |
EP1485395A4 (en) | 2002-02-28 | 2011-04-13 | Biota Scient Management | NUCLEOTIDE MIMETICS AND PRODRUGS THEREOF |
EP1750740A4 (en) | 2004-05-06 | 2009-06-10 | Molichem Medicines Inc | TREATMENT OF MEMBRANE-ASSOCIATED DISEASES AND DISORDERS USING COMPOSITIONS CONTAINING LANTIBIOTICS |
US7479481B2 (en) | 2004-05-06 | 2009-01-20 | Molichem Medicines, Inc. | Treatment of ocular diseases and disorders using lantibiotic compositions |
US20070014833A1 (en) * | 2005-03-30 | 2007-01-18 | Sirtris Pharmaceuticals, Inc. | Treatment of eye disorders with sirtuin modulators |
US7368439B2 (en) * | 2005-06-15 | 2008-05-06 | Bar - Ilan University | Dinucleoside poly(borano)phosphate derivatives and uses thereof |
US20090220516A1 (en) * | 2005-06-22 | 2009-09-03 | Alan Laties | Neuroprotection of retinal ganglion cells |
US8618074B2 (en) * | 2007-03-15 | 2013-12-31 | Board Of Regents Of The University Of Texas System | GPCR enhanced neuroprotection to treat brain injury |
WO2010048341A1 (en) * | 2008-10-22 | 2010-04-29 | Inspire Pharmaceuticals, Inc. | Method for treating cystic fibrosis |
WO2011133580A1 (en) * | 2010-04-19 | 2011-10-27 | Back Bay Scientific Llc | Use of drugs that activate p2y receptors to enhance synaptogenesis |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2122529A1 (de) | 1971-05-06 | 1972-12-14 | Max Planck Gesellschaft zur Förde rung der Wissenschaften e V , 3400 Gottin gen | Thiophosphatanaloge der Nucleosid di und tnphosphate sowie Verfahren zu ihrer Herstellung |
US5667968A (en) | 1989-08-30 | 1997-09-16 | Regeneron Pharmaceuticals, Inc. | Prevention of retinal injury and degeneration by specific factors |
US5641750A (en) | 1995-11-29 | 1997-06-24 | Amgen Inc. | Methods for treating photoreceptors using glial cell line-derived neurotrophic factor (GDNF) protein product |
US5837861A (en) | 1997-02-10 | 1998-11-17 | Inspire Pharmaceuticals, Inc. | Dinucleotides and their use as modulators of mucociliary clearance and ciliary beat frequency |
US5900407A (en) * | 1997-02-06 | 1999-05-04 | Inspire Pharmaceuticals, Inc. | Method of treating dry eye disease with uridine triphosphates and related compounds |
RU2119316C1 (ru) * | 1996-06-24 | 1998-09-27 | Александр Иванович Муха | Способ лечения кровоизлияний во внутренние среды и оболочки глаза |
US5763447C1 (en) | 1996-07-23 | 2002-05-07 | Inspire Pharmaceuticals | Method of preventing or treating pneumonia in immobilized patients with uridine triphosphates and related compounds |
US6921755B2 (en) * | 1998-02-06 | 2005-07-26 | Inspire Pharmaceuticals, Inc. | Method of treating dry eye disease with purinergic receptor agonists |
PT981534E (pt) * | 1997-02-06 | 2006-09-29 | Inspire Pharmaceuticals Inc | Dinucleotidos e suas utilizacoes |
US6696425B2 (en) * | 1997-02-06 | 2004-02-24 | Inspire Pharmaceuticals, Inc. | Method of treating dry eye disease with purinergic receptor agonists |
US6596725B2 (en) * | 1997-02-10 | 2003-07-22 | Inspire Pharmaceuticals, Inc. | Use of certain dinucleotides to stimulate removal of fluid in retinal detachment and retinal edema |
US6818629B2 (en) * | 1997-02-10 | 2004-11-16 | Inspire Pharmaceuticals, Inc. | Pharmaceutical formulation comprising P1-(2'-deoxycytidine 5'-)P4-(uridine 5'-) tetraphosphate |
DE19718826A1 (de) * | 1997-05-05 | 1998-11-12 | Marion S Dr Eckmiller | Verwendung biologisch aktiver Wirkstoffe zum Beeinflussen des Extrazellulär-Raumes von Sinneszellen und Verfahren zur Wirkstoff-Administrationssteuerung |
AR013454A1 (es) | 1997-08-29 | 2000-12-27 | Univ North Carolina | Metodo para el tratamiento de las enfermedades pulmonares con 5'-difosfato de uridina y analogos del mismo, composiciones formuladas con dichos compuestosy los compuestos mencionados. |
JP4633927B2 (ja) * | 1998-05-22 | 2011-02-16 | インスパイアー ファーマシューティカルズ,インコーポレイティド | 治療用ジヌクレオチドおよび誘導体 |
CA2359891A1 (en) | 1999-02-26 | 2000-08-31 | Inspire Pharmaceuticals, Inc. | Method of promoting mucosal hydration with certain uridine, adenine and cytidine diphosphates and analogs thereof |
WO2001008691A1 (en) | 1999-07-29 | 2001-02-08 | Steven Baranowitz | Methods for transdifferentiation of body tissues |
US6864243B1 (en) * | 2000-05-12 | 2005-03-08 | Inspire Pharmaceuticals, Inc. | Method for treating retinal degeneration with purinergic receptor agonists |
AU2001260643B9 (en) * | 2000-05-30 | 2006-10-19 | Merck Sharp & Dohme Corp. | Ectocornea extension promoters |
US7018985B1 (en) * | 2000-08-21 | 2006-03-28 | Inspire Pharmaceuticals, Inc. | Composition and method for inhibiting platelet aggregation |
US6867199B2 (en) * | 2000-08-21 | 2005-03-15 | Inspire Pharmaceuticals, Inc. | Dinucleoside polyphosphate compositions and their therapeutic use |
US6555675B2 (en) * | 2000-08-21 | 2003-04-29 | Inspire Pharmaceuticals, Inc. | Dinucleoside polyphosphate compositions and their therapuetic use as purinergic receptor agonists |
-
2000
- 2000-05-12 US US09/570,231 patent/US6864243B1/en not_active Expired - Fee Related
-
2001
- 2001-05-10 WO PCT/US2001/015606 patent/WO2001087913A2/en not_active Application Discontinuation
- 2001-05-10 BR BR0110418-7A patent/BR0110418A/pt not_active IP Right Cessation
- 2001-05-10 AU AU5977501A patent/AU5977501A/xx active Pending
- 2001-05-10 JP JP2001584306A patent/JP2003533536A/ja active Pending
- 2001-05-10 AU AU2001259775A patent/AU2001259775B2/en not_active Expired - Fee Related
- 2001-05-10 CA CA002408842A patent/CA2408842A1/en not_active Abandoned
- 2001-05-10 EP EP01933343A patent/EP1280536A2/en not_active Withdrawn
- 2001-05-10 KR KR1020027014379A patent/KR20030005303A/ko not_active Application Discontinuation
- 2001-05-10 MX MXPA02008827A patent/MXPA02008827A/es active IP Right Grant
- 2001-05-11 AR ARP010102245A patent/AR029082A1/es unknown
-
2004
- 2004-08-10 US US10/916,086 patent/US20050009778A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU5977501A (en) | 2001-11-26 |
EP1280536A2 (en) | 2003-02-05 |
WO2001087913A9 (en) | 2003-03-20 |
US6864243B1 (en) | 2005-03-08 |
CA2408842A1 (en) | 2001-11-22 |
AU2001259775B2 (en) | 2006-07-13 |
WO2001087913A3 (en) | 2002-05-30 |
MXPA02008827A (es) | 2003-02-10 |
WO2001087913A2 (en) | 2001-11-22 |
KR20030005303A (ko) | 2003-01-17 |
JP2003533536A (ja) | 2003-11-11 |
AR029082A1 (es) | 2003-06-04 |
US20050009778A1 (en) | 2005-01-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR0110418A (pt) | Método para tratamento da degeneração retiniana com agonistas do receptor purinérgico | |
MY120023A (en) | Method of treating dry eye disease with uridine triphosphates and related compounds. | |
Craig et al. | N‐methyl‐D‐aspartate‐and non‐N‐methyl‐D‐aspartate‐evoked adenosine release from rat cortical slices: distinct purinergic sources and mechanisms of release | |
D’Ambrosi et al. | Interaction between ATP and nerve growth factor signalling in the survival and neuritic outgrowth from PC12 cells | |
Schmidt et al. | Proposal of a guanine-based purinergic system in the mammalian central nervous system | |
White et al. | Topiramate modulates GABA‐evoked currents in murine cortical neurons by a nonbenzodiazepine mechanism | |
McAdoo et al. | Changes in amino acid concentrations over time and space around an impact injury and their diffusion through the rat spinal cord | |
WO2008113072A3 (en) | Gpcr enhanced neuroprotection to treat brain injury | |
MXPA01008547A (es) | Metodo para promover la hidratacion de mucosas con ciertos difosfatos de uridina, adenina y citidina, y analogos de estos. | |
Barbieri et al. | Apoptosis by 2-chloro-2′-deoxy-adenosine and 2-chloro-adenosine in human peripheral blood mononuclear cells | |
KR20010072392A (ko) | B형 간염의 치료용 β-L-2'-데옥시-뉴클레오시드 | |
BR9810436A (pt) | Processo para a produção em larga escala de di (5'-tetrafosfato de uridina) e sais do mesmo | |
KR960703605A (ko) | 우리딘 분비를 저해하는 방법 및 조성물(methods and compositions for inhibiting uridine secretion) | |
Hosoya et al. | Nucleoside transport mechanisms in the pigmented rabbit conjunctiva. | |
WO2001045691A3 (en) | Method of treating gastrointestinal tract disease with purinergic receptor agonists | |
Nicholls et al. | Characterization of adenosine receptors on rat ileum, ileal longitudinal muscle and muscularis mucosae | |
Godoy et al. | Functional crosstalk between the adenosine transporter CNT3 and purinergic receptors in the biliary epithelia | |
Trendelenburg et al. | P2 receptor-mediated inhibition of dopamine release in rat neostriatum | |
KR20050043761A (ko) | 염증성 질환의 치료 또는 예방 방법 | |
McLaren et al. | Comparison of the actions of ATP and UTP at P2X1 receptors in smooth muscle of the rat tail artery | |
Kessey et al. | Adenosine A2 receptors modulate hippocampal synaptic transmission via a cyclic-AMP-dependent pathway | |
Zona et al. | Effect of P2 purinoceptor antagonists on kainate-induced currents in rat cultured neurons | |
Lundy et al. | Pharmacological differentiation of the P2X7 receptor and the maitotoxin-activated cationic channel | |
Masaki et al. | Reduction by sevoflurane of adenosine 5′-triphosphate-activated inward current of locus coeruleus neurons in pontine slices of rats | |
Elsing et al. | Sodium, hydrogen antiporter activation by extracellular adenosine triphosphate in biliary epithelial cells |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE 7A. E 8A. ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 2008 DE 30/06/2009. |