AU2002342672A1 - Method for screening for inhibitors of protein/protein interaction and corresponding ribozymes - Google Patents

Method for screening for inhibitors of protein/protein interaction and corresponding ribozymes

Info

Publication number
AU2002342672A1
AU2002342672A1 AU2002342672A AU2002342672A AU2002342672A1 AU 2002342672 A1 AU2002342672 A1 AU 2002342672A1 AU 2002342672 A AU2002342672 A AU 2002342672A AU 2002342672 A AU2002342672 A AU 2002342672A AU 2002342672 A1 AU2002342672 A1 AU 2002342672A1
Authority
AU
Australia
Prior art keywords
protein
inhibitors
screening
corresponding ribozymes
interaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002342672A
Inventor
Michael Famulok
Jorg Hartig
Seyed Hani Najafi-Shoushtari
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NascaCell GmbH
Original Assignee
NascaCell GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10144647A external-priority patent/DE10144647A1/en
Application filed by NascaCell GmbH filed Critical NascaCell GmbH
Publication of AU2002342672A1 publication Critical patent/AU2002342672A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C12N2310/122—Hairpin
AU2002342672A 2001-09-11 2002-09-10 Method for screening for inhibitors of protein/protein interaction and corresponding ribozymes Abandoned AU2002342672A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE10144647.0 2001-09-11
DE10144647A DE10144647A1 (en) 2001-09-11 2001-09-11 New allosterically regulatable hairpin ribozyme, useful for identifying compounds that bind specific targets, has extra sequence between substrate binding and catalytic domains
DE10229393 2002-06-29
DE10229393.7 2002-06-29
PCT/EP2002/010140 WO2003022858A2 (en) 2001-09-11 2002-09-10 Method for screening for inhibitors of protein/protein interaction and corresponding ribozymes

Publications (1)

Publication Number Publication Date
AU2002342672A1 true AU2002342672A1 (en) 2003-03-24

Family

ID=26010109

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002342672A Abandoned AU2002342672A1 (en) 2001-09-11 2002-09-10 Method for screening for inhibitors of protein/protein interaction and corresponding ribozymes

Country Status (2)

Country Link
AU (1) AU2002342672A1 (en)
WO (1) WO2003022858A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7115396B2 (en) 1998-12-10 2006-10-03 Compound Therapeutics, Inc. Protein scaffolds for antibody mimics and other binding proteins
CA2497047A1 (en) * 2002-08-27 2004-03-11 Compound Therapeutics, Inc. Adzymes and uses thereof
WO2005056764A2 (en) 2003-12-05 2005-06-23 Compound Therapeutics, Inc. Inhibitors of type 2 vascular endothelial growth factor receptors
JP5537946B2 (en) 2006-11-22 2014-07-02 ブリストル−マイヤーズ スクイブ カンパニー Targeted therapeutic agents based on modified proteins for tyrosine kinase receptors including IGF-IR
WO2009102421A2 (en) 2008-02-14 2009-08-20 Bristol-Myers Squibb Company Targeted therapeutics based on engineered proteins that bind egfr
WO2009142773A2 (en) 2008-05-22 2009-11-26 Bristol-Myers Squibb Company Multivalent fibronectin based scaffold domain proteins
TWI496582B (en) 2008-11-24 2015-08-21 必治妥美雅史谷比公司 Bispecific egfr/igfir binding molecules
TW201138808A (en) 2010-05-03 2011-11-16 Bristol Myers Squibb Co Serum albumin binding molecules
EP3091028A1 (en) 2010-05-26 2016-11-09 Bristol-Myers Squibb Company Fibronectin based scaffold proteins having improved stability
IL275497B (en) 2014-03-20 2022-09-01 Bristol Myers Squibb Co Serum albumin-binding fibronectin type iii domains
WO2017053617A1 (en) 2015-09-23 2017-03-30 Bristol-Myers Squibb Company Fast-off rate serum albumin binding fibronectin type iii domains

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA88227B (en) * 1987-01-28 1988-06-30 Warner-Lambert Company Thrombin preparations
US4959212A (en) * 1988-06-22 1990-09-25 Alexandra Stancesco Oxidizing-energizing composition and method for the treatment of diabetes
IT1243358B (en) * 1990-07-23 1994-06-10 Iketon Farmaceutici Srl PHARMACEUTICAL COMPOSITIONS FOR THE ORAL ADMINISTRATION OF IRUDINA
US5900407A (en) * 1997-02-06 1999-05-04 Inspire Pharmaceuticals, Inc. Method of treating dry eye disease with uridine triphosphates and related compounds
AU2002235737A1 (en) * 2000-11-22 2002-06-03 Nascacell Gmbh Method for identifying compounds or lead structures against rna target motifs and rna/protein interactions

Also Published As

Publication number Publication date
WO2003022858A2 (en) 2003-03-20
WO2003022858A3 (en) 2003-08-28

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase