PT1003474E - Método de tratamento de olho seco com agonistas de receptores purinérgicos - Google Patents
Método de tratamento de olho seco com agonistas de receptores purinérgicos Download PDFInfo
- Publication number
- PT1003474E PT1003474E PT98907434T PT98907434T PT1003474E PT 1003474 E PT1003474 E PT 1003474E PT 98907434 T PT98907434 T PT 98907434T PT 98907434 T PT98907434 T PT 98907434T PT 1003474 E PT1003474 E PT 1003474E
- Authority
- PT
- Portugal
- Prior art keywords
- triphosphate
- purinergic receptor
- subject
- disclosed
- methods
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- 239000003227 purinergic agonist Substances 0.000 title abstract 2
- 208000003556 Dry Eye Syndromes Diseases 0.000 title 1
- ZKHQWZAMYRWXGA-KQYNXXCUSA-N Adenosine triphosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O ZKHQWZAMYRWXGA-KQYNXXCUSA-N 0.000 abstract 2
- ZKHQWZAMYRWXGA-UHFFFAOYSA-N Adenosine triphosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C1O ZKHQWZAMYRWXGA-UHFFFAOYSA-N 0.000 abstract 2
- PCDQPRRSZKQHHS-UHFFFAOYSA-N Cytidine 5'-triphosphate Natural products O=C1N=C(N)C=CN1C1C(O)C(O)C(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 PCDQPRRSZKQHHS-UHFFFAOYSA-N 0.000 abstract 2
- PGAVKCOVUIYSFO-XVFCMESISA-N UTP Chemical compound O[C@@H]1[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1N1C(=O)NC(=O)C=C1 PGAVKCOVUIYSFO-XVFCMESISA-N 0.000 abstract 2
- 229960001456 adenosine triphosphate Drugs 0.000 abstract 2
- PCDQPRRSZKQHHS-ZAKLUEHWSA-N cytidine-5'-triphosphate Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@H](O)[C@@H](O)[C@H](CO[P@](O)(=O)O[P@@](O)(=O)OP(O)(O)=O)O1 PCDQPRRSZKQHHS-ZAKLUEHWSA-N 0.000 abstract 2
- 239000007788 liquid Substances 0.000 abstract 2
- 230000028327 secretion Effects 0.000 abstract 2
- PGAVKCOVUIYSFO-UHFFFAOYSA-N uridine-triphosphate Natural products OC1C(O)C(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)OC1N1C(=O)NC(=O)C=C1 PGAVKCOVUIYSFO-UHFFFAOYSA-N 0.000 abstract 2
- 239000006071 cream Substances 0.000 abstract 1
- -1 dinucleotides Chemical compound 0.000 abstract 1
- 239000012530 fluid Substances 0.000 abstract 1
- 239000000499 gel Substances 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 239000007923 nasal drop Substances 0.000 abstract 1
- 229940100662 nasal drops Drugs 0.000 abstract 1
- 239000007922 nasal spray Substances 0.000 abstract 1
- 229940097496 nasal spray Drugs 0.000 abstract 1
- 239000006199 nebulizer Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000006187 pill Substances 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
- 239000000829 suppository Substances 0.000 abstract 1
- 238000007910 systemic administration Methods 0.000 abstract 1
- 238000011200 topical administration Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Ophthalmology & Optometry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/797,472 US5900407A (en) | 1997-02-06 | 1997-02-06 | Method of treating dry eye disease with uridine triphosphates and related compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1003474E true PT1003474E (pt) | 2009-06-26 |
Family
ID=25170925
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT98907434T PT1003474E (pt) | 1997-02-06 | 1998-02-06 | Método de tratamento de olho seco com agonistas de receptores purinérgicos |
Country Status (19)
| Country | Link |
|---|---|
| US (6) | US5900407A (enExample) |
| EP (1) | EP1003474B1 (enExample) |
| JP (3) | JP3652707B2 (enExample) |
| KR (1) | KR100378443B1 (enExample) |
| CN (1) | CN1151775C (enExample) |
| AT (1) | ATE428400T1 (enExample) |
| AU (1) | AU735684B2 (enExample) |
| BR (1) | BR9809562A (enExample) |
| CA (1) | CA2280183C (enExample) |
| DE (1) | DE69840746D1 (enExample) |
| DK (1) | DK1003474T3 (enExample) |
| ES (1) | ES2325892T3 (enExample) |
| ID (1) | ID23375A (enExample) |
| MY (1) | MY120023A (enExample) |
| NO (1) | NO329118B1 (enExample) |
| NZ (1) | NZ337405A (enExample) |
| PT (1) | PT1003474E (enExample) |
| WO (1) | WO1998034593A1 (enExample) |
| ZA (1) | ZA98979B (enExample) |
Families Citing this family (88)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6423694B1 (en) * | 1996-02-21 | 2002-07-23 | Inspire Pharmaceuticals, Inc. | Method of treating otitis media with uridine triphosphates and related compounds |
| US6673779B2 (en) * | 1996-03-27 | 2004-01-06 | Inspire Pharmaceuticals, Inc. | Method of treating ciliary dyskinesia with dinucleoside polyphosphate compounds or UTP analogues |
| US6420347B1 (en) * | 1997-03-27 | 2002-07-16 | Inspire Pharmaceuticals, Inc. | Method of treating ciliary dyskinesia with uridine triphosphates and related compounds |
| US5900407A (en) * | 1997-02-06 | 1999-05-04 | Inspire Pharmaceuticals, Inc. | Method of treating dry eye disease with uridine triphosphates and related compounds |
| US6319908B1 (en) | 1996-07-03 | 2001-11-20 | Inspire Pharmaceuticals, Inc. | Method for large-scale production of di(uridine 5′-tetraphosphate) and salts thereof |
| US5763447C1 (en) * | 1996-07-23 | 2002-05-07 | Inspire Pharmaceuticals | Method of preventing or treating pneumonia in immobilized patients with uridine triphosphates and related compounds |
| US6696425B2 (en) * | 1997-02-06 | 2004-02-24 | Inspire Pharmaceuticals, Inc. | Method of treating dry eye disease with purinergic receptor agonists |
| US6921755B2 (en) * | 1998-02-06 | 2005-07-26 | Inspire Pharmaceuticals, Inc. | Method of treating dry eye disease with purinergic receptor agonists |
| US7223744B2 (en) * | 1997-02-10 | 2007-05-29 | Inspire Pharmaceuticals, Inc. | Pharmaceutical formulation comprising dinucleoside polyphosphates and salts thereof |
| US6596725B2 (en) | 1997-02-10 | 2003-07-22 | Inspire Pharmaceuticals, Inc. | Use of certain dinucleotides to stimulate removal of fluid in retinal detachment and retinal edema |
| US7078391B2 (en) | 1997-02-10 | 2006-07-18 | Inspire Pharmaceuticals, Inc. | Method of treating edematous retinal disorders |
| KR20010013797A (ko) * | 1997-07-25 | 2001-02-26 | 인스파이어 파마슈티컬스 인코퍼레이티드 | 디(우리딘 5'-테트라포스페이트) 염 및 그의 제조방법과용도 |
| TW593331B (en) * | 1997-07-25 | 2004-06-21 | Inspire Pharmaceuticals Inc | Method for large-scale production of di(uridine 5')-tetraphosphate and salts thereof |
| US6462028B2 (en) | 1997-07-25 | 2002-10-08 | Inspire Pharmaceuticals, Inc. | Method of promoting cervical and vaginal secretions |
| US6872710B2 (en) * | 1997-07-25 | 2005-03-29 | Inspire Pharmaceuticals, Inc. | Di(uridine 5′)-tetraphosphate and salts thereof |
| US6548658B2 (en) * | 1997-07-25 | 2003-04-15 | Inspire Pharmaceuticals, Inc. | Di-(uridine 5′)-tetraphosphate and salts thereof |
| JP4633927B2 (ja) * | 1998-05-22 | 2011-02-16 | インスパイアー ファーマシューティカルズ，インコーポレイティド | 治療用ジヌクレオチドおよび誘導体 |
| EP1140967A1 (en) * | 1998-12-23 | 2001-10-10 | University Of North Carolina At Chapel Hill | Targeted gene transfer using g protein coupled receptors |
| WO2000050024A2 (en) * | 1999-02-26 | 2000-08-31 | Inspire Pharmaceuticals, Inc. | Method of promoting mucosal hydration with certain uridine, adenine and cytidine diphosphates and analogs thereof |
| DE60021629T2 (de) * | 1999-06-30 | 2006-01-05 | Yamasa Corp., Choshi | Dinukleotid-Kristalle |
| US20020061281A1 (en) * | 1999-07-06 | 2002-05-23 | Osbakken Robert S. | Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis |
| US6576224B1 (en) * | 1999-07-06 | 2003-06-10 | Sinuspharma, Inc. | Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis |
| US6723737B1 (en) * | 1999-10-20 | 2004-04-20 | Eliezer Rapaport | Methods, pharmaceutical and therapeutic compostions for administering adenosine |
| WO2001028528A1 (en) * | 1999-10-20 | 2001-04-26 | Eliezer Rapaport | Methods, pharmaceutical and therapeutic compositions for administering adenosine |
| US6277855B1 (en) | 2000-04-21 | 2001-08-21 | Inspire Pharmaceuticals, Inc. | Method of treating dry eye disease with nicotinic acetylcholine receptor agonists |
| US6864243B1 (en) | 2000-05-12 | 2005-03-08 | Inspire Pharmaceuticals, Inc. | Method for treating retinal degeneration with purinergic receptor agonists |
| AU6064301A (en) * | 2000-05-30 | 2001-12-11 | Santen Pharmaceutical Co Ltd | Ectocornea extension promoters |
| US7018985B1 (en) | 2000-08-21 | 2006-03-28 | Inspire Pharmaceuticals, Inc. | Composition and method for inhibiting platelet aggregation |
| US7132408B2 (en) * | 2000-08-21 | 2006-11-07 | Inspire Pharmaceuticals, Inc. | Composition and method for inhibiting platelet aggregation |
| US6867199B2 (en) | 2000-08-21 | 2005-03-15 | Inspire Pharmaceuticals, Inc. | Dinucleoside polyphosphate compositions and their therapeutic use |
| US6555675B2 (en) | 2000-08-21 | 2003-04-29 | Inspire Pharmaceuticals, Inc. | Dinucleoside polyphosphate compositions and their therapuetic use as purinergic receptor agonists |
| US7115585B2 (en) * | 2000-08-21 | 2006-10-03 | Inspire Pharmaceuticals, Inc. | Compositions for treating epithelial and retinal tissue diseases |
| US7452870B2 (en) * | 2000-08-21 | 2008-11-18 | Inspire Pharmaceuticals, Inc. | Drug-eluting stents coated with P2Y12 receptor antagonist compound |
| JP3945625B2 (ja) * | 2001-03-30 | 2007-07-18 | 株式会社イーエムアイ | 角膜上皮障害モデル動物及びそのモデル動物を用いた薬剤の評価方法並びにその評価方法を用いて選択された薬剤 |
| US7629329B2 (en) | 2001-06-04 | 2009-12-08 | Tsi Health Sciences, Inc. | Method for increasing muscle mass and strength through administration of adenosine triphosphate |
| GB2394419B (en) | 2001-06-25 | 2005-09-07 | Inspire Pharmaceuticals Inc | Joint lubrication with p2y purinergic receptor agonists |
| CN1228053C (zh) * | 2001-09-11 | 2005-11-23 | 参天制药株式会社 | 含有二尿苷磷酸的滴眼液 |
| WO2003022858A2 (de) * | 2001-09-11 | 2003-03-20 | Nascacell Gmbh | Verfahren zum screenen von inhibitoren für die protein-protein-wechselwirkung sowie ribozyme hierzu |
| WO2003028712A2 (en) * | 2001-09-28 | 2003-04-10 | Universite Libre De Bruxelles | Purinergic and pyrimidinergic receptor agonists for the treatment of activated cd4+ t lymphocyte-mediated immune diseases |
| WO2003030894A1 (en) * | 2001-10-11 | 2003-04-17 | Alcon, Inc. | Methods for treating dry eye |
| US20030109488A1 (en) * | 2001-10-11 | 2003-06-12 | Alcon, Inc. | Methods for treating dry eye |
| CA2462272A1 (en) * | 2001-10-11 | 2003-04-17 | Alcon, Inc. | Methods for treating dry eye by a combination of an antiinflammatory steroid and a muc-1 secretagogue |
| CN1612739A (zh) * | 2001-11-06 | 2005-05-04 | 印斯拜尔药品股份有限公司 | 治疗或预防炎性疾病的方法 |
| US7084128B2 (en) * | 2002-01-18 | 2006-08-01 | Inspire Pharmaceuticals, Inc. | Method for reducing intraocular pressure |
| US7435724B2 (en) | 2002-02-27 | 2008-10-14 | Inspire Pharmaceutical, Inc. | Degradation-resistant mononucleoside phosphate compounds |
| EP1560540A4 (en) * | 2002-10-18 | 2008-03-19 | Molichem Medicines Inc | METHOD FOR TREATING DRY EYES WITH LANTIBIOTICS |
| US6984628B2 (en) * | 2003-07-15 | 2006-01-10 | Allergan, Inc. | Ophthalmic compositions comprising trefoil factor family peptides |
| EP1753445A4 (en) * | 2004-05-06 | 2009-05-20 | Molichem Medicines Inc | TREATMENT OF EYE DISEASES AND EYE TREATMENTS WITH LANTIBIOTIC COMPOSITIONS |
| US7326683B2 (en) * | 2004-05-06 | 2008-02-05 | Molichem Medicines, Inc. | Treatment of membrane-associated diseases and disorders using lantibiotic containing compositions |
| WO2006082588A2 (en) * | 2005-02-07 | 2006-08-10 | Pharmalight Inc. | Method and device for ophthalmic administration of active pharmaceutical ingredients |
| RU2287159C1 (ru) * | 2005-03-14 | 2006-11-10 | Уральская государственная медицинская академия дополнительного образования | Способ прогнозирования течения синдрома "сухого глаза" |
| RU2271184C1 (ru) * | 2005-06-02 | 2006-03-10 | Федеральное государственное учреждение "Всероссийский центр глазной и пластической хирургии Федерального агентства по здравоохранению и социальному развитию" | Способ хирургического лечения синдрома сухого глаза |
| US7368439B2 (en) * | 2005-06-15 | 2008-05-06 | Bar - Ilan University | Dinucleoside poly(borano)phosphate derivatives and uses thereof |
| KR100870104B1 (ko) | 2005-11-28 | 2008-11-26 | 주식회사 머젠스 | 안구건조증 치료 및 예방용 조성물 |
| KR101037095B1 (ko) * | 2006-01-27 | 2011-05-26 | 캔-파이트 바이오파마 리미티드 | 건성안 장애의 치료를 위한 아데노신 ａ3 수용체 아고니스트 |
| US20080107713A1 (en) * | 2006-11-08 | 2008-05-08 | Orilla Werhner C | Contact lens as a sustained drug delivery implant |
| US20080317819A1 (en) * | 2007-06-21 | 2008-12-25 | Orilla Werhner C | Iop lowering drug combination or non-combination loaded contact lens with zonal drug delivery areas |
| US20090004244A1 (en) * | 2007-06-27 | 2009-01-01 | Orilla Werhner C | Iris design as a drug depot for zonal drug delivery by contact lens |
| US20090004245A1 (en) * | 2007-06-28 | 2009-01-01 | Orilla Werhner C | Use of an iris simulated layer to allow aesthetic appearance drug loaded contact lens |
| US10117906B2 (en) * | 2009-01-09 | 2018-11-06 | The Schepens Eye Research Institute, Inc. | Methods for reducing corneal nerves damage, corneal lymphangiogenesis or immunity to corneal antigens in dry-eye associated ocular surface diseases by IL-1Ra |
| EP2538965B1 (en) | 2010-02-25 | 2017-04-12 | Schepens Eye Research Institute | Therapeutic compositions for the treatment of dry eye disease |
| ES2634551T3 (es) | 2010-04-03 | 2017-09-28 | Praful Doshi | Métodos para revestir una lente de contacto |
| US10413506B2 (en) | 2010-04-03 | 2019-09-17 | Praful Doshi | Medical devices including medicaments and methods of making and using same including enhancing comfort, enhancing drug penetration, and treatment of myopia |
| CN103096929A (zh) | 2010-09-10 | 2013-05-08 | 参天制药株式会社 | 以组合p2y2受体激动剂和透明质酸或其盐为特征的干眼症治疗剂、干眼症的治疗方法、及干眼症治疗剂的应用 |
| US9821159B2 (en) | 2010-11-16 | 2017-11-21 | The Board Of Trustees Of The Leland Stanford Junior University | Stimulation devices and methods |
| JP2013542838A (ja) | 2010-11-16 | 2013-11-28 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | ドライアイを治療するためのシステムおよび方法 |
| JP2012149057A (ja) | 2010-12-28 | 2012-08-09 | Santen Pharmaceut Co Ltd | ジクアホソル含有点眼液およびその製造方法、不溶性析出物発生の抑制方法 |
| KR101943593B1 (ko) * | 2011-04-06 | 2019-01-30 | 케이엘에이-텐코 코포레이션 | 공정 제어를 개선하기 위한 품질 메트릭 제공 방법 및 시스템 |
| SG10201607872PA (en) | 2012-03-26 | 2016-11-29 | Santen Pharmaceutical Co Ltd | Ophthalmic solution comprising diquafosol |
| US9717627B2 (en) | 2013-03-12 | 2017-08-01 | Oculeve, Inc. | Implant delivery devices, systems, and methods |
| AU2014253754C1 (en) | 2013-04-19 | 2015-07-30 | Oculeve, Inc. | Nasal stimulation devices and methods |
| CN111298285A (zh) | 2014-02-25 | 2020-06-19 | 奥库利维公司 | 用于鼻泪刺激的聚合物制剂 |
| EP3171928B1 (en) | 2014-07-25 | 2020-02-26 | Oculeve, Inc. | Stimulation patterns for treating dry eye |
| AU2015335774B2 (en) | 2014-10-22 | 2020-07-16 | Oculeve, Inc. | Implantable nasal stimulator systems and methods |
| MX2017005204A (es) | 2014-10-22 | 2017-12-14 | Oculeve Inc | Dispositivos y métodos de estimulación para tratar el ojo seco. |
| CA2965514A1 (en) | 2014-10-22 | 2016-04-28 | Oculeve, Inc. | Contact lens for increasing tear production |
| CN107635565A (zh) | 2015-06-05 | 2018-01-26 | 参天制药株式会社 | 以向佩戴有软性隐形眼镜的干眼症患者的眼中滴入的方式使用为特征的干眼症治疗剂 |
| US10426958B2 (en) | 2015-12-04 | 2019-10-01 | Oculeve, Inc. | Intranasal stimulation for enhanced release of ocular mucins and other tear proteins |
| US10252048B2 (en) | 2016-02-19 | 2019-04-09 | Oculeve, Inc. | Nasal stimulation for rhinitis, nasal congestion, and ocular allergies |
| EP3452166A4 (en) | 2016-05-02 | 2019-12-18 | Oculeve, Inc. | INTRANASAL STIMULATION FOR THE TREATMENT OF DISEASES OF MEIBOM'S GLANDS AND BLEPHARITIS |
| RU2019118600A (ru) | 2016-12-02 | 2021-01-11 | Окулив, Инк. | Аппарат и способ составления прогноза синдрома сухого глаза и рекомендаций по лечению |
| TWI833406B (zh) * | 2018-02-28 | 2024-02-21 | 日商參天製藥股份有限公司 | 含有迪夸弗索（Ｄｉｑｕａｆｏｓｏｌ）及陽離子性聚合物之眼科用組合物 |
| TWI833913B (zh) | 2019-02-27 | 2024-03-01 | 日商參天製藥股份有限公司 | 含有迪夸弗索(diquafosol)或其鹽、乙烯系高分子及纖維素系高分子之眼科用組合物 |
| MA55805A (fr) | 2019-05-03 | 2022-03-09 | Flagship Pioneering Innovations V Inc | Métodes de modulation de l'activité immunitaire |
| KR20240049646A (ko) * | 2019-08-27 | 2024-04-16 | 산텐 세이야꾸 가부시키가이샤 | 디쿠아포솔 또는 그 염 및 폴리비닐피롤리돈을 함유하는 수성 안과용 조성물 |
| KR20210110055A (ko) * | 2020-02-28 | 2021-09-07 | 주식회사 종근당바이오 | P1, p4-디(우리딘 5'-)테트라포스페이트 나트륨염 4 수화물 결정형 a의 제조방법 |
| KR102548710B1 (ko) | 2020-12-24 | 2023-06-28 | 주식회사 종근당 | 디쿠아포솔 또는 이의 약제학적으로 허용가능한 염과 토코페롤을 함유하는 건성안 예방 또는 치료용 약제학적 조성물 |
| JP2025528009A (ja) | 2022-07-15 | 2025-08-26 | ドーシ，プラフル | 医薬品と薬剤などの不安定な構成要素の安定剤とを含むコンタクトレンズを作製及び使用する方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2330902A1 (de) * | 1973-06-18 | 1975-03-20 | Helmut Dr Med Zander | Heilungsfoerderndes und vorbeugendes, zur aeusserlichen oertlichen anwendung auf der haut und im auge fuer mensch und tier bestimmtes arznei- bzw. hautpflegemittel |
| US4380239A (en) | 1979-12-20 | 1983-04-19 | The Hospital For Sick Children | Intubation of lacrimal ducts |
| US4658816A (en) | 1984-11-14 | 1987-04-21 | Concept Incorporated | Lighted canaliculus intubation sets |
| US4753945A (en) * | 1986-02-19 | 1988-06-28 | Eye Research Institute Of Retina Foundation | Stimulation of tear secretion with phosphodiesterase inhibitors |
| US4868154A (en) * | 1986-02-19 | 1989-09-19 | Eye Research Institute Of Retina Foundation | Stimulation of tear secretion with melanocyte stimulating hormones |
| US5062831A (en) | 1988-09-28 | 1991-11-05 | Griffiths John D | Catheter for use in the surgical correction of a nasolacrimal duct obstruction |
| US4921485A (en) | 1988-09-28 | 1990-05-01 | Griffiths John D | Catheter for use in the surgical correction of a nasolacrimal duct obstruction |
| US5169386A (en) | 1989-09-11 | 1992-12-08 | Bruce B. Becker | Method and catheter for dilatation of the lacrimal system |
| US5021043A (en) | 1989-09-11 | 1991-06-04 | C. R. Bard, Inc. | Method and catheter for dilatation of the lacrimal system |
| US5292498A (en) * | 1991-06-19 | 1994-03-08 | The University Of North Carolina At Chapel Hill | Method of treating lung disease with uridine triphosphates |
| US5345948A (en) | 1993-04-08 | 1994-09-13 | Donnell Jr Francis E O | Method of performing translactrimal laser dacryocystorhinostomy |
| US5900407A (en) * | 1997-02-06 | 1999-05-04 | Inspire Pharmaceuticals, Inc. | Method of treating dry eye disease with uridine triphosphates and related compounds |
| AU727314B2 (en) * | 1996-03-27 | 2000-12-07 | Inspire Pharmaceuticals, Inc. | Method of treating ciliary dyskinesia with uridine triphosphates and related compounds |
| US5789391A (en) * | 1996-07-03 | 1998-08-04 | Inspire Pharmaceuticals, Inc. | Method of treating sinusitis with uridine triphosphates and related compounds |
| US5763447C1 (en) | 1996-07-23 | 2002-05-07 | Inspire Pharmaceuticals | Method of preventing or treating pneumonia in immobilized patients with uridine triphosphates and related compounds |
| US6921755B2 (en) | 1998-02-06 | 2005-07-26 | Inspire Pharmaceuticals, Inc. | Method of treating dry eye disease with purinergic receptor agonists |
| US6696425B2 (en) * | 1997-02-06 | 2004-02-24 | Inspire Pharmaceuticals, Inc. | Method of treating dry eye disease with purinergic receptor agonists |
| TW567456B (en) * | 2001-02-15 | 2003-12-21 | Au Optronics Corp | Apparatus capable of improving flicker of thin film transistor liquid crystal display |
| FR2904554B1 (fr) * | 2006-08-04 | 2010-11-05 | Zheng Xu | Lipides moleculaires heterogenes cytotropes (lmhc), procede de preparation, et methodes de traitement de patients porteurs de cancers multiples |
-
1997
- 1997-02-06 US US08/797,472 patent/US5900407A/en not_active Expired - Lifetime
-
1998
- 1998-02-06 DE DE69840746T patent/DE69840746D1/de not_active Expired - Lifetime
- 1998-02-06 EP EP98907434A patent/EP1003474B1/en not_active Expired - Lifetime
- 1998-02-06 BR BR9809562-5A patent/BR9809562A/pt not_active Application Discontinuation
- 1998-02-06 CA CA002280183A patent/CA2280183C/en not_active Expired - Lifetime
- 1998-02-06 AT AT98907434T patent/ATE428400T1/de active
- 1998-02-06 ES ES98907434T patent/ES2325892T3/es not_active Expired - Lifetime
- 1998-02-06 DK DK98907434T patent/DK1003474T3/da active
- 1998-02-06 WO PCT/US1998/002701 patent/WO1998034593A1/en not_active Ceased
- 1998-02-06 ZA ZA98979A patent/ZA98979B/xx unknown
- 1998-02-06 PT PT98907434T patent/PT1003474E/pt unknown
- 1998-02-06 ID IDW990977A patent/ID23375A/id unknown
- 1998-02-06 MY MYPI98000483A patent/MY120023A/en unknown
- 1998-02-06 JP JP53505498A patent/JP3652707B2/ja not_active Expired - Lifetime
- 1998-02-06 KR KR10-1999-7007113A patent/KR100378443B1/ko not_active Expired - Lifetime
- 1998-02-06 NZ NZ337405A patent/NZ337405A/en not_active IP Right Cessation
- 1998-02-06 US US09/171,169 patent/US6887858B1/en not_active Expired - Lifetime
- 1998-02-06 AU AU63241/98A patent/AU735684B2/en not_active Expired
- 1998-02-06 CN CNB988032619A patent/CN1151775C/zh not_active Expired - Lifetime
-
1999
- 1999-08-04 NO NO19993777A patent/NO329118B1/no not_active IP Right Cessation
-
2002
- 2002-01-03 US US10/041,826 patent/US6916794B2/en not_active Expired - Lifetime
-
2004
- 2004-09-13 JP JP2004265998A patent/JP4664027B2/ja not_active Expired - Lifetime
-
2005
- 2005-04-25 US US11/114,957 patent/US7235535B2/en not_active Expired - Fee Related
-
2007
- 2007-06-20 US US11/821,091 patent/US7759322B2/en not_active Expired - Lifetime
-
2009
- 2009-12-11 JP JP2009281951A patent/JP5373576B2/ja not_active Expired - Lifetime
-
2010
- 2010-06-28 US US12/825,051 patent/US8097600B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ZA98979B (en) | Method of treating dry eye disease with purinergic receptor agonists | |
| MXPA01008547A (es) | Metodo para promover la hidratacion de mucosas con ciertos difosfatos de uridina, adenina y citidina, y analogos de estos. | |
| CA2250188A1 (en) | Method of treating ciliary dyskinesia with uridine triphosphates and related compounds | |
| WO2001080844A3 (en) | Method of treating dry eye disease with nicotinic acetylcholine receptor agonists | |
| AU2003287005B2 (en) | Vaginal health products | |
| WO1998003182A3 (en) | Use of uridine triphosphates and related compounds for the prevention and treatment of pneumonia in immobilized patients | |
| NO996189L (no) | FremgangsmÕte for fremstilling av di (uridin 5') - tetrafosfat) og salter derav i stor mÕlestokk | |
| IL122803A0 (en) | Method fo detecting lung disease | |
| ATE225663T1 (de) | Verfahren zur behandlung von mittelohrentzündung mittels uridintriphosphaten und verwandten mitteln | |
| KR920703041A (ko) | 통증을 수반하는 염증성 또는 알레르기성 질환치료에 사용되는 성분물과 그 방법 | |
| BR0110418A (pt) | Método para tratamento da degeneração retiniana com agonistas do receptor purinérgico | |
| US7056889B2 (en) | Compounds that bind P2Y2 or P2Y1 receptors | |
| WO2007022541A3 (en) | Method of treating dry eye disease with non-drying antihistamines | |
| IT1254280B (it) | Composizioni farmaceutiche comprendenti monosialoganglioside gm1 o un suo derivato atte al trattamento della malattia di parkinson | |
| ATE260118T1 (de) | Zusammensetzungen von adenosin a1 agonisten mit 5ht1 agonisten | |
| WO1999065501A1 (en) | A process for the treatment of organophosphate poisoning |