DK1003474T3 - Fremgangsmåde til behandling af tör öjensygdom med purinergiske receptoragonister - Google Patents
Fremgangsmåde til behandling af tör öjensygdom med purinergiske receptoragonisterInfo
- Publication number
- DK1003474T3 DK1003474T3 DK98907434T DK98907434T DK1003474T3 DK 1003474 T3 DK1003474 T3 DK 1003474T3 DK 98907434 T DK98907434 T DK 98907434T DK 98907434 T DK98907434 T DK 98907434T DK 1003474 T3 DK1003474 T3 DK 1003474T3
- Authority
- DK
- Denmark
- Prior art keywords
- triphosphate
- purinergic receptor
- subject
- disclosed
- methods
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- 239000003227 purinergic agonist Substances 0.000 title abstract 2
- 208000003556 Dry Eye Syndromes Diseases 0.000 title 1
- ZKHQWZAMYRWXGA-KQYNXXCUSA-N Adenosine triphosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O ZKHQWZAMYRWXGA-KQYNXXCUSA-N 0.000 abstract 2
- ZKHQWZAMYRWXGA-UHFFFAOYSA-N Adenosine triphosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C1O ZKHQWZAMYRWXGA-UHFFFAOYSA-N 0.000 abstract 2
- PCDQPRRSZKQHHS-UHFFFAOYSA-N Cytidine 5'-triphosphate Natural products O=C1N=C(N)C=CN1C1C(O)C(O)C(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 PCDQPRRSZKQHHS-UHFFFAOYSA-N 0.000 abstract 2
- PGAVKCOVUIYSFO-XVFCMESISA-N UTP Chemical compound O[C@@H]1[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1N1C(=O)NC(=O)C=C1 PGAVKCOVUIYSFO-XVFCMESISA-N 0.000 abstract 2
- 229960001456 adenosine triphosphate Drugs 0.000 abstract 2
- PCDQPRRSZKQHHS-ZAKLUEHWSA-N cytidine-5'-triphosphate Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@H](O)[C@@H](O)[C@H](CO[P@](O)(=O)O[P@@](O)(=O)OP(O)(O)=O)O1 PCDQPRRSZKQHHS-ZAKLUEHWSA-N 0.000 abstract 2
- 239000007788 liquid Substances 0.000 abstract 2
- 230000028327 secretion Effects 0.000 abstract 2
- PGAVKCOVUIYSFO-UHFFFAOYSA-N uridine-triphosphate Natural products OC1C(O)C(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)OC1N1C(=O)NC(=O)C=C1 PGAVKCOVUIYSFO-UHFFFAOYSA-N 0.000 abstract 2
- 239000006071 cream Substances 0.000 abstract 1
- -1 dinucleotides Chemical compound 0.000 abstract 1
- 239000012530 fluid Substances 0.000 abstract 1
- 239000000499 gel Substances 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 239000007923 nasal drop Substances 0.000 abstract 1
- 229940100662 nasal drops Drugs 0.000 abstract 1
- 239000007922 nasal spray Substances 0.000 abstract 1
- 229940097496 nasal spray Drugs 0.000 abstract 1
- 239000006199 nebulizer Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000006187 pill Substances 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
- 239000000829 suppository Substances 0.000 abstract 1
- 238000007910 systemic administration Methods 0.000 abstract 1
- 238000011200 topical administration Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Ophthalmology & Optometry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/797,472 US5900407A (en) | 1997-02-06 | 1997-02-06 | Method of treating dry eye disease with uridine triphosphates and related compounds |
| PCT/US1998/002701 WO1998034593A1 (en) | 1997-02-06 | 1998-02-06 | Method of treating dry eye disease with purinergic receptor agonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1003474T3 true DK1003474T3 (da) | 2009-07-20 |
Family
ID=25170925
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98907434T DK1003474T3 (da) | 1997-02-06 | 1998-02-06 | Fremgangsmåde til behandling af tör öjensygdom med purinergiske receptoragonister |
Country Status (19)
| Country | Link |
|---|---|
| US (6) | US5900407A (enExample) |
| EP (1) | EP1003474B1 (enExample) |
| JP (3) | JP3652707B2 (enExample) |
| KR (1) | KR100378443B1 (enExample) |
| CN (1) | CN1151775C (enExample) |
| AT (1) | ATE428400T1 (enExample) |
| AU (1) | AU735684B2 (enExample) |
| BR (1) | BR9809562A (enExample) |
| CA (1) | CA2280183C (enExample) |
| DE (1) | DE69840746D1 (enExample) |
| DK (1) | DK1003474T3 (enExample) |
| ES (1) | ES2325892T3 (enExample) |
| ID (1) | ID23375A (enExample) |
| MY (1) | MY120023A (enExample) |
| NO (1) | NO329118B1 (enExample) |
| NZ (1) | NZ337405A (enExample) |
| PT (1) | PT1003474E (enExample) |
| WO (1) | WO1998034593A1 (enExample) |
| ZA (1) | ZA98979B (enExample) |
Families Citing this family (88)
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|---|---|---|---|---|
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| US6420347B1 (en) * | 1997-03-27 | 2002-07-16 | Inspire Pharmaceuticals, Inc. | Method of treating ciliary dyskinesia with uridine triphosphates and related compounds |
| US6319908B1 (en) | 1996-07-03 | 2001-11-20 | Inspire Pharmaceuticals, Inc. | Method for large-scale production of di(uridine 5′-tetraphosphate) and salts thereof |
| US5763447C1 (en) * | 1996-07-23 | 2002-05-07 | Inspire Pharmaceuticals | Method of preventing or treating pneumonia in immobilized patients with uridine triphosphates and related compounds |
| US6921755B2 (en) * | 1998-02-06 | 2005-07-26 | Inspire Pharmaceuticals, Inc. | Method of treating dry eye disease with purinergic receptor agonists |
| US6696425B2 (en) * | 1997-02-06 | 2004-02-24 | Inspire Pharmaceuticals, Inc. | Method of treating dry eye disease with purinergic receptor agonists |
| US7223744B2 (en) * | 1997-02-10 | 2007-05-29 | Inspire Pharmaceuticals, Inc. | Pharmaceutical formulation comprising dinucleoside polyphosphates and salts thereof |
| US6596725B2 (en) | 1997-02-10 | 2003-07-22 | Inspire Pharmaceuticals, Inc. | Use of certain dinucleotides to stimulate removal of fluid in retinal detachment and retinal edema |
| US7078391B2 (en) | 1997-02-10 | 2006-07-18 | Inspire Pharmaceuticals, Inc. | Method of treating edematous retinal disorders |
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| EP1012154B1 (en) | 1997-07-25 | 2004-03-17 | Inspire Pharmaceuticals, Inc. | Salts of di(uridine 5'-tetraphosphate), method for preparation and uses thereof |
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| US9821159B2 (en) | 2010-11-16 | 2017-11-21 | The Board Of Trustees Of The Leland Stanford Junior University | Stimulation devices and methods |
| ES2739490T3 (es) | 2010-11-16 | 2020-01-31 | Univ Leland Stanford Junior | Sistemas para el tratamiento del ojo seco |
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| JP2020500609A (ja) | 2016-12-02 | 2020-01-16 | オキュリーブ， インコーポレイテッド | ドライアイ予測及び治療勧告のための装置及び方法 |
| KR102472773B1 (ko) | 2018-02-28 | 2022-11-30 | 산텐 세이야꾸 가부시키가이샤 | 디쿠아포솔 및 양이온성 폴리머를 함유하는 안과용 조성물 |
| CN113518646B (zh) | 2019-02-27 | 2023-12-12 | 参天制药株式会社 | 含有地夸磷索或其盐，乙烯基系高分子及纤维素系高分子的眼科用组合物 |
| EP3962493A2 (en) | 2019-05-03 | 2022-03-09 | Flagship Pioneering Innovations V, Inc. | Methods of modulating immune activity/level of irf or sting or of treating cancer, comprising the administration of a sting modulator and/or purinergic receptor modulator or postcellular signaling factor |
| KR102656181B1 (ko) * | 2019-08-27 | 2024-04-08 | 산텐 세이야꾸 가부시키가이샤 | 디쿠아포솔 또는 그 염 및 폴리비닐피롤리돈을 함유하는 수성 안과용 조성물 |
| KR20210110055A (ko) * | 2020-02-28 | 2021-09-07 | 주식회사 종근당바이오 | P1, p4-디(우리딘 5'-)테트라포스페이트 나트륨염 4 수화물 결정형 a의 제조방법 |
| KR102548710B1 (ko) | 2020-12-24 | 2023-06-28 | 주식회사 종근당 | 디쿠아포솔 또는 이의 약제학적으로 허용가능한 염과 토코페롤을 함유하는 건성안 예방 또는 치료용 약제학적 조성물 |
| JP2025528009A (ja) | 2022-07-15 | 2025-08-26 | ドーシ，プラフル | 医薬品と薬剤などの不安定な構成要素の安定剤とを含むコンタクトレンズを作製及び使用する方法 |
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| DE2330902A1 (de) * | 1973-06-18 | 1975-03-20 | Helmut Dr Med Zander | Heilungsfoerderndes und vorbeugendes, zur aeusserlichen oertlichen anwendung auf der haut und im auge fuer mensch und tier bestimmtes arznei- bzw. hautpflegemittel |
| US4380239A (en) | 1979-12-20 | 1983-04-19 | The Hospital For Sick Children | Intubation of lacrimal ducts |
| US4658816A (en) | 1984-11-14 | 1987-04-21 | Concept Incorporated | Lighted canaliculus intubation sets |
| US4868154A (en) * | 1986-02-19 | 1989-09-19 | Eye Research Institute Of Retina Foundation | Stimulation of tear secretion with melanocyte stimulating hormones |
| US4753945A (en) * | 1986-02-19 | 1988-06-28 | Eye Research Institute Of Retina Foundation | Stimulation of tear secretion with phosphodiesterase inhibitors |
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| CA2250188C (en) * | 1996-03-27 | 2008-12-09 | Inspire Pharmaceuticals, Inc. | Method of treating ciliary dyskinesia with uridine triphosphates and related compounds |
| US5900407A (en) * | 1997-02-06 | 1999-05-04 | Inspire Pharmaceuticals, Inc. | Method of treating dry eye disease with uridine triphosphates and related compounds |
| US5789391A (en) * | 1996-07-03 | 1998-08-04 | Inspire Pharmaceuticals, Inc. | Method of treating sinusitis with uridine triphosphates and related compounds |
| US5763447C1 (en) * | 1996-07-23 | 2002-05-07 | Inspire Pharmaceuticals | Method of preventing or treating pneumonia in immobilized patients with uridine triphosphates and related compounds |
| US6921755B2 (en) | 1998-02-06 | 2005-07-26 | Inspire Pharmaceuticals, Inc. | Method of treating dry eye disease with purinergic receptor agonists |
| US6696425B2 (en) * | 1997-02-06 | 2004-02-24 | Inspire Pharmaceuticals, Inc. | Method of treating dry eye disease with purinergic receptor agonists |
| TW567456B (en) * | 2001-02-15 | 2003-12-21 | Au Optronics Corp | Apparatus capable of improving flicker of thin film transistor liquid crystal display |
| FR2904554B1 (fr) * | 2006-08-04 | 2010-11-05 | Zheng Xu | Lipides moleculaires heterogenes cytotropes (lmhc), procede de preparation, et methodes de traitement de patients porteurs de cancers multiples |
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- 1998-02-06 AT AT98907434T patent/ATE428400T1/de active
- 1998-02-06 US US09/171,169 patent/US6887858B1/en not_active Expired - Lifetime
- 1998-02-06 CA CA002280183A patent/CA2280183C/en not_active Expired - Lifetime
- 1998-02-06 DE DE69840746T patent/DE69840746D1/de not_active Expired - Lifetime
- 1998-02-06 DK DK98907434T patent/DK1003474T3/da active
- 1998-02-06 ID IDW990977A patent/ID23375A/id unknown
- 1998-02-06 MY MYPI98000483A patent/MY120023A/en unknown
- 1998-02-06 CN CNB988032619A patent/CN1151775C/zh not_active Expired - Lifetime
- 1998-02-06 AU AU63241/98A patent/AU735684B2/en not_active Expired
- 1998-02-06 WO PCT/US1998/002701 patent/WO1998034593A1/en not_active Ceased
- 1998-02-06 PT PT98907434T patent/PT1003474E/pt unknown
- 1998-02-06 NZ NZ337405A patent/NZ337405A/en not_active IP Right Cessation
- 1998-02-06 JP JP53505498A patent/JP3652707B2/ja not_active Expired - Lifetime
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- 1998-02-06 ES ES98907434T patent/ES2325892T3/es not_active Expired - Lifetime
- 1998-02-06 BR BR9809562-5A patent/BR9809562A/pt not_active Application Discontinuation
- 1998-02-06 KR KR10-1999-7007113A patent/KR100378443B1/ko not_active Expired - Lifetime
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- 1999-08-04 NO NO19993777A patent/NO329118B1/no not_active IP Right Cessation
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- 2002-01-03 US US10/041,826 patent/US6916794B2/en not_active Expired - Lifetime
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