PL92565B1 - - Google Patents

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Publication number
PL92565B1
PL92565B1 PL1973182614A PL18261473A PL92565B1 PL 92565 B1 PL92565 B1 PL 92565B1 PL 1973182614 A PL1973182614 A PL 1973182614A PL 18261473 A PL18261473 A PL 18261473A PL 92565 B1 PL92565 B1 PL 92565B1
Authority
PL
Poland
Prior art keywords
acid
found
phenyl
calculated
group
Prior art date
Application number
PL1973182614A
Other languages
English (en)
Polish (pl)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of PL92565B1 publication Critical patent/PL92565B1/pl

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/38Heterocyclic compounds having sulfur as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D263/57Aryl or substituted aryl radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
PL1973182614A 1972-05-18 1973-05-18 PL92565B1 (instruction)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2340972A GB1435721A (en) 1972-05-18 1972-05-18 Benzoxazole derivatives

Publications (1)

Publication Number Publication Date
PL92565B1 true PL92565B1 (instruction) 1977-04-30

Family

ID=10195157

Family Applications (3)

Application Number Title Priority Date Filing Date
PL1973183011A PL94208B1 (instruction) 1972-05-18 1973-05-18
PL1973182614A PL92565B1 (instruction) 1972-05-18 1973-05-18
PL1973162653A PL89247B1 (instruction) 1972-05-18 1973-05-18

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL1973183011A PL94208B1 (instruction) 1972-05-18 1973-05-18

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL1973162653A PL89247B1 (instruction) 1972-05-18 1973-05-18

Country Status (31)

Country Link
US (1) US3912748A (instruction)
JP (6) JPS5912672B2 (instruction)
KR (1) KR780000234B1 (instruction)
AR (4) AR230991A1 (instruction)
AT (1) AT333752B (instruction)
BE (1) BE799790A (instruction)
BG (1) BG21408A3 (instruction)
CA (1) CA1029019A (instruction)
CH (5) CH587834A5 (instruction)
CS (1) CS200455B2 (instruction)
CY (1) CY1016A (instruction)
DD (1) DD105229A5 (instruction)
DE (1) DE2324443A1 (instruction)
DK (1) DK140340B (instruction)
ES (1) ES414863A1 (instruction)
FR (2) FR2184966B1 (instruction)
GB (1) GB1435721A (instruction)
HK (1) HK72579A (instruction)
HU (1) HU167933B (instruction)
IE (2) IE37564B1 (instruction)
IL (2) IL42102A (instruction)
KE (1) KE2975A (instruction)
MY (1) MY8000063A (instruction)
NL (1) NL170145C (instruction)
PH (3) PH9685A (instruction)
PL (3) PL94208B1 (instruction)
RO (2) RO66800A (instruction)
SE (3) SE386174B (instruction)
SU (3) SU574157A3 (instruction)
YU (3) YU130473A (instruction)
ZA (1) ZA732791B (instruction)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1495488A (en) * 1976-06-23 1977-12-21 Ippco Int Pharma Patents Co Es Optically active 2-(2-phenyl-5-benzoxazolyl)propionic acids
US4087437A (en) * 1976-09-07 1978-05-02 Eli Lilly And Company 2-Phenyl-5-benzoxazolylalkanoic acid purification process
GB1590587A (en) * 1977-06-28 1981-06-03 Lilly Industries Ltd Benoxaprofen
IT1099589B (it) * 1978-08-04 1985-09-18 Ravizza Spa Processo per la preparazione di derivati dell'acido benzoxazolil propionico
CA1125768A (en) * 1978-10-31 1982-06-15 Hoffmann-La Roche Limited Benzoxazole derivatives
GR75153B (instruction) * 1981-03-27 1984-07-13 Lilly Co Eli
IT1157295B (it) * 1982-07-19 1987-02-11 Ravizza Spa Processo perfezionato per la preparazione di derivati dell'acido benzoxazolil propionico
DE3413875A1 (de) * 1984-04-12 1985-10-17 Ludwig Heumann & Co GmbH, 8500 Nürnberg Benzothiazolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltendes arzneimittel
IT1177017B (it) * 1984-10-22 1987-08-26 Ravizza Spa Processo per la preparazione dell'acido 2(4-flurofenil)alfa-metil-5-benzox azoloacetico
US4873259A (en) * 1987-06-10 1989-10-10 Abbott Laboratories Indole, benzofuran, benzothiophene containing lipoxygenase inhibiting compounds
US4822809A (en) * 1987-11-13 1989-04-18 Abbott Laboratories Benzazole lipoxygenase inhibiting compounds
IT1233836B (it) * 1988-01-13 1992-04-21 Euroresearch Srl Sali idrosolubili dell'acido (+)2-(4 fluorofenil)-alfa-metil-5 benzoxazolo acetato.
UA83620C2 (ru) * 2001-12-05 2008-08-11 Уайт Замещенные бензоксазолы и их аналоги как эстрогенные агенты
AU2003283597A1 (en) * 2002-11-16 2004-06-15 Oxford Glycosciences (Uk) Ltd Benzoxazole, benzthiazole and benzimidazole acid derivatives and their use as heparanase inhibitors
AU2004215624B2 (en) * 2003-02-25 2011-06-02 Topotarget Uk Limited Hydroxamic acid compounds comprising a bicyclic heteroaryl group as HDAC inhibitors
PL1856031T3 (pl) * 2004-12-15 2009-07-31 Dompe Farm Spa Pochodne kwasu 2-arylopropionowego i kompozycje farmaceutyczne je zawierające
RU2419610C2 (ru) 2005-05-26 2011-05-27 Ньюрон Системз, Инк. Композиции и способы лечения заболевания сетчатки
JP5369854B2 (ja) 2008-04-21 2013-12-18 住友化学株式会社 有害節足動物防除組成物および縮合複素環化合物
WO2011072141A1 (en) 2009-12-11 2011-06-16 Neuron Systems, Inc. Compositions and methods for the treatment of macular degeneration
CN105120866B (zh) 2013-01-23 2020-02-14 奥尔德拉医疗公司 与毒性醛相关的疾病和治疗
AU2014209585A1 (en) 2013-01-25 2015-07-23 Aldeyra Therapeutics, Inc. Novel traps in the treatment of macular degeneration
CN107001267A (zh) * 2014-08-08 2017-08-01 马合伙人株式会社 稠合杂环化合物
KR102664994B1 (ko) 2015-08-21 2024-05-13 알데이라 테라퓨틱스, 아이엔씨. 중수소화 화합물 및 이의 용도
US11129823B2 (en) 2016-05-09 2021-09-28 Aldeyra Therapeutics, Inc. Combination treatment of ocular inflammatory disorders and diseases
CN110431130A (zh) 2017-03-16 2019-11-08 奥尔德拉医疗公司 多晶型化合物和其用途
CA3077362A1 (en) 2017-10-10 2019-04-18 Aldeyra Therapeutics, Inc. Treatment of inflammatory disorders
AU2019319740A1 (en) 2018-08-06 2021-03-25 Aldeyra Therapeutics, Inc. Polymorphic compounds and uses thereof
CN113056353B (zh) 2018-09-25 2022-11-01 奥尔德拉医疗公司 用于治疗干眼病的调配物
US11786518B2 (en) 2019-03-26 2023-10-17 Aldeyra Therapeutics, Inc. Ophthalmic formulations and uses thereof
WO2020223685A1 (en) 2019-05-02 2020-11-05 Aldeyra Therapeutics, Inc. Polymorphic compounds and uses thereof
US12098132B2 (en) 2019-05-02 2024-09-24 Aldeyra Therapeutics, Inc. Process for preparation of aldehyde scavenger and intermediates
WO2021231792A1 (en) 2020-05-13 2021-11-18 Aldeyra Therapeutics, Inc. Pharmaceutical formulations and uses thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD70860A (instruction) *
NL285932A (instruction) * 1961-11-27
CH516339A (de) * 1969-03-03 1971-12-15 Ciba Geigy Ag Verwendung von Azolverbindungen als Antioxydantien
DE2118315C3 (de) * 1970-04-20 1975-04-03 Sumitomo Chemical Co., Ltd., Osaka (Japan) 2-(1H)-Chinazolinonderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
IL37633A (en) * 1970-09-10 1975-08-31 Merck & Co Inc 2-(4-(2-benzoxazolyl)phenyl)alkanoic acid derivatives
DE2115926C3 (de) * 1971-04-01 1978-05-03 C.H. Boehringer Sohn, 6507 Ingelheim 1 -(4-Hydroxy-3-dimethylaminosuIfamidophenyI)-2-aminoäthanderivate, Verfahren zu ihrer Herstellung und diese enthaltende Mittel
GB1491863A (en) * 1973-10-23 1977-11-16 Lilly Industries Ltd 2,5-or 2,6-disubstituted benzoxazoles
GB1590587A (en) * 1977-06-28 1981-06-03 Lilly Industries Ltd Benoxaprofen

Also Published As

Publication number Publication date
JPS4954363A (instruction) 1974-05-27
DD105229A5 (instruction) 1974-04-12
BE799790A (fr) 1973-11-19
CH595361A5 (instruction) 1978-02-15
FR2184966B1 (instruction) 1979-01-12
YU117079A (en) 1981-08-31
YU117179A (en) 1981-08-31
ES414863A1 (es) 1976-02-01
JPS56167645A (en) 1981-12-23
JPS6021976B2 (ja) 1985-05-30
US3912748A (en) 1975-10-14
AR212010A1 (es) 1978-04-28
CH594643A5 (instruction) 1978-01-13
IE37563B1 (en) 1977-08-17
AR230991A1 (es) 1984-08-31
AR205021A1 (es) 1976-03-31
HU167933B (instruction) 1976-01-28
GB1435721A (en) 1976-05-12
DK140340C (instruction) 1979-12-31
PH9685A (en) 1976-02-10
CY1016A (en) 1979-11-23
JPS5929185B2 (ja) 1984-07-18
CH595362A5 (instruction) 1978-02-15
IE37563L (en) 1973-11-18
PL94208B1 (instruction) 1977-07-30
JPS59161346A (ja) 1984-09-12
KE2975A (en) 1979-07-20
RO66278A (ro) 1981-06-26
NL7307018A (instruction) 1973-11-20
IE37564L (en) 1973-11-18
AT333752B (de) 1976-12-10
IL48711A0 (en) 1976-02-29
ZA732791B (en) 1974-12-24
FR2184966A1 (instruction) 1973-12-28
CA1029019A (en) 1978-04-04
KR780000234B1 (en) 1978-07-01
CH592071A5 (instruction) 1977-10-14
CH587834A5 (instruction) 1977-05-13
DE2324443A1 (de) 1973-11-29
IE37564B1 (en) 1977-08-17
CS200455B2 (en) 1980-09-15
PH11718A (en) 1978-05-30
JPS56167673A (en) 1981-12-23
PH10704A (en) 1977-08-24
SE386174B (sv) 1976-08-02
IL42102A (en) 1977-07-31
FR2284592A1 (fr) 1976-04-09
SU574157A3 (ru) 1977-09-25
SE435838B (sv) 1984-10-22
SE7710602L (sv) 1977-09-21
AR207857A1 (es) 1976-11-08
YU36298B (en) 1982-06-18
NL170145B (nl) 1982-05-03
ATA432573A (de) 1976-04-15
SU580837A3 (ru) 1977-11-15
JPS56167675A (en) 1981-12-23
AU5590773A (en) 1974-11-21
SE434399B (sv) 1984-07-23
FR2284592B1 (instruction) 1979-01-05
DK140340B (da) 1979-08-06
JPS5912672B2 (ja) 1984-03-24
NL170145C (nl) 1982-10-01
SE7509387L (sv) 1975-08-22
YU130473A (en) 1981-08-31
HK72579A (en) 1979-10-19
RO66800A (ro) 1982-03-24
PL89247B1 (instruction) 1976-11-30
JPS56167674A (en) 1981-12-23
MY8000063A (en) 1980-12-31
BG21408A3 (bg) 1976-05-20
SU582762A3 (ru) 1977-11-30
IL42102A0 (en) 1973-06-29

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