PL404913A1 - Zwiazek 2,3-dihydro-6-nitroimidazo[2,1-b]oksazolowy - Google Patents
Zwiazek 2,3-dihydro-6-nitroimidazo[2,1-b]oksazolowyInfo
- Publication number
- PL404913A1 PL404913A1 PL404913A PL40491303A PL404913A1 PL 404913 A1 PL404913 A1 PL 404913A1 PL 404913 A PL404913 A PL 404913A PL 40491303 A PL40491303 A PL 40491303A PL 404913 A1 PL404913 A1 PL 404913A1
- Authority
- PL
- Poland
- Prior art keywords
- oxazole
- nitroimidazo
- dihydro
- compound
- mycobacterium tuberculosis
- Prior art date
Links
- QISRGAUYEHQMJV-UHFFFAOYSA-N 6-nitro-2,3-dihydroimidazo[2,1-b][1,3]oxazole Chemical compound C1COC2=NC([N+](=O)[O-])=CN21 QISRGAUYEHQMJV-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 241000187479 Mycobacterium tuberculosis Species 0.000 abstract 2
- XYWOINJZYYVBQY-UHFFFAOYSA-N 2,3-dihydroimidazo[2,1-b][1,3]oxazole Chemical class C1=CN=C2OCCN21 XYWOINJZYYVBQY-UHFFFAOYSA-N 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002298259 | 2002-10-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL404913A1 true PL404913A1 (pl) | 2013-09-30 |
Family
ID=32089299
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL404913A PL404913A1 (pl) | 2002-10-11 | 2003-10-10 | Zwiazek 2,3-dihydro-6-nitroimidazo[2,1-b]oksazolowy |
| PL376157A PL217919B1 (pl) | 2002-10-11 | 2003-10-10 | Związek 2,3-dihydro-6-nitroimidazo[2,1-b]oksazolowy, kompozycja go zawierająca oraz zastosowanie |
| PL409525A PL409525A1 (pl) | 2002-10-11 | 2003-10-10 | Związek 2,3-dihydro-6-nitroimidazo[2,1-b]oksazolowy |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL376157A PL217919B1 (pl) | 2002-10-11 | 2003-10-10 | Związek 2,3-dihydro-6-nitroimidazo[2,1-b]oksazolowy, kompozycja go zawierająca oraz zastosowanie |
| PL409525A PL409525A1 (pl) | 2002-10-11 | 2003-10-10 | Związek 2,3-dihydro-6-nitroimidazo[2,1-b]oksazolowy |
Country Status (26)
Families Citing this family (83)
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|---|---|---|---|---|
| ATE502928T1 (de) | 2000-11-01 | 2011-04-15 | Millennium Pharm Inc | Stickstoffhaltige heterozyklische verbindungen und verfahren zu deren herstellung |
| ES2526892T3 (es) * | 2002-10-15 | 2015-01-16 | Otsuka Pharmaceutical Co., Ltd. | Método para preparar un compuesto 2-halo-4-nitroimidazol |
| ATE410430T1 (de) | 2003-10-31 | 2008-10-15 | Otsuka Pharma Co Ltd | 2,3-dihydro-6-nitroimidazoä2,1- büoxazolverbindungen zur behandlung von tuberkulose |
| JP4761756B2 (ja) * | 2003-10-31 | 2011-08-31 | 大塚製薬株式会社 | ２，３−ジヒドロイミダゾ［２，１−ｂ］オキサゾ−ル化合物 |
| TWI300409B (en) | 2004-02-18 | 2008-09-01 | Otsuka Pharma Co Ltd | Method for producing 4-nitroimidazole compound |
| SI1731518T1 (sl) | 2004-03-31 | 2014-11-28 | Nippon Soda Co., Ltd. | Spojina cikličen amin in sredstvo za nadzorovanje škodljivcev |
| JP4789966B2 (ja) * | 2004-04-09 | 2011-10-12 | 大塚製薬株式会社 | 医薬組成物 |
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| ES2337728T3 (es) * | 2005-06-20 | 2010-04-28 | Schering Corporation | Piperidinas sustituidas unidas a carbono y sus derivados utiles como antagonistas de histamina h3. |
| WO2007013477A1 (en) * | 2005-07-28 | 2007-02-01 | Otsuka Pharmaceutical Co., Ltd. | Pharmaceutical composition comprising 2 , 3-dihydro-6-nitroimidazo [2 , 1-b] oxazole derivatives |
| JP5105818B2 (ja) * | 2005-10-05 | 2012-12-26 | 大塚製薬株式会社 | 医薬組成物 |
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| WO2008106128A2 (en) * | 2007-02-26 | 2008-09-04 | Vitae Pharmaceuticals, Inc. | CYCLIC UREA AND CARBAMATE INHIBITORS OF 11β -HYDROXYSTEROID DEHYDROGENASE 1 |
| AR070301A1 (es) * | 2007-05-08 | 2010-03-31 | Otsuka Pharma Co Ltd | Compuesto epoxi y metodo para producir el mismo |
| AR067673A1 (es) * | 2007-07-26 | 2009-10-21 | Vitae Pharmaceuticals Inc | Derivados de 1,3 oxazinan - 2 - ona como inhibidores ciclicos de la 11 beta -hidroxiesteroide deshidrogenasa 1. composiciones farmaceuticas. |
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| JP2011500634A (ja) * | 2007-10-16 | 2011-01-06 | グラクソ グループ リミテッド | 炎症性疾患およびアレルギー性疾患の治療に用いるキノリン誘導体 |
| AR069207A1 (es) * | 2007-11-07 | 2010-01-06 | Vitae Pharmaceuticals Inc | Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1 |
| US8440658B2 (en) | 2007-12-11 | 2013-05-14 | Vitae Pharmaceuticals, Inc. | Cyclic urea inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
| TW200934490A (en) * | 2008-01-07 | 2009-08-16 | Vitae Pharmaceuticals Inc | Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1 |
| JP5490020B2 (ja) | 2008-01-24 | 2014-05-14 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状カルバゼート及びセミカルバジドインヒビター |
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| AU2009283195A1 (en) * | 2008-08-18 | 2010-02-25 | Yale University | MIF modulators |
| US9540322B2 (en) | 2008-08-18 | 2017-01-10 | Yale University | MIF modulators |
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| JP5679997B2 (ja) | 2009-02-04 | 2015-03-04 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状阻害剤 |
| TW201039034A (en) * | 2009-04-27 | 2010-11-01 | Chunghwa Picture Tubes Ltd | Pixel structure and the method of forming the same |
| UA109255C2 (ru) | 2009-04-30 | 2015-08-10 | Берінгер Інгельхайм Інтернешнл Гмбх | Циклические ингибиторы 11бета-гидроксистероиддегидрогеназы 1 |
| KR20120061771A (ko) * | 2009-04-30 | 2012-06-13 | 비타이 파마슈티컬즈, 인코포레이티드 | 11베타-하이드록시스테로이드 탈수소효소 1의 고리형 억제제 |
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| FR3000064A1 (fr) | 2012-12-21 | 2014-06-27 | Univ Lille Ii Droit & Sante | Composes de type spiroisoxazoline ayant une activite potentialisatrice de l'activite d'un antibiotique-composition et produit pharmaceutiques comprenant de tels composes |
| WO2015049693A1 (en) | 2013-10-04 | 2015-04-09 | Council Of Scientific & Industrial Research | 6-NITRO-2,3-DIHYDROIMIDAZO[2,1-b]OXAZOLES AND A PROCESS FOR THE PREPARATION THEREOF |
| CN103524492A (zh) * | 2013-10-23 | 2014-01-22 | 中国药科大学 | 侧链含硝基咪唑基团取代的喹诺酮类化合物、其制备及用途 |
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| EP3209669B1 (en) | 2014-10-21 | 2018-11-07 | Council of Scientific and Industrial Research | Substituted 1,2,3-triazol-1-yl-methyl-2,3-dihydro-2-methyl-6-nitroimidazo[2,1-b]oxazoles as anti-mycobacterial agents and a process for the preparation thereof |
| CN105732659B (zh) * | 2014-12-12 | 2019-07-16 | 上海阳帆医药科技有限公司 | 硝基咪唑类化合物及其制备方法和在制药中的用途 |
| RU2675622C1 (ru) * | 2015-01-29 | 2018-12-21 | Медшайн Дискавери Инк. | Производное нитроимидазола против туберкулеза легких |
| KR102597449B1 (ko) * | 2015-03-27 | 2023-11-03 | 오츠카 세이야쿠 가부시키가이샤 | 1-(4-히드록시페닐)-4-(4-트리플루오로메톡시페녹시)피페리딘 또는 그 염의 제조방법 |
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| CN105859628B (zh) * | 2016-04-19 | 2018-08-07 | 清远职业技术学院 | 一种抗菌化合物对n咪唑苯甲醛缩邻甲苯胺希夫碱及其制备方法和应用 |
| RU2019104974A (ru) * | 2016-07-22 | 2020-08-24 | Медшайн Дискавери Инк. | Кристалл и соль нитроимидазола и способ их изготовления |
| AU2018317804B2 (en) * | 2017-08-16 | 2021-04-22 | BioVersys AG | Novel compounds |
| SG11202011908YA (en) | 2018-06-11 | 2020-12-30 | Otsuka Pharma Co Ltd | Delamanid-containing composition |
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| CN112300192B (zh) * | 2019-08-02 | 2023-08-11 | 南京长澳医药科技有限公司 | 硝基咪唑类化合物及其制备方法和用途 |
| CN110483549B (zh) * | 2019-08-30 | 2021-03-05 | 沈阳药科大学 | 一种硝基咪唑吡喃类抗结核药物的制备方法 |
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| JPWO2024024938A1 (cg-RX-API-DMAC10.html) | 2022-07-29 | 2024-02-01 | ||
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Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5668127A (en) * | 1995-06-26 | 1997-09-16 | Pathogenesis Corporation | Nitroimidazole antibacterial compounds and methods of use thereof |
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2003
- 2003-10-09 TW TW092128165A patent/TWI347946B/zh not_active IP Right Cessation
- 2003-10-09 AR ARP030103673A patent/AR041198A1/es active IP Right Grant
- 2003-10-10 US US10/530,429 patent/US7262212B2/en not_active Expired - Lifetime
- 2003-10-10 MY MYPI20033866A patent/MY139244A/en unknown
- 2003-10-10 UA UAA200504391A patent/UA83200C2/ru unknown
- 2003-10-10 WO PCT/JP2003/013070 patent/WO2004033463A1/ja not_active Ceased
- 2003-10-10 DK DK03754085.3T patent/DK1555267T3/da active
- 2003-10-10 ES ES03754085T patent/ES2400179T3/es not_active Expired - Lifetime
- 2003-10-10 CN CNB2003801017508A patent/CN100366624C/zh not_active Expired - Lifetime
- 2003-10-10 CN CN201110416170.4A patent/CN102532162B/zh not_active Expired - Lifetime
- 2003-10-10 EP EP03754085A patent/EP1555267B1/en not_active Expired - Lifetime
- 2003-10-10 SI SI200332254T patent/SI1555267T1/sl unknown
- 2003-10-10 KR KR1020057004567A patent/KR100723847B1/ko not_active Expired - Lifetime
- 2003-10-10 EP EP12193820.3A patent/EP2570418A3/en not_active Withdrawn
- 2003-10-10 AU AU2003272979A patent/AU2003272979B2/en not_active Expired
- 2003-10-10 PL PL404913A patent/PL404913A1/pl unknown
- 2003-10-10 PL PL376157A patent/PL217919B1/pl unknown
- 2003-10-10 MX MXPA05003674A patent/MXPA05003674A/es active IP Right Grant
- 2003-10-10 BR BRPI0314344A patent/BRPI0314344B8/pt not_active IP Right Cessation
- 2003-10-10 CA CA2497569A patent/CA2497569C/en not_active Expired - Lifetime
- 2003-10-10 PT PT37540853T patent/PT1555267E/pt unknown
- 2003-10-10 CN CNA2007100040367A patent/CN101172981A/zh active Pending
- 2003-10-10 CN CNA2007100040371A patent/CN101255170A/zh active Pending
- 2003-10-10 RU RU2005114017A patent/RU2326121C3/ru active Protection Beyond IP Right Term
- 2003-10-10 PL PL409525A patent/PL409525A1/pl unknown
- 2003-10-14 JP JP2003353868A patent/JP4186065B2/ja not_active Expired - Lifetime
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2005
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2012
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2013
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2014
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- 2014-08-14 HU HUS1400046C patent/HUS1400046I1/hu unknown
- 2014-09-09 BE BE2014C053C patent/BE2014C053I2/fr unknown
- 2014-09-11 FR FR14C0066C patent/FR14C0066I2/fr active Active
- 2014-09-24 CY CY2014041C patent/CY2014041I1/el unknown
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