DE602004004808D1 - Acyloxymethylcarbamat-prodrugs von oxazolidinonen - Google Patents

Acyloxymethylcarbamat-prodrugs von oxazolidinonen

Info

Publication number
DE602004004808D1
DE602004004808D1 DE602004004808T DE602004004808T DE602004004808D1 DE 602004004808 D1 DE602004004808 D1 DE 602004004808D1 DE 602004004808 T DE602004004808 T DE 602004004808T DE 602004004808 T DE602004004808 T DE 602004004808T DE 602004004808 D1 DE602004004808 D1 DE 602004004808D1
Authority
DE
Germany
Prior art keywords
oxazolidinones
carbamate prodrugs
acyloxymethyl
acyloxymethyl carbamate
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE602004004808T
Other languages
English (en)
Other versions
DE602004004808T2 (de
Inventor
Vara Prasad Venkata Na Josyula
Robert C Gadwood
Lisa Marie Thomasco
Ji-Young Kim
Allison Laura Choy
Frederick Earl Boyer Jr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co LLC
Original Assignee
Pharmacia and Upjohn Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn Co LLC filed Critical Pharmacia and Upjohn Co LLC
Publication of DE602004004808D1 publication Critical patent/DE602004004808D1/de
Application granted granted Critical
Publication of DE602004004808T2 publication Critical patent/DE602004004808T2/de
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE602004004808T 2003-09-23 2004-09-13 Acyloxymethylcarbamatoxazolidinone und ihre Präparationen Expired - Fee Related DE602004004808T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US50532903P 2003-09-23 2003-09-23
US505329P 2003-09-23
PCT/IB2004/002983 WO2005028473A1 (en) 2003-09-23 2004-09-13 Acyloxymethylcarbamate prodrugs of oxazolidinones

Publications (2)

Publication Number Publication Date
DE602004004808D1 true DE602004004808D1 (de) 2007-03-29
DE602004004808T2 DE602004004808T2 (de) 2007-12-06

Family

ID=34375571

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004004808T Expired - Fee Related DE602004004808T2 (de) 2003-09-23 2004-09-13 Acyloxymethylcarbamatoxazolidinone und ihre Präparationen

Country Status (10)

Country Link
US (1) US7265140B2 (de)
EP (1) EP1668005B1 (de)
JP (1) JP2007505890A (de)
AT (1) ATE353894T1 (de)
BR (1) BRPI0414694A (de)
CA (1) CA2539848A1 (de)
DE (1) DE602004004808T2 (de)
ES (1) ES2278342T3 (de)
MX (1) MXPA06003124A (de)
WO (1) WO2005028473A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7109239B2 (en) * 2003-08-20 2006-09-19 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
EP1716115B1 (de) 2003-12-30 2013-02-27 XenoPort, Inc. Synthese von acyloxyalkylcarbamat-prodrugs und zwischenprodukten davon
WO2005113520A1 (en) * 2004-05-20 2005-12-01 Pharmacia & Upjohn Company Llc Substituted 2,3,5-trifluorphenyl oxazolidinones for use as antibacterial agents
DE102006007146A1 (de) 2006-02-16 2007-08-23 Bayer Healthcare Ag Aminoacyl-Prodrugs
CN101395158A (zh) 2006-03-07 2009-03-25 百时美施贵宝公司 可作为激酶抑制剂的吡咯并三嗪苯胺前体药物化合物
US7776855B2 (en) * 2006-07-27 2010-08-17 Janssen Pharmaceutica N.V. Antimicrobial oxazolidinone prodrugs
DE102006039589A1 (de) * 2006-08-24 2008-03-06 Bayer Healthcare Ag Aminoacyl-Prodrugs II
DE102007028319A1 (de) * 2007-06-20 2008-12-24 Bayer Healthcare Ag Substituierte Oxazolidinone und ihre Verwendung
DE102007028407A1 (de) * 2007-06-20 2008-12-24 Bayer Healthcare Ag Substituierte Oxazolidinone und ihre Verwendung
DE102007032345A1 (de) 2007-07-11 2009-01-15 Bayer Healthcare Ag Aminoacyl-Prodrugs
DE102007032344A1 (de) 2007-07-11 2009-01-15 Bayer Healthcare Ag Prodrug-Derivate von 1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridin-3-carboxamid
DE102007032347A1 (de) * 2007-07-11 2009-01-15 Bayer Healthcare Ag Aminoacyl-Prodrugs
US20100069441A1 (en) 2008-09-02 2010-03-18 Mikhail Fedorovich Gordeev Antimicrobial indoline compounds for treatment of bacterial infections
CN101798302B (zh) 2009-02-06 2014-11-05 上海盟科药业有限公司 抗生素类药物1-(邻-氟苯基)二氢吡啶酮的合成及生产的方法和工艺
DE102010028362A1 (de) 2010-04-29 2011-11-03 Bayer Schering Pharma Aktiengesellschaft Herstellverfahren
US20120065170A1 (en) 2010-09-10 2012-03-15 Micurx Pharmaceuticals, Inc. Antimicrobial Cyclocarbonyl Heterocyclic Compounds For Treatment Of Bacterial Infections
CA2858787C (en) * 2011-12-15 2017-11-21 Alkermes Pharma Ireland Limited Prodrugs of tertiary amine compounds
US9145411B2 (en) 2012-08-02 2015-09-29 Asana Biosciences, Llc Substituted amino-pyrimidine derivatives
ES2900838T3 (es) 2014-02-21 2022-03-18 Shanghai Micurx Pharmaceutical Co Ltd Profármacos de O-carbonil fosforamidato solubles en agua para administración terapéutica
GB201518950D0 (en) 2015-10-27 2015-12-09 Glaxosmithkline Ip Dev Ltd Compound
ES2965965T3 (es) * 2017-08-25 2024-04-17 Guangzhou Henovcom Bioscience Co Ltd Profármaco de rasagilina de acción prolongada, método de preparación y uso del mismo
US11897914B2 (en) * 2021-11-29 2024-02-13 Hongene Biotech Corporation Synthesis of 2′ protected nucleosides

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE207487T1 (de) 1995-09-01 2001-11-15 Upjohn Co Phenyloxazolidinone mit einer c-c-bindung zu 4-8 gliedrigen heterocyclen
WO2000032599A1 (en) * 1998-11-27 2000-06-08 Pharmacia & Upjohn Company Oxazolidinone antibacterial agents having a thiocarbonyl functionality
JP2003518117A (ja) * 1999-12-21 2003-06-03 ファルマシア・アンド・アップジョン・カンパニー スルホキシミン官能基を有するオキサゾリジノンおよび抗微生物剤としてのその使用
GB0108793D0 (en) * 2001-04-07 2001-05-30 Astrazeneca Ab Chemical compounds
GB0108764D0 (en) * 2001-04-07 2001-05-30 Astrazeneca Ab Chemical compounds
WO2003062231A1 (en) * 2002-01-24 2003-07-31 Pharmacia & Upjohn Company Antimicrobial dihydrothiazine and dihydrothiopyran oxazolidinones
TW200403240A (en) * 2002-06-28 2004-03-01 Upjohn Co Difluorothioacetamides of oxazolidinones as antibacterial agents

Also Published As

Publication number Publication date
MXPA06003124A (es) 2006-06-20
ES2278342T3 (es) 2007-08-01
US7265140B2 (en) 2007-09-04
EP1668005B1 (de) 2007-02-14
ATE353894T1 (de) 2007-03-15
JP2007505890A (ja) 2007-03-15
EP1668005A1 (de) 2006-06-14
BRPI0414694A (pt) 2006-11-28
DE602004004808T2 (de) 2007-12-06
CA2539848A1 (en) 2005-03-31
WO2005028473A1 (en) 2005-03-31
US20050267104A1 (en) 2005-12-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee