DE602004004808D1 - Acyloxymethylcarbamat-prodrugs von oxazolidinonen - Google Patents

Acyloxymethylcarbamat-prodrugs von oxazolidinonen

Info

Publication number
DE602004004808D1
DE602004004808D1 DE602004004808T DE602004004808T DE602004004808D1 DE 602004004808 D1 DE602004004808 D1 DE 602004004808D1 DE 602004004808 T DE602004004808 T DE 602004004808T DE 602004004808 T DE602004004808 T DE 602004004808T DE 602004004808 D1 DE602004004808 D1 DE 602004004808D1
Authority
DE
Germany
Prior art keywords
oxazolidinones
carbamate prodrugs
acyloxymethyl
acyloxymethyl carbamate
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE602004004808T
Other languages
English (en)
Other versions
DE602004004808T2 (de
Inventor
Vara Prasad Venkata Na Josyula
Robert C Gadwood
Lisa Marie Thomasco
Ji-Young Kim
Allison Laura Choy
Frederick Earl Boyer Jr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co LLC
Original Assignee
Pharmacia and Upjohn Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn Co LLC filed Critical Pharmacia and Upjohn Co LLC
Publication of DE602004004808D1 publication Critical patent/DE602004004808D1/de
Application granted granted Critical
Publication of DE602004004808T2 publication Critical patent/DE602004004808T2/de
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE602004004808T 2003-09-23 2004-09-13 Acyloxymethylcarbamatoxazolidinone und ihre Präparationen Expired - Fee Related DE602004004808T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US50532903P 2003-09-23 2003-09-23
US505329P 2003-09-23
PCT/IB2004/002983 WO2005028473A1 (en) 2003-09-23 2004-09-13 Acyloxymethylcarbamate prodrugs of oxazolidinones

Publications (2)

Publication Number Publication Date
DE602004004808D1 true DE602004004808D1 (de) 2007-03-29
DE602004004808T2 DE602004004808T2 (de) 2007-12-06

Family

ID=34375571

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004004808T Expired - Fee Related DE602004004808T2 (de) 2003-09-23 2004-09-13 Acyloxymethylcarbamatoxazolidinone und ihre Präparationen

Country Status (10)

Country Link
US (1) US7265140B2 (de)
EP (1) EP1668005B1 (de)
JP (1) JP2007505890A (de)
AT (1) ATE353894T1 (de)
BR (1) BRPI0414694A (de)
CA (1) CA2539848A1 (de)
DE (1) DE602004004808T2 (de)
ES (1) ES2278342T3 (de)
MX (1) MXPA06003124A (de)
WO (1) WO2005028473A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1660440E (pt) 2003-08-20 2012-05-15 Xenoport Inc Pró-fármacos de aciloxialquilcarbamato, métodos de síntese e utilização
CN102702065A (zh) 2003-12-30 2012-10-03 什诺波特有限公司 酰氧基烃基氨基甲酸酯前药及其中间体的合成
WO2005113520A1 (en) * 2004-05-20 2005-12-01 Pharmacia & Upjohn Company Llc Substituted 2,3,5-trifluorphenyl oxazolidinones for use as antibacterial agents
DE102006007146A1 (de) * 2006-02-16 2007-08-23 Bayer Healthcare Ag Aminoacyl-Prodrugs
BRPI0708644A2 (pt) 2006-03-07 2011-06-07 Bristol-Myers Squibb Company compostos de pró-fármaco de anilina de pirrolotriazina úteis como inibidores de cinase
US7776855B2 (en) * 2006-07-27 2010-08-17 Janssen Pharmaceutica N.V. Antimicrobial oxazolidinone prodrugs
DE102006039589A1 (de) * 2006-08-24 2008-03-06 Bayer Healthcare Ag Aminoacyl-Prodrugs II
DE102007028407A1 (de) * 2007-06-20 2008-12-24 Bayer Healthcare Ag Substituierte Oxazolidinone und ihre Verwendung
DE102007028319A1 (de) * 2007-06-20 2008-12-24 Bayer Healthcare Ag Substituierte Oxazolidinone und ihre Verwendung
DE102007032344A1 (de) 2007-07-11 2009-01-15 Bayer Healthcare Ag Prodrug-Derivate von 1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridin-3-carboxamid
DE102007032347A1 (de) * 2007-07-11 2009-01-15 Bayer Healthcare Ag Aminoacyl-Prodrugs
DE102007032345A1 (de) 2007-07-11 2009-01-15 Bayer Healthcare Ag Aminoacyl-Prodrugs
WO2010047737A2 (en) 2008-09-02 2010-04-29 Micurx Pharmaceuticals, Inc. Antimicrobial indoline compounds for treatment of bacterial infections
CN101798302B (zh) 2009-02-06 2014-11-05 上海盟科药业有限公司 抗生素类药物1-(邻-氟苯基)二氢吡啶酮的合成及生产的方法和工艺
DE102010028362A1 (de) 2010-04-29 2011-11-03 Bayer Schering Pharma Aktiengesellschaft Herstellverfahren
US20120065170A1 (en) 2010-09-10 2012-03-15 Micurx Pharmaceuticals, Inc. Antimicrobial Cyclocarbonyl Heterocyclic Compounds For Treatment Of Bacterial Infections
ES2715562T3 (es) 2011-12-15 2019-06-04 Alkermes Pharma Ireland Ltd Profármacos de compuestos de amina secundaria
US9145411B2 (en) 2012-08-02 2015-09-29 Asana Biosciences, Llc Substituted amino-pyrimidine derivatives
CN105612166B (zh) 2014-02-21 2019-02-19 上海盟科药业有限公司 治疗用水溶性(o-羰基)氨基磷酸酯前药
GB201518950D0 (en) 2015-10-27 2015-12-09 Glaxosmithkline Ip Dev Ltd Compound
EP3674289B9 (de) * 2017-08-25 2023-12-13 Guangzhou Henovcom Bioscience Co., Ltd Langwirkendes rasagilin-prodrug, herstellungsverfahren und verwendung davon
WO2023097308A1 (en) * 2021-11-29 2023-06-01 Hongene Biotech Corporation Synthesis of 2' acetyl-ester protected nucleosides

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0856002T3 (da) 1995-09-01 2002-02-11 Upjohn Co Phenyloxazolidinoner med en C-C-binding til 4-8 ledede heterocycliske ringe
KR20010107987A (ko) * 1998-11-27 2001-12-07 로렌스 티. 마이젠헬더 티오카르보닐 관능기를 갖는 옥사졸리디논 항균제
JP2003518117A (ja) * 1999-12-21 2003-06-03 ファルマシア・アンド・アップジョン・カンパニー スルホキシミン官能基を有するオキサゾリジノンおよび抗微生物剤としてのその使用
GB0108793D0 (en) * 2001-04-07 2001-05-30 Astrazeneca Ab Chemical compounds
GB0108764D0 (en) * 2001-04-07 2001-05-30 Astrazeneca Ab Chemical compounds
ES2288607T3 (es) * 2002-01-24 2008-01-16 PHARMACIA & UPJOHN COMPANY LLC Dihidrotiazina y dihidrotiopirano oxazolidinonas antimicrobianas.
TW200403240A (en) * 2002-06-28 2004-03-01 Upjohn Co Difluorothioacetamides of oxazolidinones as antibacterial agents

Also Published As

Publication number Publication date
DE602004004808T2 (de) 2007-12-06
WO2005028473A1 (en) 2005-03-31
EP1668005B1 (de) 2007-02-14
MXPA06003124A (es) 2006-06-20
US20050267104A1 (en) 2005-12-01
US7265140B2 (en) 2007-09-04
CA2539848A1 (en) 2005-03-31
ES2278342T3 (es) 2007-08-01
JP2007505890A (ja) 2007-03-15
EP1668005A1 (de) 2006-06-14
ATE353894T1 (de) 2007-03-15
BRPI0414694A (pt) 2006-11-28

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee