NO20050210L - Antibakterielle amid-makrocykluser - Google Patents

Antibakterielle amid-makrocykluser

Info

Publication number
NO20050210L
NO20050210L NO20050210A NO20050210A NO20050210L NO 20050210 L NO20050210 L NO 20050210L NO 20050210 A NO20050210 A NO 20050210A NO 20050210 A NO20050210 A NO 20050210A NO 20050210 L NO20050210 L NO 20050210L
Authority
NO
Norway
Prior art keywords
antibacterial amide
amide macrocycles
macrocycles
antibacterial
prophylaxis
Prior art date
Application number
NO20050210A
Other languages
English (en)
Inventor
Hein-Peter Kroll
Rainer Endermann
Siegfried Raddatz
Thomas Lampe
Stefan Weigand
Isabelle Adelt
Dieter Beyer
Nina Brunner
Kerstin Ehlert
Franz Von Nussbaum
Joachim Rudolph
Guido Schiffer
Andreas Schumacher
Yolanda Cancho-Grande
Martin Michels
Original Assignee
Bayer Healthcare Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Ag filed Critical Bayer Healthcare Ag
Publication of NO20050210L publication Critical patent/NO20050210L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D245/00—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms
    • C07D245/04—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Det er beskrevet antibakterielle amid makrosyklyser, fremgangsmåter for fremstilling derav, og anvendelse av disse for fremstilling av farmasøytiske midler for behandling og/eller profilakse av sykdom, spesielt bakterielle infeksjoner.
NO20050210A 2002-06-17 2005-01-13 Antibakterielle amid-makrocykluser NO20050210L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10226921A DE10226921A1 (de) 2002-06-17 2002-06-17 Antibakterielle Amid-Makrozyklen
PCT/EP2003/006078 WO2003106480A1 (de) 2002-06-17 2003-06-10 Antibakterielle amid-makrozyklen

Publications (1)

Publication Number Publication Date
NO20050210L true NO20050210L (no) 2005-03-01

Family

ID=29594575

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20050210A NO20050210L (no) 2002-06-17 2005-01-13 Antibakterielle amid-makrocykluser

Country Status (22)

Country Link
US (1) US20070129288A1 (no)
EP (1) EP1515983B1 (no)
JP (1) JP4437078B2 (no)
KR (1) KR20050010060A (no)
CN (1) CN1326870C (no)
AT (1) ATE354585T1 (no)
AU (1) AU2003245928B2 (no)
BR (1) BR0311948A (no)
CA (1) CA2489454A1 (no)
DE (2) DE10226921A1 (no)
EC (1) ECSP045499A (no)
ES (1) ES2282643T3 (no)
HK (1) HK1083511A1 (no)
HR (1) HRP20050043A2 (no)
MA (1) MA28613B1 (no)
MX (1) MXPA04012438A (no)
NO (1) NO20050210L (no)
PL (1) PL374554A1 (no)
PT (1) PT1515983E (no)
RU (1) RU2005100954A (no)
WO (1) WO2003106480A1 (no)
ZA (1) ZA200410006B (no)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2338789T3 (es) 2003-06-18 2010-05-12 Tranzyme Pharma Inc. Antagonistas macrociclicos del receptor de motilina.
JP2008502583A (ja) * 2003-10-01 2008-01-31 バイエル・ヘルスケア・アクチェンゲゼルシャフト 抗細菌性アミド大員環
DE10358824A1 (de) 2003-12-16 2005-07-21 Bayer Healthcare Ag Antibakterielle Makrozyklen mit substituiertem Biphenyl
DE102004018405A1 (de) * 2004-04-16 2005-11-03 Bayer Healthcare Ag Antibakterielle Amid-Makrozyklen II
DE102004025731A1 (de) * 2004-05-26 2005-12-15 Bayer Healthcare Ag Antibakterielle Amid-Makrozyklen III
DE102005014240A1 (de) * 2004-09-24 2006-03-30 Bayer Healthcare Ag Antibakterielle Amid-Makrozyklen IV
DE102005014247A1 (de) * 2005-03-30 2006-10-05 Aicuris Gmbh & Co. Kg Antibakterielle Amid-Makrozyklen VI
DE102005014245A1 (de) * 2005-03-30 2006-10-05 Aicuris Gmbh & Co. Kg Antibakterielle Amid-Makrozyklen V
DE102005032781A1 (de) * 2005-07-14 2007-01-18 Aicuris Gmbh & Co. Kg Antibakterielle Amid-Markozyklen VII
ES2684821T3 (es) 2005-12-29 2018-10-04 Lexicon Pharmaceuticals, Inc. Derivados de aminoácidos multicíclicos y métodos de su uso
US20110250137A1 (en) * 2008-12-04 2011-10-13 Bayer Schering Pharma Aktiengesellchaft Radioisotope-labeled lysine and ornithine derivatives, their use and processes for their preparation
US10501493B2 (en) 2011-05-27 2019-12-10 Rqx Pharmaceuticals, Inc. Broad spectrum antibiotics
BR112015011697A2 (pt) * 2012-11-21 2017-07-11 Rqx Pharmaceuticals Inc antibióticos macrocíclicos de amplo espectro
JP5437525B1 (ja) * 2012-12-28 2014-03-12 株式会社ナード研究所 チロシン誘導体およびチロシン誘導体の製造方法
US10392422B2 (en) 2014-05-20 2019-08-27 Rqx Pharmaceuticals, Inc. Macrocyclic broad spectrum antibiotics
WO2016057931A1 (en) 2014-10-10 2016-04-14 The Research Foundation For The State University Of New York Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration
WO2017072062A1 (en) 2015-10-27 2017-05-04 F. Hoffmann-La Roche Ag Peptide macrocycles against acinetobacter baumannii
CN109219596B (zh) 2015-11-20 2022-04-19 阿奇克斯制药公司 大环广谱抗生素
EP3388444A1 (en) 2017-04-10 2018-10-17 F. Hoffmann-La Roche AG Anti-bacterial peptide macrocycles and use thereof
US11505573B2 (en) 2018-03-28 2022-11-22 Hoffmann-La Roche Inc. Peptide macrocycles against Acinetobacter baumannii
US11819532B2 (en) 2018-04-23 2023-11-21 Hoffmann-La Roche Inc. Peptide macrocycles against Acinetobacter baumannii
SG11202112920SA (en) 2019-05-28 2021-12-30 Hoffmann La Roche Macrocyclic broad spectrum antibiotics

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3452136A (en) * 1968-04-17 1969-06-24 American Cyanamid Co Antibiotic af283 and production thereof
FR2720066B1 (fr) * 1994-05-20 1996-06-28 Rhone Poulenc Rorer Sa Peptides antagonistes de la neurotensine.
DE10234422A1 (de) * 2002-07-29 2004-02-12 Bayer Ag Antibakterielle Ester-Makrozyklen
JP2008502583A (ja) * 2003-10-01 2008-01-31 バイエル・ヘルスケア・アクチェンゲゼルシャフト 抗細菌性アミド大員環
DE10358824A1 (de) * 2003-12-16 2005-07-21 Bayer Healthcare Ag Antibakterielle Makrozyklen mit substituiertem Biphenyl
DE102005014240A1 (de) * 2004-09-24 2006-03-30 Bayer Healthcare Ag Antibakterielle Amid-Makrozyklen IV

Also Published As

Publication number Publication date
DE50306587D1 (de) 2007-04-05
ES2282643T3 (es) 2007-10-16
MA28613B1 (fr) 2007-06-01
AU2003245928B2 (en) 2009-03-05
RU2005100954A (ru) 2005-07-10
PT1515983E (pt) 2007-03-30
AU2003245928A1 (en) 2003-12-31
CN1326870C (zh) 2007-07-18
ECSP045499A (es) 2005-03-10
US20070129288A1 (en) 2007-06-07
ZA200410006B (en) 2006-02-22
KR20050010060A (ko) 2005-01-26
DE10226921A1 (de) 2003-12-24
JP4437078B2 (ja) 2010-03-24
HRP20050043A2 (hr) 2006-04-30
ATE354585T1 (de) 2007-03-15
HK1083511A1 (en) 2006-07-07
MXPA04012438A (es) 2005-04-19
WO2003106480A1 (de) 2003-12-24
JP2006511446A (ja) 2006-04-06
EP1515983B1 (de) 2007-02-21
PL374554A1 (en) 2005-10-31
CA2489454A1 (en) 2004-12-14
CN1675236A (zh) 2005-09-28
BR0311948A (pt) 2005-03-29
EP1515983A1 (de) 2005-03-23

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