BR0311948A - Macrociclos de amida antibacterianos - Google Patents

Macrociclos de amida antibacterianos

Info

Publication number
BR0311948A
BR0311948A BR0311948-3A BR0311948A BR0311948A BR 0311948 A BR0311948 A BR 0311948A BR 0311948 A BR0311948 A BR 0311948A BR 0311948 A BR0311948 A BR 0311948A
Authority
BR
Brazil
Prior art keywords
antibacterial amide
amide macrocycles
macrocycles
antibacterial
prophylaxis
Prior art date
Application number
BR0311948-3A
Other languages
English (en)
Inventor
Thomas Lampe
Isabelle Adelt
Dieter Beyer
Nina Brunner
Rainer Endermann
Kertin Ehlert
Hein-Peter Kroll
Franz Von Nussbaum
Siegfried Raddatz
Joachim Rudolph
Guido Schiffer
Andreas Schumacher
Yolanda Cancho-Grande
Martin Michels
Stefan Weigand
Original Assignee
Bayer Healthcare Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Ag filed Critical Bayer Healthcare Ag
Publication of BR0311948A publication Critical patent/BR0311948A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D245/00—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms
    • C07D245/04—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

"MACROCICLOS DE AMIDA ANTIBACTERIANOS". A invenção refere-se a macrociclos de amida antibacterianos e processos para a sua preparação, bem como seu emprego para a preparação de medicamentos para o tratamento e/ou profilaxia de doenças, especialmente de infecções bacterianas.
BR0311948-3A 2002-06-17 2003-06-10 Macrociclos de amida antibacterianos BR0311948A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10226921A DE10226921A1 (de) 2002-06-17 2002-06-17 Antibakterielle Amid-Makrozyklen
PCT/EP2003/006078 WO2003106480A1 (de) 2002-06-17 2003-06-10 Antibakterielle amid-makrozyklen

Publications (1)

Publication Number Publication Date
BR0311948A true BR0311948A (pt) 2005-03-29

Family

ID=29594575

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0311948-3A BR0311948A (pt) 2002-06-17 2003-06-10 Macrociclos de amida antibacterianos

Country Status (22)

Country Link
US (1) US20070129288A1 (pt)
EP (1) EP1515983B1 (pt)
JP (1) JP4437078B2 (pt)
KR (1) KR20050010060A (pt)
CN (1) CN1326870C (pt)
AT (1) ATE354585T1 (pt)
AU (1) AU2003245928B2 (pt)
BR (1) BR0311948A (pt)
CA (1) CA2489454A1 (pt)
DE (2) DE10226921A1 (pt)
EC (1) ECSP045499A (pt)
ES (1) ES2282643T3 (pt)
HK (1) HK1083511A1 (pt)
HR (1) HRP20050043A2 (pt)
MA (1) MA28613B1 (pt)
MX (1) MXPA04012438A (pt)
NO (1) NO20050210L (pt)
PL (1) PL374554A1 (pt)
PT (1) PT1515983E (pt)
RU (1) RU2005100954A (pt)
WO (1) WO2003106480A1 (pt)
ZA (1) ZA200410006B (pt)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004111077A1 (en) 2003-06-18 2004-12-23 Tranzyme Pharma Inc. Macrocyclic antagonists of the motilin receptor
JP2008502583A (ja) * 2003-10-01 2008-01-31 バイエル・ヘルスケア・アクチェンゲゼルシャフト 抗細菌性アミド大員環
DE10358824A1 (de) * 2003-12-16 2005-07-21 Bayer Healthcare Ag Antibakterielle Makrozyklen mit substituiertem Biphenyl
DE102004018405A1 (de) * 2004-04-16 2005-11-03 Bayer Healthcare Ag Antibakterielle Amid-Makrozyklen II
DE102004025731A1 (de) * 2004-05-26 2005-12-15 Bayer Healthcare Ag Antibakterielle Amid-Makrozyklen III
DE102005014240A1 (de) 2004-09-24 2006-03-30 Bayer Healthcare Ag Antibakterielle Amid-Makrozyklen IV
DE102005014247A1 (de) * 2005-03-30 2006-10-05 Aicuris Gmbh & Co. Kg Antibakterielle Amid-Makrozyklen VI
DE102005014245A1 (de) * 2005-03-30 2006-10-05 Aicuris Gmbh & Co. Kg Antibakterielle Amid-Makrozyklen V
DE102005032781A1 (de) * 2005-07-14 2007-01-18 Aicuris Gmbh & Co. Kg Antibakterielle Amid-Markozyklen VII
EP2386547B1 (en) 2005-12-29 2018-06-20 Lexicon Pharmaceuticals, Inc. Multicyclic amino acid derivatives and methods of their use
EP2373597A2 (en) * 2008-12-04 2011-10-12 Bayer Pharma Aktiengesellschaft Radioisotope-labeled lysine and ornithine derivatives, their use and processes for their preparation
US10501493B2 (en) 2011-05-27 2019-12-10 Rqx Pharmaceuticals, Inc. Broad spectrum antibiotics
JP6437443B2 (ja) * 2012-11-21 2018-12-12 アールキューエックス ファーマシューティカルズ，インク． 大環状広域抗生物質
JP5437525B1 (ja) * 2012-12-28 2014-03-12 株式会社ナード研究所 チロシン誘導体およびチロシン誘導体の製造方法
CN106661084B (zh) 2014-05-20 2021-08-31 阿奇克斯制药公司 大环广谱抗生素
US10118890B2 (en) 2014-10-10 2018-11-06 The Research Foundation For The State University Of New York Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration
CN108350028B (zh) 2015-10-27 2021-12-07 豪夫迈·罗氏有限公司 对抗鲍曼不动杆菌(Acinetobacter baumannii)的肽大环
JP6873993B2 (ja) 2015-11-20 2021-05-19 アールキューエックス ファーマシューティカルズ，インク． 大環状広域抗生物質
EP3388444A1 (en) 2017-04-10 2018-10-17 F. Hoffmann-La Roche AG Anti-bacterial peptide macrocycles and use thereof
US11505573B2 (en) 2018-03-28 2022-11-22 Hoffmann-La Roche Inc. Peptide macrocycles against Acinetobacter baumannii
US11819532B2 (en) 2018-04-23 2023-11-21 Hoffmann-La Roche Inc. Peptide macrocycles against Acinetobacter baumannii
BR112021024010A2 (pt) 2019-05-28 2022-05-17 Hoffmann La Roche Antibióticos macrocíclicos de amplo espectro

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3452136A (en) * 1968-04-17 1969-06-24 American Cyanamid Co Antibiotic af283 and production thereof
FR2720066B1 (fr) * 1994-05-20 1996-06-28 Rhone Poulenc Rorer Sa Peptides antagonistes de la neurotensine.
DE10234422A1 (de) * 2002-07-29 2004-02-12 Bayer Ag Antibakterielle Ester-Makrozyklen
JP2008502583A (ja) * 2003-10-01 2008-01-31 バイエル・ヘルスケア・アクチェンゲゼルシャフト 抗細菌性アミド大員環
DE10358824A1 (de) * 2003-12-16 2005-07-21 Bayer Healthcare Ag Antibakterielle Makrozyklen mit substituiertem Biphenyl
DE102005014240A1 (de) * 2004-09-24 2006-03-30 Bayer Healthcare Ag Antibakterielle Amid-Makrozyklen IV

Also Published As

Publication number Publication date
US20070129288A1 (en) 2007-06-07
ZA200410006B (en) 2006-02-22
DE50306587D1 (de) 2007-04-05
CA2489454A1 (en) 2004-12-14
WO2003106480A1 (de) 2003-12-24
AU2003245928B2 (en) 2009-03-05
ES2282643T3 (es) 2007-10-16
CN1326870C (zh) 2007-07-18
NO20050210L (no) 2005-03-01
DE10226921A1 (de) 2003-12-24
EP1515983B1 (de) 2007-02-21
ECSP045499A (es) 2005-03-10
KR20050010060A (ko) 2005-01-26
PT1515983E (pt) 2007-03-30
MXPA04012438A (es) 2005-04-19
JP2006511446A (ja) 2006-04-06
EP1515983A1 (de) 2005-03-23
JP4437078B2 (ja) 2010-03-24
PL374554A1 (en) 2005-10-31
AU2003245928A1 (en) 2003-12-31
RU2005100954A (ru) 2005-07-10
MA28613B1 (fr) 2007-06-01
HK1083511A1 (en) 2006-07-07
HRP20050043A2 (hr) 2006-04-30
CN1675236A (zh) 2005-09-28
ATE354585T1 (de) 2007-03-15

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: AICURIS GMBH AND CO. KG (DE)

Free format text: TRANSFERIDO DE: BAYER HEALTHCARE AG

B25G Requested change of headquarter approved

Owner name: AICURIS GMBH AND CO. KG (DE)

Free format text: SEDE ALTERADA CONFORME SOLICITADO NA PETICAO NO 020070107873/RJ DE 03/08/2007.

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 9A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2157 DE 08/05/2012.