PL366584A1 - Związki przydatne jako związki pośrednie - Google Patents

Związki przydatne jako związki pośrednie

Info

Publication number
PL366584A1
PL366584A1 PL02366584A PL36658402A PL366584A1 PL 366584 A1 PL366584 A1 PL 366584A1 PL 02366584 A PL02366584 A PL 02366584A PL 36658402 A PL36658402 A PL 36658402A PL 366584 A1 PL366584 A1 PL 366584A1
Authority
PL
Poland
Prior art keywords
intermediates
compounds useful
compounds
useful
Prior art date
Application number
PL02366584A
Other languages
English (en)
Inventor
David Burns Damon
Robert Wayne Dugger
Robert William Scott
Original Assignee
Pfizer Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of PL366584A1 publication Critical patent/PL366584A1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/62—Compounds containing any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylcarbamates
    • C07C271/64—Y being a hydrogen or a carbon atom, e.g. benzoylcarbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Quinoline Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
PL02366584A 2001-04-30 2002-04-08 Związki przydatne jako związki pośrednie PL366584A1 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28752201P 2001-04-30 2001-04-30

Publications (1)

Publication Number Publication Date
PL366584A1 true PL366584A1 (pl) 2005-02-07

Family

ID=23103272

Family Applications (2)

Application Number Title Priority Date Filing Date
PL02366584A PL366584A1 (pl) 2001-04-30 2002-04-08 Związki przydatne jako związki pośrednie
PL02366700A PL366700A1 (pl) 2001-04-30 2002-04-08 Sposoby wytwarzania inhibitorów CETP

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL02366700A PL366700A1 (pl) 2001-04-30 2002-04-08 Sposoby wytwarzania inhibitorów CETP

Country Status (24)

Country Link
US (3) US6600045B2 (pl)
EP (2) EP1425270B1 (pl)
JP (2) JP3924251B2 (pl)
KR (2) KR100639745B1 (pl)
CN (3) CN100357265C (pl)
AR (3) AR036331A1 (pl)
AT (2) ATE316957T1 (pl)
AU (1) AU2002253448B2 (pl)
BR (2) BR0209291A (pl)
CA (2) CA2445623A1 (pl)
CZ (2) CZ20032898A3 (pl)
DE (2) DE60210265T2 (pl)
DK (2) DK1425270T3 (pl)
ES (2) ES2259080T3 (pl)
HU (2) HU225777B1 (pl)
IL (2) IL157544A0 (pl)
MX (2) MXPA03009935A (pl)
PL (2) PL366584A1 (pl)
PT (1) PT1425270E (pl)
RU (2) RU2259355C2 (pl)
TW (1) TWI250974B (pl)
WO (2) WO2002088069A2 (pl)
YU (2) YU84403A (pl)
ZA (2) ZA200306600B (pl)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6197786B1 (en) * 1998-09-17 2001-03-06 Pfizer Inc 4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines
US20040002615A1 (en) * 2002-06-28 2004-01-01 Allen David Robert Preparation of chiral amino-nitriles
JP2006021999A (ja) * 2002-07-12 2006-01-26 Kaneka Corp 光学活性β−アミノニトリル化合物およびその対掌体アミド化合物の製造方法
US20090181966A1 (en) * 2002-10-04 2009-07-16 Millennium Pharmaceuticals, Inc. PGD2 receptor antagonists for the treatment of inflammatory diseases
US7504508B2 (en) 2002-10-04 2009-03-17 Millennium Pharmaceuticals, Inc. PGD2 receptor antagonists for the treatment of inflammatory diseases
US7211672B2 (en) * 2002-10-04 2007-05-01 Millennium Pharmaceuticals, Inc. PGD2 receptor antagonists for the treatment of inflammatory diseases
JP2006513186A (ja) 2002-12-20 2006-04-20 ファイザー・プロダクツ・インク Ｃｅｔｐ阻害剤およびｈｍｇ−ｃｏａレダクターゼ阻害剤を含む剤形
EP1594843B1 (en) 2003-02-18 2013-05-22 Takasago International Corporation METHOD FOR PRODUCING AN OPTICALLY ACTIVE beta-amino acid derivative
US7223859B2 (en) 2003-03-17 2007-05-29 Pfizer Inc. Method for producing (R)-3-[4-(trifluoromethyl) phenylamino]-pentanoic acid amide derivative
CA2515789A1 (en) * 2003-03-17 2004-09-30 Kaneka Corporation Method for producing(r)-3-[4-(trifluoromethyl)phenylamino]-pentanoic acid amide derivative
KR20060080214A (ko) 2003-09-26 2006-07-07 니뽄 다바코 산교 가부시키가이샤 잔여 리포프로테인 생산 저해 방법
ES2332051T3 (es) * 2003-10-08 2010-01-25 Eli Lilly And Company Compuestos y procedimientos para tratar dislipidemia.
EP1680099B1 (en) * 2003-11-07 2009-04-15 JJ Pharma, Inc. Hdl-boosting combination therapy complexes
AR048528A1 (es) * 2004-04-07 2006-05-03 Millennium Pharm Inc Compuestos derivados de quinolina como antagonistas del receptor de pgd2 para el tratamiento de enfermedades inflamatorias y composiciones farmacéuticas que los contienen.
MXPA06014716A (es) * 2004-06-24 2007-03-12 Lilly Co Eli Compuestos y metodos para el tratamiento de dislipidemia.
DE102004031656A1 (de) * 2004-06-30 2006-01-19 Merck Patent Gmbh Tetrahydrochinoline
WO2006069162A1 (en) * 2004-12-20 2006-06-29 Reddy Us Therapeutics, Inc. Novel heterocyclic compounds and their pharmaceutical compositions
CN101146776A (zh) 2005-02-24 2008-03-19 米伦纽姆医药公司 治疗炎性疾病的pgd2受体拮抗剂
US20100041911A1 (en) * 2005-06-20 2010-02-18 Astrazeneca Ab Process For The Production Of (Alkoxycarbonylamino)alkyl Sulfonates
TW200808731A (en) 2006-03-30 2008-02-16 Tanabe Seiyaku Co A process for preparing tetrahydroquinoline derivatives
DE102006031149A1 (de) * 2006-07-04 2008-01-10 Merck Patent Gmbh Fluortenside
DE102006031151A1 (de) * 2006-07-04 2008-01-10 Merck Patent Gmbh Fluortenside
DE102006032391A1 (de) * 2006-07-04 2008-01-17 Merck Patent Gmbh Fluortenside
DE102006031262A1 (de) * 2006-07-04 2008-01-10 Merck Patent Gmbh Fluortenside
DE102006031143A1 (de) * 2006-07-04 2008-01-24 Merck Patent Gmbh Fluortenside
EP2134169A2 (en) 2007-03-09 2009-12-23 Indigene Pharmaceuticals Inc. Combination of metformin r-(+) lipoate and antihyperlipidemic agents for the treatment of diabetic hyperglycemia and diabetic complications
JP2011256110A (ja) * 2008-09-30 2011-12-22 Takeda Chem Ind Ltd ヘキサヒドロピロロキノリンの製造法
TWI450896B (zh) * 2009-06-30 2014-09-01 Lilly Co Eli 反式－４－〔〔（５ｓ）－５－〔〔〔３，５－雙（三氟甲基）苯基〕甲基〕（２－甲基－２ｈ－四唑－５－基）胺基〕－２，３，４，５－四氫－７，９－二甲基－１ｈ－１－苯并氮呯－１－基〕甲基〕－環己基羧酸
JP5820056B2 (ja) 2011-04-12 2015-11-24 チョン クン ダン ファーマシューティカル コーポレーション Ｃｅｔｐ阻害剤としてのシクロアルケニルアリール誘導体
WO2013008164A2 (en) * 2011-07-08 2013-01-17 Novartis Ag Method of treating atherosclerosis in high triglyceride subjects
RU2627361C2 (ru) 2013-01-31 2017-08-07 Чонг Кун Данг Фармасьютикал Корп. Биарил- или гетероциклические биарилзамещенные производные циклогексена в качестве ингибиторов сетр
CA2926010A1 (en) * 2013-11-11 2015-05-14 Lonza Ltd Method for preparation of cyano compounds of the 13th group with a lewis acid
EA034357B1 (ru) * 2014-08-12 2020-01-30 Дезима Фарма Б.В. Способ получения синтетических промежуточных соединений для получения производных тетрагидрохинолина
CN105294559B (zh) * 2015-06-24 2017-11-14 厦门法茉维特动物药业有限公司 一种医药中间体4‑氨基喹啉类化合物的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW205037B (pl) * 1989-10-06 1993-05-01 Takeda Pharm Industry Co Ltd
WO2000002887A2 (en) 1998-07-10 2000-01-20 Massachusetts Institute Of Technology Ligands for metals and metal-catalyzed processes
US6197786B1 (en) 1998-09-17 2001-03-06 Pfizer Inc 4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines
GT199900147A (es) 1998-09-17 1999-09-06 1, 2, 3, 4- tetrahidroquinolinas 2-sustituidas 4-amino sustituidas.

Also Published As

Publication number Publication date
DE60209004T2 (de) 2006-09-28
ZA200306599B (en) 2004-10-22
KR100591998B1 (ko) 2006-06-22
KR20040030603A (ko) 2004-04-09
RU2259355C2 (ru) 2005-08-27
TWI250974B (en) 2006-03-11
WO2002088069A3 (en) 2003-02-20
DK1425270T3 (da) 2006-07-03
JP3924251B2 (ja) 2007-06-06
YU84303A (sh) 2006-05-25
WO2002088085A2 (en) 2002-11-07
AU2002253448B2 (en) 2007-07-05
KR100639745B1 (ko) 2006-10-30
RU2003131871A (ru) 2005-04-10
US6689897B2 (en) 2004-02-10
ATE321755T1 (de) 2006-04-15
IL157544A0 (en) 2004-03-28
EP1425270A2 (en) 2004-06-09
BR0209291A (pt) 2004-07-13
HUP0304039A2 (hu) 2004-03-29
ES2256461T3 (es) 2006-07-16
WO2002088069A2 (en) 2002-11-07
HUP0304041A2 (hu) 2004-04-28
MXPA03009935A (es) 2004-01-29
HK1062294A1 (en) 2004-10-29
AR035963A1 (es) 2004-07-28
CN1529696A (zh) 2004-09-15
CA2445693A1 (en) 2002-11-07
JP2004531541A (ja) 2004-10-14
CN1505609A (zh) 2004-06-16
CN1297541C (zh) 2007-01-31
ES2259080T3 (es) 2006-09-16
CN100357265C (zh) 2007-12-26
CZ20032898A3 (cs) 2004-07-14
MXPA03009936A (es) 2004-01-29
HUP0304041A3 (en) 2005-08-29
HUP0304039A3 (en) 2005-10-28
HU225777B1 (en) 2007-08-28
EP1383734B1 (en) 2006-02-01
EP1425270B1 (en) 2006-03-29
JP2004527556A (ja) 2004-09-09
DE60210265D1 (de) 2006-05-18
CA2445623A1 (en) 2002-11-07
WO2002088085A3 (en) 2004-03-25
US20030216576A1 (en) 2003-11-20
DK1383734T3 (da) 2006-05-15
KR20040015200A (ko) 2004-02-18
IL157546A0 (en) 2004-03-28
ZA200306600B (en) 2004-08-25
JP3924250B2 (ja) 2007-06-06
WO2002088069A9 (en) 2003-12-04
US6600045B2 (en) 2003-07-29
DE60209004D1 (de) 2006-04-13
CZ20032900A3 (cs) 2004-06-16
US20030073843A1 (en) 2003-04-17
PT1425270E (pt) 2006-07-31
RU2003131870A (ru) 2005-01-27
AR044706A2 (es) 2005-09-21
EP1383734A2 (en) 2004-01-28
US6706881B2 (en) 2004-03-16
YU84403A (sh) 2006-08-17
DE60210265T2 (de) 2006-10-12
CN1680292A (zh) 2005-10-12
US20020177716A1 (en) 2002-11-28
PL366700A1 (pl) 2005-02-07
CN1267411C (zh) 2006-08-02
ATE316957T1 (de) 2006-02-15
AR036331A1 (es) 2004-09-01
BR0209238A (pt) 2004-06-15
RU2265010C2 (ru) 2005-11-27

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Legal Events

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REFS Decisions on refusal to grant patents (taken after the publication of the particulars of the applications)