PL358788A1 - Novel heteroaryl derivatives and the use thereof as pharmaceuticals - Google Patents

Novel heteroaryl derivatives and the use thereof as pharmaceuticals

Info

Publication number
PL358788A1
PL358788A1 PL01358788A PL35878801A PL358788A1 PL 358788 A1 PL358788 A1 PL 358788A1 PL 01358788 A PL01358788 A PL 01358788A PL 35878801 A PL35878801 A PL 35878801A PL 358788 A1 PL358788 A1 PL 358788A1
Authority
PL
Poland
Prior art keywords
pharmaceuticals
heteroaryl derivatives
novel heteroaryl
novel
derivatives
Prior art date
Application number
PL01358788A
Other languages
English (en)
Polish (pl)
Inventor
Peter Emig
Eckhard Gunther
Jurgen Schmidt
Bernd Nickel
Bernhard Kutscher
Original Assignee
Zentaris Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentaris Gmbh filed Critical Zentaris Gmbh
Publication of PL358788A1 publication Critical patent/PL358788A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PL01358788A 2000-07-21 2001-07-18 Novel heteroaryl derivatives and the use thereof as pharmaceuticals PL358788A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10035928A DE10035928A1 (de) 2000-07-21 2000-07-21 Neue Heteroaryl-Derivate und deren Verwendung als Arzneimittel
PCT/EP2001/008261 WO2002008192A1 (de) 2000-07-21 2001-07-18 Neue heteroaryl-derivate und deren verwendung als arzneimittel

Publications (1)

Publication Number Publication Date
PL358788A1 true PL358788A1 (en) 2004-08-23

Family

ID=7649980

Family Applications (1)

Application Number Title Priority Date Filing Date
PL01358788A PL358788A1 (en) 2000-07-21 2001-07-18 Novel heteroaryl derivatives and the use thereof as pharmaceuticals

Country Status (23)

Country Link
US (5) US6890926B2 (enExample)
EP (1) EP1305290A1 (enExample)
JP (1) JP2004504381A (enExample)
KR (1) KR20030022287A (enExample)
CN (1) CN1443171A (enExample)
AR (1) AR033678A1 (enExample)
AU (2) AU2001279757B2 (enExample)
BG (1) BG107508A (enExample)
BR (1) BR0112589A (enExample)
CA (1) CA2353369A1 (enExample)
CZ (1) CZ2003415A3 (enExample)
DE (1) DE10035928A1 (enExample)
HU (1) HUP0300838A2 (enExample)
IL (1) IL153361A0 (enExample)
MX (1) MXPA02012565A (enExample)
NO (1) NO20030298L (enExample)
NZ (1) NZ524154A (enExample)
PL (1) PL358788A1 (enExample)
RU (1) RU2265602C2 (enExample)
SK (1) SK1842003A3 (enExample)
TW (1) TWI228505B (enExample)
WO (1) WO2002008192A1 (enExample)
ZA (1) ZA200210180B (enExample)

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MXPA04012959A (es) * 2002-06-29 2005-05-16 Zentaris Gmbh Arilcarbonilpiperacinas y heteroarilcarbonilpiperacinas y su uso para tratamiento de enfermedades de tumor benigno y maligno.
EP1521748A1 (de) * 2002-07-17 2005-04-13 Zentaris GmbH Neue anthracen-derivate und deren verwendung als arzneimittel
BRPI0407088A (pt) * 2003-01-28 2006-01-24 Aventis Pharma Sa Produtos n-aril-heteroaromáticos, composições contendo os mesmos e seu uso
AR044586A1 (es) * 2003-06-04 2005-09-21 Aventis Pharma Sa Productos aril - heteroaromaticos, composiciones que los contienen y su utilizacion
FR2855825B1 (fr) * 2003-06-04 2008-08-22 Aventis Pharma Sa Produits aryl-heteroaromatiques, compositions les contenant et utilisation
WO2005068445A2 (en) * 2004-01-08 2005-07-28 Syngenta Participations Ag Pesticidal heterocyclic dihaloallyl compounds
DE102004003428A1 (de) * 2004-01-23 2005-08-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue langwirksame Beta-2-Agonisten, und deren Verwendung als Arzneimittel
FR2871157A1 (fr) * 2004-06-04 2005-12-09 Aventis Pharma Sa Produits biaryl aromatiques, compositions les contenant et utilisation
CN1830964B (zh) * 2005-03-11 2011-06-15 中国科学院上海药物研究所 4-取代苯氨基-3-硝基喹啉类化合物及其制备方法和用途
US8440692B2 (en) * 2006-12-07 2013-05-14 China Medical University Hydrophilic derivatives of 2-aryl-4-quinolones as anticancer agents
EP2125750B1 (en) * 2007-02-26 2014-05-21 Vitae Pharmaceuticals, Inc. Cyclic urea and carbamate inhibitors of 11beta-hydroxysteroid dehydrogenase 1
JP5470557B2 (ja) * 2007-07-26 2014-04-16 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１型の阻害剤の合成
AR069207A1 (es) * 2007-11-07 2010-01-06 Vitae Pharmaceuticals Inc Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1
US8440658B2 (en) 2007-12-11 2013-05-14 Vitae Pharmaceuticals, Inc. Cyclic urea inhibitors of 11β-hydroxysteroid dehydrogenase 1
TW200934490A (en) * 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
JP5490020B2 (ja) * 2008-01-24 2014-05-14 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状カルバゼート及びセミカルバジドインヒビター
WO2009102428A2 (en) * 2008-02-11 2009-08-20 Vitae Pharmaceuticals, Inc. 1,3-OXAZEPAN-2-ONE AND 1,3-DIAZEPAN-2-ONE INHIBITORS OF 11β -HYDROXYSTEROID DEHYDROGENASE 1
CA2715290A1 (en) * 2008-02-15 2009-08-20 Vitae Pharmaceuticals, Inc. Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
EP2274287B1 (en) * 2008-03-18 2016-03-09 Vitae Pharmaceuticals, Inc. Inhibitors of 11beta-hydroxysteroid dehydrogenase type 1
US8592410B2 (en) 2008-05-01 2013-11-26 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11BETA-hydroxysteroid dehydrogenase 1
TW201004945A (en) 2008-05-01 2010-02-01 Vitae Pharmaceuticals Inc Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
EP2291373B1 (en) * 2008-05-01 2013-09-11 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
JP5301563B2 (ja) * 2008-05-01 2013-09-25 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状インヒビター
CA2729998A1 (en) 2008-07-25 2010-01-28 Boehringer Ingelheim International Gmbh Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
WO2010127237A2 (en) * 2009-04-30 2010-11-04 Boehringer Ingelheim International Gmbh Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
JP5379160B2 (ja) 2008-07-25 2013-12-25 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状インヒビター
US8637505B2 (en) 2009-02-04 2014-01-28 Boehringer Ingelheim International Gmbh Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
TW201039034A (en) * 2009-04-27 2010-11-01 Chunghwa Picture Tubes Ltd Pixel structure and the method of forming the same
MA33216B1 (fr) 2009-04-30 2012-04-02 Boehringer Ingelheim Int Inhibiteurs cycliques de la 11béta-hydroxysteroïde déshydrogénase 1
EP2440537A1 (en) 2009-06-11 2012-04-18 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure
EP2448928B1 (en) 2009-07-01 2014-08-13 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
EP2582698B1 (en) 2010-06-16 2016-09-14 Vitae Pharmaceuticals, Inc. Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use
EP2585444B1 (en) 2010-06-25 2014-10-22 Boehringer Ingelheim International GmbH Azaspirohexanones as inhibitors of 11-beta-hsd1 for the treatment of metabolic disorders
WO2012059416A1 (en) 2010-11-02 2012-05-10 Boehringer Ingelheim International Gmbh Pharmaceutical combinations for the treatment of metabolic disorders
US11084807B2 (en) 2016-08-18 2021-08-10 Vidac Pharama Ltd. Piperazine derivatives, pharmaceutical compositions and methods of use thereof

Family Cites Families (16)

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Publication number Priority date Publication date Assignee Title
GR79603B (enExample) * 1982-07-24 1984-10-31 Pfizer
FR2538388B1 (fr) 1982-12-24 1985-06-21 Pharmuka Lab Nouveaux derives de naphtalene- ou azanaphtalenecarboxamide, leurs procedes de preparation et leur utilisation comme medicaments
EP0318235A3 (en) * 1987-11-25 1991-05-02 Takeda Chemical Industries, Ltd. Paf antagonist, 1,4-disubstituted piperazine compounds and production thereof
US5432175A (en) 1990-10-10 1995-07-11 Schering Corporation Pyridine and pyridine N-oxide derivatives of diaryl methyl piperidines or piperazines, and compositions and methods of use thereof
US5736539A (en) * 1993-06-18 1998-04-07 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
ATE209192T1 (de) 1996-05-20 2001-12-15 Teijin Ltd Cyclischer diarylalkyl diaminederivate als antogoniste von chemokinerezeptoren
WO1997044036A1 (en) * 1996-05-20 1997-11-27 Darwin Discovery Limited Quinoline carboxamides as tnf inhibitors and as pde-iv inhibitors
TR199800371T1 (xx) * 1996-06-29 1998-06-22 Samjin Pharmaceutical Co.Ltd. Piperazine t�revleri ve bunlar�n haz�rlanma prosesi.
US5861395A (en) 1996-09-13 1999-01-19 Schering Corporation Compounds useful for inhibition of farnesyl proteins transferase
FR2753706B1 (fr) 1996-09-20 1998-10-30 Nouvelles amines cycliques n-substituees, leur procede de preparation et les compositions pharmaceutiques les renfermant
WO1999002520A1 (en) * 1997-07-07 1999-01-21 Kowa Co., Ltd. Diamine derivatives and pharmaceutical containing the same
DE19743435A1 (de) 1997-10-01 1999-04-08 Merck Patent Gmbh Benzamidinderivate
WO2000012074A2 (en) * 1998-08-28 2000-03-09 Scios Inc. Use of piperidines and/or piperazines as inhibitors of p38-alpha kinase
CA2362495A1 (en) 1999-03-03 2000-09-08 Theresa M. Williams Inhibitors of prenyl-protein transferases
DE10035927A1 (de) * 2000-07-21 2002-03-07 Asta Medica Ag Neue Heteroaryl-Derivate und deren Verwendung als Arzneimittel
US6610274B1 (en) * 2000-12-22 2003-08-26 Wallace J. Gardner Anti-inflammatory composition comprising tetracycline

Also Published As

Publication number Publication date
US20040132747A1 (en) 2004-07-08
NO20030298D0 (no) 2003-01-20
NO20030298L (no) 2003-01-20
US7056912B2 (en) 2006-06-06
US6936615B2 (en) 2005-08-30
US20040097530A1 (en) 2004-05-20
US7026310B2 (en) 2006-04-11
CZ2003415A3 (cs) 2004-05-12
AU7975701A (en) 2002-02-05
EP1305290A1 (de) 2003-05-02
US6890926B2 (en) 2005-05-10
CN1443171A (zh) 2003-09-17
BR0112589A (pt) 2003-05-20
JP2004504381A (ja) 2004-02-12
US20050176744A1 (en) 2005-08-11
AU2001279757B2 (en) 2005-05-26
WO2002008192A1 (de) 2002-01-31
AR033678A1 (es) 2004-01-07
TWI228505B (en) 2005-03-01
HUP0300838A2 (hu) 2003-07-28
IL153361A0 (en) 2003-07-06
BG107508A (bg) 2003-09-30
US20050245523A1 (en) 2005-11-03
NZ524154A (en) 2005-02-25
ZA200210180B (en) 2003-02-12
MXPA02012565A (es) 2003-09-22
DE10035928A1 (de) 2002-03-07
SK1842003A3 (en) 2004-10-05
RU2265602C2 (ru) 2005-12-10
KR20030022287A (ko) 2003-03-15
CA2353369A1 (en) 2002-01-21
US20020103214A1 (en) 2002-08-01

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Legal Events

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REFS Decisions on refusal to grant patents (taken after the publication of the particulars of the applications)