JP2004504381A - 新規のヘテロアリール誘導体および医薬としてのその使用 - Google Patents

新規のヘテロアリール誘導体および医薬としてのその使用 Download PDF

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Publication number
JP2004504381A
JP2004504381A JP2002514099A JP2002514099A JP2004504381A JP 2004504381 A JP2004504381 A JP 2004504381A JP 2002514099 A JP2002514099 A JP 2002514099A JP 2002514099 A JP2002514099 A JP 2002514099A JP 2004504381 A JP2004504381 A JP 2004504381A
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JP
Japan
Prior art keywords
alkyl
alkylamino
aryl
substituted
unsubstituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2002514099A
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English (en)
Japanese (ja)
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JP2004504381A5 (enExample
Inventor
ペーター　エーミヒ
エックハルト　ギュンター
ユルゲン　シュミット
ベルント　ニッケル
ベルンハルト　クッチャー
Original Assignee
ツェンタリス　アクチエンゲゼルシャフト
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by ツェンタリス　アクチエンゲゼルシャフト filed Critical ツェンタリス　アクチエンゲゼルシャフト
Publication of JP2004504381A publication Critical patent/JP2004504381A/ja
Publication of JP2004504381A5 publication Critical patent/JP2004504381A5/ja
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2002514099A 2000-07-21 2001-07-18 新規のヘテロアリール誘導体および医薬としてのその使用 Pending JP2004504381A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10035928A DE10035928A1 (de) 2000-07-21 2000-07-21 Neue Heteroaryl-Derivate und deren Verwendung als Arzneimittel
PCT/EP2001/008261 WO2002008192A1 (de) 2000-07-21 2001-07-18 Neue heteroaryl-derivate und deren verwendung als arzneimittel

Publications (2)

Publication Number Publication Date
JP2004504381A true JP2004504381A (ja) 2004-02-12
JP2004504381A5 JP2004504381A5 (enExample) 2005-02-17

Family

ID=7649980

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002514099A Pending JP2004504381A (ja) 2000-07-21 2001-07-18 新規のヘテロアリール誘導体および医薬としてのその使用

Country Status (23)

Country Link
US (5) US6890926B2 (enExample)
EP (1) EP1305290A1 (enExample)
JP (1) JP2004504381A (enExample)
KR (1) KR20030022287A (enExample)
CN (1) CN1443171A (enExample)
AR (1) AR033678A1 (enExample)
AU (2) AU2001279757B2 (enExample)
BG (1) BG107508A (enExample)
BR (1) BR0112589A (enExample)
CA (1) CA2353369A1 (enExample)
CZ (1) CZ2003415A3 (enExample)
DE (1) DE10035928A1 (enExample)
HU (1) HUP0300838A2 (enExample)
IL (1) IL153361A0 (enExample)
MX (1) MXPA02012565A (enExample)
NO (1) NO20030298D0 (enExample)
NZ (1) NZ524154A (enExample)
PL (1) PL358788A1 (enExample)
RU (1) RU2265602C2 (enExample)
SK (1) SK1842003A3 (enExample)
TW (1) TWI228505B (enExample)
WO (1) WO2002008192A1 (enExample)
ZA (1) ZA200210180B (enExample)

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JP2019524789A (ja) * 2016-08-18 2019-09-05 ヴィダック ファーマ リミテッド ピペラジン誘導体、医薬組成物、及びその使用方法

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AU2003232785A1 (en) * 2002-07-17 2004-02-02 Zentaris Gmbh Novel anthracene derivatives and the use thereof as a medicament
WO2004078732A1 (fr) * 2003-01-28 2004-09-16 Aventis Pharma S.A. Produits n-aryl-heteroaromatiques, compositions les contenant et utilisation
FR2855825B1 (fr) * 2003-06-04 2008-08-22 Aventis Pharma Sa Produits aryl-heteroaromatiques, compositions les contenant et utilisation
PE20050226A1 (es) * 2003-06-04 2005-05-18 Aventis Pharma Sa Productos aril-heteroaromaticos y composiciones que los contienen
US7723362B2 (en) * 2004-01-08 2010-05-25 Syngenta Crop Protection, Inc. Pesticidal heterocyclic dihaloallyl compounds
DE102004003428A1 (de) * 2004-01-23 2005-08-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue langwirksame Beta-2-Agonisten, und deren Verwendung als Arzneimittel
FR2871157A1 (fr) * 2004-06-04 2005-12-09 Aventis Pharma Sa Produits biaryl aromatiques, compositions les contenant et utilisation
CN1830964B (zh) * 2005-03-11 2011-06-15 中国科学院上海药物研究所 4-取代苯氨基-3-硝基喹啉类化合物及其制备方法和用途
CN101583280B (zh) * 2006-12-07 2013-04-24 中国医药大学 作为抗癌剂的2-芳基-4-喹诺酮的亲水性衍生物
EP2125750B1 (en) * 2007-02-26 2014-05-21 Vitae Pharmaceuticals, Inc. Cyclic urea and carbamate inhibitors of 11beta-hydroxysteroid dehydrogenase 1
WO2009017671A1 (en) * 2007-07-26 2009-02-05 Vitae Pharmaceuticals, Inc. Synthesis of inhibitors of 11beta-hydroxysteroid dehydrogenase type 1
AR069207A1 (es) * 2007-11-07 2010-01-06 Vitae Pharmaceuticals Inc Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1
US8440658B2 (en) 2007-12-11 2013-05-14 Vitae Pharmaceuticals, Inc. Cyclic urea inhibitors of 11β-hydroxysteroid dehydrogenase 1
TW200934490A (en) * 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
US8592409B2 (en) * 2008-01-24 2013-11-26 Vitae Pharmaceuticals, Inc. Cyclic carbazate and semicarbazide inhibitors of 11β-hydroxysteroid dehydrogenase 1
JP5734666B2 (ja) * 2008-02-11 2015-06-17 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の１，３−オキサアゼパン−２−オン及び１，３−ジアゼパン−２−オン阻害剤
CA2715290A1 (en) * 2008-02-15 2009-08-20 Vitae Pharmaceuticals, Inc. Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
WO2009117109A1 (en) * 2008-03-18 2009-09-24 Vitae Pharmaceuticals, Inc. Inhibitors of 11beta-hydroxysteroid dehydrogenase type 1
JP5301563B2 (ja) * 2008-05-01 2013-09-25 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状インヒビター
CA2723034A1 (en) 2008-05-01 2009-11-05 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
EP2291371B1 (en) 2008-05-01 2015-06-10 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
EP2291373B1 (en) * 2008-05-01 2013-09-11 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
CA2729998A1 (en) 2008-07-25 2010-01-28 Boehringer Ingelheim International Gmbh Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
PL2324018T3 (pl) 2008-07-25 2014-02-28 Boehringer Ingelheim Int Cykliczne inhibitory dehydrogenazy 11 beta-hydroksysteroidowej typu 1
JP5679997B2 (ja) 2009-02-04 2015-03-04 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状阻害剤
TW201039034A (en) * 2009-04-27 2010-11-01 Chunghwa Picture Tubes Ltd Pixel structure and the method of forming the same
KR20120061771A (ko) * 2009-04-30 2012-06-13 비타이 파마슈티컬즈, 인코포레이티드 11베타-하이드록시스테로이드 탈수소효소 1의 고리형 억제제
MA33216B1 (fr) 2009-04-30 2012-04-02 Boehringer Ingelheim Int Inhibiteurs cycliques de la 11béta-hydroxysteroïde déshydrogénase 1
WO2011011123A1 (en) 2009-06-11 2011-01-27 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure
EP2448928B1 (en) 2009-07-01 2014-08-13 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US8933072B2 (en) 2010-06-16 2015-01-13 Vitae Pharmaceuticals, Inc. Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use
EP2585444B1 (en) 2010-06-25 2014-10-22 Boehringer Ingelheim International GmbH Azaspirohexanones as inhibitors of 11-beta-hsd1 for the treatment of metabolic disorders
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FR2538388B1 (fr) 1982-12-24 1985-06-21 Pharmuka Lab Nouveaux derives de naphtalene- ou azanaphtalenecarboxamide, leurs procedes de preparation et leur utilisation comme medicaments
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WO1992006971A1 (en) * 1990-10-10 1992-04-30 Schering Corporation Pyridine and pyridine n-oxide derivatives of diaryl methyl piperidines or piperazines, and compositions and methods of use thereof
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019524789A (ja) * 2016-08-18 2019-09-05 ヴィダック ファーマ リミテッド ピペラジン誘導体、医薬組成物、及びその使用方法

Also Published As

Publication number Publication date
NO20030298L (no) 2003-01-20
AU7975701A (en) 2002-02-05
EP1305290A1 (de) 2003-05-02
US7026310B2 (en) 2006-04-11
US20020103214A1 (en) 2002-08-01
US20050245523A1 (en) 2005-11-03
US20040097530A1 (en) 2004-05-20
US7056912B2 (en) 2006-06-06
NO20030298D0 (no) 2003-01-20
AR033678A1 (es) 2004-01-07
US20040132747A1 (en) 2004-07-08
PL358788A1 (en) 2004-08-23
SK1842003A3 (en) 2004-10-05
US6890926B2 (en) 2005-05-10
TWI228505B (en) 2005-03-01
NZ524154A (en) 2005-02-25
CA2353369A1 (en) 2002-01-21
RU2265602C2 (ru) 2005-12-10
WO2002008192A1 (de) 2002-01-31
US20050176744A1 (en) 2005-08-11
CN1443171A (zh) 2003-09-17
MXPA02012565A (es) 2003-09-22
KR20030022287A (ko) 2003-03-15
BR0112589A (pt) 2003-05-20
IL153361A0 (en) 2003-07-06
CZ2003415A3 (cs) 2004-05-12
US6936615B2 (en) 2005-08-30
HUP0300838A2 (hu) 2003-07-28
BG107508A (bg) 2003-09-30
ZA200210180B (en) 2003-02-12
AU2001279757B2 (en) 2005-05-26
DE10035928A1 (de) 2002-03-07

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