PL3154959T3 - 1-((3S,4R)-4-(3-Fluorofenylo)-1-(2-metoksyetylo)pirolidyn-3-ylo)-3-(4-metylo-3- (2- metylopirymidyn-5-ylo)-1-fenylo-1H-pirazol-5-ilo)-mocznik jako inhibitor kinazy TrkA - Google Patents

1-((3S,4R)-4-(3-Fluorofenylo)-1-(2-metoksyetylo)pirolidyn-3-ylo)-3-(4-metylo-3- (2- metylopirymidyn-5-ylo)-1-fenylo-1H-pirazol-5-ilo)-mocznik jako inhibitor kinazy TrkA

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Publication number
PL3154959T3
PL3154959T3 PL15726455T PL15726455T PL3154959T3 PL 3154959 T3 PL3154959 T3 PL 3154959T3 PL 15726455 T PL15726455 T PL 15726455T PL 15726455 T PL15726455 T PL 15726455T PL 3154959 T3 PL3154959 T3 PL 3154959T3
Authority
PL
Poland
Prior art keywords
methylpyrimidin
pyrazol
pyrrolidin
methoxyethyl
fluorophenyl
Prior art date
Application number
PL15726455T
Other languages
English (en)
Polish (pl)
Inventor
Shelley Allen
Steven W. Andrews
Brian BAER
Zackary CRANE
Weidong Liu
Daniel John Watson
Original Assignee
Array Biopharma, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Array Biopharma, Inc. filed Critical Array Biopharma, Inc.
Publication of PL3154959T3 publication Critical patent/PL3154959T3/pl

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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PL15726455T 2014-05-15 2015-05-14 1-((3S,4R)-4-(3-Fluorofenylo)-1-(2-metoksyetylo)pirolidyn-3-ylo)-3-(4-metylo-3- (2- metylopirymidyn-5-ylo)-1-fenylo-1H-pirazol-5-ilo)-mocznik jako inhibitor kinazy TrkA PL3154959T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461993426P 2014-05-15 2014-05-15
PCT/US2015/030795 WO2015175788A1 (en) 2014-05-15 2015-05-14 1-((3s,4r)-4-(3-fluorophenyl)-1-(2-methoxyethyl)pyrrolidin-3-yl)-3-(4-methyl-3-(2-methylpyrimidin-5-yl)-1-phenyl-1h-pyrazol-5-yl)urea as a trka kinase inhibitor
EP15726455.7A EP3154959B1 (en) 2014-05-15 2015-05-14 1-((3s,4r)-4-(3-fluorophenyl)-1-(2-methoxyethyl)pyrrolidin-3-yl)-3-(4-methyl-3-(2-methylpyrimidin-5-yl)-1-phenyl-1h-pyrazol-5-yl)urea as a trka kinase inhibitor

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PL3154959T3 true PL3154959T3 (pl) 2019-12-31

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PL15726455T PL3154959T3 (pl) 2014-05-15 2015-05-14 1-((3S,4R)-4-(3-Fluorofenylo)-1-(2-metoksyetylo)pirolidyn-3-ylo)-3-(4-metylo-3- (2- metylopirymidyn-5-ylo)-1-fenylo-1H-pirazol-5-ilo)-mocznik jako inhibitor kinazy TrkA

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JP2017518981A (ja) 2017-07-13
KR102321883B1 (ko) 2021-11-03
CN106459013A (zh) 2017-02-22
PH12016502242B1 (en) 2017-01-09
KR20190083377A (ko) 2019-07-11
CY1122075T1 (el) 2020-11-25
AU2015259075A1 (en) 2017-01-12
AU2019201400A1 (en) 2019-03-21
DK3154959T3 (da) 2019-09-30
RU2016149233A3 (enExample) 2018-12-03
SG11201609550PA (en) 2016-12-29
PH12016502242A1 (en) 2017-01-09
CN109970614A (zh) 2019-07-05
IL248924A0 (en) 2017-01-31
EP3564236A1 (en) 2019-11-06
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RU2719489C2 (ru) 2020-04-17
EP3154959A1 (en) 2017-04-19
JP6499672B2 (ja) 2019-04-10
CN106459013B (zh) 2019-10-25
BR112016026672A8 (pt) 2021-07-20
JP2019085427A (ja) 2019-06-06
EP3154959B1 (en) 2019-07-10
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US10835533B2 (en) 2020-11-17
IL248924B (en) 2020-01-30

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