PL2300497T3 - Sposób oczyszczania czynnika krzepnięcia VIII - Google Patents

Sposób oczyszczania czynnika krzepnięcia VIII

Info

Publication number
PL2300497T3
PL2300497T3 PL09769279T PL09769279T PL2300497T3 PL 2300497 T3 PL2300497 T3 PL 2300497T3 PL 09769279 T PL09769279 T PL 09769279T PL 09769279 T PL09769279 T PL 09769279T PL 2300497 T3 PL2300497 T3 PL 2300497T3
Authority
PL
Poland
Prior art keywords
factor viii
coagulation factor
purifying coagulation
purifying
viii
Prior art date
Application number
PL09769279T
Other languages
English (en)
Polish (pl)
Inventor
Carin Borgvall
Ulrika Ericsson
Gustav Gilljam
Mats Jernberg
Stefan Winge
Original Assignee
Octapharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40076764&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2300497(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Octapharma Ag filed Critical Octapharma Ag
Publication of PL2300497T3 publication Critical patent/PL2300497T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3847—Multimodal interactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/647—Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
PL09769279T 2008-06-24 2009-06-24 Sposób oczyszczania czynnika krzepnięcia VIII PL2300497T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US12940208P 2008-06-24 2008-06-24
EP08158893 2008-06-24
EP09769279A EP2300497B1 (en) 2008-06-24 2009-06-24 A process of purifying coagulation factor viii
PCT/EP2009/057883 WO2009156430A1 (en) 2008-06-24 2009-06-24 A process of purifying coagulation factor viii

Publications (1)

Publication Number Publication Date
PL2300497T3 true PL2300497T3 (pl) 2013-02-28

Family

ID=40076764

Family Applications (1)

Application Number Title Priority Date Filing Date
PL09769279T PL2300497T3 (pl) 2008-06-24 2009-06-24 Sposób oczyszczania czynnika krzepnięcia VIII

Country Status (19)

Country Link
US (1) US8329871B2 (cg-RX-API-DMAC7.html)
EP (2) EP2300497B1 (cg-RX-API-DMAC7.html)
JP (1) JP5619738B2 (cg-RX-API-DMAC7.html)
KR (3) KR20160104740A (cg-RX-API-DMAC7.html)
CN (1) CN102066417B (cg-RX-API-DMAC7.html)
AU (1) AU2009264282B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0914695B1 (cg-RX-API-DMAC7.html)
CA (1) CA2728047C (cg-RX-API-DMAC7.html)
DK (2) DK2537862T3 (cg-RX-API-DMAC7.html)
ES (2) ES2391613T3 (cg-RX-API-DMAC7.html)
IL (3) IL209758A (cg-RX-API-DMAC7.html)
MX (1) MX2010013908A (cg-RX-API-DMAC7.html)
PL (1) PL2300497T3 (cg-RX-API-DMAC7.html)
PT (1) PT2300497E (cg-RX-API-DMAC7.html)
RU (2) RU2567811C2 (cg-RX-API-DMAC7.html)
SI (1) SI2300497T1 (cg-RX-API-DMAC7.html)
UA (1) UA100901C2 (cg-RX-API-DMAC7.html)
WO (1) WO2009156430A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201009162B (cg-RX-API-DMAC7.html)

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EP2027875A1 (en) * 2007-08-23 2009-02-25 Octapharma AG A Process for Isolation and Purification of a Target Protein free of Prion Protein (PrPSC)
RU2011110459A (ru) 2008-08-21 2012-09-27 Октафарма АГ (CH) Рекомбинантно полученный человеческий фактор viii и ix
CN107050437A (zh) * 2008-09-03 2017-08-18 奥克塔法马股份有限公司 重组制备的因子viii的新型保护组合物
US20110166332A1 (en) * 2008-09-12 2011-07-07 Ge Healthcare Bio-Sciences Ab Enhanced antibody aggregate removal with capto adhere in the presence of protein-excluded zwitterions
DK3040346T3 (en) * 2010-03-30 2018-06-14 Octapharma Ag PROCEDURE FOR CLEANING THE GRANULOCYT COLONY STIMULATING FACTOR, G-CSF
ES2740825T3 (es) * 2010-03-30 2020-02-06 Octapharma Ag Un procedimiento de purificación de proteínas dependientes de vitamina K
KR102049254B1 (ko) 2010-04-20 2019-11-28 옥타파마 아게 약학 단백질을 위한 신규한 안정화제
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EP2964663A2 (en) * 2013-03-08 2016-01-13 Genzyme Corporation Continuous purification of therapeutic proteins
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CA2910770C (en) 2013-07-12 2018-02-27 Merck Patent Gmbh Removal of fragments from a sample containing a target protein using activated carbon
EP3875106A1 (en) * 2013-08-08 2021-09-08 Bioverativ Therapeutics Inc. Purification of chimeric fviii molecules
AU2014326257B2 (en) 2013-09-24 2017-08-10 Pfizer Inc. Compositions comprising heterogeneous populations of recombinant human clotting factor Xa proteins
TWI709569B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析樹脂及其用於製造方法的用途
TWI709570B (zh) * 2014-01-17 2020-11-11 美商健臻公司 無菌層析法及製法
CA2934705C (en) * 2014-01-20 2020-03-31 Octapharma Ag A process for manufacturing factor viii having an improved ratio of fviii:c/fviii:ag
DK3097188T3 (en) * 2014-01-24 2018-10-08 Am Pharma Bv DOWNSTREAM PREPARATION OF AN ALKALIC PHOSPHATASE
JP6609561B2 (ja) * 2014-02-04 2019-11-20 バイオジェン・エムエイ・インコーポレイテッド 翻訳後修飾を濃縮するための、フロースルーモードにおける陽イオン交換クロマトグラフィーの使用
CN104861060A (zh) * 2014-02-21 2015-08-26 神州细胞工程有限公司 一种纯化凝血因子viii的方法
EP3149023A4 (en) 2014-05-29 2017-11-22 Agency for Science, Technology and Research Protein Extraction Methods
US10626164B2 (en) * 2014-07-25 2020-04-21 Csl Limited Purification of VWF
GB201506113D0 (en) 2015-04-10 2015-05-27 Ge Healthcare Bio Sciences Ab Method for chromatography
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WO2016207328A1 (en) * 2015-06-24 2016-12-29 Glycotope Gmbh PROCESS FOR THE PURIFICATION OF γ-CARBOXYLATED POLYPEPTIDES
EP3205665A1 (en) 2016-02-11 2017-08-16 Octapharma AG Method of separating factor viii from blood products
GB201617240D0 (en) * 2016-10-11 2016-11-23 Profactor Pharma Ltd Purification process
US11299533B2 (en) 2017-06-23 2022-04-12 Takeda Pharmaceutical Company Limited Purification of factor VIII subspecies
CN107226859B (zh) * 2017-08-10 2020-11-24 博雅生物制药集团股份有限公司 一种人凝血因子ⅷ的制备方法
KR102286260B1 (ko) 2017-08-31 2021-08-05 주식회사 녹십자 설파타아제 단백질을 정제하는 방법
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Also Published As

Publication number Publication date
RU2567811C2 (ru) 2015-11-10
CA2728047C (en) 2019-07-30
KR20170102065A (ko) 2017-09-06
IL229583B (en) 2018-03-29
RU2011102437A (ru) 2012-07-27
RU2015141849A3 (cg-RX-API-DMAC7.html) 2018-12-28
AU2009264282A1 (en) 2009-12-30
IL209758A0 (en) 2011-02-28
KR101700722B1 (ko) 2017-01-31
ES2391613T3 (es) 2012-11-28
US20110160435A1 (en) 2011-06-30
JP2011525523A (ja) 2011-09-22
AU2009264282B2 (en) 2013-04-18
BRPI0914695A2 (pt) 2015-10-20
DK2300497T3 (da) 2012-10-29
KR101804136B1 (ko) 2017-12-04
UA100901C2 (ru) 2013-02-11
JP5619738B2 (ja) 2014-11-05
EP2537862A1 (en) 2012-12-26
DK2537862T3 (en) 2015-06-15
WO2009156430A1 (en) 2009-12-30
IL209758A (en) 2014-02-27
MX2010013908A (es) 2011-01-21
SI2300497T1 (sl) 2013-02-28
ZA201009162B (en) 2011-10-26
IL229583A0 (en) 2014-01-30
EP2300497B1 (en) 2012-08-08
RU2015141849A (ru) 2018-12-28
US8329871B2 (en) 2012-12-11
ES2538706T3 (es) 2015-06-23
RU2698392C2 (ru) 2019-08-26
KR20160104740A (ko) 2016-09-05
PT2300497E (pt) 2012-10-30
CN102066417A (zh) 2011-05-18
CA2728047A1 (en) 2009-12-30
EP2300497A1 (en) 2011-03-30
BRPI0914695B1 (pt) 2022-04-19
EP2537862B1 (en) 2015-03-18
KR20110038634A (ko) 2011-04-14
CN102066417B (zh) 2015-11-25

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