DK2300497T3 - Fremgangsmåde til oprensning af koagulationsfaktor VIII - Google Patents

Fremgangsmåde til oprensning af koagulationsfaktor VIII

Info

Publication number
DK2300497T3
DK2300497T3 DK09769279.2T DK09769279T DK2300497T3 DK 2300497 T3 DK2300497 T3 DK 2300497T3 DK 09769279 T DK09769279 T DK 09769279T DK 2300497 T3 DK2300497 T3 DK 2300497T3
Authority
DK
Denmark
Prior art keywords
factor viii
coagulation factor
purifying coagulation
purifying
viii
Prior art date
Application number
DK09769279.2T
Other languages
English (en)
Inventor
Carin Borgvall
Ulrika Ericsson
Gustav Gilljam
Mats Jernberg
Stefan Winge
Original Assignee
Octapharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40076764&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2300497(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Octapharma Ag filed Critical Octapharma Ag
Application granted granted Critical
Publication of DK2300497T3 publication Critical patent/DK2300497T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3847—Multimodal interactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/647—Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups
DK09769279.2T 2008-06-24 2009-06-24 Fremgangsmåde til oprensning af koagulationsfaktor VIII DK2300497T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12940208P 2008-06-24 2008-06-24
EP08158893 2008-06-24
PCT/EP2009/057883 WO2009156430A1 (en) 2008-06-24 2009-06-24 A process of purifying coagulation factor viii

Publications (1)

Publication Number Publication Date
DK2300497T3 true DK2300497T3 (da) 2012-10-29

Family

ID=40076764

Family Applications (2)

Application Number Title Priority Date Filing Date
DK09769279.2T DK2300497T3 (da) 2008-06-24 2009-06-24 Fremgangsmåde til oprensning af koagulationsfaktor VIII
DK12179389.7T DK2537862T3 (da) 2008-06-24 2009-06-24 En fremgangsmåde til at oprense koagulationsfaktor VIII

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK12179389.7T DK2537862T3 (da) 2008-06-24 2009-06-24 En fremgangsmåde til at oprense koagulationsfaktor VIII

Country Status (19)

Country Link
US (1) US8329871B2 (da)
EP (2) EP2300497B1 (da)
JP (1) JP5619738B2 (da)
KR (3) KR101700722B1 (da)
CN (1) CN102066417B (da)
AU (1) AU2009264282B2 (da)
BR (1) BRPI0914695B1 (da)
CA (1) CA2728047C (da)
DK (2) DK2300497T3 (da)
ES (2) ES2538706T3 (da)
IL (3) IL229583B (da)
MX (1) MX2010013908A (da)
PL (1) PL2300497T3 (da)
PT (1) PT2300497E (da)
RU (2) RU2567811C2 (da)
SI (1) SI2300497T1 (da)
UA (1) UA100901C2 (da)
WO (1) WO2009156430A1 (da)
ZA (1) ZA201009162B (da)

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EP2337580B1 (en) * 2008-09-03 2012-03-28 Octapharma AG Stabilized compositions for recombinantly produced factor viii
EP2326658A4 (en) * 2008-09-12 2013-04-10 Ge Healthcare Bio Sciences Ab IMPROVED PROTEIN-AGGREGATE SEPARATION WITH MULTIMODAL ANION EXCHANGERS IN THE PRESENCE OF ZWITTERIONS EXCLUDED FROM THE PROTEIN
RU2731720C2 (ru) * 2010-03-30 2020-09-08 Октафарма Аг Способ очистки витамин к-зависимых белков, таких как коагуляционный фактор vii
ES2596727T3 (es) * 2010-03-30 2017-01-11 Octapharma Ag Procedimiento de purificación de un factor proteico de crecimiento G-CSF
KR101872203B1 (ko) 2010-04-20 2018-08-02 옥타파마 아게 약학 단백질을 위한 신규한 안정화제
WO2012049285A1 (en) 2010-10-14 2012-04-19 Octapharma Ag A method for the quantitative glycosylation analysis of proteins
JP5947802B2 (ja) * 2010-11-05 2016-07-06 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト ミックスモードクロマトグラフィーによる抗体捕捉の最適化方法
DK3626737T3 (da) * 2011-05-13 2024-02-05 Octapharma Ag Fremgangsmåde til at forøge produktiviteten af eukaryote celler i produktionen af rekombinant fviii
WO2012173260A1 (ja) 2011-06-17 2012-12-20 学校法人東日本学園・北海道医療大学 ループスアンチコアグラント検出用血液凝固時間の測定方法
WO2013062841A1 (en) * 2011-10-26 2013-05-02 Bio-Rad Laboratories, Inc. Removal of virucidal agents in mixed mode chromatography
EP2911759A1 (en) * 2012-10-24 2015-09-02 Genzyme Corporation Elution of biomolecules from multi-modal resins using mes and mops as mobile phase modifiers
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US10188965B2 (en) 2012-12-05 2019-01-29 Csl Behring Gmbh Hydrophobic charge induction chromatographic depletion of a protein from a solution
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CN105377874A (zh) * 2013-03-08 2016-03-02 建新公司 治疗性蛋白药物物质的整合连续制造
US20160130361A1 (en) * 2013-06-13 2016-05-12 Biogen Ma Inc. Anti-factor viii antibodies or uses thereof
US10519194B2 (en) 2013-07-12 2019-12-31 Merck Patent Gmbh Removal of fragments from a sample containing a target protein using activated carbon
WO2015021423A2 (en) * 2013-08-08 2015-02-12 Biogen Idec Ma Inc. Purification of chimeric fviii molecules
WO2015044836A1 (en) 2013-09-24 2015-04-02 Pfizer Inc. Compositions comprising heterogeneous populations of recombinant human clotting factor xa proteins
TWI709570B (zh) * 2014-01-17 2020-11-11 美商健臻公司 無菌層析法及製法
TWI709569B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析樹脂及其用於製造方法的用途
AU2015207472B2 (en) * 2014-01-20 2018-11-22 Octapharma Ag A process for manufacturing factor VIII having an improved ratio of FVIII:C/FVIII:Ag
JP6609561B2 (ja) * 2014-02-04 2019-11-20 バイオジェン・エムエイ・インコーポレイテッド 翻訳後修飾を濃縮するための、フロースルーモードにおける陽イオン交換クロマトグラフィーの使用
CN104861060A (zh) * 2014-02-21 2015-08-26 神州细胞工程有限公司 一种纯化凝血因子viii的方法
WO2015183183A1 (en) 2014-05-29 2015-12-03 Agency For Science, Technology And Research Protein Extraction Methods
US10626164B2 (en) * 2014-07-25 2020-04-21 Csl Limited Purification of VWF
GB201506117D0 (en) 2015-04-10 2015-05-27 Ge Healthcare Bio Sciences Ab Method for chromatography
GB201506113D0 (en) 2015-04-10 2015-05-27 Ge Healthcare Bio Sciences Ab Method for chromatography
WO2016207328A1 (en) * 2015-06-24 2016-12-29 Glycotope Gmbh PROCESS FOR THE PURIFICATION OF γ-CARBOXYLATED POLYPEPTIDES
EP3205665A1 (en) * 2016-02-11 2017-08-16 Octapharma AG Method of separating factor viii from blood products
GB201617240D0 (en) * 2016-10-11 2016-11-23 Profactor Pharma Ltd Purification process
CA3068121A1 (en) * 2017-06-23 2018-12-27 Baxalta Incorporated Purification of factor viii subspecies
CN107226859B (zh) * 2017-08-10 2020-11-24 博雅生物制药集团股份有限公司 一种人凝血因子ⅷ的制备方法
CN111065735B (zh) * 2017-08-31 2023-07-07 株式会社绿十字 用于纯化硫酸酯酶蛋白的方法
SG11202101860UA (en) 2018-08-31 2021-03-30 Genzyme Corp Sterile chromatography resin and use thereof in manufacturing processes
EP4093745A4 (en) * 2020-01-20 2024-03-06 Wuxi Biologics Ireland Ltd NEW WASH BUFFER SOLUTION FOR AFFINITY CHROMATOGRAPHY

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Also Published As

Publication number Publication date
CN102066417A (zh) 2011-05-18
PT2300497E (pt) 2012-10-30
JP2011525523A (ja) 2011-09-22
US8329871B2 (en) 2012-12-11
BRPI0914695B1 (pt) 2022-04-19
CN102066417B (zh) 2015-11-25
IL209758A0 (en) 2011-02-28
EP2300497A1 (en) 2011-03-30
JP5619738B2 (ja) 2014-11-05
US20110160435A1 (en) 2011-06-30
ES2391613T3 (es) 2012-11-28
PL2300497T3 (pl) 2013-02-28
EP2300497B1 (en) 2012-08-08
EP2537862B1 (en) 2015-03-18
DK2537862T3 (da) 2015-06-15
ES2538706T3 (es) 2015-06-23
CA2728047C (en) 2019-07-30
KR101700722B1 (ko) 2017-01-31
RU2015141849A (ru) 2018-12-28
KR20110038634A (ko) 2011-04-14
RU2011102437A (ru) 2012-07-27
EP2537862A1 (en) 2012-12-26
BRPI0914695A2 (pt) 2015-10-20
IL229583A0 (en) 2014-01-30
KR20170102065A (ko) 2017-09-06
RU2015141849A3 (da) 2018-12-28
SI2300497T1 (sl) 2013-02-28
KR20160104740A (ko) 2016-09-05
MX2010013908A (es) 2011-01-21
CA2728047A1 (en) 2009-12-30
AU2009264282A1 (en) 2009-12-30
ZA201009162B (en) 2011-10-26
RU2698392C2 (ru) 2019-08-26
RU2567811C2 (ru) 2015-11-10
UA100901C2 (ru) 2013-02-11
WO2009156430A1 (en) 2009-12-30
KR101804136B1 (ko) 2017-12-04
IL229583B (en) 2018-03-29
AU2009264282B2 (en) 2013-04-18
IL209758A (en) 2014-02-27

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