UA100901C2 - Способ очищения фактора свертывания крови viii - Google Patents

Способ очищения фактора свертывания крови viii

Info

Publication number
UA100901C2
UA100901C2 UAA201100699A UAA201100699A UA100901C2 UA 100901 C2 UA100901 C2 UA 100901C2 UA A201100699 A UAA201100699 A UA A201100699A UA A201100699 A UAA201100699 A UA A201100699A UA 100901 C2 UA100901 C2 UA 100901C2
Authority
UA
Ukraine
Prior art keywords
fviii
aqueous
factor viii
purifying
coagulation factor
Prior art date
Application number
UAA201100699A
Other languages
English (en)
Ukrainian (uk)
Inventor
Карин Боргвалл
Ульрика Эрикссон
Густав Джиллйам
Метс Йернберг
Стефан ВИНГЕ
Original Assignee
Октафарма Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40076764&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA100901(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Октафарма Аг filed Critical Октафарма Аг
Publication of UA100901C2 publication Critical patent/UA100901C2/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3847—Multimodal interactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/647—Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Способ очистки или обогащения фактора свертывания крови FVIII с использованием хроматографии, который включает стадии обеспечения фракции, которая содержит FVIII, в водном растворе с высокой ионной силой; приведение фракции, которая содержит FVIII, в контакт с многомодальной смолой; необязательного промывания многомодальной смолы, на которую абсорбирован FVIII, водным промывочным буфером; элюирование фракций, которая содержат FVIII, водным элюирующим буфером, который содержит, по крайней мере, одну аминокислоту, которая положительно заряжена при величине рН 6-8; и необязательного сбора фракций, которые содержат FVIII, в очищенной или обогащенной форме.
UAA201100699A 2008-06-24 2009-06-24 Способ очищения фактора свертывания крови viii UA100901C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08158893 2008-06-24
PCT/EP2009/057883 WO2009156430A1 (en) 2008-06-24 2009-06-24 A process of purifying coagulation factor viii

Publications (1)

Publication Number Publication Date
UA100901C2 true UA100901C2 (ru) 2013-02-11

Family

ID=40076764

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201100699A UA100901C2 (ru) 2008-06-24 2009-06-24 Способ очищения фактора свертывания крови viii

Country Status (19)

Country Link
US (1) US8329871B2 (ru)
EP (2) EP2537862B1 (ru)
JP (1) JP5619738B2 (ru)
KR (3) KR101804136B1 (ru)
CN (1) CN102066417B (ru)
AU (1) AU2009264282B2 (ru)
BR (1) BRPI0914695B1 (ru)
CA (1) CA2728047C (ru)
DK (2) DK2537862T3 (ru)
ES (2) ES2391613T3 (ru)
IL (3) IL209758A (ru)
MX (1) MX2010013908A (ru)
PL (1) PL2300497T3 (ru)
PT (1) PT2300497E (ru)
RU (2) RU2567811C2 (ru)
SI (1) SI2300497T1 (ru)
UA (1) UA100901C2 (ru)
WO (1) WO2009156430A1 (ru)
ZA (1) ZA201009162B (ru)

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CN106414491B (zh) * 2014-01-20 2021-06-18 奥克塔法马股份有限公司 一种制备FVIII:C/FVIII:Ag比例提高的因子VIII的方法
KR20230136616A (ko) * 2014-02-04 2023-09-26 바이오젠 엠에이 인코포레이티드 번역 후 변형을 강화시키기 위한 통류 방식 양이온교환 크로마토그래피의 용도
CN104861060A (zh) * 2014-02-21 2015-08-26 神州细胞工程有限公司 一种纯化凝血因子viii的方法
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Also Published As

Publication number Publication date
MX2010013908A (es) 2011-01-21
RU2015141849A (ru) 2018-12-28
RU2015141849A3 (ru) 2018-12-28
KR20110038634A (ko) 2011-04-14
CN102066417A (zh) 2011-05-18
BRPI0914695A2 (pt) 2015-10-20
AU2009264282B2 (en) 2013-04-18
US20110160435A1 (en) 2011-06-30
IL229583B (en) 2018-03-29
SI2300497T1 (sl) 2013-02-28
DK2537862T3 (en) 2015-06-15
DK2300497T3 (da) 2012-10-29
BRPI0914695B1 (pt) 2022-04-19
ZA201009162B (en) 2011-10-26
PT2300497E (pt) 2012-10-30
RU2698392C2 (ru) 2019-08-26
CA2728047A1 (en) 2009-12-30
EP2300497A1 (en) 2011-03-30
KR20170102065A (ko) 2017-09-06
IL209758A0 (en) 2011-02-28
CA2728047C (en) 2019-07-30
KR20160104740A (ko) 2016-09-05
RU2011102437A (ru) 2012-07-27
KR101804136B1 (ko) 2017-12-04
JP2011525523A (ja) 2011-09-22
IL209758A (en) 2014-02-27
EP2300497B1 (en) 2012-08-08
AU2009264282A1 (en) 2009-12-30
IL229583A0 (en) 2014-01-30
CN102066417B (zh) 2015-11-25
EP2537862A1 (en) 2012-12-26
ES2538706T3 (es) 2015-06-23
EP2537862B1 (en) 2015-03-18
KR101700722B1 (ko) 2017-01-31
RU2567811C2 (ru) 2015-11-10
PL2300497T3 (pl) 2013-02-28
US8329871B2 (en) 2012-12-11
WO2009156430A1 (en) 2009-12-30
ES2391613T3 (es) 2012-11-28
JP5619738B2 (ja) 2014-11-05

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