IL209758A - Process for purifying or enriching coagulation factor viii - Google Patents

Process for purifying or enriching coagulation factor viii

Info

Publication number
IL209758A
IL209758A IL209758A IL20975810A IL209758A IL 209758 A IL209758 A IL 209758A IL 209758 A IL209758 A IL 209758A IL 20975810 A IL20975810 A IL 20975810A IL 209758 A IL209758 A IL 209758A
Authority
IL
Israel
Prior art keywords
purifying
factor viii
coagulation factor
enriching
enriching coagulation
Prior art date
Application number
IL209758A
Other languages
English (en)
Hebrew (he)
Other versions
IL209758A0 (en
Original Assignee
Octapharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40076764&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL209758(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Octapharma Ag filed Critical Octapharma Ag
Publication of IL209758A0 publication Critical patent/IL209758A0/en
Publication of IL209758A publication Critical patent/IL209758A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3847—Multimodal interactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/647—Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
IL209758A 2008-06-24 2010-12-05 Process for purifying or enriching coagulation factor viii IL209758A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12940208P 2008-06-24 2008-06-24
EP08158893 2008-06-24
PCT/EP2009/057883 WO2009156430A1 (en) 2008-06-24 2009-06-24 A process of purifying coagulation factor viii

Publications (2)

Publication Number Publication Date
IL209758A0 IL209758A0 (en) 2011-02-28
IL209758A true IL209758A (en) 2014-02-27

Family

ID=40076764

Family Applications (3)

Application Number Title Priority Date Filing Date
IL209758A IL209758A (en) 2008-06-24 2010-12-05 Process for purifying or enriching coagulation factor viii
IL229583A IL229583B (en) 2008-06-24 2010-12-05 A preparation obtained by a process for the purification of coagulation factor viii
IL229583A IL229583A0 (en) 2008-06-24 2013-11-24 A process for the purification of coagulation factor viii

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL229583A IL229583B (en) 2008-06-24 2010-12-05 A preparation obtained by a process for the purification of coagulation factor viii
IL229583A IL229583A0 (en) 2008-06-24 2013-11-24 A process for the purification of coagulation factor viii

Country Status (19)

Country Link
US (1) US8329871B2 (cg-RX-API-DMAC7.html)
EP (2) EP2300497B1 (cg-RX-API-DMAC7.html)
JP (1) JP5619738B2 (cg-RX-API-DMAC7.html)
KR (3) KR20160104740A (cg-RX-API-DMAC7.html)
CN (1) CN102066417B (cg-RX-API-DMAC7.html)
AU (1) AU2009264282B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0914695B1 (cg-RX-API-DMAC7.html)
CA (1) CA2728047C (cg-RX-API-DMAC7.html)
DK (2) DK2537862T3 (cg-RX-API-DMAC7.html)
ES (2) ES2391613T3 (cg-RX-API-DMAC7.html)
IL (3) IL209758A (cg-RX-API-DMAC7.html)
MX (1) MX2010013908A (cg-RX-API-DMAC7.html)
PL (1) PL2300497T3 (cg-RX-API-DMAC7.html)
PT (1) PT2300497E (cg-RX-API-DMAC7.html)
RU (2) RU2567811C2 (cg-RX-API-DMAC7.html)
SI (1) SI2300497T1 (cg-RX-API-DMAC7.html)
UA (1) UA100901C2 (cg-RX-API-DMAC7.html)
WO (1) WO2009156430A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201009162B (cg-RX-API-DMAC7.html)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101293504B1 (ko) 2007-07-11 2013-08-07 노보 노르디스크 에이/에스 혼합형 또는 다중형 수지를 사용하는 인자 ｖⅰⅰⅰ의 정제
EP2027875A1 (en) * 2007-08-23 2009-02-25 Octapharma AG A Process for Isolation and Purification of a Target Protein free of Prion Protein (PrPSC)
RU2011110459A (ru) 2008-08-21 2012-09-27 Октафарма АГ (CH) Рекомбинантно полученный человеческий фактор viii и ix
CN107050437A (zh) * 2008-09-03 2017-08-18 奥克塔法马股份有限公司 重组制备的因子viii的新型保护组合物
US20110166332A1 (en) * 2008-09-12 2011-07-07 Ge Healthcare Bio-Sciences Ab Enhanced antibody aggregate removal with capto adhere in the presence of protein-excluded zwitterions
DK3040346T3 (en) * 2010-03-30 2018-06-14 Octapharma Ag PROCEDURE FOR CLEANING THE GRANULOCYT COLONY STIMULATING FACTOR, G-CSF
ES2740825T3 (es) * 2010-03-30 2020-02-06 Octapharma Ag Un procedimiento de purificación de proteínas dependientes de vitamina K
KR102049254B1 (ko) 2010-04-20 2019-11-28 옥타파마 아게 약학 단백질을 위한 신규한 안정화제
WO2012049285A1 (en) 2010-10-14 2012-04-19 Octapharma Ag A method for the quantitative glycosylation analysis of proteins
MX342235B (es) * 2010-11-05 2016-09-21 Hoffmann La Roche Metodo optimizado para captura de anticuerpo por cromatografia de modo mixto.
DK3626737T3 (da) * 2011-05-13 2024-02-05 Octapharma Ag Fremgangsmåde til at forøge produktiviteten af eukaryote celler i produktionen af rekombinant fviii
JP5640189B2 (ja) 2011-06-17 2014-12-17 学校法人東日本学園 ループスアンチコアグラント検出用血液凝固時間の測定方法
EP2771358A4 (en) * 2011-10-26 2015-08-26 Bio Rad Laboratories ELIMINATION OF VIRAL AGENTS IN MIXED MODE CHROMATOGRAPHY
MX379269B (es) 2012-10-24 2025-03-11 Genzyme Corp Elucion de biomoleculas de resinas multimodales utilizando mes y mops como modificadores de fase movil.
US20140154233A1 (en) * 2012-12-05 2014-06-05 Csl Limited Method of purifying therapeutic proteins
US10188965B2 (en) 2012-12-05 2019-01-29 Csl Behring Gmbh Hydrophobic charge induction chromatographic depletion of a protein from a solution
CN103880947B (zh) * 2012-12-21 2016-01-13 武汉禾元生物科技股份有限公司 一种分离纯化高纯度重组人血清白蛋白的层析方法
EP2964663A2 (en) * 2013-03-08 2016-01-13 Genzyme Corporation Continuous purification of therapeutic proteins
EP3008085A4 (en) * 2013-06-13 2017-05-10 Biogen MA Inc. Anti-factor viii antibodies or uses thereof
CA2910770C (en) 2013-07-12 2018-02-27 Merck Patent Gmbh Removal of fragments from a sample containing a target protein using activated carbon
EP3875106A1 (en) * 2013-08-08 2021-09-08 Bioverativ Therapeutics Inc. Purification of chimeric fviii molecules
AU2014326257B2 (en) 2013-09-24 2017-08-10 Pfizer Inc. Compositions comprising heterogeneous populations of recombinant human clotting factor Xa proteins
TWI709569B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析樹脂及其用於製造方法的用途
TWI709570B (zh) * 2014-01-17 2020-11-11 美商健臻公司 無菌層析法及製法
CA2934705C (en) * 2014-01-20 2020-03-31 Octapharma Ag A process for manufacturing factor viii having an improved ratio of fviii:c/fviii:ag
DK3097188T3 (en) * 2014-01-24 2018-10-08 Am Pharma Bv DOWNSTREAM PREPARATION OF AN ALKALIC PHOSPHATASE
JP6609561B2 (ja) * 2014-02-04 2019-11-20 バイオジェン・エムエイ・インコーポレイテッド 翻訳後修飾を濃縮するための、フロースルーモードにおける陽イオン交換クロマトグラフィーの使用
CN104861060A (zh) * 2014-02-21 2015-08-26 神州细胞工程有限公司 一种纯化凝血因子viii的方法
EP3149023A4 (en) 2014-05-29 2017-11-22 Agency for Science, Technology and Research Protein Extraction Methods
US10626164B2 (en) * 2014-07-25 2020-04-21 Csl Limited Purification of VWF
GB201506113D0 (en) 2015-04-10 2015-05-27 Ge Healthcare Bio Sciences Ab Method for chromatography
GB201506117D0 (en) 2015-04-10 2015-05-27 Ge Healthcare Bio Sciences Ab Method for chromatography
WO2016207328A1 (en) * 2015-06-24 2016-12-29 Glycotope Gmbh PROCESS FOR THE PURIFICATION OF γ-CARBOXYLATED POLYPEPTIDES
EP3205665A1 (en) 2016-02-11 2017-08-16 Octapharma AG Method of separating factor viii from blood products
GB201617240D0 (en) * 2016-10-11 2016-11-23 Profactor Pharma Ltd Purification process
US11299533B2 (en) 2017-06-23 2022-04-12 Takeda Pharmaceutical Company Limited Purification of factor VIII subspecies
CN107226859B (zh) * 2017-08-10 2020-11-24 博雅生物制药集团股份有限公司 一种人凝血因子ⅷ的制备方法
KR102286260B1 (ko) 2017-08-31 2021-08-05 주식회사 녹십자 설파타아제 단백질을 정제하는 방법
AU2018357917B2 (en) 2017-10-30 2024-08-01 Takeda Pharmaceutical Company Limited Environmentally compatible detergents for inactivation of lipid-enveloped viruses
BR112021003420A2 (pt) 2018-08-31 2021-05-18 Genzyme Corporation resina cromatográfica estéril e uso da mesma em processos de manufatura
TWI787710B (zh) * 2020-01-20 2022-12-21 中國大陸商上海藥明生物技術有限公司 用於親和層析的新型清洗緩衝液
CN118217951B (zh) * 2024-04-01 2025-05-23 山东建筑大学 一种水中的高纯度磷回收装置和方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4540573A (en) 1983-07-14 1985-09-10 New York Blood Center, Inc. Undenatured virus-free biologically active protein derivatives
US5605884A (en) * 1987-10-29 1997-02-25 Rhone-Poulenc Rorer Pharmaceuticals Inc. Factor VIII formulations in high ionic strength media
US5316680A (en) * 1992-10-21 1994-05-31 Cornell Research Foundation, Inc. Multimodal chromatographic separation media and process for using same
JPH08506710A (ja) 1993-06-11 1996-07-16 ノーザン・テレコム・リミテッド ユーザ制御呼管理サービス方法および装置
DE4337573C1 (de) 1993-11-04 1995-05-18 Octapharma Ag Verfahren zur Herstellung einer virusinaktivierten Faktor VIII enthaltenden Fraktion mittels chromatographischer Methoden
SE9403915D0 (sv) 1994-11-14 1994-11-14 Annelie Almstedt Process A
AUPR638801A0 (en) * 2001-07-13 2001-08-09 Life Therapeutics Limited Factor viii separation
NZ548126A (en) 2004-02-27 2009-10-30 Ge Healthcare Bio Sciences Ab A process for the purification of antibodies involving addition of a second resin
EP1765866B1 (en) * 2004-06-07 2014-01-08 Therapure Biopharma Inc. Isolation of plasma or serum proteins
EP1707634A1 (en) * 2005-03-29 2006-10-04 Octapharma AG Method for isolation of recombinantly produced proteins
FR2887883B1 (fr) * 2005-06-29 2007-08-31 Lab Francais Du Fractionnement Procede de separation des proteines fibrinogene, facteur xiii et colle biologique d'une fraction plasmatique solubilisee et de preparation de concentres lyophilises desdites proteines
EP1739179A1 (en) 2005-06-30 2007-01-03 Octapharma AG Serum-free stable transfection and production of recombinant human proteins in human cell lines
KR101520105B1 (ko) * 2006-07-14 2015-05-21 제넨테크, 인크. 재조합 단백질의 리폴딩
RU2324495C1 (ru) * 2006-08-31 2008-05-20 Федеральное государственное унитарное предприятие "Научно-производственное объединение по медицинским иммунобиологическим препаратам "Микроген" Министерства здравоохранения Российской Федерации Способ получения препарата фактора свертывания viii крови человека
WO2008092644A2 (en) * 2007-02-01 2008-08-07 Baxter International Inc. Fviii-independent fix-mutant proteins for hemophilia a treatment
JP2010529155A (ja) * 2007-06-13 2010-08-26 ツェー・エス・エル・ベーリング・ゲー・エム・ベー・ハー 出血性疾患の治療及び予防的処置における血管外投与のためのｖｗｆ安定化ｆｖｉｉｉ製剤及びｆｖｉｉｉなしのｖｗｆ製剤の使用
KR101293504B1 (ko) 2007-07-11 2013-08-07 노보 노르디스크 에이/에스 혼합형 또는 다중형 수지를 사용하는 인자 ｖⅰⅰⅰ의 정제
GB0723712D0 (en) * 2007-12-04 2008-01-16 Apitope Technology Bristol Ltd Peptides
DE102008032361A1 (de) * 2008-07-10 2010-01-21 Csl Behring Gmbh Der Einsatz von Faktor VIII und vWF bzw. vWF-enthaltenden Konzentraten zur Therapie der durch Thrombocyten-Inhibitoren induzierte Koagulopathie

Also Published As

Publication number Publication date
RU2567811C2 (ru) 2015-11-10
CA2728047C (en) 2019-07-30
KR20170102065A (ko) 2017-09-06
IL229583B (en) 2018-03-29
RU2011102437A (ru) 2012-07-27
RU2015141849A3 (cg-RX-API-DMAC7.html) 2018-12-28
AU2009264282A1 (en) 2009-12-30
IL209758A0 (en) 2011-02-28
KR101700722B1 (ko) 2017-01-31
ES2391613T3 (es) 2012-11-28
US20110160435A1 (en) 2011-06-30
JP2011525523A (ja) 2011-09-22
AU2009264282B2 (en) 2013-04-18
BRPI0914695A2 (pt) 2015-10-20
DK2300497T3 (da) 2012-10-29
KR101804136B1 (ko) 2017-12-04
UA100901C2 (ru) 2013-02-11
JP5619738B2 (ja) 2014-11-05
EP2537862A1 (en) 2012-12-26
PL2300497T3 (pl) 2013-02-28
DK2537862T3 (en) 2015-06-15
WO2009156430A1 (en) 2009-12-30
MX2010013908A (es) 2011-01-21
SI2300497T1 (sl) 2013-02-28
ZA201009162B (en) 2011-10-26
IL229583A0 (en) 2014-01-30
EP2300497B1 (en) 2012-08-08
RU2015141849A (ru) 2018-12-28
US8329871B2 (en) 2012-12-11
ES2538706T3 (es) 2015-06-23
RU2698392C2 (ru) 2019-08-26
KR20160104740A (ko) 2016-09-05
PT2300497E (pt) 2012-10-30
CN102066417A (zh) 2011-05-18
CA2728047A1 (en) 2009-12-30
EP2300497A1 (en) 2011-03-30
BRPI0914695B1 (pt) 2022-04-19
EP2537862B1 (en) 2015-03-18
KR20110038634A (ko) 2011-04-14
CN102066417B (zh) 2015-11-25

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