PL170580B1 - Sposób wytwarzania nowych pochodnych tiazolilowych i pirydynylowych PL PL - Google Patents

Sposób wytwarzania nowych pochodnych tiazolilowych i pirydynylowych PL PL

Info

Publication number
PL170580B1
PL170580B1 PL91297612A PL29761291A PL170580B1 PL 170580 B1 PL170580 B1 PL 170580B1 PL 91297612 A PL91297612 A PL 91297612A PL 29761291 A PL29761291 A PL 29761291A PL 170580 B1 PL170580 B1 PL 170580B1
Authority
PL
Poland
Prior art keywords
formula
group
alk
radical
alkyl
Prior art date
Application number
PL91297612A
Other languages
English (en)
Polish (pl)
Other versions
PL297612A1 (enExample
Inventor
Frans E Janssens
Francois M Sommen
Gaston S M Diels
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of PL297612A1 publication Critical patent/PL297612A1/xx
Publication of PL170580B1 publication Critical patent/PL170580B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PL91297612A 1990-07-19 1991-07-09 Sposób wytwarzania nowych pochodnych tiazolilowych i pirydynylowych PL PL PL170580B1 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55432590A 1990-07-19 1990-07-19
PCT/EP1991/001292 WO1992001697A1 (en) 1990-07-19 1991-07-09 Novel substituted thiazolyl and substituted pyridinyl derivatives

Publications (2)

Publication Number Publication Date
PL297612A1 PL297612A1 (enExample) 1992-07-13
PL170580B1 true PL170580B1 (pl) 1997-01-31

Family

ID=24212925

Family Applications (1)

Application Number Title Priority Date Filing Date
PL91297612A PL170580B1 (pl) 1990-07-19 1991-07-09 Sposób wytwarzania nowych pochodnych tiazolilowych i pirydynylowych PL PL

Country Status (27)

Country Link
EP (1) EP0539420B1 (enExample)
JP (1) JP3085707B2 (enExample)
KR (1) KR100206723B1 (enExample)
CN (1) CN1037770C (enExample)
AT (1) ATE188477T1 (enExample)
AU (1) AU646280B2 (enExample)
CA (1) CA2086546A1 (enExample)
CZ (1) CZ279903B6 (enExample)
DE (1) DE69131895T2 (enExample)
DK (1) DK0539420T3 (enExample)
ES (1) ES2142802T3 (enExample)
FI (1) FI102753B (enExample)
GR (1) GR3032999T3 (enExample)
HU (1) HU221298B1 (enExample)
IE (1) IE912533A1 (enExample)
IL (1) IL98865A (enExample)
MX (1) MX9100307A (enExample)
NO (1) NO304791B1 (enExample)
NZ (1) NZ238863A (enExample)
PH (1) PH31063A (enExample)
PL (1) PL170580B1 (enExample)
PT (1) PT98366B (enExample)
RU (1) RU2067978C1 (enExample)
SK (1) SK280690B6 (enExample)
TW (1) TW209217B (enExample)
WO (1) WO1992001697A1 (enExample)
ZA (1) ZA915654B (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2048109B1 (es) * 1992-07-20 1994-12-16 Espanola Prod Quimicos Procedimiento de preparacion de nuevos derivados piperidicos del bencimidazol.
US6211199B1 (en) 1995-11-17 2001-04-03 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases
US6423704B2 (en) 1995-12-20 2002-07-23 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases
US6194406B1 (en) 1995-12-20 2001-02-27 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease
US5922737A (en) * 1996-02-21 1999-07-13 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-Benzimidazol-2-YL-amino) piperidin-1-YL)-2-(arlyl) butyl) benzamides useful for the treatment of allergic diseases
US5932571A (en) * 1996-02-21 1999-08-03 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) {1,4}diazepan-1-yl)-2-(aryl) butyl) benzamides useful for the treatment of allergic diseases
US5998439A (en) 1996-02-21 1999-12-07 Hoescht Marion Roussel, Inc. Substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases
MXPA02000120A (es) 1999-06-28 2002-07-02 Janssen Pharmaceutica Nv Inhibidores de la replicacion del virus sincitial respiratorio.
JP2003503403A (ja) 1999-06-28 2003-01-28 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 呼吸合胞体ウイルス複製阻害剤
EP1418175A1 (en) * 1999-06-28 2004-05-12 Janssen Pharmaceutica N.V. Respiratory syncytial virus replication inhibitors
KR100756592B1 (ko) * 1999-10-08 2007-09-10 그뤼넨탈 게엠베하 비사이클릭 이미다조-3-일-아민 유도체, 이의 제조방법 및 이를 포함하는 진통제
RS20050532A (sr) 2003-01-14 2007-12-31 Arena Pharmaceuticals Inc., Derivati 1,2,3-trisupstituisanog arila i heteroarila kao modulatori metabolizma za profilaksu i tretman poremećaja povezanih sa njim, kao što su dijebetes i hiperglikemija
AR045047A1 (es) 2003-07-11 2005-10-12 Arena Pharm Inc Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos
RU2239637C1 (ru) * 2003-07-17 2004-11-10 Дж.Б.Кемикалс Энд Фармасьютикалс Лтд. Улучшенный способ получения 5-[2-этокси-5-(4-метилпиперазин-1-илсульфонил)фенил]-1 метил-3-н-пропил-1,6-дигидро-7h-пиразол [4,3-d] пиримидин-7-она
RU2264814C2 (ru) * 2003-12-29 2005-11-27 Открытое акционерное общество "Химико-фармацевтический комбинат "АКРИХИН" (ОАО "АКРИХИН") Антигистаминная фармацевтическая композиция
AU2005245389A1 (en) * 2004-05-12 2005-12-01 Bristol-Myers Squibb Company Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
DE102004044884A1 (de) * 2004-09-14 2006-05-24 Grünenthal GmbH Substituierte bizyklische Imidazo-3-yl-amin-Verbindungen
DOP2006000010A (es) 2005-01-10 2006-07-31 Arena Pharm Inc Procedimiento para preparar eteres aromáticos
CN103221410B (zh) 2010-09-22 2017-09-15 艾尼纳制药公司 Gpr119受体调节剂和对与其相关的障碍的治疗
EP3040334A1 (en) * 2014-12-29 2016-07-06 Faes Farma, S.A. New benzimidazole derivatives as antihistamine agents
CA3002540C (en) 2015-01-06 2023-11-07 Arena Pharmaceuticals, Inc. Use of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid for treating conditions related to the s1p1 receptor
JP6838744B2 (ja) 2015-06-22 2021-03-03 アリーナ ファーマシューティカルズ， インコーポレイテッド Ｓ１Ｐ１レセプター関連障害における使用のための（Ｒ）−２−（７−（４−シクロペンチル−３−（トリフルオロメチル）ベンジルオキシ）−１，２，３，４−テトラヒドロシクロペンタ［ｂ］インドール−３−イル）酢酸（化合物１）の結晶性Ｌ−アルギニン塩
JP7397011B2 (ja) 2018-06-06 2023-12-12 アリーナ ファーマシューティカルズ， インコーポレイテッド Ｓ１ｐ１受容体に関連する状態を治療する方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4556660A (en) * 1982-07-12 1985-12-03 Janssen Pharmaceutica N.V. N-(Bicyclic heterocyclyl)-4-piperidinamines
US4634704A (en) * 1983-10-06 1987-01-06 Janssen Pharmaceutica, N.V. Anti-allergic five membered heterocyclic ring containing N-(bicyclic heterocycyl)-4-piperidinamines
US4695569A (en) * 1983-11-30 1987-09-22 Janssen Pharmaceutica N.V. Bicyclic heterocyclyl containing N-(bicyclic heterocyclyl)-4-piperidinamines
US4695575A (en) 1984-11-13 1987-09-22 Janssen Pharmaceutica, N.V. 4-[(bicycle heterocyclyl)-methyl and -hetero]-piperidines
US4588722A (en) * 1984-01-09 1986-05-13 Janssen Pharmaceutica N.V. N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives
GB8515934D0 (en) * 1985-06-24 1985-07-24 Janssen Pharmaceutica Nv (4-piperidinomethyl and-hetero)purines
US4835161A (en) * 1986-02-03 1989-05-30 Janssen Pharmaceutica N.V. Anti-histaminic compositions containing n-heterocyclyl-4-piperidinamines
DE3701863A1 (de) * 1987-01-23 1988-08-04 Standard Elektrik Lorenz Ag Sender zur kohaerent optischen nachrichtenuebertragung
US4897401A (en) * 1987-06-19 1990-01-30 Janssen Pharmaceutical N.V. N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives useful in treating allergic diseases
CA1317939C (en) * 1987-07-01 1993-05-18 Janssen Pharmaceutica Naamloze Vennootschap ¬(bicyclic heterocyclyl)methyl and -hetero| substituted hexahydro-1h-azepines and pyrrolidines
GB8900380D0 (en) * 1989-01-09 1989-03-08 Janssen Pharmaceutica Nv 2-aminopyrimidinone derivatives

Also Published As

Publication number Publication date
PT98366B (pt) 1999-01-29
JP3085707B2 (ja) 2000-09-11
NO304791B1 (no) 1999-02-15
PT98366A (pt) 1992-05-29
NZ238863A (en) 1993-03-26
DE69131895D1 (de) 2000-02-10
ZA915654B (en) 1993-03-31
CN1058216A (zh) 1992-01-29
CA2086546A1 (en) 1992-01-20
MX9100307A (es) 1992-02-28
IL98865A (en) 1995-11-27
FI102753B1 (fi) 1999-02-15
HU221298B1 (en) 2002-09-28
NO930139D0 (no) 1993-01-15
ES2142802T3 (es) 2000-05-01
FI930199A0 (fi) 1993-01-18
PL297612A1 (enExample) 1992-07-13
KR100206723B1 (ko) 1999-07-01
GR3032999T3 (en) 2000-07-31
CS223991A3 (en) 1992-02-19
FI930199A7 (fi) 1993-01-18
CN1037770C (zh) 1998-03-18
JPH05508638A (ja) 1993-12-02
CZ279903B6 (cs) 1995-08-16
DK0539420T3 (da) 2000-05-29
IE912533A1 (en) 1992-01-29
WO1992001697A1 (en) 1992-02-06
PH31063A (en) 1998-02-05
FI102753B (fi) 1999-02-15
IL98865A0 (en) 1992-07-15
TW209217B (enExample) 1993-07-11
NO930139L (no) 1993-01-15
EP0539420A1 (en) 1993-05-05
AU8209391A (en) 1992-02-18
RU2067978C1 (ru) 1996-10-20
HUT64066A (en) 1993-11-29
HU9300096D0 (en) 1993-04-28
EP0539420B1 (en) 2000-01-05
AU646280B2 (en) 1994-02-17
DE69131895T2 (de) 2000-07-20
SK280690B6 (sk) 2000-06-12
ATE188477T1 (de) 2000-01-15

Similar Documents

Publication Publication Date Title
JP2938492B2 (ja) ２―アミノピリミジノン誘導体
JP5997335B2 (ja) Ｎ含有複素環式化合物
CA2778680C (en) N-containing heteroaryl derivatives as jak3 kinase inhibitors
RU2382785C2 (ru) Конденсированные n-гетероциклические соединения и их применение в качестве антагонистов рецепторов crf
FI71737B (fi) Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 3-(piperidinylalkyl)-4h-pyrido/1,2-a/ pyrimidin-4-on-derivat
CA3150515A1 (en) PRMT5 INHIBITORS IN COOPERATION WITH MTA
CA1257258A (en) Bicyclic heterocyclyl containing n-(bicyclic heterocyclyl)-4-piperidinamines
PL169361B1 (pl) Sposób wytwarzania nowych pochodnych oksazolilowych PL PL PL
PL142880B1 (en) Method of obtaining novel imidazole derivatives
KR100206723B1 (ko) 신규 치환된 티아졸릴 및 치환된 피리디닐 유도체
HU221016B1 (hu) Imidazo[2,1-b][3]benzazepin-származékok, ezeket tartalmazó gyógyszerkészítmények, eljárás előállításukra és intermedierek
RU1825364C (ru) Способ получени производных 2-амино-пиримидинона и их приемлемых в фармацевтическом отношении кислых аддуктов
WO1999043678A1 (en) Remedies/preventives for parkinson's disease
KR880000044B1 (ko) N-(비사이클 헤테로사이클릴)-4-피페리딘아민의 제조 방법
Singh et al. Novel and potent adenosine 3', 5'-cyclic phosphate phosphodiesterase III inhibitors: thiazolo [4, 5-b][1, 6] naphthyridin-2-ones
PL183291B1 (pl) Nowe pochodne 4-(1H-indol-1-ilo)-1-podstawionej piperydyny o działaniu antypsychotycznym, środek farmaceutyczny i sposób wytwarzania nowej pochodnej 4-(1H-indol-1-ilo)-1-podstawionej piperydyny
CA1262348A (en) 1h-indol-3-yl containing 1,3-dimethyl-1h-purine-2,6- diones
KR880000489B1 (ko) N-(비사이클 헤테로사이클릴)-4-피페리딘 아민의 제조방법
WO2021168521A1 (en) Inhibitors of necroptosis
CN113620956A (zh) 转化生长因子受体拮抗剂、其制备方法和应用
IE43150B1 (en) N-/(1-piperidinyl)alkyl/arylcarboxamide derivatives
El-Taweel et al. Utility of anilides as building block to synthesize some heterocyclic compounds for biological evaluation: New synthesis of dihydropyridine, pyrazolo [1, 5-a] pyrimidine and thiazolo [3, 2-a] pyrimidine derivatives

Legal Events

Date Code Title Description
LAPS Decisions on the lapse of the protection rights

Effective date: 20050709