PL168671B1 - Sposób wytwarzania nowych 1-(pirydo/3,4-b/-1,4-oksazinylo-4-ilo)-1 H-indoli PL PL PL - Google Patents

Sposób wytwarzania nowych 1-(pirydo/3,4-b/-1,4-oksazinylo-4-ilo)-1 H-indoli PL PL PL

Info

Publication number
PL168671B1
PL168671B1 PL92294221A PL29422192A PL168671B1 PL 168671 B1 PL168671 B1 PL 168671B1 PL 92294221 A PL92294221 A PL 92294221A PL 29422192 A PL29422192 A PL 29422192A PL 168671 B1 PL168671 B1 PL 168671B1
Authority
PL
Poland
Prior art keywords
formula
compound
lower alkyl
hydrogen atom
pyrido
Prior art date
Application number
PL92294221A
Other languages
English (en)
Polish (pl)
Other versions
PL294221A1 (en
Inventor
Richard Ch Effland
Larry Davis
Gordon E Olsen
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Publication of PL294221A1 publication Critical patent/PL294221A1/xx
Publication of PL168671B1 publication Critical patent/PL168671B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PL92294221A 1991-04-15 1992-04-14 Sposób wytwarzania nowych 1-(pirydo/3,4-b/-1,4-oksazinylo-4-ilo)-1 H-indoli PL PL PL PL168671B1 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/684,758 US5214038A (en) 1991-04-15 1991-04-15 1-(pyrido[3,4-b]-1,4-oxazinyl-4-yl)-1H-indoles and intermediates for the preparation thereof

Publications (2)

Publication Number Publication Date
PL294221A1 PL294221A1 (en) 1993-08-09
PL168671B1 true PL168671B1 (pl) 1996-03-29

Family

ID=24749434

Family Applications (1)

Application Number Title Priority Date Filing Date
PL92294221A PL168671B1 (pl) 1991-04-15 1992-04-14 Sposób wytwarzania nowych 1-(pirydo/3,4-b/-1,4-oksazinylo-4-ilo)-1 H-indoli PL PL PL

Country Status (22)

Country Link
US (3) US5214038A (cg-RX-API-DMAC7.html)
EP (1) EP0509400B1 (cg-RX-API-DMAC7.html)
JP (1) JP2608359B2 (cg-RX-API-DMAC7.html)
KR (1) KR100201509B1 (cg-RX-API-DMAC7.html)
AT (1) ATE140006T1 (cg-RX-API-DMAC7.html)
AU (1) AU643135B2 (cg-RX-API-DMAC7.html)
CA (1) CA2065986C (cg-RX-API-DMAC7.html)
CZ (1) CZ282054B6 (cg-RX-API-DMAC7.html)
DE (1) DE69211892T2 (cg-RX-API-DMAC7.html)
DK (1) DK0509400T3 (cg-RX-API-DMAC7.html)
ES (1) ES2094840T3 (cg-RX-API-DMAC7.html)
FI (1) FI97544C (cg-RX-API-DMAC7.html)
GR (1) GR3020612T3 (cg-RX-API-DMAC7.html)
HU (1) HUT62588A (cg-RX-API-DMAC7.html)
IE (1) IE74907B1 (cg-RX-API-DMAC7.html)
IL (1) IL101589A (cg-RX-API-DMAC7.html)
NO (1) NO301765B1 (cg-RX-API-DMAC7.html)
NZ (2) NZ248131A (cg-RX-API-DMAC7.html)
PL (1) PL168671B1 (cg-RX-API-DMAC7.html)
RU (1) RU2042680C1 (cg-RX-API-DMAC7.html)
TW (1) TW211016B (cg-RX-API-DMAC7.html)
ZA (1) ZA922721B (cg-RX-API-DMAC7.html)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5360811A (en) * 1990-03-13 1994-11-01 Hoechst-Roussel Pharmaceuticals Incorporated 1-alkyl-, 1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols and related compounds as anti-inflammatory agents
US5264442A (en) * 1990-08-13 1993-11-23 Hoechst-Roussel Pharmaceuticals Incorporated Carbamoyl-1-(pyridinylalkyl)-1H-indoles, indolines and related analogs
GB9225859D0 (en) * 1992-12-11 1993-02-03 Smithkline Beecham Plc Novel treatment
US5356910A (en) * 1993-07-19 1994-10-18 Hoechst-Roussel Pharmaceuticals Inc. Use of N-(pyridinyl)-1H-indol-1-amines for the treatment of obsessive-compulsive disorder
GB9521680D0 (en) * 1995-10-23 1996-01-03 Orion Yhtymo Oy New use of imidazole derivatives
GB0119435D0 (en) * 2001-02-15 2001-10-03 Aventis Pharm Prod Inc Method of treating of demyelinating diseases or conditions
WO2003022813A1 (en) * 2001-09-07 2003-03-20 Ono Pharmaceutical Co., Ltd. Indole derivatives, process for producing the same and drugs containing the same as the active ingredient
GT200500063A (es) * 2004-04-01 2005-10-14 Metodo para tratar la esquizofrenia y/o anormalidades glucoregulatorias
JP5597649B2 (ja) 2009-01-28 2014-10-01 カルス セラピューティクス リミテッド スクリプタイドアイソスター（ｓｃｒｉｐｔａｉｄｉｓｏｓｔｅｒｅｓ）およびその治療における使用
NZ707366A (en) * 2012-11-07 2018-11-30 Karus Therapeutics Ltd Novel histone deacetylase inhibitors and their use in therapy
NZ714283A (en) 2013-05-10 2020-04-24 Karus Therapeutics Ltd Novel histone deacetylase inhibitors
GB201419228D0 (en) 2014-10-29 2014-12-10 Karus Therapeutics Ltd Compounds
GB201419264D0 (en) 2014-10-29 2014-12-10 Karus Therapeutics Ltd Compounds
UA127629C2 (uk) * 2018-08-13 2023-11-08 Ф. Хоффманн-Ля Рош Аг Нові гетероциклічні сполуки як інгібітори моноацилгліцеролліпази
MX2022002311A (es) 2019-09-12 2022-03-25 Hoffmann La Roche Compuestos de 4,4a,5,7,8,8a-hexapirido[4,3-b][1,4]oxazin-3-ona como inhibidores de monoacilglicerol lipasa (magl).

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4029657A (en) * 1976-06-14 1977-06-14 The Dow Chemical Company 6,7-Dichloro-3,4-dihydro-2H-pyrazino(2,3-B)(1,4)oxazines
DE2726437A1 (de) * 1977-06-11 1978-12-21 Bayer Ag Hydrazonfarbstoffe
US5039811A (en) * 1987-04-24 1991-08-13 Hoechst-Roussel Pharmaceuticals Inc. Preparation of N-(pyridinyl)-1H-indol-1-amines
ATE115143T1 (de) * 1987-04-24 1994-12-15 Hoechst Roussel Pharma N-(pyridinyl)-1h-indol-1-amine, verfahren zu deren herstellung und ihre verwendung als arzneimittel.
US4880822A (en) * 1987-04-24 1989-11-14 Hoechst-Roussel Pharmaceuticals, Inc. N-(pyridinyl)-1H-indol-1-amines
US4970218A (en) * 1987-04-24 1990-11-13 Hoechst-Roussel Pharmaceuticals Inc. N-(pyridinyl)-1H-indol-1-amines
US4916135A (en) * 1989-05-08 1990-04-10 Hoechst Roussel Pharmaceuticals Inc. N-heteroaryl-4-quinolinamines
US5006537A (en) * 1989-08-02 1991-04-09 Hoechst-Roussel Pharmaceuticals, Inc. 1,3-dihydro-1-(pyridinylamino)-2H-indol-2-ones
DE69016531T2 (de) * 1989-08-02 1995-07-06 Hoechst Roussel Pharma 2,3-Dihydro-1-(pyridinylamino)-indole, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel.
US4983608A (en) * 1989-09-05 1991-01-08 Hoechst-Roussell Pharmaceuticals, Inc. N-substituted-4-pyrimidinamines and pyrimidinediamines

Also Published As

Publication number Publication date
US5276156A (en) 1994-01-04
US5214038A (en) 1993-05-25
KR920019796A (ko) 1992-11-20
IL101589A0 (en) 1992-12-30
CA2065986A1 (en) 1992-10-16
EP0509400B1 (en) 1996-07-03
DE69211892T2 (de) 1996-12-19
IL101589A (en) 1996-10-31
IE74907B1 (en) 1997-08-13
HU9201290D0 (en) 1992-07-28
AU643135B2 (en) 1993-11-04
IE921190A1 (en) 1992-10-21
RU2042680C1 (ru) 1995-08-27
DK0509400T3 (da) 1996-10-28
FI921641A7 (fi) 1992-10-16
CA2065986C (en) 2006-02-21
GR3020612T3 (en) 1996-10-31
DE69211892D1 (de) 1996-08-08
US5519131A (en) 1996-05-21
FI97544C (fi) 1997-01-10
NO301765B1 (no) 1997-12-08
ZA922721B (en) 1992-11-25
FI97544B (fi) 1996-09-30
KR100201509B1 (ko) 1999-06-15
JP2608359B2 (ja) 1997-05-07
ES2094840T3 (es) 1997-02-01
NO921490L (no) 1992-10-16
HUT62588A (en) 1993-05-28
ATE140006T1 (de) 1996-07-15
JPH05112572A (ja) 1993-05-07
CZ282054B6 (cs) 1997-05-14
NO921490D0 (no) 1992-04-14
AU1485292A (en) 1992-10-22
NZ242309A (en) 1995-07-26
TW211016B (cg-RX-API-DMAC7.html) 1993-08-11
PL294221A1 (en) 1993-08-09
EP0509400A1 (en) 1992-10-21
NZ248131A (en) 1995-07-26
FI921641A0 (fi) 1992-04-13
CS113592A3 (en) 1992-11-18

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