DK0509400T3 - 1-(Pyrido(3,4-b)-1,4-oxazinyl-4-yl)-1H-indoler, mellemprodukter og en fremgangsmåde til deres fremstiling, og deres anvendelse som lægemidler - Google Patents

1-(Pyrido(3,4-b)-1,4-oxazinyl-4-yl)-1H-indoler, mellemprodukter og en fremgangsmåde til deres fremstiling, og deres anvendelse som lægemidler

Info

Publication number
DK0509400T3
DK0509400T3 DK92106160.2T DK92106160T DK0509400T3 DK 0509400 T3 DK0509400 T3 DK 0509400T3 DK 92106160 T DK92106160 T DK 92106160T DK 0509400 T3 DK0509400 T3 DK 0509400T3
Authority
DK
Denmark
Prior art keywords
loweralkyl
hydrogen
chem
oxazinyl
indoles
Prior art date
Application number
DK92106160.2T
Other languages
English (en)
Inventor
Richard Charles Effland
Larry Davis
Gordon Edward Olsen
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Application granted granted Critical
Publication of DK0509400T3 publication Critical patent/DK0509400T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
DK92106160.2T 1991-04-15 1992-04-09 1-(Pyrido(3,4-b)-1,4-oxazinyl-4-yl)-1H-indoler, mellemprodukter og en fremgangsmåde til deres fremstiling, og deres anvendelse som lægemidler DK0509400T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/684,758 US5214038A (en) 1991-04-15 1991-04-15 1-(pyrido[3,4-b]-1,4-oxazinyl-4-yl)-1H-indoles and intermediates for the preparation thereof

Publications (1)

Publication Number Publication Date
DK0509400T3 true DK0509400T3 (da) 1996-10-28

Family

ID=24749434

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92106160.2T DK0509400T3 (da) 1991-04-15 1992-04-09 1-(Pyrido(3,4-b)-1,4-oxazinyl-4-yl)-1H-indoler, mellemprodukter og en fremgangsmåde til deres fremstiling, og deres anvendelse som lægemidler

Country Status (22)

Country Link
US (3) US5214038A (da)
EP (1) EP0509400B1 (da)
JP (1) JP2608359B2 (da)
KR (1) KR100201509B1 (da)
AT (1) ATE140006T1 (da)
AU (1) AU643135B2 (da)
CA (1) CA2065986C (da)
CZ (1) CZ282054B6 (da)
DE (1) DE69211892T2 (da)
DK (1) DK0509400T3 (da)
ES (1) ES2094840T3 (da)
FI (1) FI97544C (da)
GR (1) GR3020612T3 (da)
HU (1) HUT62588A (da)
IE (1) IE74907B1 (da)
IL (1) IL101589A (da)
NO (1) NO301765B1 (da)
NZ (2) NZ248131A (da)
PL (1) PL168671B1 (da)
RU (1) RU2042680C1 (da)
TW (1) TW211016B (da)
ZA (1) ZA922721B (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5360811A (en) * 1990-03-13 1994-11-01 Hoechst-Roussel Pharmaceuticals Incorporated 1-alkyl-, 1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols and related compounds as anti-inflammatory agents
US5264442A (en) * 1990-08-13 1993-11-23 Hoechst-Roussel Pharmaceuticals Incorporated Carbamoyl-1-(pyridinylalkyl)-1H-indoles, indolines and related analogs
GB9225859D0 (en) * 1992-12-11 1993-02-03 Smithkline Beecham Plc Novel treatment
US5356910A (en) * 1993-07-19 1994-10-18 Hoechst-Roussel Pharmaceuticals Inc. Use of N-(pyridinyl)-1H-indol-1-amines for the treatment of obsessive-compulsive disorder
GB0119435D0 (en) * 2001-02-15 2001-10-03 Aventis Pharm Prod Inc Method of treating of demyelinating diseases or conditions
WO2003022813A1 (fr) * 2001-09-07 2003-03-20 Ono Pharmaceutical Co., Ltd. Derives indole, methode de fabrication et medicaments renfermant lesdits derives en tant que principe actif
GT200500063A (es) * 2004-04-01 2005-10-14 Metodo para tratar la esquizofrenia y/o anormalidades glucoregulatorias
CN102333761B (zh) 2009-01-28 2017-12-19 卡鲁斯治疗有限公司 Scriptaid电子等排体及其在治疗中的用途
AU2013343291B2 (en) * 2012-11-07 2018-05-10 Karus Therapeutics Ltd Novel histone deacetylase inhibitors and their use in therapy
US9862685B2 (en) 2013-05-10 2018-01-09 Karus Therapeutics Limited Histone deacetylase inhibitors
GB201419228D0 (en) 2014-10-29 2014-12-10 Karus Therapeutics Ltd Compounds
GB201419264D0 (en) 2014-10-29 2014-12-10 Karus Therapeutics Ltd Compounds
MX2021001433A (es) 2018-08-13 2021-04-12 Hoffmann La Roche Nuevos compuestos heterociclicos como inhibidores de la monoacilglicerol lipasa.
CN114269755A (zh) 2019-09-12 2022-04-01 豪夫迈·罗氏有限公司 作为magl抑制剂的4,4a,5,7,8,8a-六吡啶并[4,3-b][1,4]噁嗪-3-酮化合物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4029657A (en) * 1976-06-14 1977-06-14 The Dow Chemical Company 6,7-Dichloro-3,4-dihydro-2H-pyrazino(2,3-B)(1,4)oxazines
DE2726437A1 (de) * 1977-06-11 1978-12-21 Bayer Ag Hydrazonfarbstoffe
US5039811A (en) * 1987-04-24 1991-08-13 Hoechst-Roussel Pharmaceuticals Inc. Preparation of N-(pyridinyl)-1H-indol-1-amines
US4970218A (en) * 1987-04-24 1990-11-13 Hoechst-Roussel Pharmaceuticals Inc. N-(pyridinyl)-1H-indol-1-amines
EP0287982B1 (en) * 1987-04-24 1994-12-07 Hoechst-Roussel Pharmaceuticals Incorporated N-(Pyridinyl)-1H-indol-1-amines, a process for their preparation and their use as medicaments
US4880822A (en) * 1987-04-24 1989-11-14 Hoechst-Roussel Pharmaceuticals, Inc. N-(pyridinyl)-1H-indol-1-amines
US4916135A (en) * 1989-05-08 1990-04-10 Hoechst Roussel Pharmaceuticals Inc. N-heteroaryl-4-quinolinamines
US5006537A (en) * 1989-08-02 1991-04-09 Hoechst-Roussel Pharmaceuticals, Inc. 1,3-dihydro-1-(pyridinylamino)-2H-indol-2-ones
ATE118002T1 (de) * 1989-08-02 1995-02-15 Hoechst Roussel Pharma 2,3-dihydro-1-(pyridinylamino)-indole, verfahren zu ihrer herstellung und ihre anwendung als arzneimittel.
US4983608A (en) * 1989-09-05 1991-01-08 Hoechst-Roussell Pharmaceuticals, Inc. N-substituted-4-pyrimidinamines and pyrimidinediamines

Also Published As

Publication number Publication date
JPH05112572A (ja) 1993-05-07
NO921490L (no) 1992-10-16
NZ242309A (en) 1995-07-26
US5519131A (en) 1996-05-21
ATE140006T1 (de) 1996-07-15
FI921641A0 (fi) 1992-04-13
DE69211892T2 (de) 1996-12-19
CZ282054B6 (cs) 1997-05-14
PL168671B1 (pl) 1996-03-29
IE921190A1 (en) 1992-10-21
DE69211892D1 (de) 1996-08-08
GR3020612T3 (en) 1996-10-31
IL101589A (en) 1996-10-31
PL294221A1 (en) 1993-08-09
CA2065986A1 (en) 1992-10-16
KR100201509B1 (ko) 1999-06-15
FI97544B (fi) 1996-09-30
US5214038A (en) 1993-05-25
EP0509400A1 (en) 1992-10-21
RU2042680C1 (ru) 1995-08-27
US5276156A (en) 1994-01-04
HU9201290D0 (en) 1992-07-28
TW211016B (da) 1993-08-11
NO921490D0 (no) 1992-04-14
NZ248131A (en) 1995-07-26
HUT62588A (en) 1993-05-28
ES2094840T3 (es) 1997-02-01
EP0509400B1 (en) 1996-07-03
KR920019796A (ko) 1992-11-20
ZA922721B (en) 1992-11-25
CA2065986C (en) 2006-02-21
IE74907B1 (en) 1997-08-13
AU1485292A (en) 1992-10-22
NO301765B1 (no) 1997-12-08
FI97544C (fi) 1997-01-10
JP2608359B2 (ja) 1997-05-07
AU643135B2 (en) 1993-11-04
IL101589A0 (en) 1992-12-30
CS113592A3 (en) 1992-11-18
FI921641A (fi) 1992-10-16

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