FI921641A - Menetelmä lääkeaineina käyttökelpoisten 1-(pyrido/3,4-b/-1,4-oksatsin-4-yyli)-1H-indolien valmistamiseksi - Google Patents

Menetelmä lääkeaineina käyttökelpoisten 1-(pyrido/3,4-b/-1,4-oksatsin-4-yyli)-1H-indolien valmistamiseksi Download PDF

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Publication number
FI921641A
FI921641A FI921641A FI921641A FI921641A FI 921641 A FI921641 A FI 921641A FI 921641 A FI921641 A FI 921641A FI 921641 A FI921641 A FI 921641A FI 921641 A FI921641 A FI 921641A
Authority
FI
Finland
Prior art keywords
loweralkyl
hydrogen
chem
oxazin
indoles
Prior art date
Application number
FI921641A
Other languages
English (en)
Swedish (sv)
Other versions
FI97544C (fi
FI921641A0 (fi
FI97544B (fi
Inventor
Richard Charles Effland
Larry Davis
Gordon Edward Olsen
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Publication of FI921641A0 publication Critical patent/FI921641A0/fi
Publication of FI921641A publication Critical patent/FI921641A/fi
Application granted granted Critical
Publication of FI97544B publication Critical patent/FI97544B/fi
Publication of FI97544C publication Critical patent/FI97544C/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FI921641A 1991-04-15 1992-04-13 Menetelmä lääkeaineina käyttökelpoisten 1-(pyrido/3,4-b/-1,4-oksatsin-4-yyli)-1H-indolien valmistamiseksi FI97544C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/684,758 US5214038A (en) 1991-04-15 1991-04-15 1-(pyrido[3,4-b]-1,4-oxazinyl-4-yl)-1H-indoles and intermediates for the preparation thereof
US68475891 1991-04-15

Publications (4)

Publication Number Publication Date
FI921641A0 FI921641A0 (fi) 1992-04-13
FI921641A true FI921641A (fi) 1992-10-16
FI97544B FI97544B (fi) 1996-09-30
FI97544C FI97544C (fi) 1997-01-10

Family

ID=24749434

Family Applications (1)

Application Number Title Priority Date Filing Date
FI921641A FI97544C (fi) 1991-04-15 1992-04-13 Menetelmä lääkeaineina käyttökelpoisten 1-(pyrido/3,4-b/-1,4-oksatsin-4-yyli)-1H-indolien valmistamiseksi

Country Status (22)

Country Link
US (3) US5214038A (fi)
EP (1) EP0509400B1 (fi)
JP (1) JP2608359B2 (fi)
KR (1) KR100201509B1 (fi)
AT (1) ATE140006T1 (fi)
AU (1) AU643135B2 (fi)
CA (1) CA2065986C (fi)
CZ (1) CZ282054B6 (fi)
DE (1) DE69211892T2 (fi)
DK (1) DK0509400T3 (fi)
ES (1) ES2094840T3 (fi)
FI (1) FI97544C (fi)
GR (1) GR3020612T3 (fi)
HU (1) HUT62588A (fi)
IE (1) IE74907B1 (fi)
IL (1) IL101589A (fi)
NO (1) NO301765B1 (fi)
NZ (2) NZ242309A (fi)
PL (1) PL168671B1 (fi)
RU (1) RU2042680C1 (fi)
TW (1) TW211016B (fi)
ZA (1) ZA922721B (fi)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5360811A (en) * 1990-03-13 1994-11-01 Hoechst-Roussel Pharmaceuticals Incorporated 1-alkyl-, 1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols and related compounds as anti-inflammatory agents
US5264442A (en) * 1990-08-13 1993-11-23 Hoechst-Roussel Pharmaceuticals Incorporated Carbamoyl-1-(pyridinylalkyl)-1H-indoles, indolines and related analogs
GB9225859D0 (en) * 1992-12-11 1993-02-03 Smithkline Beecham Plc Novel treatment
US5356910A (en) * 1993-07-19 1994-10-18 Hoechst-Roussel Pharmaceuticals Inc. Use of N-(pyridinyl)-1H-indol-1-amines for the treatment of obsessive-compulsive disorder
GB0119435D0 (en) * 2001-02-15 2001-10-03 Aventis Pharm Prod Inc Method of treating of demyelinating diseases or conditions
JP4292402B2 (ja) * 2001-09-07 2009-07-08 小野薬品工業株式会社 インドール誘導体化合物、それらの製造方法およびそれらを有効成分として含有する薬剤
GT200500063A (es) * 2004-04-01 2005-10-14 Metodo para tratar la esquizofrenia y/o anormalidades glucoregulatorias
US8748458B2 (en) 2009-01-28 2014-06-10 Karus Therapeutics Limited Scriptaid isosteres and their use in therapy
WO2014072714A1 (en) * 2012-11-07 2014-05-15 Karus Therapeutics Ltd Novel histone deacetylase inhibitors and their use in therapy
AU2014264370B2 (en) 2013-05-10 2017-12-14 Karus Therapeutics Ltd Novel histone deacetylase inhibitors
GB201419228D0 (en) 2014-10-29 2014-12-10 Karus Therapeutics Ltd Compounds
GB201419264D0 (en) 2014-10-29 2014-12-10 Karus Therapeutics Ltd Compounds
KR20210045992A (ko) 2018-08-13 2021-04-27 에프. 호프만-라 로슈 아게 모노아실글리세롤 리파제 저해제로서의 신규 헤테로시클릭 화합물
CA3151516A1 (en) 2019-09-12 2021-03-18 F. Hoffmann-La Roche Ag 4,4a,5,7,8,8a-hexapyrido[4,3-b][1,4]oxazin-3-one compounds as magl inhibitors

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4029657A (en) * 1976-06-14 1977-06-14 The Dow Chemical Company 6,7-Dichloro-3,4-dihydro-2H-pyrazino(2,3-B)(1,4)oxazines
DE2726437A1 (de) * 1977-06-11 1978-12-21 Bayer Ag Hydrazonfarbstoffe
US4970218A (en) * 1987-04-24 1990-11-13 Hoechst-Roussel Pharmaceuticals Inc. N-(pyridinyl)-1H-indol-1-amines
EP0287982B1 (en) * 1987-04-24 1994-12-07 Hoechst-Roussel Pharmaceuticals Incorporated N-(Pyridinyl)-1H-indol-1-amines, a process for their preparation and their use as medicaments
US4880822A (en) * 1987-04-24 1989-11-14 Hoechst-Roussel Pharmaceuticals, Inc. N-(pyridinyl)-1H-indol-1-amines
US5039811A (en) * 1987-04-24 1991-08-13 Hoechst-Roussel Pharmaceuticals Inc. Preparation of N-(pyridinyl)-1H-indol-1-amines
US4916135A (en) * 1989-05-08 1990-04-10 Hoechst Roussel Pharmaceuticals Inc. N-heteroaryl-4-quinolinamines
US5006537A (en) * 1989-08-02 1991-04-09 Hoechst-Roussel Pharmaceuticals, Inc. 1,3-dihydro-1-(pyridinylamino)-2H-indol-2-ones
EP0415103B1 (en) * 1989-08-02 1995-02-01 Hoechst-Roussel Pharmaceuticals Incorporated 2,3-Dihydro-1-(pyridinylamino)-indoles, a process for their preparation and their use as medicaments
US4983608A (en) * 1989-09-05 1991-01-08 Hoechst-Roussell Pharmaceuticals, Inc. N-substituted-4-pyrimidinamines and pyrimidinediamines

Also Published As

Publication number Publication date
US5276156A (en) 1994-01-04
EP0509400B1 (en) 1996-07-03
CA2065986C (en) 2006-02-21
US5519131A (en) 1996-05-21
TW211016B (fi) 1993-08-11
EP0509400A1 (en) 1992-10-21
CZ282054B6 (cs) 1997-05-14
ZA922721B (en) 1992-11-25
IE921190A1 (en) 1992-10-21
JP2608359B2 (ja) 1997-05-07
DK0509400T3 (da) 1996-10-28
PL168671B1 (pl) 1996-03-29
AU643135B2 (en) 1993-11-04
ES2094840T3 (es) 1997-02-01
FI97544C (fi) 1997-01-10
IL101589A0 (en) 1992-12-30
KR100201509B1 (ko) 1999-06-15
NO921490L (no) 1992-10-16
NO921490D0 (no) 1992-04-14
NZ242309A (en) 1995-07-26
FI921641A0 (fi) 1992-04-13
FI97544B (fi) 1996-09-30
HUT62588A (en) 1993-05-28
ATE140006T1 (de) 1996-07-15
NO301765B1 (no) 1997-12-08
IE74907B1 (en) 1997-08-13
US5214038A (en) 1993-05-25
KR920019796A (ko) 1992-11-20
AU1485292A (en) 1992-10-22
CA2065986A1 (en) 1992-10-16
DE69211892T2 (de) 1996-12-19
RU2042680C1 (ru) 1995-08-27
HU9201290D0 (en) 1992-07-28
NZ248131A (en) 1995-07-26
DE69211892D1 (de) 1996-08-08
GR3020612T3 (en) 1996-10-31
IL101589A (en) 1996-10-31
JPH05112572A (ja) 1993-05-07
CS113592A3 (en) 1992-11-18
PL294221A1 (en) 1993-08-09

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Legal Events

Date Code Title Description
BB Publication of examined application
PC Transfer of assignment of patent

Owner name: HOECHST MARION ROUSSEL, INC.

PC Transfer of assignment of patent

Owner name: AVENTIS PHARMACEUTICALS INC.